Abstract:
:We report a case of human herpes virus-8-associated multicentric Castleman's disease in an HIV-positive patient with hyponatraemia. A 65-year-old man was admitted with relapsing and remitting fever, scattered skin eruptions and hepatosplenomegaly following combination antiretroviral therapy for his HIV infection. Based on histopathological findings, he was diagnosed as having human herpes virus-8-associated multicentric Castleman's disease and was treated with four-weekly infusions of rituximab. Prior to receiving chemotherapy, we observed several suspected biomarkers of disease activity, positive correlations between plasma human herpes virus-8 viral load and the levels of plasma interleukin-6, C-reactive protein and soluble interleukin-2 receptor, and negative correlations between platelet count, albumin levels and especially serum sodium levels. We hypothesize that non-osmotic release of plasma antidiuretic hormone is a cause of hyponatraemia in human herpes virus-8-associated multicentric Castleman's disease and that relapsing and remitting hyponatraemia could be correlated with plasma human herpes virus-8 viral load.
journal_name
Int J STD AIDSjournal_title
International journal of STD & AIDSauthors
Sasaki H,Maeda T,Hara Y,Osa M,Imai K,Moriguchi K,Mikita K,Fujikura Y,Kaida K,Kawana Adoi
10.1177/0956462414562050subject
Has Abstractpub_date
2015-10-01 00:00:00pages
909-11issue
12eissn
0956-4624issn
1758-1052pii
0956462414562050journal_volume
26pub_type
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