Cushing's syndrome with adrenal suppression induced by inhaled budesonide due to a ritonavir drug interaction in a woman with HIV infection.

Abstract:

:A 48-year-old woman with HIV infection developed Cushingoid features while she was taking ritonavir-boosted darunavir. Cushing's syndrome was confirmed due to the drug interaction between ritonavir and budesonide. Diagnosis of iatrogenic Cushing's syndrome in HIV-positive patients who are on ritonavir-boosted protease inhibitors (PIs) presents a clinical challenge due to similar clinical features of lipohypertrophy related to ritonavir-boosted PIs. Although this complication has been widely described with the use of inhaled fluticasone, the interaction with inhaled budesonide at therapeutic dose is not widely recognized.

journal_name

Int J STD AIDS

authors

Yoganathan K,David L,Williams C,Jones K

doi

10.1258/ijsa.2011.011408

subject

Has Abstract

pub_date

2012-07-01 00:00:00

pages

520-1

issue

7

eissn

0956-4624

issn

1758-1052

pii

23/7/520

journal_volume

23

pub_type

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