Abstract:
:Protective response rates to hepatitis B (HB) vaccination have been reported as low as 18-62% in HIV-infected persons. The relative importance of various predictors for this poor response has not been fully characterized. In this retrospective cohort study, we examined the relationship between clinical characteristics and vaccine non-response (HB surface antibody <10 IU/L) among patients attending an urban HIV clinic. Among the 97 patients who met the inclusion criteria, 43 (44%) developed a protective antibody response. In multivariate analyses, age >40 years (odds ratio [OR] 3.03 [95% confidence interval [CI], 1.14-8.06]; P = 0.026) and alcohol abuse (OR 4.92 [95% CI, 1.72-20.89]; P = 0.007) were independent predictors of failure to develop vaccine response. In addition, CD4 nadir <200 (OR 7.24 [95% CI, 1.91-27.41]; P = 0.004), rather than CD4 current to vaccination, remained a strong independent risk factor. Patients with HIV viral suppression on highly active antiretroviral therapy had a significantly lower rate of vaccine failure (OR 0.31 [95% CI, 0.11-0.91]; P = 0.033), after adjusting for these other covariates. Our findings underscore the importance of confirming seroconversion after HB vaccination in HIV-infected patients and initiating vaccination early in the course of HIV infection.
journal_name
Int J STD AIDSjournal_title
International journal of STD & AIDSauthors
Kim HN,Harrington RD,Van Rompaey SE,Kitahata MMdoi
10.1258/ijsa.2007.007197subject
Has Abstractpub_date
2008-09-01 00:00:00pages
600-4issue
9eissn
0956-4624issn
1758-1052pii
19/9/600journal_volume
19pub_type
杂志文章abstract::Pneumocystis jirovecii pneumonia (PCP) prophylaxis may be discontinued when CD4 is > or =200 cells/mm(3) for three months in response to highly active antiretroviral therapy (HAART). Unlike CD4, the total lymphocyte count (TLC) is inexpensive and widely available in resource-constrained countries. Paired TLC and CD4 v...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/ijsa.2009.009090
更新日期:2010-06-01 00:00:00
abstract::This study aimed to examine the prevalence of the Epstein-Barr virus (EBV), herpes simplex virus (HSV) and human papillomavirus (HPV) in the anal and oral mucosa of homosexual men with and without HIV infection and to correlate these findings to CD4+ count and anal cytology. Anal and oral cell samples from 20 HIV-infe...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/0956462991914762
更新日期:1999-09-01 00:00:00
abstract::A 46-year-old Caucasian heterosexual male was referred to a dedicated AIN clinic from colorectal multidisciplinary meeting (MDM) with AIN 3 following complete resection of anal squamous cell carcinoma (SCC). On further questioning, he revealed that he also had a lesion on his penis. Histology of the penile lesion demo...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/ijsa.2011.011255
更新日期:2012-04-01 00:00:00
abstract::Both herpes simplex virus type 2 (HSV-2) seroprevalence and the proportion of HSV-1 genital ulcers are increasing in industrialized countries. The consequences of these epidemiological changes, in pregnant women in France, for both the genital shedding of HSV and vertical transmission, have been poorly evaluated. The ...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/095646207781568457
更新日期:2007-09-01 00:00:00
abstract::Sexual behavioural factors associated with gonococcal infection among 991 STD clinic attenders in Trinidad, West Indies (WI) were determined by univariate and stepwise multiple logistic regression analysis. Casual sex (odds ratios [OR] 1.6) was the only predictor of gonorrhoea. Among males, significant associations we...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/0956462021924479
更新日期:2002-01-01 00:00:00
abstract::To determine the frequency, imaging characteristics, neuroanatomical distribution and dynamics of magnetic resonance imaging findings in HIV-associated cryptococcal meningitis in immunocompromised patients we compared patients without antiretroviral therapy with patients undergoing immune reconstitution. Neuroimaging ...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1177/0956462415574633
更新日期:2016-02-01 00:00:00
abstract::We sought to analyse reasons for attendance of older women (defined as aged 46 years and over) to genitourinary (GU) medicine services at two UK clinics. We used KC60 coding data to count new episode attendances by year from 1998 to 2008 and to further dissect reason for attendance in 2827 new episodes during 2003-200...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/ijsa.2012.011426
更新日期:2012-08-01 00:00:00
abstract::Gonorrhoea in the UK is now a highly focal problem that is localized to certain inner city areas where it presents a significant public health concern. However, the majority of men and a proportion of women infested with Neisseria gonorrhoeae do not experience symptoms of sufficient intensity to prompt them to seek me...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/0956462981922539
更新日期:1998-08-01 00:00:00
abstract::An HIV-positive African woman developed severe constitutional symptoms associated with rebound viraemia during a planned antiretroviral treatment interruption, requiring reinitiation of highly active antiretroviral therapy. ...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/0956462041558131
更新日期:2004-08-01 00:00:00
abstract::Advancements in the diagnosis and treatment of testicular cancer now give a five-year survival rate of 97.2%. Delayed presentation remains the primary cause of poor outcome and recommendations have stressed that men, particularly those with risk factors, should undertake regular testicular self-examination. This study...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1177/0956462414522774
更新日期:2014-10-01 00:00:00
abstract::The main purpose of this study was to investigate how loneliness was associated with social support and family function among people living with HIV/AIDS (PLWHA) in an HIV-stricken area of China. Two hundred and nineteen PLWHA were surveyed using the UCLA (University of California at Los Angeles)-Loneliness Scale, the...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/ijsa.2008.008348
更新日期:2009-04-01 00:00:00
abstract::To study dysglycaemia in human immunodeficiency virus (HIV)-infected patients we conducted a retrospective cohort study of the glucose profile in HIV-infected patients. The fasting blood glucose was analysed taking into consideration conventional risk factors as well as HIV infection and highly active antiretroviral t...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1177/0956462414554814
更新日期:2015-10-01 00:00:00
abstract::The prevalence of urogenital infection caused by Chlamydia trachomatis was examined in 100 non-pregnant women with cervicitis, and 100 healthy women, in San Salvador City, El Salvador. Pharmacia Chlamydia EIA test was used for the detection of chlamydial antigen in urethral and cervical specimens from all the women. D...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1177/095646249200300607
更新日期:1992-11-01 00:00:00
abstract::These clinical standards for the screening and management of acquired syphilis in HIV-positive patients in the UK were first made available on the MSSVD website in February 2002. They have been updated by the 2006 UK National Guideline on the Sexual Health of People with HIV which is also published in this issue of th...
journal_title:International journal of STD & AIDS
pub_type: 指南,杂志文章
doi:10.1258/095646206778113096
更新日期:2006-09-01 00:00:00
abstract::The expense in time and money limit the use of randomized clinical trials (RCT) and cohort studies for evaluating long-term AIDS treatment outcomes. We conducted a case-control study to characterize predictors of AIDS mortality after the availability of highly active antiretroviral therapy (HAART) in San Francisco, in...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/ijsa.2008.008381
更新日期:2009-05-01 00:00:00
abstract::The HIV-infected population is ageing. Issues including polypharmacy and co-morbidities led us to develop a dedicated clinic for HIV-infected individuals over 50. We describe our service evaluation after two years. The over 50 clinic commenced in January 2009. The team comprises a registrar, consultant, nurse practiti...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/ijsa.2012.011412
更新日期:2012-08-01 00:00:00
abstract::We aim to assess the usefulness of the cytomegalovirus (CMV) pp65 antigenaemia test, also called the CMV direct antigen test (DAT), in the management of patients with advanced human immunodeficiency virus (HIV) infection; we studied all patients who had pp65 assays between 8 September 1995 and 30 August 1996. Twenty-t...
journal_title:International journal of STD & AIDS
pub_type: 临床试验,杂志文章
doi:10.1258/0956462981922809
更新日期:1998-09-01 00:00:00
abstract::Perigenital molluscum contagiosum in adults is recognized as being a sexually transmitted infection. A retrospective casenote review was performed on patients attending a department of genitourinary medicine (GUM) who had been diagnosed as having molluscum. One or more co-existent sexually transmitted diseases (STD) w...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1177/095646249100200604
更新日期:1991-11-01 00:00:00
abstract::A 26-year-old heterosexual man presented with urethral discharge and penile oedema, two days after having a Reverse Prince Albert penile ring replaced. Clinically, he also had genital warts at the piercing tract openings. Investigations revealed positive chlamydial and gonococcal infection of the urethra. The gonococc...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/ijsa.2008.008021
更新日期:2008-07-01 00:00:00
abstract::Despite many reports of HIV-infected African children who have HIV-uninfected mothers, little is known about the extent and modes of horizontal HIV transmission in African children. We estimated the extent of horizontal HIV transmission in Swazi children by comparing child and mother HIV statuses in the 2006-2007 Swaz...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/ijsa.2009.009204
更新日期:2009-12-01 00:00:00
abstract::The limited published data support the assumption that lesbians are a low risk group for sexually transmitted diseases (STDs). However, there are virtually no contemporary data and the older papers do not take into account genital wart virus infection, now the third most prevalent STD in Britain. One of the dangers in...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1177/095646249000100304
更新日期:1990-05-01 00:00:00
abstract::A recent survey reported that 36% of UK genitourinary medicine clinics offer testing for pharyngeal Chlamydia trachomatis (CT). Screening at this site is targeted at high-risk groups attending our centre, including female sex workers (FSWs) and male sex workers (MSWs). A total of 2406 patients were screened between No...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/ijsa.2010.009494
更新日期:2010-11-01 00:00:00
abstract::A cross-sectional study of 360 patients presenting with sexually transmitted diseases (STDs) to a primary care clinic in KwaZulu/Natal, South Africa was done. Prevalence of HIV infection was 42.5%. HIV-infected patients were of similar age to uninfected patients (mean age 25.1 vs 26.1 years), but were less likely to b...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/0956462981921486
更新日期:1998-12-01 00:00:00
abstract::Patients were recruited for hypnotherapy from a clinic for patients with frequently recurrent genital herpes simplex virus (rgHSV). Psychological and immunological parameters were measured 6 weeks prior to hypnotherapy and 6 weeks afterwards, during which time each patient kept a diary of symptoms of rgHSV. Following ...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/0956462991913420
更新日期:1999-11-01 00:00:00
abstract::The objective was to comprehensively assess the prevalence of condom-use errors and problems among male clients attending a public sexually transmitted disease (STD) clinic. Men (n = 278) attending an STD clinic completed an anonymous questionnaire. Seven errors and six problems were assessed. Summative scores were te...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/ijsa.2007.007103
更新日期:2008-02-01 00:00:00
abstract::Sweden was the first country to introduce online Chlamydia trachomatis testing for both men and women and this article provides information about the user characteristics and which risk groups are reached with this method. During the years 2005-2007 a questionnaire was administered with a response rate of 86% (n = 602...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/ijsa.2011.011030
更新日期:2012-02-01 00:00:00
abstract::Premature ejaculation is a common sexual problem which presents to genitourinary (GU) medicine services. Five main treatment approaches have been used in clinical trials: behavioural therapy, antidepressants, phosphodiesterase-5 (PDE5) inhibitors, topical anaesthetic agents and alpha-blockers. We have carried out a sy...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章,评审
doi:10.1258/095646205774357299
更新日期:2005-10-01 00:00:00
abstract::The objective of this study was to assess the impact on men's liking for the condoms they use of a range of factors including demographic variables and variables that describe men's experience of using particular condoms. One hundred and ninety-four men used 3765 condoms for which they provided a liking rating. The co...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/0956462991913907
更新日期:1999-04-01 00:00:00
abstract::Patients who acquire repeated infections of gonorrhoea are well described. A study was undertaken of male patients attending a central London clinic in an attempt to identify features of those acquiring repeated infections to facilitate risk reduction strategies. During the 3 years 1990 to 1992, 18.8% of patients cont...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/0956462961917807
更新日期:1996-07-01 00:00:00
abstract::The aim of this study was to assess the HIV/AIDS-related knowledge among junior high-school students in Shanghai, China, and the factors influencing this knowledge. A cross-sectional study was conducted in 20 middle schools of two districts by a cluster-stratified selection procedure in Shanghai, China. The 2432 sampl...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/ijsa.2009.009065
更新日期:2012-03-01 00:00:00