Abstract：
:The aim of this study was to investigate the effect of asymptomatic rectal bacterial sexually transmitted infections (STIs) on rectal HIV viral load (VL). A prospective cohort study of HIV-positive men who have sex with men attending a tertiary centre in London, UK, for their routine HIV care was performed. Forty-two HIV-positive men who have sex with men were recruited between January and August 2014. In participants on antiretroviral therapy (ART), there was no significant difference in rectal VL in those with and without STI ( p = 0.4). All rectal HIV VLs were below the limit of detection (<100 copies/µg of total RNA) whether an STI was present or not. In those not on ART, rectal HIV VL was on average 0.6log10 lower post STI treatment. The presence of asymptomatic rectal chlamydia and gonorrhoea was not associated with increased rectal HIV VL in those fully suppressed on ART. In the context of effective ART, the presence of rectal gonorrhoea or chlamydia does not appear to increase rectal HIV VL and the risk of increased viral infectivity.
journal_name
Int J STD AIDSjournal_title
International journal of STD & AIDSauthors
Davies O,Costelloe S,Cross G,Dew T,O'Shea S,White J,Fox Jdoi
10.1177/0956462416686513subject
Has Abstractpub_date
2017-09-01 00:00:00pages
1034-1037issue
10eissn
0956-4624issn
1758-1052journal_volume
28pub_type
杂志文章abstract：:Summary HIV transmission risk is increased during antiretroviral therapy (ART) use if individuals are not virologically suppressed and engage in high risk transmission behaviour. Baseline data of HIV-infected men who have sex with men (MSM) with recent history of risky behaviour on ART for ≥3 months (n = 139) were eva...
journal_title：International journal of STD & AIDS
pub_type： 杂志文章
doi：10.1177/0956462413518500
更新日期：2014-09-01 00:00:00
abstract：:In a retrospective database study at two HIV treatment centres, medical records were accessed to evaluate long-term efficacy and safety parameters in all HIV-infected adults who had achieved HIV-1 RNA <50 copies/mL following the initiation of fosamprenavir (FPV)/ritonavir (RTV) 1400 mg/100 mg once-daily (QD)-containin...
journal_title：International journal of STD & AIDS
pub_type： 杂志文章
doi：10.1258/ijsa.2009.009161
更新日期：2012-03-01 00:00:00
abstract：:Prior research indicates that injection drug users forget substantial proportions of their injection partners when asked to recall them. Such under-reporting hampers both ascertainment of the injection networks that underlie transmission of blood-borne pathogens and contact-tracing efforts for disease control. We repo...
journal_title：International journal of STD & AIDS
pub_type： 杂志文章
doi：10.1258/ijsa.2007.007167
更新日期：2008-03-01 00:00:00
abstract：:A 46-year-old Caucasian heterosexual male was referred to a dedicated AIN clinic from colorectal multidisciplinary meeting (MDM) with AIN 3 following complete resection of anal squamous cell carcinoma (SCC). On further questioning, he revealed that he also had a lesion on his penis. Histology of the penile lesion demo...
journal_title：International journal of STD & AIDS
pub_type： 杂志文章
doi：10.1258/ijsa.2011.011255
更新日期：2012-04-01 00:00:00
abstract：:Herpes simplex virus 1 and 2 (HSV-1 and HSV-2) infections continue to be among the most common and unrecognized sexually transmitted infections in the world. Although treatable, HSV-1 and HSV-2 infections remain incurable. Hence, there is interest in the development of a vaccine to prevent genital herpes. As part of a...
journal_title：International journal of STD & AIDS
pub_type： 杂志文章,随机对照试验
doi：10.1177/0956462412472822
更新日期：2013-05-01 00:00:00
abstract：:We investigated our patients' preferences for weekend services at the same time as commencing a new Saturday clinic. Patients were asked for their views on weekend services: 374 questionnaires were returned; 210 (56%) from women and 164 (44%) from men. Saturday services were rated as more important than Sunday service...
journal_title：International journal of STD & AIDS
pub_type： 杂志文章
doi：10.1258/ijsa.2009.009208
更新日期：2010-04-01 00:00:00
abstract：:National guidelines state that hepatitis B and C testing should be targeted to those with risk factors. However, there is little data to support this recommendation. There is also limited data of viral hepatitis prevalence in attendees at genitourinary medicine clinics. We report the prevalence of hepatitis B infectio...
journal_title：International journal of STD & AIDS
pub_type： 杂志文章
doi：10.1177/0956462416641528
更新日期：2017-03-01 00:00:00
abstract：:A vaginal tampon specimen was previously shown to be suitable for the molecular diagnosis of non-ulcerative sexually transmitted infections (STIs). Different tampon fluid preparations were evaluated for the diagnosis of bacterial vaginosis (BV). Women with pregnancy related problems were enrolled. Two observers evalua...
journal_title：International journal of STD & AIDS
pub_type： 杂志文章
doi：10.1258/095646202760159693
更新日期：2002-08-01 00:00:00
abstract：:The persistent sexual arousal syndrome (PSAS) is a newly described entity where women become involuntarily aroused genitally for extended periods in time in the absence of sexual desire. Genital vasoengorgement and oedema have been observed. These women are found to be usually very distressed. The cause of the syndrom...
journal_title：International journal of STD & AIDS
pub_type： 杂志文章,评审
doi：10.1258/095646206776253480
更新日期：2006-04-01 00:00:00
abstract：:Forty asymptomatic HIV-infected individuals with CD4+ lymphocyte levels above 400x10(6)/l were immunized over 5 years with recombinant envelope glycoprotein gp160 (rgp160). After 5 years there was a trend towards more non-progressors in the immunized group as compared to the matched controls. Since immunizations could...
journal_title：International journal of STD & AIDS
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1999-08-01 00:00:00
abstract：:In this structured review, we evaluated purulent vaginal and cervical discharge as diagnostic tests for pelvic inflammatory disease (PID). Using a pretest probability of PID (diagnosed clinically) of 50%, we used the odds-likelihood formulation of Bayes' theorem to calculate post-test probabilities of PID (proven by l...
journal_title：International journal of STD & AIDS
pub_type： 杂志文章,评审
doi：10.1258/ijsa.2008.008261
更新日期：2009-02-01 00:00:00
abstract：:Chancroid is a sexually acquired disease caused by Haemophilus ducreyi. The infection is characterized by one or more genital ulcers, which are soft and painful, and regional lymphadenitis which may develop into buboes. The infection may easily be misidentified due to its rare occurrence in Europe and difficulties in ...
journal_title：International journal of STD & AIDS
pub_type： 杂志文章,实务指引
doi：10.1258/ijsa.2010.010432
更新日期：2011-05-01 00:00:00
abstract：:Understanding the epidemiologic definition of epidemic versus non-epidemic spread of an infectious disease agent and the different patterns of heterosexual HIV transmission are needed to fully understand the low potential for heterosexual HIV epidemics in most heterosexual populations. Epidemic sexual HIV transmission...
journal_title：International journal of STD & AIDS
pub_type： 杂志文章,评审
doi：10.1258/095646207781439667
更新日期：2007-08-01 00:00:00
abstract：:The aetiology of chronic prostatitis is poorly understood. A cross-sectional study of a population of male undergraduates in Nigeria, using a questionnaire containing the National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI) and some other relevant sex-related questions, was conducted. A total of ...
journal_title：International journal of STD & AIDS
pub_type： 杂志文章
doi：10.1258/ijsa.2010.010317
更新日期：2011-02-01 00:00:00
abstract：:A heterosexual man with acquired syphilis had an uncommon presentation in the form of acute visual loss. The unusual clinical presentation and a high cerebrospinal fluid lymphocyte count led to delayed diagnosis and treatment. Recognition of uncommon presentation of syphilis in the current epidemic is essential for th...
journal_title：International journal of STD & AIDS
pub_type： 杂志文章
doi：10.1258/095646207781024847
更新日期：2007-06-01 00:00:00
abstract：:The incidence of anogenital warts (condyloma acuminatum) is rapidly increasing while there is still no totally satisfactory treatment available. In light of the emphasis of experimental approaches toward the prevention of viral replication and evidence of the antiviral action of lithium salts it was proposed to invest...
journal_title：International journal of STD & AIDS
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1258/0956462971920677
更新日期：1997-08-01 00:00:00
abstract：:Despite many reports of HIV-infected African children who have HIV-uninfected mothers, little is known about the extent and modes of horizontal HIV transmission in African children. We estimated the extent of horizontal HIV transmission in Swazi children by comparing child and mother HIV statuses in the 2006-2007 Swaz...
journal_title：International journal of STD & AIDS
pub_type： 杂志文章
doi：10.1258/ijsa.2009.009204
更新日期：2009-12-01 00:00:00
abstract：:The irregular use of antiretroviral therapy (ART) can result in ART-resistance but can also lead to a sensitization between agents with a cross-sensitivity. We report a case of nevirapine-associated toxic epidermal necrolysis resulting in death in an HIV-infected man. ...
journal_title：International journal of STD & AIDS
pub_type： 杂志文章
doi：10.1258/ijsa.2008.008062
更新日期：2008-09-01 00:00:00
abstract：:Individuals infected with HIV who are out of care are at a higher risk of HIV-related morbidity and mortality. It has been difficult to recruit a representative sample of out-of-care patients for epidemiological studies. Using a novel weighting method, we constructed a representative sample of out-of-care HIV patients...
journal_title：International journal of STD & AIDS
pub_type： 杂志文章
doi：10.1177/0956462415608334
更新日期：2016-10-01 00:00:00
abstract：:We measured plasma human herpesvirus 8 (HHV8) DNA load in consecutive patients presenting with HIV-associated multicentric Castleman disease (MCD) and in contemporaneous patients who had Kaposi sarcoma (KS), lymphoma or other diagnoses. All 11 patients with MCD had detectable plasma HHV8 DNA compared with 18 (72%) of ...
journal_title：International journal of STD & AIDS
pub_type： 杂志文章
doi：10.1258/ijsa.2011.010464
更新日期：2011-10-01 00:00:00
abstract：:The objective of this study was to quantitatively measure the nature of concurrent sex partnering in two samples of drug users having large numbers of sex partners. The purpose of this study was to measure concurrent sex partnering and overlap in concurrent sex partners in two samples of drug users in which some or al...
journal_title：International journal of STD & AIDS
pub_type： 杂志文章
doi：10.1258/095646206776790123
更新日期：2006-05-01 00:00:00
abstract：:Today, Kaposi is remembered for giving the first description of the angiosarcoma which bears his name. During his lifetime, he was acknowledged as one of the great masters of the Vienna School of Dermatology, a superb clinician and renowned teacher. ...
journal_title：International journal of STD & AIDS
pub_type： 传,历史文章,杂志文章
doi：10.1258/0956462971918968
更新日期：1997-11-01 00:00:00
abstract：:Integrase strand transfer inhibitors (INSTIs) are a class of antiretroviral drugs with high virologic efficacy and excellent tolerability. Recent evidence showed a possible link of dolutegravir-based regimens with weight gain, and a relationship between raltegravir use and changes in adipose tissue density and metabol...
journal_title：International journal of STD & AIDS
pub_type： 杂志文章
doi：10.1177/0956462420955075
更新日期：2020-12-01 00:00:00
abstract：:Public health authorities have long believed that the preponderance of AIDS cases in Africa are attributable to 'heterosexual transmission'; most people silently assume this rubric to indicate penile-vaginal intercourse only. Recent epidemiologic analyses suggest that the majority of HIV cases in sub-Saharan Africa ma...
journal_title：International journal of STD & AIDS
pub_type： 杂志文章,评审
doi：10.1258/095646203322025704
更新日期：2003-07-01 00:00:00
abstract：:Within the UK, the majority of hepatitis A occurs in high risk groups such as men who have sex with men (MSM). It has been estimated that 70% of MSM need immunity to provide adequate herd immunity. We aimed to estimate the proportion of hepatitis A susceptibility in MSM throughout a 10-year period (2010-2019), and exp...
journal_title：International journal of STD & AIDS
pub_type： 杂志文章
doi：10.1177/0956462420961960
更新日期：2020-12-18 00:00:00
abstract：:Chlamydia trachomatis and Neisseria gonorrhoeae testing guidance recommends extragenital screening with locally validated nucleic acid amplification tests, with anatomical sites tested separately. Evidence supports multi-patient combined aliquot pooled sampling (PS) for population screening; evidence for within-patien...
journal_title：International journal of STD & AIDS
pub_type： 杂志文章
doi：10.1177/0956462417742318
更新日期：2018-05-01 00:00:00
abstract：:Antioxidants significantly inhibit oxidative processes. The study seeks to determine the activity of endogenous antioxidants and CD4+ T-cell expression in HIV-serodiscordant-heterosexual partners. The case-control study had the following groups; A- (13 serodiscordant-seronegative subjects), B- (13 serodiscordant-serop...
journal_title：International journal of STD & AIDS
pub_type： 杂志文章
doi：10.1258/ijsa.2008.008031
更新日期：2008-08-01 00:00:00
abstract：:High annual figures of sexually transmitted infections (STIs) are diagnosed in the Netherlands despite significant efforts to control them. Herein, we analyse trends and determinants of STI diagnoses, co-infections, and sexual risks among visitors of 26 STI clinics between 2007 and 2011. We recorded increased positivi...
journal_title：International journal of STD & AIDS
pub_type： 杂志文章
doi：10.1177/0956462413491736
更新日期：2014-01-01 00:00:00
abstract：:Seventy-eight men with symptoms of chronic or subacute prostatitis were enrolled. Investigations for the presence of Chlamydia trachomatis in urethral swabs were carried out. The expressed prostatic secretions were additionally examined for Mycoplasma hominis, Ureaplasma urealyticum, Gardnerella vaginalis, other gram-...
journal_title：International journal of STD & AIDS
pub_type： 杂志文章
doi：10.1258/0956462981922395
更新日期：1998-06-01 00:00:00
abstract：:In order to determine inpatient hospital mortality rates, causes of mortality and characteristics of inpatients at Kamuzu Central Hospital (KCH) in Lilongwe, Malawi, we conducted a prospective observational study of all patients admitted to KCH medical ward from 20 September 2008 to April 2, 2009. All admission diagno...
journal_title：International journal of STD & AIDS
pub_type： 杂志文章
doi：10.1258/ijsa.2011.011021
更新日期：2011-08-01 00:00:00
