Abstract：
:The expense in time and money limit the use of randomized clinical trials (RCT) and cohort studies for evaluating long-term AIDS treatment outcomes. We conducted a case-control study to characterize predictors of AIDS mortality after the availability of highly active antiretroviral therapy (HAART) in San Francisco, in which cases were matched with controls on stage of disease, year of AIDS diagnosis and year of HAART initiation. Overall, 266 cases and 1173 controls were included, representing >90% of eligible patients. The class of initial HAART regimen was not associated with mortality. Predictors of mortality were older age ([adjusted odds ratio] AOR 1.23, 95% [confidence interval] CI: 1.13-1.35), public versus private health insurance (AOR 2.80, 95% CI: 1.77-4.42), no versus private insurance (AOR 1.45, 95% CI: 1.02-2.07) and unboosted saquinavir (AOR 2.50, 95% CI: 1.34-4.65). Survival benefit was found in following the 2004 US Department of Health and Human Services preferred treatment guidelines; borderline survival benefits were found in following the guidelines from other years. Similar predictors were found for all-cause and AIDS-specific mortality. Our findings mirrored those of RCT and multi-centre cohort studies, and may be applicable to other settings. Our findings support similar survival benefit to persons initiating HAART with non-nucleoside reverse transcriptase inhibitor- or protease inhibitor-based regimens.
journal_name
Int J STD AIDSjournal_title
International journal of STD & AIDSauthors
Chen SY,Moss WJ,Pipkin SS,McFarland Wdoi
10.1258/ijsa.2008.008381subject
Has Abstractpub_date
2009-05-01 00:00:00pages
330-5issue
5eissn
0956-4624issn
1758-1052pii
20/5/330journal_volume
20pub_type
杂志文章abstract：:Adolescents in Africa are at high risk for HIV infection, other sexually transmitted infections (STIs) and bacterial vaginosis (BV). Since behavior and burden of STIs/BV may influence HIV risk, behavioral risk factors and prevalence of STIs/BV were compared in HIV-seronegative adolescent females (n = 298; 16-22 years)...
journal_title：International journal of STD & AIDS
pub_type： 杂志文章
doi：10.1177/0956462417740487
更新日期：2018-05-01 00:00:00
abstract：:Forty asymptomatic HIV-infected individuals with CD4+ lymphocyte levels above 400x10(6)/l were immunized over 5 years with recombinant envelope glycoprotein gp160 (rgp160). After 5 years there was a trend towards more non-progressors in the immunized group as compared to the matched controls. Since immunizations could...
journal_title：International journal of STD & AIDS
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1999-08-01 00:00:00
abstract：:The aim of this revision is to evaluate ethnicity and gender rate of enrolment in registrative clinical trials of the protease inhibitors (Pls) from 1996 to 2009. Company-sponsored, phase II or III registrative clinical trials of PIs were evaluated. Forty-nine clinical trials were included. Clinical trials were conduc...
journal_title：International journal of STD & AIDS
pub_type： 杂志文章,评审
doi：10.1258/ijsa.2012.012047
更新日期：2012-12-01 00:00:00
abstract：:The brain gumma is a rare manifestation of the tertiary stage of syphilis. A case of neurosyphilitic gumma was confirmed by the Treponema pallidum polymerase chain reaction in a 46-year-old HIV-positive homosexual man. The patient presented with a severe headache and was hospitalized. A computed tomography scan was pe...
journal_title：International journal of STD & AIDS
pub_type： 杂志文章
doi：10.1258/ijsa.2007.007287
更新日期：2008-08-01 00:00:00
abstract：:Public health authorities have long believed that the preponderance of AIDS cases in Africa are attributable to 'heterosexual transmission'; most people silently assume this rubric to indicate penile-vaginal intercourse only. Recent epidemiologic analyses suggest that the majority of HIV cases in sub-Saharan Africa ma...
journal_title：International journal of STD & AIDS
pub_type： 杂志文章,评审
doi：10.1258/095646203322025704
更新日期：2003-07-01 00:00:00
abstract：:High annual figures of sexually transmitted infections (STIs) are diagnosed in the Netherlands despite significant efforts to control them. Herein, we analyse trends and determinants of STI diagnoses, co-infections, and sexual risks among visitors of 26 STI clinics between 2007 and 2011. We recorded increased positivi...
journal_title：International journal of STD & AIDS
pub_type： 杂志文章
doi：10.1177/0956462413491736
更新日期：2014-01-01 00:00:00
abstract：:This unique report describes a fatal case of immune reconstitution syndrome associated with Kaposi's sarcoma (KS). This case also illustrates the possibility of cryptic visceral KS with minimal cutaneous disease, as well as the potential for differential responses of cutaneous and visceral KS to treatment. ...
journal_title：International journal of STD & AIDS
pub_type： 杂志文章
doi：10.1258/0956462052932647
更新日期：2005-01-01 00:00:00
abstract：:In the ARTEMIS trial, 689 treatment-naïve, HIV-1-infected adults received darunavir/ritonavir (DRV/r) 800/100 mg every day or lopinavir/ritonavir (LPV/r) 800/200 mg total daily dose plus fixed-dose tenofovir/emtricitabine. Week 96 metabolic parameters are reported. Adverse events (AEs) classed as metabolism/nutrition ...
journal_title：International journal of STD & AIDS
pub_type： 杂志文章,随机对照试验
doi：10.1258/ijsa.2012.012120
更新日期：2013-01-01 00:00:00
abstract：:This study compared the distributions of known human immunodeficiency virus (HIV) and acute hepatitis B virus (HBV) infection among drug injectors in Glasgow over a 3.5 year period. Data were obtained from all relevant laboratory request forms submitted to Glasgow's 3 virology laboratories during the period 1 January ...
journal_title：International journal of STD & AIDS
pub_type： 杂志文章
doi：10.1177/095646249100200509
更新日期：1991-09-01 00:00:00
abstract：:Australian and New South Wales Sexually Transmissible Infections Strategies recommend sexual health clinics actively target particular populations, including men who have sex with men (MSM), who have increasing rates of sexually transmitted infections (STIs). We describe trends in MSM attendances, STI testing and diag...
journal_title：International journal of STD & AIDS
pub_type： 杂志文章
doi：10.1258/ijsa.2010.010458
更新日期：2011-06-01 00:00:00
abstract：:We present the case of a 58-year-old HIV-infected patient with adrenal insufficiency after local injection of triamcinolone, most likely due to drug-drug interaction with his ritonavir-boosted antiretroviral therapy (ART). This is the first case of adrenal insufficiency occurring without prior symptoms of Cushing's sy...
journal_title：International journal of STD & AIDS
pub_type： 杂志文章
doi：10.1177/0956462418768689
更新日期：2018-11-01 00:00:00
abstract：:The copper intrauterine contraceptive device (IUCD) is strongly associated with bacterial vaginosis (BV). Hormonal influences may play a role in the control of vaginal flora. It is unclear whether use of the progesterone-incorporated intrauterine system (IUS; Mirena) is associated with abnormal vaginal flora or genita...
journal_title：International journal of STD & AIDS
pub_type： 临床试验,杂志文章
doi：10.1258/ijsa.2008.008391
更新日期：2009-06-01 00:00:00
abstract：:Requests for hepatitis C antibodies (HCV Ab) made by the Oxford Department of Genito-urinary (GU) Medicine were audited against national guidelines to determine how the service performed and to develop locally applicable standards. This resulted in more effective screening and cost savings. ...
journal_title：International journal of STD & AIDS
pub_type： 杂志文章
doi：10.1258/095646206777689026
更新日期：2006-07-01 00:00:00
abstract：:Little information is available on the prevalence of herpes simplex type-2 (HSV-2) antibodies among groups at potential high risk of HIV in Asia. This study was carried out to determine the prevalence of HSV-2 antibodies and correlates of HSV-2 infection in female sex workers (FSWs) in border provinces of Vietnam. Nin...
journal_title：International journal of STD & AIDS
pub_type： 杂志文章
doi：10.1258/095646206778691176
更新日期：2006-11-01 00:00:00
abstract：:Successful cervical screening programmes depend on the participation of an informed target population. A national cervical screening programme is shortly to be introduced in the Republic of Ireland. We compare the knowledge, attitudes and practice of 395 Irish urban women with 323 high-risk women, genitourinary medici...
journal_title：International journal of STD & AIDS
pub_type： 杂志文章
doi：10.1258/0956462011916974
更新日期：2001-03-01 00:00:00
abstract：:Genital elephantiasis is an important medical problem in the tropics. It usually affects young and productive age group, and is associated with physical disability and extreme mental anguish. The majority of cases are due to filariasis; however, a small but significant proportion of patients develop genital elephantia...
journal_title：International journal of STD & AIDS
pub_type： 杂志文章,评审
doi：10.1258/095646206775809150
更新日期：2006-03-01 00:00:00
abstract：:Adolescents are at high risk for HIV acquisition, and thus need to be included in HIV vaccine trials. In preparation for inclusion of adolescents in HIV vaccine trials in an urban community in Cape Town with a high antenatal HIV prevalence, the study assessed the attitudes towards the inclusion of adolescents in HIV v...
journal_title：International journal of STD & AIDS
pub_type： 杂志文章
doi：10.1258/ijsa.2009.008484
更新日期：2010-03-01 00:00:00
abstract：:A 46-year-old Caucasian heterosexual male was referred to a dedicated AIN clinic from colorectal multidisciplinary meeting (MDM) with AIN 3 following complete resection of anal squamous cell carcinoma (SCC). On further questioning, he revealed that he also had a lesion on his penis. Histology of the penile lesion demo...
journal_title：International journal of STD & AIDS
pub_type： 杂志文章
doi：10.1258/ijsa.2011.011255
更新日期：2012-04-01 00:00:00
abstract：:The study was aimed at investigating the conditions and circumstances for the recruitment of prostitutes, as well as their reproductive history, working conditions, knowledge of and attitudes to sexually transmitted diseases (STDs), and use of prophylactic antibiotic therapy of these diseases. Two hundred prostitutes ...
journal_title：International journal of STD & AIDS
pub_type： 杂志文章
doi：10.1258/0956462971919697
更新日期：1997-03-01 00:00:00
abstract：:This study investigated the epidemiological and clinical characteristics of hepatitis B virus (HBV) in HIV-infected adults at the time of antiretroviral therapy (ART) initiation in Guangdong province, China. A total of 2793 HIV-infected adults were enrolled between January 2004 and September 2011. Demographic data and...
journal_title：International journal of STD & AIDS
pub_type： 杂志文章
doi：10.1177/0956462415600570
更新日期：2016-09-01 00:00:00
abstract：:A 41-year-old HIV-positive man who has sex with men (MSM) with a family history of deep vein thrombosis (DVT) presented to the emergency department with an acutely swollen lower limb. The initial clinical diagnosis was of a possible DVT and the patient was anticoagulated. However, investigations subsequently excluded ...
journal_title：International journal of STD & AIDS
pub_type： 杂志文章
doi：10.1258/ijsa.2011.011217
更新日期：2012-03-01 00:00:00
abstract：:Immune reconstitution inflammatory syndrome is a clinical entity with a broad presentation, described in both HIV and non-HIV-infected patients. We report a case of Mycobacterium avium-complex pericarditis as a rare but life-threatening manifestation of this syndrome in a patient with AIDS. ...
journal_title：International journal of STD & AIDS
pub_type： 杂志文章
doi：10.1177/0956462413495821
更新日期：2014-02-01 00:00:00
abstract：:This paper assesses the associations between intimate partner violence (IPV) and sexually transmitted infections (STIs) and sexual risks among HIV-positive female drinkers in St Petersburg, Russia. Survey and STI data were analysed from 285 women in HERMITAGE, a secondary prevention study of HIV-positive heavy drinker...
journal_title：International journal of STD & AIDS
pub_type： 杂志文章
doi：10.1177/0956462412472809
更新日期：2013-04-01 00:00:00
abstract：:Renal transplant recipients represent a patient subgroup for whom the effective treatment of genital warts poses a significant problem in genitourinary medicine. This case demonstrates the safe and effective treatment of resistant perianal warts in a male renal transplant recipient using imiquimod. ...
journal_title：International journal of STD & AIDS
pub_type： 杂志文章
doi：10.1258/0956462021925180
更新日期：2002-05-01 00:00:00
abstract：:Patients who acquire repeated infections of gonorrhoea are well described. A study was undertaken of male patients attending a central London clinic in an attempt to identify features of those acquiring repeated infections to facilitate risk reduction strategies. During the 3 years 1990 to 1992, 18.8% of patients cont...
journal_title：International journal of STD & AIDS
pub_type： 杂志文章
doi：10.1258/0956462961917807
更新日期：1996-07-01 00:00:00
abstract：:Limited data exist on hepatitis B revaccination strategies for HIV-infected individuals who do not develop immunity after the first vaccination series. A retrospective cohort study was conducted to assess the immunogenicity of the second series of hepatitis B vaccine given in standard dosing (SD) and double dosing (DD...
journal_title：International journal of STD & AIDS
pub_type： 杂志文章
doi：10.1177/0956462415596498
更新日期：2016-09-01 00:00:00
abstract：:This study assessed lubricant use during receptive anal intercourse (RAI) among Peruvian men who have sex with men (MSM) and willingness to use a hypothetical rectal microbicide (RM) formulated as a lubricant to prevent HIV infection. Data were collected from 843 Peruvian MSM for the 2008 HIV Sentinel Surveillance usi...
journal_title：International journal of STD & AIDS
pub_type： 杂志文章
doi：10.1258/ijsa.2010.010134
更新日期：2010-08-01 00:00:00
abstract：:To follow the progression of HIV seropositivity among heterosexual adults at risk for HIV infection in the country of Rwanda prospectively, up to 100 patients with sexually transmitted diseases (STD) were tested each month from 1988 to 1991 at the health centre of Biryogo, which is located in a very crowded sector of ...
journal_title：International journal of STD & AIDS
pub_type： 杂志文章
doi：10.1177/095646249300400406
更新日期：1993-07-01 00:00:00
abstract：:During the mid-1980s Australia experienced a remarkable decline in HIV incidence that can rightly be considered a public health milestone of global importance. The effects of this decline lasted for about 20 years and greatly benefited all Australians. In contrast, as we enter the mid-2000s, we see the global epidemic...
journal_title：International journal of STD & AIDS
pub_type： 杂志文章,评审
doi：10.1258/095646206779307612
更新日期：2006-12-01 00:00:00
abstract：:The prevalence of gonorrhoea and urogenital chlamydial infection was investigated in female prostitutes in Tegucigalpa, Honduras. Epidemiological data were recorded according to a standardized questionnaire. The median age of the prostitutes was 27 years and the median period of prostitution was 2-4 years. Most of the...
journal_title：International journal of STD & AIDS
pub_type： 杂志文章
doi：10.1177/095646249100200309
更新日期：1991-05-01 00:00:00
