Abstract:
:The aim of this study was to develop and evaluate a simple V3 peptide-based enzyme immunoassay (PEIA) for large-scale serotyping of HIV-1 specimens derived from injecting drug users (IDUs) in the Russian Federation. Two synthetic peptides were evaluated, named P1 (RKSIHIGPGRAFYATGD) and P2 (RTSVRIGPGQVFYKTGD), in an PEIA on 63 HIV-1 IDUs sera for which genotypes had been determined by heteroduplex mobility assay (HMA) and sequencing. The sensitivities of P1 (subtype B) and P2 (subtype A) were 87% and 75% respectively. Specificity of the assay was 100% for both peptides, with 100% predictive values of a monoreactive positive test for both peptides. Using the PEIA with peptides P1 and P2, we have serotyped 375 of 477 serum samples derived from IDUs in 4 main sites of the HIV-1 epidemic in Russia. The results demonstrated a high level of subtype homogeneity in all regions studied. In 3 of 4 territories, Tver' (n=345), and Rostov-on-Don (n=61) regions, and Krasnodar Kray (n=27), 100% of typable sera were found to belong to env subtype A. On the other hand, all specimens serotyped in the Kaliningrad region (n=38) belonged to env subtype B, and there is strong evidence that the recombinant gagAenvB virus which has caused the largest outbreak of HIV-1 in Russia is located in this region. At the present time another parental strain with gagBenvB genotype is of minor importance in the IDUs HIV-1 epidemic in Russia.
journal_name
Int J STD AIDSjournal_title
International journal of STD & AIDSauthors
Bobkova MR,Kazennova EV,Selimova LM,Buravtsova EV,Lister S,Prilipov AG,Weber JN,Pokrovsky VV,Bobkov AFsubject
Has Abstractpub_date
2001-01-01 00:00:00pages
34-40issue
1eissn
0956-4624issn
1758-1052journal_volume
12pub_type
杂志文章abstract::The blood-taking practices and prevalence of needle-stick injuries were recorded for 46 house officers working at the two largest teaching hospitals in Sheffield and 38 house officers working at three hospitals in London. Wearing gloves when performing venesection or inserting an intravenous cannula was generally perc...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1177/095646249100200109
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abstract::For people immunosuppressed by human immunodeficiency virus (HIV), we expect an increase in cancer incidence similar to that documented in transplant patients. We examined the cancer spectrum in an HIV-infected cohort, specifically malignancies not currently associated with acquired immunodeficiency syndrome (AIDS), i...
journal_title:International journal of STD & AIDS
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journal_title:International journal of STD & AIDS
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doi:10.1258/ijsa.2009.009240
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journal_title:International journal of STD & AIDS
pub_type: 社论
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journal_title:International journal of STD & AIDS
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abstract::There is a need for new hypotheses to supplement existing explanations for the observed differences in HIV prevalence between countries and within countries. Due to high levels of viraemia during the initial phase of HIV infection, networks of concurrent regular partnerships in a community could be the determining fac...
journal_title:International journal of STD & AIDS
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abstract::The management of cases of gonorrhoea in the Genitourinary Medicine Department (GUM) of Newcastle upon Tyne in 1999 was audited. The sensitivity of microscopy in diagnosis was 90.4% for male urethral gonorrhoea and 26.6% for female genital gonorrhoea. The sensitivity of laboratory culture was 98.5%. Screening for Chla...
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pub_type: 杂志文章,评审
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journal_title:International journal of STD & AIDS
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journal_title:International journal of STD & AIDS
pub_type: 杂志文章,随机对照试验
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journal_title:International journal of STD & AIDS
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journal_title:International journal of STD & AIDS
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pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:International journal of STD & AIDS
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abstract::Integrase strand transfer inhibitors (INSTIs) are a class of antiretroviral drugs with high virologic efficacy and excellent tolerability. Recent evidence showed a possible link of dolutegravir-based regimens with weight gain, and a relationship between raltegravir use and changes in adipose tissue density and metabol...
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