Abstract:
:Highly active antiretroviral therapy (HAART) has transformed HIV-1 infection from an invariably fatal disease into a chronic infection requiring lifelong treatment. However, the challenges we still face are the urgent need to provide affordable sustainable therapy to the millions of infected individuals who live in resource-poor countries, and the limitations posed by serious drug toxicity and viral resistance associated with long-term therapy. Augmentation of HIV-specific immunity by therapeutic vaccination is a possible alternative to continuous HAART. In this review, progress in the development of therapeutic immunization strategies is discussed.
journal_name
Int J STD AIDSjournal_title
International journal of STD & AIDSauthors
Dorrell Ldoi
10.1258/095646206777689035subject
Has Abstractpub_date
2006-07-01 00:00:00pages
436-41; quiz 442issue
7eissn
0956-4624issn
1758-1052journal_volume
17pub_type
杂志文章,评审abstract::Patients with HIV infection have a higher propensity for infectious, inflammatory, neoplastic and metabolic disorders. The link with psoriasis vulgaris is explained by well-known pathophysiological phenomena and can be observed at any stage of infection. The aim of our study was to characterize the clinical spectrum o...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/ijsa.2011.010525
更新日期:2011-11-01 00:00:00
abstract::The primary aim of the current study was to test the effect of the presentation design of a test alert system on healthcare workers' (HCWs') decision-making regarding blood-borne virus (BBV) testing. The secondary aim was to determine HCWs' acceptance of the system. An online survey used a within-subjects research des...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1177/0956462420906998
更新日期:2020-07-01 00:00:00
abstract::In this structured review, we evaluated purulent vaginal and cervical discharge as diagnostic tests for pelvic inflammatory disease (PID). Using a pretest probability of PID (diagnosed clinically) of 50%, we used the odds-likelihood formulation of Bayes' theorem to calculate post-test probabilities of PID (proven by l...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章,评审
doi:10.1258/ijsa.2008.008261
更新日期:2009-02-01 00:00:00
abstract::We assessed the validity of a syndromic case management approach for reproductive tract infections (RTIs) among 371 pregnant women attending antenatal care facilities in Kingston, Jamaica, using an algorithm previously validated in high-risk Jamaican women. For our antenatal attenders, the algorithm had low sensitivit...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/095646204774195209
更新日期:2004-06-01 00:00:00
abstract::Cervical cancer is the leading incident cancer and the main cause of cancer-related mortality among women in sub-Saharan Africa. Furthermore, HIV-infected women are at a higher risk of developing cervical cancer than HIV-negative women. The purpose of this study was to distinguish differences in characteristics of HIV...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1177/0956462415606252
更新日期:2016-10-01 00:00:00
abstract::This is the first in a series of articles reviewing four viral infections, Ebola virus, Zika virus, human T-cell lymphotropic virus, type 1 and hepatitis C virus, with an emphasis on recent advances in our understanding of their sexual transmission. With current day speed and ease of travel it is important for staff i...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章,评审
doi:10.1177/0956462417703572
更新日期:2017-11-01 00:00:00
abstract::HIV-infected women have a high prevalence of abnormal Papanicolaou smears and cervical intraepithelial neoplasia. A multiparametric analysis of epidemiological and behavioural risk factors has been performed in a cohort of 204 HIV-infected women in an outpatient clinic with the aim to investigate risk factors associat...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/0956462971920316
更新日期:1997-06-01 00:00:00
abstract::Cutaneous Candida infections may occur in patients with HIV/AIDS, cancer, receiving chemotherapy and solid organ transplantation. A 32-year-old woman was admitted to the department suffering from pruritic and erythematous plaque on left side of her face for the past two months. The patient was HIV positive, diagnosed ...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1177/0956462413479897
更新日期:2013-09-01 00:00:00
abstract::Little is known about the incidence of bacterial sexually transmitted infections (STIs) among HIV-infected versus HIV-uninfected adolescents. This secondary analysis of a national, multisite study included adolescents aged 12-18 years who were behaviourally HIV-infected (n = 346) or HIV-uninfected but at-risk (n = 182...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1177/0956462412472425
更新日期:2013-02-01 00:00:00
abstract::The aim of this study was to investigate the effect of asymptomatic rectal bacterial sexually transmitted infections (STIs) on rectal HIV viral load (VL). A prospective cohort study of HIV-positive men who have sex with men attending a tertiary centre in London, UK, for their routine HIV care was performed. Forty-two ...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1177/0956462416686513
更新日期:2017-09-01 00:00:00
abstract::Using data from the Prevention of Pelvic Infection (POPI) chlamydia screening trial, we compared the characteristics of female students who did or did not get tested for chlamydia outside the trial during 12 months' follow-up. Of the 2529 women in the trial, we excluded 68 chlamydia positives in the intervention group...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1177/0956462415587636
更新日期:2016-06-01 00:00:00
abstract::Despite many reports of HIV-infected African children who have HIV-uninfected mothers, little is known about the extent and modes of horizontal HIV transmission in African children. We estimated the extent of horizontal HIV transmission in Swazi children by comparing child and mother HIV statuses in the 2006-2007 Swaz...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/ijsa.2009.009204
更新日期:2009-12-01 00:00:00
abstract::In Latin America, men who have sex with men (MSM) remain disproportionately impacted by HIV. Pre-exposure prophylaxis (PrEP) is an effective HIV prevention tool and has been FDA approved in the United States since 2012, but no Latin American state, with the recent exception of Brazil, has implemented PrEP guidelines. ...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1177/0956462419825944
更新日期:2019-05-01 00:00:00
abstract::For people immunosuppressed by human immunodeficiency virus (HIV), we expect an increase in cancer incidence similar to that documented in transplant patients. We examined the cancer spectrum in an HIV-infected cohort, specifically malignancies not currently associated with acquired immunodeficiency syndrome (AIDS), i...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/0956462991913574
更新日期:1999-12-01 00:00:00
abstract::We adapted the Healthy Love Workshop (HLW), an HIV prevention workshop for African American women in the United States, for African, Caribbean and Black (ACB) women in Toronto, Canada. We conducted a pilot study with ACB women ( n = 80) in ten community-based settings with pre-test (T1), post-test (T2) and three-month...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1177/0956462418754971
更新日期:2018-07-01 00:00:00
abstract::This study describes antimicrobial susceptibility patterns of Neisseria gonorrhoeae isolates obtained from female sex workers in Cotonou, Bénin. All isolates were susceptible to spectinomycin, ceftriaxone and ciprofloxacin, and susceptible to moderately susceptible to kanamycin; 9.8% of isolates were resistant to thia...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/0956462011916848
更新日期:2001-02-01 00:00:00
abstract::The object of this study was to determine the factors associated with partner notification (PN) of sexually transmitted infection (STI) exposure among pregnant, low income, Mexican-American (MA) and African-American (AA) women and their male sexual partners. We used a cross-sectional analysis of 166 pregnant women wit...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/ijsa.2007.007295
更新日期:2008-05-01 00:00:00
abstract::Domestic violence (DV) occurs frequently within the UK, with one in four women and one in six men experiencing DV during their life. DV is the leading cause of morbidity for women aged 19-44 years and is associated with sexual health problems. However, few data exist on the prevalence of DV in UK genitourinary (GU) me...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1177/0956462412472799
更新日期:2013-05-01 00:00:00
abstract::The aim of this study was to develop and evaluate a simple V3 peptide-based enzyme immunoassay (PEIA) for large-scale serotyping of HIV-1 specimens derived from injecting drug users (IDUs) in the Russian Federation. Two synthetic peptides were evaluated, named P1 (RKSIHIGPGRAFYATGD) and P2 (RTSVRIGPGQVFYKTGD), in an P...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:
更新日期:2001-01-01 00:00:00
abstract::The copper intrauterine contraceptive device (IUCD) is strongly associated with bacterial vaginosis (BV). Hormonal influences may play a role in the control of vaginal flora. It is unclear whether use of the progesterone-incorporated intrauterine system (IUS; Mirena) is associated with abnormal vaginal flora or genita...
journal_title:International journal of STD & AIDS
pub_type: 临床试验,杂志文章
doi:10.1258/ijsa.2008.008391
更新日期:2009-06-01 00:00:00
abstract:SUMMARY:Point-of-care microscopy is the gold standard for the diagnosis of vaginal discharge in genitourinary (GU) medicine clinics but not used in primary care settings and reproductive health clinics to which many patients present. In our GU medicine clinic setting, we conducted an audit to assess the utility of micr...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/ijsa.2008.008212
更新日期:2008-12-01 00:00:00
abstract::Few studies investigate sexual health among Chinese international students in Australia. We recruited domestic (n = 623) and Chinese international (n = 500) students for separate online surveys on sexual behaviours and knowledge. Samples were compared using Chi square, Fisher's exact and equality of medians tests. Dom...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1177/0956462420921726
更新日期:2020-07-01 00:00:00
abstract::A retrospective casenote study was conducted to examine the risk factors for patients who were diagnosed as hepatitis C (HCV)-positive (between 1999 and 2001) in a semi-rural genitourinary medicine (GUM) setting in Staffordshire, UK. There was a remarkable escalation in the number of reported HCV-positive cases, year ...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/095646202321020143
更新日期:2002-12-01 00:00:00
abstract::We report the case of a patient with a large Buschke-Lowenstein tumour which had previously recurred following local excision. A preferred treatment modality for this rare variant of human papillomavirus has not been clearly defined. Treatment with chemo-radiotherapy in this case resulted in complete resolution of the...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/ijsa.2009.009012
更新日期:2009-10-01 00:00:00
abstract::Toxoplasma encephalitis (TE) is usually diagnosed in advanced stages of HIV infection when the CD4+ count is <100-200 cells/µl. A 55-year-old woman with HIV/AIDS, well controlled on antiretroviral therapy (ART), CD4+ count in the 300 cells/μl range for >1 year presented with acute onset of headache, nausea and vomitin...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1177/0956462413506891
更新日期:2014-04-01 00:00:00
abstract::Self sampling of the secretions of the female genital tract for microbiological investigations for Neisseria gonorrhoeae, Chlamydia trachomatis and Trichomonas vaginalis was assessed in female attenders of the genitourinary medicine clinic in Coventry and Warwickshire Hospital. The purpose of the study was to evaluate...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1177/095646249400500411
更新日期:1994-07-01 00:00:00
abstract::A heterosexual man with acquired syphilis had an uncommon presentation in the form of acute visual loss. The unusual clinical presentation and a high cerebrospinal fluid lymphocyte count led to delayed diagnosis and treatment. Recognition of uncommon presentation of syphilis in the current epidemic is essential for th...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/095646207781024847
更新日期:2007-06-01 00:00:00
abstract::Patients who do not attend (DNA) clinic appointments are wasteful of resources and may also pose a potential public health risk through the onward transmission of untreated sexually transmitted infections (STIs). This service evaluation was performed to assess the demographics of DNAs, patient reasons for non-attendan...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/ijsa.2009.009349
更新日期:2010-05-01 00:00:00
abstract::All category III chronic prostatitis cases in two hospital sites were retrospectively reviewed from the year 2000 until 2005. The mean age of the patients was 38.7 years. Of these, 56.6% were St Bartholomew's Genitourinary Medicine Department patients and 43.5% were Southend Genitourinary Medicine Clinic patients. We ...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/095646207780658917
更新日期:2007-04-01 00:00:00
abstract::Household contacts of hepatitis B (HBV) are at risk of infection, and guidelines advise vaccination of these contacts in addition to sexual partners (along with traditional high-risk groups). We present a case of intrafamilial transmission of acute hepatitis B virus (HBV) following failure to self-disclose status to f...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/ijsa.2009.009482
更新日期:2011-11-01 00:00:00