Abstract:
:Influenza vaccination can reduce disease in HIV-infected children. The durability of the antibody response after trivalent influenza vaccine is important for management. The aim of this prospective study was to assess the durability of seroprotection for trivalent influenza vaccine strains and the factors effecting seroprotective response regardless of immunogenicity before trivalent influenza vaccine at one and six months after immunisation. Hemagglutination inhibition assay was done at one and six months. Seventy-five HIV-infected children were enrolled after vaccination. Four children were lost to follow-up. None of the children had confirmed influenza infection between immunisation and hemagglutination inhibition at six months after influenza vaccination. Seventy-one children were included in the final analysis and immunogenicity of trivalent influenza vaccine strains at one and six months. Of these, 27 (38%) had complete seroprotection (Group A) and 44 (62%) had non-complete seroprotection (Group B). Sex, age and the body mass index of both groups were not different from each other (p > 0.05). There was a higher mean CD4 level and more children with RNA ≤40 copies/mL among Group A compared with Group B (p < 0.05). Other factors did not differ significantly. The durability of the seroprotective response after trivalent influenza vaccine was associated with a high CD4 level and virological suppression before vaccination.
journal_name
Int J STD AIDSjournal_title
International journal of STD & AIDSauthors
Moolasart V,Manosuthi W,Ausavapipit J,Chottanapund S,Likanonsakul S,Uttayamakul S,Srisopha S,Lerdsamran H,Puthavathana Pdoi
10.1177/0956462415594061subject
Has Abstractpub_date
2016-08-01 00:00:00pages
761-8issue
9eissn
0956-4624issn
1758-1052pii
0956462415594061journal_volume
27pub_type
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