Abstract:
:Detection of Haemophilus ducreyi in genital ulcer specimens by culture lacks sensitivity. To enhance detection, a heminested polymerase chain reaction (PCR) assay was developed targeting the nucleotide sequence of a gene, designated p27, which encodes for a 27 kDa H. ducreyi-specific protein. The p27 PCR assay detected all (37/37) H. ducreyi strains tested and gave no amplified product from DNA extracts of any of 31 other microorganisms, from 30 non-genital ulcer specimens, or from 29 urethral and vaginal swab specimens collected from non-chancroid STD patients. In genital ulcer disease specimens, compared to combined positive results obtained by culture and a previously described PCR assay, the p27 PCR assay showed a sensitivity of 91% (48/53). The p27 PCR assay provides a specific and a sensitive detection of H. ducreyi in clinical specimens.
journal_name
Int J STD AIDSjournal_title
International journal of STD & AIDSauthors
Tekle-Michael T,Van Dyck E,Abdellati S,Laga Mdoi
10.1258/0956462011924425subject
Has Abstractpub_date
2001-12-01 00:00:00pages
797-803issue
12eissn
0956-4624issn
1758-1052journal_volume
12pub_type
杂志文章abstract::Novel HIV testing strategies may improve the uptake of the test. The aim of the present study was to investigate the uptake of HIV testing during Birmingham Pride events in 2009 and 2010. The project was a collaboration between Whittall Street Clinic and Healthy Gay Life. This was a nurse-delivered service that was of...
journal_title:International journal of STD & AIDS
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