Abstract:
:We measured plasma human herpesvirus 8 (HHV8) DNA load in consecutive patients presenting with HIV-associated multicentric Castleman disease (MCD) and in contemporaneous patients who had Kaposi sarcoma (KS), lymphoma or other diagnoses. All 11 patients with MCD had detectable plasma HHV8 DNA compared with 18 (72%) of 25 patients with KS, none with lymphoma and one of 38 patients with other diagnoses. Detectable plasma HHV8 DNA levels were higher among MCD patients, median (interquartile range [IQR]) = 43,500 (5200-150,000) copies/mL, when compared with those with KS, median (IQR) = 320 (167-822) copies/mL and those with lymphoma and other diagnoses (one-way analysis of variance; P = 0.0303). Using receiver operating characteristic analysis, a cut-off of >1000 copies HHV8 DNA/mL of plasma helped to discriminate between MCD and other diagnoses, with a specificity of 94.7% and a negative predictive value of 97.3%. The level of HHV8 viraemia, while not diagnostic, may aid discrimination between patients with MCD and those with KS and other systemic illnesses.
journal_name
Int J STD AIDSjournal_title
International journal of STD & AIDSauthors
Sayer R,Paul J,Tuke PW,Hargreaves S,Noursadeghi M,Tedder RS,Grant P,Edwards SG,Miller RFdoi
10.1258/ijsa.2011.010464subject
Has Abstractpub_date
2011-10-01 00:00:00pages
585-9issue
10eissn
0956-4624issn
1758-1052pii
22/10/585journal_volume
22pub_type
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