Abstract:
:A group of 14 women infected with hepatitis C virus (HCV) was evaluated for vaginal shedding of the virus. The HCV-RNA detection was performed in plasma, peripheral blood mononuclear cells (PBMC) and in supernatant and pellet of vaginal washings. HCV-RNA positive results were obtained in all plasma samples, in 57% of the PBMC samples, in 36% pellets obtained following centrifugation of vaginal washings and in 36% of the supernatants. In 21% of the women a positive result was found, at the same time, in every analysed product. The HCV genotypes identified in the plasma samples (1a: 38%; 1b: 36%; 3a: 13% and 1b+3a: 14%) matched with those in PBMC and vaginal washings in every sample, with the exception of cases where mixed infection (1b+3a) was detected. In these, genotype 1b was only detected in plasma. HCV viral load was not associated with the presence of HCV-RNA in PBMC or in vaginal washings (either cells or supernatant).
journal_name
Int J STD AIDSjournal_title
International journal of STD & AIDSauthors
Gameiro R,Venneno T,Prieto E,Castro R,Carnall V,Canas-Ferreira W,Exposto Fdoi
10.1258/0956462011924209subject
Has Abstractpub_date
2001-11-01 00:00:00pages
717-21issue
11eissn
0956-4624issn
1758-1052journal_volume
12pub_type
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journal_title:International journal of STD & AIDS
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