Therapeutic immunization for the control of HIV-1: where are we now?

Abstract:

:Highly active antiretroviral therapy (HAART) has transformed HIV-1 infection from an invariably fatal disease into a chronic infection requiring lifelong treatment. However, the challenges we still face are the urgent need to provide affordable sustainable therapy to the millions of infected individuals who live in resource-poor countries, and the limitations posed by serious drug toxicity and viral resistance associated with long-term therapy. Augmentation of HIV-specific immunity by therapeutic vaccination is a possible alternative to continuous HAART. In this review, progress in the development of therapeutic immunization strategies is discussed.

journal_name

Int J STD AIDS

authors

Dorrell L

doi

10.1258/095646206777689035

subject

Has Abstract

pub_date

2006-07-01 00:00:00

pages

436-41; quiz 442

issue

7

eissn

0956-4624

issn

1758-1052

journal_volume

17

pub_type

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