Abstract:
:The aim of this revision is to evaluate ethnicity and gender rate of enrolment in registrative clinical trials of the protease inhibitors (Pls) from 1996 to 2009. Company-sponsored, phase II or III registrative clinical trials of PIs were evaluated. Forty-nine clinical trials were included. Clinical trials were conducted in centres in North America (n = 39), Central-South America (n = 22), Europe (n = 22), Africa (n = 8), Asia (n = 5), Australia (n = 10). Overall mean age was 39.6 years; median proportion of women was 16.3%. The most represented ethnic group was Caucasian. A test for trend over time (1996-2009) shows a significant increase in the proportion of women included (P = 0.012), and a decrease in the proportion of Caucasians included, reaching borderline significance (P = 0.061). An inverse correlation was observed between the proportion of Caucasians and that of women enrolled in each study (r = -0.65, P < 0.0001). Women were less likely to be included in double-blind studies (11.2% versus 17%, P = 0.019). Clinical trials for treatment-naive subjects were more likely to enrol ethnicities other than Caucasian compared with Caucasian (44.7% versus 27.1%, respectively, P = 0.04). Rates of enrolment of minorities in registrative clinical trials for Pls show a positive trend since 1996, mirroring the growing number of people of different ethnic groups accessing ART.
journal_name
Int J STD AIDSjournal_title
International journal of STD & AIDSauthors
Seminari E,De Silvestri A,Scudeller L,Scotti V,Tinelli Cdoi
10.1258/ijsa.2012.012047subject
Has Abstractpub_date
2012-12-01 00:00:00pages
837-42issue
12eissn
0956-4624issn
1758-1052pii
23/12/837journal_volume
23pub_type
杂志文章,评审abstract::This study examined whether social vulnerability is associated with HIV testing among South African men who have sex with men (MSM). A community-based survey was conducted with 300 MSM in Pretoria in 2008. The sample was stratified by age, race and residential status. Social vulnerability was assessed using measures o...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/ijsa.2011.010350
更新日期:2011-12-01 00:00:00
abstract::We examined the association between education and prevalent HIV-1 infection in the Rakai district, rural Uganda based on a cross-sectional analysis of a population-based cohort. In 1990, 1397 men and 1705 women aged 13 years and older, were enrolled in 31 randomly selected communities. Strata were comprised of main ro...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/0956462991914456
更新日期:1999-07-01 00:00:00
abstract::Sub-Saharan Africa disproportionately represents the largest incidence of both HIV/AIDS and internal conflicts. The impact of conflict on HIV incidence is largely unknown. Current epidemiological evidence paradoxically suggests that in most populations affected by conflict, HIV prevalence is lower than surrounding com...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章,评审
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abstract::Sexual functioning is often neglected in the care of HIV-infected patients. Little information exists about the relationship between hormonal factors, psychological factors, medication, HIV disease stage and sexual functioning among persons with HIV disease. In this study, 50 HIV+ men completed the Derogatis Sexual Fu...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/0956462981921332
更新日期:1998-11-01 00:00:00
abstract::We aim to assess the usefulness of the cytomegalovirus (CMV) pp65 antigenaemia test, also called the CMV direct antigen test (DAT), in the management of patients with advanced human immunodeficiency virus (HIV) infection; we studied all patients who had pp65 assays between 8 September 1995 and 30 August 1996. Twenty-t...
journal_title:International journal of STD & AIDS
pub_type: 临床试验,杂志文章
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更新日期:1998-09-01 00:00:00
abstract::Our objectives were to determine the prevalence of Neisseria gonorrhoeae not fully sensitive to ciprofloxacin from a sexually transmitted infection (STI) clinic in London and where the isolates were acquired from. Data of antibiotic sensitivities of N. gonorrhoeae from 292 patients were reviewed over a 6-month period ...
journal_title:International journal of STD & AIDS
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doi:10.1258/0956462001915264
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abstract::It is important to assess uptake of a new vaccine. The present survey estimated the uptake of the recently introduced human papillomavirus vaccine (HPVV) in the emirate of Abu Dhabi and also explored barriers to uptake. A questionnaire survey was conducted in secondary schools, enrolling 334 girls. The uptake percenta...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/ijsa.2009.009380
更新日期:2011-07-01 00:00:00
abstract::Given the disproportionate HIV burden faced by female sex workers FSWs and limited data regarding their engagement in the HIV cascade of care in conflict-affected settings, we characterized the cascade of care and examined associations with new HIV diagnoses and antiretroviral therapy (ART) use in a community-based co...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1177/0956462418804658
更新日期:2019-03-01 00:00:00
abstract:SUMMARY:The objective of this study was to identify factors associated with (i) longer patient travel time to genitourinary (GU) medicine clinics and (ii) not attending the nearest clinic. Questionnaires were completed by 4600 new attendees from seven sociodemographically and geographically different GU clinics across ...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/ijsa.2008.008205
更新日期:2008-12-01 00:00:00
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journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/095646206778145604
更新日期:2006-08-01 00:00:00
abstract::Over the Christmas and New Year period the Health Education Authority launched a sexual health promotion campaign aimed at increasing the awareness of and reducing the incidence of sexually transmitted infections (STIs) and unwanted pregnancy. We undertook a study to assess the effect of this campaign locally in 2 gen...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/0956462001916560
更新日期:2000-09-01 00:00:00
abstract::This is the case of a black African woman who presented with three distinct episodes of herpes simplex virus (HSV) infection unresponsive to first-line therapy. Clinical and virological resistance to aciclovir therapy was demonstrated, and although the first two episodes manifested as the deep ulceration often associa...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/095646207780132361
更新日期:2007-03-01 00:00:00
abstract::Sexually transmitted rectal infections with Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (GC) have been well documented in men who have sex with men (MSM). Few studies have described infections in women who engage in anal intercourse. We performed testing for rectal infections in women who reported ano-recepti...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/ijsa.2010.009279
更新日期:2010-12-01 00:00:00
abstract::Genitourinary (GU) medicine services are under increasing pressure due to increased workload. The Department of Health responded to this crisis by allocating pump-priming funding of ?5 million direct to GU medicine clinics in 2002-03. A survey was performed of all clinics in England to determine if funding was receive...
journal_title:International journal of STD & AIDS
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doi:10.1177/095646240401501004
更新日期:2004-10-01 00:00:00
abstract::Global data on cervical lesion incidence and progression in HIV-positive women are essential for understanding the natural history of cervical neoplasia and informing screening policy. A systematic review was performed summarizing the incidence and progression of cervical lesions in HIV-positive women. Of 5882 HIV-pos...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章,评审
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更新日期:2014-03-01 00:00:00
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journal_title:International journal of STD & AIDS
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更新日期:2018-09-01 00:00:00
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journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1177/0956462412472809
更新日期:2013-04-01 00:00:00
abstract::In Bambari and Bria, 2 towns in the Central African Republic (CAR), we analysed a patient-led partner referral programme within enhanced sexually transmitted disease (STD) services. New (index) patients received syndromic management, counselling about notifying and treating contacts, and vouchers for distribution. Fro...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:
更新日期:1999-06-01 00:00:00
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journal_title:International journal of STD & AIDS
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更新日期:2018-01-01 00:00:00
abstract::In a study to determine the herpes simplex virus (HSV) type isolated from patients with primary (first-attack) genital herpes and to identify any clinical or epidemiological features that might influence the reported incidence of any particular viral type, there was almost an equal incidence of HSV-1 and HSV-2 isolate...
journal_title:International journal of STD & AIDS
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journal_title:International journal of STD & AIDS
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journal_title:International journal of STD & AIDS
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更新日期:2008-05-01 00:00:00
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journal_title:International journal of STD & AIDS
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journal_title:International journal of STD & AIDS
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journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1177/095646249100200309
更新日期:1991-05-01 00:00:00
abstract::'Fuckbuddies' are a type of regular sexual partner with whom men have ongoing sexual contact, generally in the absence of romantic attachment. We surveyed 989 men who have sex with men (MSM) at the Melbourne Sexual Health Centre, Australia, with the aim of determining the frequency of 'fuckbuddy' partnerships among se...
journal_title:International journal of STD & AIDS
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abstract::Progression of lipodystrophy syndrome is a big challenge in HIV treatment. Nowadays, fat loss at the lower part of buttocks has become another problem as patients have started to complain that it is painful to be seated for a long time and/or on hard surfaces. We developed a method for buttock lipoatrophy treatment wi...
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journal_title:International journal of STD & AIDS
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更新日期:2012-06-01 00:00:00
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