A review of controlled trials in the pharmacological treatment of premature ejaculation.

Abstract:

:Premature ejaculation is a common sexual problem which presents to genitourinary (GU) medicine services. Five main treatment approaches have been used in clinical trials: behavioural therapy, antidepressants, phosphodiesterase-5 (PDE5) inhibitors, topical anaesthetic agents and alpha-blockers. We have carried out a systematic review of published pharmacological trials. All antidepressants appeared to delay ejaculation to some extent at all doses. Anaesthetic creams appeared to be as successful in slowing ejaculation as antidepressants without systemic side-effects, although some patients did experience erectile problems or unpleasant local symptoms. Anecdotally, behavioural therapy is effective and appears to have long-lasting efficacy. There is a need for quality comparative trial of behavioural therapy, topical anaesthetic agents and antidepressants, including appropriate measures of relapse, follow-up and acceptability of continuing long-term treatment.

journal_name

Int J STD AIDS

authors

Richardson D,Green J,Ritcheson A,Goldmeier D,Harris JR

doi

10.1258/095646205774357299

subject

Has Abstract

pub_date

2005-10-01 00:00:00

pages

651-8

issue

10

eissn

0956-4624

issn

1758-1052

journal_volume

16

pub_type

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