Can plasma HHV8 viral load be used to differentiate multicentric Castleman disease from Kaposi sarcoma?

Abstract:

:We measured plasma human herpesvirus 8 (HHV8) DNA load in consecutive patients presenting with HIV-associated multicentric Castleman disease (MCD) and in contemporaneous patients who had Kaposi sarcoma (KS), lymphoma or other diagnoses. All 11 patients with MCD had detectable plasma HHV8 DNA compared with 18 (72%) of 25 patients with KS, none with lymphoma and one of 38 patients with other diagnoses. Detectable plasma HHV8 DNA levels were higher among MCD patients, median (interquartile range [IQR]) = 43,500 (5200-150,000) copies/mL, when compared with those with KS, median (IQR) = 320 (167-822) copies/mL and those with lymphoma and other diagnoses (one-way analysis of variance; P = 0.0303). Using receiver operating characteristic analysis, a cut-off of >1000 copies HHV8 DNA/mL of plasma helped to discriminate between MCD and other diagnoses, with a specificity of 94.7% and a negative predictive value of 97.3%. The level of HHV8 viraemia, while not diagnostic, may aid discrimination between patients with MCD and those with KS and other systemic illnesses.

journal_name

Int J STD AIDS

authors

Sayer R,Paul J,Tuke PW,Hargreaves S,Noursadeghi M,Tedder RS,Grant P,Edwards SG,Miller RF

doi

10.1258/ijsa.2011.010464

subject

Has Abstract

pub_date

2011-10-01 00:00:00

pages

585-9

issue

10

eissn

0956-4624

issn

1758-1052

pii

22/10/585

journal_volume

22

pub_type

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