Can plasma HHV8 viral load be used to differentiate multicentric Castleman disease from Kaposi sarcoma?


:We measured plasma human herpesvirus 8 (HHV8) DNA load in consecutive patients presenting with HIV-associated multicentric Castleman disease (MCD) and in contemporaneous patients who had Kaposi sarcoma (KS), lymphoma or other diagnoses. All 11 patients with MCD had detectable plasma HHV8 DNA compared with 18 (72%) of 25 patients with KS, none with lymphoma and one of 38 patients with other diagnoses. Detectable plasma HHV8 DNA levels were higher among MCD patients, median (interquartile range [IQR]) = 43,500 (5200-150,000) copies/mL, when compared with those with KS, median (IQR) = 320 (167-822) copies/mL and those with lymphoma and other diagnoses (one-way analysis of variance; P = 0.0303). Using receiver operating characteristic analysis, a cut-off of >1000 copies HHV8 DNA/mL of plasma helped to discriminate between MCD and other diagnoses, with a specificity of 94.7% and a negative predictive value of 97.3%. The level of HHV8 viraemia, while not diagnostic, may aid discrimination between patients with MCD and those with KS and other systemic illnesses.




Sayer R,Paul J,Tuke PW,Hargreaves S,Noursadeghi M,Tedder RS,Grant P,Edwards SG,Miller RF




Has Abstract


2011-10-01 00:00:00














  • Adapting and pilot testing the Healthy Love HIV and sexually transmitted infection prevention intervention with African, Caribbean and Black women in community-based settings in Toronto, Canada.

    abstract::We adapted the Healthy Love Workshop (HLW), an HIV prevention workshop for African American women in the United States, for African, Caribbean and Black (ACB) women in Toronto, Canada. We conducted a pilot study with ACB women ( n = 80) in ten community-based settings with pre-test (T1), post-test (T2) and three-month...

    journal_title:International journal of STD & AIDS

    pub_type: 杂志文章


    authors: Logie CH,Okumu M,Ryan S,Yehdego DM,Lee-Foon N

    更新日期:2018-07-01 00:00:00

  • Treatment delay and reliance on private physicians among patients with sexually transmitted diseases in China.

    abstract::We examined health-care seeking practices among patients with sexually transmitted diseases (STDs) in south China. In 1995, we recruited a consecutive sample of 939 STD patients attending the STD clinics of the Municipal STD Control Centers of Guangzhou and Shenzhen, 'special economic zones' near Hong Kong. Attending ...

    journal_title:International journal of STD & AIDS

    pub_type: 杂志文章


    authors: Choi KH,Zheng X,Zhou H,Chen W,Mandel J

    更新日期:1999-05-01 00:00:00

  • Genital lymphoedema due to ano-genital granulomatosis.

    abstract::A 21-year-old man presented to genitourinary (GU) medicine physicians with (initially) painful penile and scrotal swelling. A diagnosis of ano-genital granulomatosis was confirmed on histological analysis of penile skin. Enquiring about systemic symptoms resulted in the additional diagnosis of gastrointestinal Crohn's...

    journal_title:International journal of STD & AIDS

    pub_type: 杂志文章


    authors: Gordon KD,Brice G,Walker Y,Pollok R,Mortimer P,Slater C

    更新日期:2013-02-01 00:00:00

  • Patients who return to care after tracking remain at high risk of attrition: experience from a large HIV clinic, Uganda.

    abstract::We determined the retention rate of patients infected with HIV who resumed care after being tracked at the Infectious Diseases Clinic (IDC) in Kampala, Uganda. Between April 2011 and September 2013, patients who missed their clinic appointment for 8-90 days were tracked, and those who returned to the clinic within 120...

    journal_title:International journal of STD & AIDS

    pub_type: 杂志文章


    authors: Nakiwogga-Muwanga A,Musaazi J,Katabira E,Worodria W,Talisuna SA,Colebunders R

    更新日期:2015-01-01 00:00:00

  • Distribution of HIV and acute hepatitis B infection among drug injectors in Glasgow.

    abstract::This study compared the distributions of known human immunodeficiency virus (HIV) and acute hepatitis B virus (HBV) infection among drug injectors in Glasgow over a 3.5 year period. Data were obtained from all relevant laboratory request forms submitted to Glasgow's 3 virology laboratories during the period 1 January ...

    journal_title:International journal of STD & AIDS

    pub_type: 杂志文章


    authors: Gruer LD,Peedle M,Carrington D,Clements GB,Follett EA

    更新日期:1991-09-01 00:00:00

  • Alternative treatment approach to cerebral toxoplasmosis in HIV/AIDS: experience from a resource-poor setting.

    abstract::The current standard treatment for cerebral toxoplasmosis (pyrimethamine/sulfadiazine) often encounters problems of poor tolerability, adverse effects, frequent dropouts and non-availability of pyrimethamine/sulfadiazine in some parts of India. We have had to use the combination of two effective alternative agents for...

    journal_title:International journal of STD & AIDS

    pub_type: 杂志文章


    authors: Goswami RP,Goswami RP,Rahman M,Ray Y,Tripathi SK

    更新日期:2015-10-01 00:00:00

  • Pediculosis pubis: presentation to ophthalmologist as pthriasis palpebrarum associated with corneal epithelial keratitis.

    abstract::Pthiriasis palpebrarum caused by infestation with Pthirus pubis (crab louse) draws attention to pediculosis in the pubic and inguinal region. As pthiriasis is usually transmitted by sexual contact, many cases are likely to have other sexually transmitted diseases. A multidisciplinary approach is essential in the manag...

    journal_title:International journal of STD & AIDS

    pub_type: 杂志文章


    authors: Manjunatha NP,Jayamanne GR,Desai SP,Moss TR,Lalik J,Woodland A

    更新日期:2006-06-01 00:00:00

  • Study of HIV/AIDS-related knowledge among junior high-school students in Shanghai, China.

    abstract::The aim of this study was to assess the HIV/AIDS-related knowledge among junior high-school students in Shanghai, China, and the factors influencing this knowledge. A cross-sectional study was conducted in 20 middle schools of two districts by a cluster-stratified selection procedure in Shanghai, China. The 2432 sampl...

    journal_title:International journal of STD & AIDS

    pub_type: 杂志文章


    authors: Cai Y,Shi R,Li S,Xu G,Huang H

    更新日期:2012-03-01 00:00:00

  • Primary HIV infection.

    abstract::Primary HIV can be asymptomatic or result in a severe symptomatic illness. Common symptoms are pyrexia, pharyngitis, malaise, lethargy, maculopapular rash, mucous membrane ulceration, lymphadenopathy and headache. It can be reliably diagnosed by a positive virologic test in the absence of HIV-specific antibodies. Prog...

    journal_title:International journal of STD & AIDS

    pub_type: 杂志文章,评审


    authors: Apoola A,Ahmad S,Radcliffe K

    更新日期:2002-02-01 00:00:00

  • The limits of health-care seeking behaviour: how long will patients travel for STI care? Evidence from England's 'Patient Access and the Transmission of Sexually Transmitted Infections' ('PATSI') study.

    abstract:SUMMARY:The objective of this study was to identify factors associated with (i) longer patient travel time to genitourinary (GU) medicine clinics and (ii) not attending the nearest clinic. Questionnaires were completed by 4600 new attendees from seven sociodemographically and geographically different GU clinics across ...

    journal_title:International journal of STD & AIDS

    pub_type: 杂志文章


    authors: Olonilua O,Ross JD,Mercer C,Keane F,Brook G,Cassell JA

    更新日期:2008-12-01 00:00:00

  • Molluscum contagiosum: a neglected sentinel infection.

    abstract::Perigenital molluscum contagiosum in adults is recognized as being a sexually transmitted infection. A retrospective casenote review was performed on patients attending a department of genitourinary medicine (GUM) who had been diagnosed as having molluscum. One or more co-existent sexually transmitted diseases (STD) w...

    journal_title:International journal of STD & AIDS

    pub_type: 杂志文章


    authors: Radcliffe KW,Daniels D,Evans BA

    更新日期:1991-11-01 00:00:00

  • Determinants of gonorrhoea infection among STD clinic attenders in Trinidad--II: sexual behavioural factors.

    abstract::Sexual behavioural factors associated with gonococcal infection among 991 STD clinic attenders in Trinidad, West Indies (WI) were determined by univariate and stepwise multiple logistic regression analysis. Casual sex (odds ratios [OR] 1.6) was the only predictor of gonorrhoea. Among males, significant associations we...

    journal_title:International journal of STD & AIDS

    pub_type: 杂志文章


    authors: Castor D,Jolly PE,Furlonge C,Rao A,Brown A,Camara B,Weiss H,Prabhakar P

    更新日期:2002-01-01 00:00:00

  • Reiter's syndrome and keratoderma blennorrhagica on glans penis--is this unusual?

    abstract::Current teaching on Reiter's syndrome is that keratoderma blennorrhagica lesions appear characteristically on the soles of feet, although they can be seen on other parts of the body infrequently. We therefore thought that it would be interesting to report the case of keratoderma blennorrhagica lesions found on the gla...

    journal_title:International journal of STD & AIDS

    pub_type: 杂志文章


    authors: Edirisinghe DN,Sankar KN,Pattman RS

    更新日期:2002-02-01 00:00:00

  • Neisseria gonorrhoeae in a London sexually transmitted infection clinic not fully sensitive to quinolones: are isolates imported and how effective is ciprofloxacin as a first-line therapy?

    abstract::Our objectives were to determine the prevalence of Neisseria gonorrhoeae not fully sensitive to ciprofloxacin from a sexually transmitted infection (STI) clinic in London and where the isolates were acquired from. Data of antibiotic sensitivities of N. gonorrhoeae from 292 patients were reviewed over a 6-month period ...

    journal_title:International journal of STD & AIDS

    pub_type: 杂志文章


    authors: Ivens D,Martin I,Ison C

    更新日期:2000-12-01 00:00:00

  • Characterizing viral subtypes to assess patterns of HIV transmission.

    abstract::We characterized HIV-1 subtypes among 204 persons newly diagnosed with HIV in Ontario from 2003 to 2005 using samples from the Canadian HIV Strain and Drug Resistance Surveillance Program. We examined HIV-1 subtype by demographic characteristics and exposure category, and determined independent predictors of infection...

    journal_title:International journal of STD & AIDS

    pub_type: 杂志文章


    authors: Rank C,Njihia JG,Remis RS,Shah L,Swantee C,Brooks JI,Jayaraman GC,Archibald CP

    更新日期:2012-10-01 00:00:00

  • Romantic love and sexually transmitted infection acquisition: hypothesis and review.

    abstract::Rates of sexually transmitted infections (STI) in the UK continue to increase. A discrepancy between knowledge and awareness of STIs, and sexual behaviour appears to be ubiquitous throughout the world. We hypothesize that human beings are biologically programmed to fall in love and bond in powerful relationships, whic...

    journal_title:International journal of STD & AIDS

    pub_type: 杂志文章,评审


    authors: Goldmeier D,Richardson D

    更新日期:2005-09-01 00:00:00

  • Pneumocystis jirovecii prophylaxis discontinuation based upon total lymphocyte count in HIV-infected adults treated with antiretroviral therapy.

    abstract::Pneumocystis jirovecii pneumonia (PCP) prophylaxis may be discontinued when CD4 is > or =200 cells/mm(3) for three months in response to highly active antiretroviral therapy (HAART). Unlike CD4, the total lymphocyte count (TLC) is inexpensive and widely available in resource-constrained countries. Paired TLC and CD4 v...

    journal_title:International journal of STD & AIDS

    pub_type: 杂志文章


    authors: Cheung C,Shuter J

    更新日期:2010-06-01 00:00:00

  • Improvement of the patient flow in a large urban clinic with high HIV seroprevalence in Kampala, Uganda.

    abstract::Antiretroviral treatment roll-out programmes in Africa often have difficulties to cope with the increasing number of clients. Based on the findings of a survey carried out in 2005 that showed long waiting times, innovative organizational changes (nurse visits and pharmacy-only refill visits) were introduced in our cli...

    journal_title:International journal of STD & AIDS

    pub_type: 杂志文章


    authors: Castelnuovo B,Babigumira J,Lamorde M,Muwanga A,Kambugu A,Colebunders R

    更新日期:2009-02-01 00:00:00

  • Can a clinical prediction tool guide HIV-testing decisions? Experience at a national hospital in Guatemala.

    abstract::The USA and international recommendations no longer emphasize using risk factors to target groups for HIV-testing. Using a Guatemalan database of HIV tests, we developed a clinical prediction rule to guide decisions on HIV-testing. Prior to HIV-testing, data were collected on demographics, risk factors and prior testi...

    journal_title:International journal of STD & AIDS

    pub_type: 杂志文章


    authors: Anderson MR,Samayoa B,O'Sullivan LF,Fletcher J,Arathoon E

    更新日期:2009-01-01 00:00:00

  • Is screening for pharyngeal Chlamydia trachomatis warranted in high-risk groups?

    abstract::A recent survey reported that 36% of UK genitourinary medicine clinics offer testing for pharyngeal Chlamydia trachomatis (CT). Screening at this site is targeted at high-risk groups attending our centre, including female sex workers (FSWs) and male sex workers (MSWs). A total of 2406 patients were screened between No...

    journal_title:International journal of STD & AIDS

    pub_type: 杂志文章


    authors: Tipple C,Hill SC,Smith A

    更新日期:2010-11-01 00:00:00

  • Anakinra in the treatment of protracted paradoxical inflammatory reactions in HIV-associated tuberculosis in the United Kingdom: a report of two cases.

    abstract::Paradoxical reactions, including immune reconstitution inflammatory syndrome (IRIS), are common in patients co-infected with human immunodeficiency virus (HIV) and tuberculosis (TB). Paradoxical reactions may confer substantial morbidity and mortality, especially in cases of central nervous system (CNS) TB, or through...

    journal_title:International journal of STD & AIDS

    pub_type: 杂志文章


    authors: Keeley AJ,Parkash V,Tunbridge A,Greig J,Collini P,McKane W,Tattersall RS

    更新日期:2020-07-01 00:00:00

  • Management of epididymo-orchitis in Genitourinary Medicine clinics in the United Kingdom's North Thames region 2000.

    abstract::A questionnaire survey and case notes audit reviewing management of epididymo-orchitis (E-O) by 34 Genitourinary Medicine (GUM) clinics located in the North Thames was undertaken. Twenty-two clinics (65%) returned completed questionnaires and audited a total of 83 newly diagnosed cases. All participating clinics offer...

    journal_title:International journal of STD & AIDS

    pub_type: 杂志文章


    authors: Dale AW,Wilson JD,Forster GE,Daniels D,Brook MG

    更新日期:2001-05-01 00:00:00

  • Heterosexual HIV transmission dynamics: implications for prevention and control.

    abstract::Understanding the epidemiologic definition of epidemic versus non-epidemic spread of an infectious disease agent and the different patterns of heterosexual HIV transmission are needed to fully understand the low potential for heterosexual HIV epidemics in most heterosexual populations. Epidemic sexual HIV transmission...

    journal_title:International journal of STD & AIDS

    pub_type: 杂志文章,评审


    authors: Chin J,Bennett A

    更新日期:2007-08-01 00:00:00

  • Binge drinking, sexual behaviour and sexually transmitted infection in the UK.

    abstract::Associations between sexual risk and alcohol consumption may be self-evident but have eluded detailed examination in the UK. A cohort of 520 genitourinary (GU) medicine clinic attenders in the south of England were given a detailed questionnaire and compared with a matched cohort from the General Household Survey (GHS...

    journal_title:International journal of STD & AIDS

    pub_type: 杂志文章


    authors: Standerwick K,Davies C,Tucker L,Sheron N

    更新日期:2007-12-01 00:00:00

  • Health literacy and current CD4 cell count in a multiethnic U.S. sample of adults living with HIV infection.

    abstract::Hispanic and Black adults are disproportionately affected by HIV and experience poorer HIV-related health outcomes relative to non-Hispanic White adults. The current study adopted Sørensen's integrated model to test the hypothesis that lower functional and critical health literacy competencies contribute to poorer HIV...

    journal_title:International journal of STD & AIDS

    pub_type: 杂志文章


    authors: Walker RL,Hong JH,Talavera DC,Verduzco M,Woods SP

    更新日期:2018-04-01 00:00:00

  • C-reactive protein: a poor marker of cardiovascular disease risk in HIV+ populations with a high prevalence of elevated serum transaminases.

    abstract::Blood lipids and high-sensitivity C-reactive protein (hsCRP) are used to assess cardiovascular disease (CVD) risk. We evaluated in a cross-sectional design the relationship of hsCRP to markers of liver function (aspartate and alanine transaminases [AST and ALT, respectively]), CVD risk factors and HIV-disease progress...

    journal_title:International journal of STD & AIDS

    pub_type: 杂志文章


    authors: Baum MK,Rafie C,Sales S,Lai S,Duan R,Jayaweera DT,Page JB,Campa A

    更新日期:2008-06-01 00:00:00

  • Cushing's syndrome with adrenal suppression induced by inhaled budesonide due to a ritonavir drug interaction in a woman with HIV infection.

    abstract::A 48-year-old woman with HIV infection developed Cushingoid features while she was taking ritonavir-boosted darunavir. Cushing's syndrome was confirmed due to the drug interaction between ritonavir and budesonide. Diagnosis of iatrogenic Cushing's syndrome in HIV-positive patients who are on ritonavir-boosted protease...

    journal_title:International journal of STD & AIDS

    pub_type: 杂志文章


    authors: Yoganathan K,David L,Williams C,Jones K

    更新日期:2012-07-01 00:00:00

  • Estimating HIV-1 transmission efficiency through unsafe medical injections.

    abstract::The transmission efficiency of HIV-1 through unsafe medical injections can be estimated from seroconversions among health care workers (HCWs) after percutaneous exposures and documented iatrogenic outbreaks. Data from a case-control study of seroconversion after percutaneous exposures among US and European HCWs shows ...

    journal_title:International journal of STD & AIDS

    pub_type: 杂志文章


    authors: Gisselquist DP

    更新日期:2002-03-01 00:00:00

  • A case of gastric syphilis with neurosyphilis presented as epigastric pain.

    abstract::Gastric syphilis has non-specific symptoms and various endoscopic and radiographic findings. Spirochetes are seen infrequently in biopsy specimens and the pathological findings are often non-specific. So it is very difficult to make a definitive diagnosis of gastric syphilis based on clinical symptoms and biopsy findi...

    journal_title:International journal of STD & AIDS

    pub_type: 杂志文章


    authors: Jeong HW,Jeon WJ,Sung RH

    更新日期:2008-11-01 00:00:00

  • Long-term HIV/AIDS survivors: Patients living with HIV infection retained in care for over 20 years. What have we learned?

    abstract::Individuals diagnosed with HIV before 1996 had poor prognoses. Few HIV care centers can track patients continuously from the 1980s to present. We determined the sociodemographic, clinical, and health care utilization characteristics of patients diagnosed and followed for >20 years (i.e. long-term HIV/AIDS survivors) t...

    journal_title:International journal of STD & AIDS

    pub_type: 杂志文章


    authors: Krentz HB,John Gill M

    更新日期:2018-11-01 00:00:00