Abstract:
:Forty asymptomatic HIV-infected individuals with CD4+ lymphocyte levels above 400x10(6)/l were immunized over 5 years with recombinant envelope glycoprotein gp160 (rgp160). After 5 years there was a trend towards more non-progressors in the immunized group as compared to the matched controls. Since immunizations could activate HIV, the first 6 immunizations were followed by 2 weeks of zidovudine or placebo, double-blind. The viral load did not change during the first 6 months and was not different from that of the matched controls after 5 years. The best effect on CD4+ lymphocyte development was seen in individuals with a high viral load randomized to rgp160+zidovudine and in individuals with a low viral load randomized to rgp160+placebo. We conclude that rgp160 is safe and results in temporarily improved CD4+ development. Concomitant antiviral treatment might be of benefit, especially in patients with a more advanced disease and can today be given with more effective combinations.
journal_name
Int J STD AIDSjournal_title
International journal of STD & AIDSauthors
Bratt G,Eriksson LE,Sandström E,Gilljam G,Hinkula J,Albert J,Redfield R,Wahren Bsubject
Has Abstractpub_date
1999-08-01 00:00:00pages
514-21issue
8eissn
0956-4624issn
1758-1052journal_volume
10pub_type
临床试验,杂志文章,随机对照试验abstract::Sexual behavioural factors associated with gonococcal infection among 991 STD clinic attenders in Trinidad, West Indies (WI) were determined by univariate and stepwise multiple logistic regression analysis. Casual sex (odds ratios [OR] 1.6) was the only predictor of gonorrhoea. Among males, significant associations we...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/0956462021924479
更新日期:2002-01-01 00:00:00
abstract::Racial/ethnic minorities in the Southeastern USA are disproportionately affected by HIV, and would benefit from a preventive vaccine. We conducted a cross-sectional survey of 220 community college students in Atlanta to evaluate racial/ethnic differences in knowledge and willingness to participate in HIV vaccine trial...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/095646206775455667
更新日期:2006-02-01 00:00:00
abstract::Both herpes simplex virus type 2 (HSV-2) seroprevalence and the proportion of HSV-1 genital ulcers are increasing in industrialized countries. The consequences of these epidemiological changes, in pregnant women in France, for both the genital shedding of HSV and vertical transmission, have been poorly evaluated. The ...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/095646207781568457
更新日期:2007-09-01 00:00:00
abstract::HIV serodisclosure to sexual partners is an important aspect of HIV prevention, treatment, and care. We investigated the association between partnership duration and serodisclosure among HIV-infected individuals in Lilongwe, Malawi. We analyzed data from a cross-sectional study of individuals attending one of two anti...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1177/0956462418769730
更新日期:2018-09-01 00:00:00
abstract::The objective of this study was to assess the impact on men's liking for the condoms they use of a range of factors including demographic variables and variables that describe men's experience of using particular condoms. One hundred and ninety-four men used 3765 condoms for which they provided a liking rating. The co...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/0956462991913907
更新日期:1999-04-01 00:00:00
abstract::This study compared the distributions of known human immunodeficiency virus (HIV) and acute hepatitis B virus (HBV) infection among drug injectors in Glasgow over a 3.5 year period. Data were obtained from all relevant laboratory request forms submitted to Glasgow's 3 virology laboratories during the period 1 January ...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1177/095646249100200509
更新日期:1991-09-01 00:00:00
abstract::This guideline is intended to serve as a framework for those working in any location where sexually transmitted infections (STIs) are managed. It offers recommendations which will need to be adapted depending on local facilities and policies, and is not intended to be all encompassing. This guideline should be read in...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章,实务指引
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更新日期:2012-09-01 00:00:00
abstract::Antiretroviral treatment roll-out programmes in Africa often have difficulties to cope with the increasing number of clients. Based on the findings of a survey carried out in 2005 that showed long waiting times, innovative organizational changes (nurse visits and pharmacy-only refill visits) were introduced in our cli...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/ijsa.2008.008174
更新日期:2009-02-01 00:00:00
abstract::The incidence of anogenital warts (condyloma acuminatum) is rapidly increasing while there is still no totally satisfactory treatment available. In light of the emphasis of experimental approaches toward the prevention of viral replication and evidence of the antiviral action of lithium salts it was proposed to invest...
journal_title:International journal of STD & AIDS
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1258/0956462971920677
更新日期:1997-08-01 00:00:00
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journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1177/0956462420945940
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abstract::The objective was to investigate the financial situation of people living with HIV in Europe. Two surveys using an anonymous questionnaire were organized in Europe among people living with HIV, the first in 1996-97 and the second in 1998-99. One thousand one hundred and sixty-one people from the 1996-97 survey and 899...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/095646202760326453
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abstract::This paper describes the incidence of sexually transmitted infections (STIs) recorded in the Weekly Returns Service (WRS) between 1994 and 2001. There were approximately 76,500 new diagnoses of STIs (7500 males, 71,000 females) and associated syndromes. Candidiasis was the commonest condition reported in males and fem...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/095646206780070992
更新日期:2006-10-01 00:00:00
abstract::A 32-year-old HIV-infected woman developed fever and systemic illness of unknown origin after being placed on phenytoin for seizures. Her clinical syndrome, skin biopsy findings, and clinical response to steroids were consistent with phenytoin hypersensitivity syndrome. ...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/0956462053057648
更新日期:2005-02-01 00:00:00
abstract::Implementation of the National Chlamydia Screening Programme in Cornwall commenced in April 2003. Initially, women in community venues were screened using urine samples. However, many of these urine samples were inhibitory to polymerase chain reaction (PCR), resulting in a high recall rate for women in the programme. ...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/095646207779949619
更新日期:2007-02-01 00:00:00
abstract::Cases of syphilis have been increasing in the UK and it remains an important public health problem. Here, we provide an overview of syphilis, its presentation, diagnosis and management. ...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章,评审
doi:10.1258/ijsa.2007.007258
更新日期:2008-03-01 00:00:00
abstract::Influenza vaccination can reduce disease in HIV-infected children. The durability of the antibody response after trivalent influenza vaccine is important for management. The aim of this prospective study was to assess the durability of seroprotection for trivalent influenza vaccine strains and the factors effecting se...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1177/0956462415594061
更新日期:2016-08-01 00:00:00
abstract::All category III chronic prostatitis cases in two hospital sites were retrospectively reviewed from the year 2000 until 2005. The mean age of the patients was 38.7 years. Of these, 56.6% were St Bartholomew's Genitourinary Medicine Department patients and 43.5% were Southend Genitourinary Medicine Clinic patients. We ...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/095646207780658917
更新日期:2007-04-01 00:00:00
abstract::As few studies have compared the clinical features of rectal gonorrhoea in men who have sex with men with or without concurrent chlamydial infection, this longitudinal study was undertaken to address this issue. The cohort consisted of 129 men with rectal gonorrhoea, 34 of whom had concurrent chlamydiae. Symptoms of p...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/095646206777323373
更新日期:2006-06-01 00:00:00
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journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1177/0956462414547090
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journal_title:International journal of STD & AIDS
pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1177/0956462417713432
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pub_type: 杂志文章
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journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/ijsa.2008.008031
更新日期:2008-08-01 00:00:00
abstract::There are few data on the impact of antiretroviral therapy (ART) regimen factors on adherence in ART-naïve HIV patients on contemporary once- or twice-daily regimens. Ninety-nine newly diagnosed patients in a prospective observational cohort study completed a visual analogue scale to assess their ART adherence. Adhere...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/ijsa.2011.011292
更新日期:2012-05-01 00:00:00
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journal_title:International journal of STD & AIDS
pub_type: 杂志文章,评审
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更新日期:2005-10-01 00:00:00
abstract::Our objective was to explore the epidemiology of HIV and syphilis at population level in young Chinese adults. The study was carried out in six areas of three Chinese provinces: Zhejiang, Yunnan and Shaanxi. All couples attending the compulsory premarital examination were recruited. Routinely taken blood was collected...
journal_title:International journal of STD & AIDS
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更新日期:2005-03-01 00:00:00
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journal_title:International journal of STD & AIDS
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更新日期:2003-06-01 00:00:00
abstract::Summary Comprehensive testing for asymptomatic sexually transmitted infections in Northern Ireland has traditionally been provided by genitourinary medicine clinics. As patient demand for services has increased while budgets have remained limited, there has been increasing difficulty in accommodating this demand. In M...
journal_title:International journal of STD & AIDS
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doi:10.1177/0956462413519430
更新日期:2014-09-01 00:00:00
abstract::We assessed prevalence of human immunodeficiency virus (HIV) risk behaviors and depressive symptoms among adolescent girls and young women (AGYW) aged 15-24 years attending four public family planning clinics in Western Kenya from January to June 2019. Moderate-to-severe depression (MSD) was defined as a Center for Ep...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1177/0956462420920423
更新日期:2020-06-01 00:00:00