Abstract:
:We measured plasma human herpesvirus 8 (HHV8) DNA load in consecutive patients presenting with HIV-associated multicentric Castleman disease (MCD) and in contemporaneous patients who had Kaposi sarcoma (KS), lymphoma or other diagnoses. All 11 patients with MCD had detectable plasma HHV8 DNA compared with 18 (72%) of 25 patients with KS, none with lymphoma and one of 38 patients with other diagnoses. Detectable plasma HHV8 DNA levels were higher among MCD patients, median (interquartile range [IQR]) = 43,500 (5200-150,000) copies/mL, when compared with those with KS, median (IQR) = 320 (167-822) copies/mL and those with lymphoma and other diagnoses (one-way analysis of variance; P = 0.0303). Using receiver operating characteristic analysis, a cut-off of >1000 copies HHV8 DNA/mL of plasma helped to discriminate between MCD and other diagnoses, with a specificity of 94.7% and a negative predictive value of 97.3%. The level of HHV8 viraemia, while not diagnostic, may aid discrimination between patients with MCD and those with KS and other systemic illnesses.
journal_name
Int J STD AIDSjournal_title
International journal of STD & AIDSauthors
Sayer R,Paul J,Tuke PW,Hargreaves S,Noursadeghi M,Tedder RS,Grant P,Edwards SG,Miller RFdoi
10.1258/ijsa.2011.010464subject
Has Abstractpub_date
2011-10-01 00:00:00pages
585-9issue
10eissn
0956-4624issn
1758-1052pii
22/10/585journal_volume
22pub_type
杂志文章abstract::In Latin America, men who have sex with men (MSM) remain disproportionately impacted by HIV. Pre-exposure prophylaxis (PrEP) is an effective HIV prevention tool and has been FDA approved in the United States since 2012, but no Latin American state, with the recent exception of Brazil, has implemented PrEP guidelines. ...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1177/0956462419825944
更新日期:2019-05-01 00:00:00
abstract::A review of published and unpublished data indicates the prevalence of high-risk behaviours for HIV transmission in segments of the Bangladeshi population. These include casual unprotected sex, heterosexual as well as between males, prior to and after marriage. Intravenous drug use (IVDU) exists though illicit drugs a...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/0956462991913862
更新日期:1999-03-01 00:00:00
abstract::UK post-exposure prophylaxis (PEP) guidelines were updated by the British Association for Sexual Health and HIV (BASHH) in 2011. In 2013, we changed policy to omit day 5 PEP follow-up at 56 Dean Street as it was felt clinically unnecessary. This audit compares our performance against BASHH standards for PEP attenders ...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1177/0956462414547090
更新日期:2015-07-01 00:00:00
abstract::AIDS-associated Kaposi's sarcoma (KS) is much more frequent in patients acquiring HIV infection via the sexual route. Epidemiological studies have confirmed the likely involvement of a sexually acquired cofactor in the pathogenesis of this form of KS. We have formulated a set of postulates, epidemiological and experim...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1177/095646249500600609
更新日期:1995-11-01 00:00:00
abstract::Five hundred and twenty consecutive women newly attending a genitourinary medicine clinic who participated in a study of sexual behaviour were also tested for type-specific antibody to herpes simplex virus type 2; 135 (26%) were seropositive, of whom only 29 (21.5%) had had clinical evidence of genital herpes. Seropos...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/095646203321043237
更新日期:2003-01-01 00:00:00
abstract::HIV disproportionately affects men who have sex with men (MSM). Substance use is common among people living with HIV and may affect antiretroviral therapy adherence. Nevertheless, research examining the association between substance use and viral suppression is lacking. The aims of this study were to determine the ass...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1177/0956462418779663
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abstract::This case is about an HIV seropositive young woman referred for the treatment of severe menorrhagia causing anaemia due to adenomyosis where the levonorgestrel-releasing intrauterine system (Mirena) proved useful in treating her heavy periods and also provided effective contraception without interference from the live...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/ijsa.2008.008107
更新日期:2008-10-01 00:00:00
abstract::Pneumocystis jirovecii pneumonia (PCP) prophylaxis may be discontinued when CD4 is > or =200 cells/mm(3) for three months in response to highly active antiretroviral therapy (HAART). Unlike CD4, the total lymphocyte count (TLC) is inexpensive and widely available in resource-constrained countries. Paired TLC and CD4 v...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/ijsa.2009.009090
更新日期:2010-06-01 00:00:00
abstract::Perigenital molluscum contagiosum in adults is recognized as being a sexually transmitted infection. A retrospective casenote review was performed on patients attending a department of genitourinary medicine (GUM) who had been diagnosed as having molluscum. One or more co-existent sexually transmitted diseases (STD) w...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1177/095646249100200604
更新日期:1991-11-01 00:00:00
abstract::Kaposi's sarcoma (KS) has a higher incidence in some parts of Africa than anywhere else in the world. Recent studies in western homosexual men with AIDS-KS suggest that KS may be caused by a putative sexually transmissible agent. Our analytical review of studies on KS in Africa before and during the AIDS era reveals a...
journal_title:International journal of STD & AIDS
pub_type: 社论,评审
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更新日期:1996-01-01 00:00:00
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journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/095646207782716947
更新日期:2007-12-01 00:00:00
abstract::The objective of this paper was to identify and describe enhanced sexual health services (ESHSs) commissioned for testing, diagnosis and management of sexually transmitted infections (STIs) in primary and community care settings in England. ESHSs commissioned by Primary Care Trusts (PCTs) in England were determined by...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/ijsa.2010.010198
更新日期:2010-09-01 00:00:00
abstract::A group of 14 women infected with hepatitis C virus (HCV) was evaluated for vaginal shedding of the virus. The HCV-RNA detection was performed in plasma, peripheral blood mononuclear cells (PBMC) and in supernatant and pellet of vaginal washings. HCV-RNA positive results were obtained in all plasma samples, in 57% of ...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/0956462011924209
更新日期:2001-11-01 00:00:00
abstract::This guideline is intended to serve as a framework for those working in any location where sexually transmitted infections (STIs) are managed. It offers recommendations which will need to be adapted depending on local facilities and policies, and is not intended to be all encompassing. This guideline should be read in...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章,实务指引
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更新日期:2012-09-01 00:00:00
abstract::Local genital tract inflammation stimulates leukocyte activity and causes HIV shedding, potentially increasing HIV sexual infectiousness. Although there are available clinical markers for genital tract inflammation, such as urinary leukocyte esterase, none have yet been examined in relation to HIV sexual risk behaviou...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
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abstract::The purpose of this paper is to assess the internal consistency of self-reported condom use among sex workers in Puerto Plata and Santo Domingo, Dominican Republic. We examined the responses to questions about condom use among 4 cross-sectional samples of sex workers. We compared measures based on: (1) questions using...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
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更新日期:1998-04-01 00:00:00
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journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/ijsa.2010.010148
更新日期:2010-07-01 00:00:00
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journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/ijsa.2007.007207
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journal_title:International journal of STD & AIDS
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pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:International journal of STD & AIDS
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更新日期:1994-09-01 00:00:00
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pub_type: 社论
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journal_title:International journal of STD & AIDS
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