Long-term immunotherapy in HIV infection, combined with short-term antiretroviral treatment.

Abstract:

:Forty asymptomatic HIV-infected individuals with CD4+ lymphocyte levels above 400x10(6)/l were immunized over 5 years with recombinant envelope glycoprotein gp160 (rgp160). After 5 years there was a trend towards more non-progressors in the immunized group as compared to the matched controls. Since immunizations could activate HIV, the first 6 immunizations were followed by 2 weeks of zidovudine or placebo, double-blind. The viral load did not change during the first 6 months and was not different from that of the matched controls after 5 years. The best effect on CD4+ lymphocyte development was seen in individuals with a high viral load randomized to rgp160+zidovudine and in individuals with a low viral load randomized to rgp160+placebo. We conclude that rgp160 is safe and results in temporarily improved CD4+ development. Concomitant antiviral treatment might be of benefit, especially in patients with a more advanced disease and can today be given with more effective combinations.

journal_name

Int J STD AIDS

authors

Bratt G,Eriksson LE,Sandström E,Gilljam G,Hinkula J,Albert J,Redfield R,Wahren B

subject

Has Abstract

pub_date

1999-08-01 00:00:00

pages

514-21

issue

8

eissn

0956-4624

issn

1758-1052

journal_volume

10

pub_type

临床试验,杂志文章,随机对照试验
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    pub_type: 临床试验,杂志文章,随机对照试验

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