Abstract:
:Two appetite stimulants, megestrol acetate and cyproheptadine were administered in a randomized trial to 14 patients who had no evidence of opportunistic infection or malabsorption but were wasted (had lost more than 5 kg body weight) as a result of human immunodeficiency virus (HIV) infection. Energy intakes were calculated from a 7 day weighed dietary record. Mean energy intakes per kilogramme body weight were similar in both treatment groups (greater than 34 kcal/kg) and were higher than that in well British males. Energy intakes increased by just over 500 kcal during both treatments, but fell to pretreatment levels after therapy. Patients in both treatment groups gained a moderate amount of weight. Megestrol acetate was associated with impotence in 4 patients. Insufficient calorie intake alone is not a common cause of wasting associated with HIV and the role of appetite stimulants is likely to be limited.
journal_name
Int J STD AIDSjournal_title
International journal of STD & AIDSauthors
Summerbell CD,Youle M,McDonald V,Catalan J,Gazzard BGdoi
10.1177/095646249200300409subject
Has Abstractpub_date
1992-07-01 00:00:00pages
278-80issue
4eissn
0956-4624issn
1758-1052journal_volume
3pub_type
临床试验,杂志文章,随机对照试验abstract::Individuals diagnosed with HIV before 1996 had poor prognoses. Few HIV care centers can track patients continuously from the 1980s to present. We determined the sociodemographic, clinical, and health care utilization characteristics of patients diagnosed and followed for >20 years (i.e. long-term HIV/AIDS survivors) t...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1177/0956462418778705
更新日期:2018-11-01 00:00:00
abstract::Stavudine is a potent nucleoside analogue and a well-recognized component of highly active antiretroviral therapy. Clinical trials have shown stavudine to have a superior or at least comparable virological efficacy and immune reconstitution when compared with other nucleoside analogues. Studies have shown that the pre...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章,评审
doi:10.1258/095646203322491842
更新日期:2003-10-01 00:00:00
abstract::Advancements in the diagnosis and treatment of testicular cancer now give a five-year survival rate of 97.2%. Delayed presentation remains the primary cause of poor outcome and recommendations have stressed that men, particularly those with risk factors, should undertake regular testicular self-examination. This study...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1177/0956462414522774
更新日期:2014-10-01 00:00:00
abstract::The main purpose of this study was to investigate how loneliness was associated with social support and family function among people living with HIV/AIDS (PLWHA) in an HIV-stricken area of China. Two hundred and nineteen PLWHA were surveyed using the UCLA (University of California at Los Angeles)-Loneliness Scale, the...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/ijsa.2008.008348
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abstract::Although important, the foreskin is not absolutely essential to penile function. Dysfunction is common and a cause of considerable morbidity, and is sometimes associated with mortality from squamous cell carcinoma (SCC). Penile dermatoses herald, complicate or cause preputial dysfunction. Their effective diagnosis and...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章,评审
doi:10.1258/0956462011922922
更新日期:2001-04-01 00:00:00
abstract::A recent survey reported that 36% of UK genitourinary medicine clinics offer testing for pharyngeal Chlamydia trachomatis (CT). Screening at this site is targeted at high-risk groups attending our centre, including female sex workers (FSWs) and male sex workers (MSWs). A total of 2406 patients were screened between No...
journal_title:International journal of STD & AIDS
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abstract::Studies in various regions of the world have shown that women infected with HIV-1 are at increased risk for cervical human papillomavirus (HPV) infection as well as for cervical cancer precursor lesions. HIV infection and cervical cancer are both widespread in West Africa, but little is known about the relationship be...
journal_title:International journal of STD & AIDS
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更新日期:1994-05-01 00:00:00
abstract::HIV seroconversions and sexually transmitted diseases (STDs) are often clustered in social networks within community populations. The present study was carried out among men who have sex with men in Russia, where a major HIV epidemic is unfolding, and where social networks have played a historically important role. In...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/095646206775220504
更新日期:2006-01-01 00:00:00
abstract::Few analytic opportunities have allowed us to evaluate the role that specific sexual acts and male latex condoms play in the acquisition of external anal warts (EAW) using longitudinal data. The acquisition of EAWs occurs from epithelial contact with other HPV-infected surfaces, and hence is dependent upon sexual beha...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章,多中心研究
doi:10.1258/0956462053420176
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abstract::The value of microscopy of a Gram-stained urethral smear in the diagnosis of non-gonococcal urethritis and chlamydial urethral infection was assessed in 153 men attending a department of genitourinary medicine. A mean of more than 4 polymorphs in 5 fields (x1000) was considered to be abnormal. In the diagnosis of uret...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1177/095646249100200409
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abstract::Genital ulcer disease as a risk factor for HIV transmission has become apparent in the fight against AIDS. In poor communities in developing countries with people living under low hygienic conditions chancroid is often reported to be the most common form of genital ulcer. It is caused by Haemophilus ducreyi; a fastidi...
journal_title:International journal of STD & AIDS
pub_type: 社论,评审
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更新日期:1993-11-01 00:00:00
abstract::Protective response rates to hepatitis B (HB) vaccination have been reported as low as 18-62% in HIV-infected persons. The relative importance of various predictors for this poor response has not been fully characterized. In this retrospective cohort study, we examined the relationship between clinical characteristics...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/ijsa.2007.007197
更新日期:2008-09-01 00:00:00
abstract::This cross-sectional study explored the prevalence and correlates of syphilis infection among people who use and inject drugs (PWUD/PWID) in Cambodia. Data were collected in 2017 from 1,677 PWUD/PWID living in the capital city of Phnom Penh and 11 other major provinces using the respondent-driven sampling method. The ...
journal_title:International journal of STD & AIDS
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abstract::We describe the first reported case of Candida pelliculosa meningitis in HIV infection. This case highlights the risk of uncommon opportunistic infections in association with the immunocompromised and the importance of autopsy as a diagnostic tool in HIV infection. We discuss the epidemiology, diagnosis and management...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
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abstract::The first national audit of the management of Chlamydia trachomatis was undertaken by non-consultant career grade doctors working in genitourinary (GU) medicine clinics in the UK. During the audit period of January--March 2004, 1670 data collection forms were completed (from 830 men and 840 women with chlamydia). In a...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
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abstract::We describe a recent outbreak of syphilis in young heterosexuals in the north west of England. A cluster of 12 cases of syphilis (7 primary and 5 early latent) was identified in Rochdale in heterosexuals aged 20 or under. Nine were women. Five were asymptomatic at presentation. This outbreak occurred in a group not us...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/ijsa.2011.011031
更新日期:2011-09-01 00:00:00
abstract::The British HIV Association (BHIVA) has published guidelines for immunization of HIV-infected adults. A chart review of 200 HIV-infected patients diagnosed was conducted to determine shortcomings in previous practice and determine which vaccines should routinely be given in specialist HIV clinics and which might be ab...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
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更新日期:2012-02-01 00:00:00
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journal_title:International journal of STD & AIDS
pub_type: 杂志文章
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abstract::Integrase strand transfer inhibitors (INSTIs) are a class of antiretroviral drugs with high virologic efficacy and excellent tolerability. Recent evidence showed a possible link of dolutegravir-based regimens with weight gain, and a relationship between raltegravir use and changes in adipose tissue density and metabol...
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abstract::The persistent sexual arousal syndrome (PSAS) is a newly described entity where the woman becomes involuntarily genitally aroused for extended periods of time in the absence of sexual desire and is distressed by this situation. The cause of this sexual problem is not well understood. We describe such a case where the ...
journal_title:International journal of STD & AIDS
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doi:10.1258/095646207779949592
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abstract::This study attempted to assess the risk behaviours for HIV/AIDS among female garment workers aged 15-24 years.A total of 300 garment workers in Dhaka city were assessed with a semi-structured interview. Their knowledge of HIV/AIDS was moderate with high rates of misperception regarding modes of transmission. Further, ...
journal_title:International journal of STD & AIDS
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abstract::We conducted a literature review of patients' conditions described under persistent genital arousal disorder and restless genital syndrome, vulvodynia and male genital skin pain of unknown aetiology (penoscrotodynia). Our aim is to improve the understanding of the condition, unify nomenclature and promote evidence-bas...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章,评审
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abstract::This paper describes the effect of HIV prevention intervention among female sex workers in Delhi. Over a 2-year period we found a marked increase in condom use with little increase in HIV seroprevalence. The prevalence of HIV infection did not increase during the study period (1 positive among 701 in 1988 vs 1 positiv...
journal_title:International journal of STD & AIDS
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更新日期:1994-01-01 00:00:00
abstract::Fusarium infections are very rare in HIV-infected patients, even in patients in advanced stages of immunosuppression. All the reported cases in the literature are of disseminated infection, and with poor outcomes despite prompt and appropriate treatment. To the best of our knowledge, this is the first report of a loca...
journal_title:International journal of STD & AIDS
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abstract::The risk of death is significantly higher in HIV-infected patients with tuberculosis (TB). This study aims to evaluate the impact of demographic, clinical and laboratory characteristics on the treatment outcome and mortality of TB/HIV co-infected patients in a tertiary TB centre in Iran. In total, 111 patients were re...
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abstract::Recognising the initial clinical presentation of acute HIV infection could enable earlier initiation of antiretroviral therapy and appropriate counselling to reduce the risk of transmission to others. Herein, we describe an unusual case of acute HIV infection presenting as limbic encephalitis and rhabdomyolysis. ...
journal_title:International journal of STD & AIDS
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abstract::Chlamydia trachomatis and Neisseria gonorrhoeae testing guidance recommends extragenital screening with locally validated nucleic acid amplification tests, with anatomical sites tested separately. Evidence supports multi-patient combined aliquot pooled sampling (PS) for population screening; evidence for within-patien...
journal_title:International journal of STD & AIDS
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abstract::We report a case of secondary syphilis mimicking lupus vulgaris in an HIV-infected patient. A 21-year-old Brazilian man presented with a two-month history of asymptomatic cutaneous lesions accompanied by fever and fatigue. Dermatological evaluation revealed an erythematous, crusted, large plaque on the neck with the '...
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abstract::Perceived health-related quality of life (QOL) of 113 adult people living with HIV/AIDS (PHA) attending an outpatient hospital clinic was assessed upon initial registration using the Medical Outcomes Study SF-36. QOL ratings on both physical functioning and psychological well-being aspects of the SF-36 were lower than...
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abstract::OptionE incorporates nurse-led HIV clinics, review of blood results by doctors, patient contact by email and the option of home delivery of medication. Patient questionnaires showed increased satisfaction associated with fewer, shorter clinic visits. A retrospective case note review suggested clinical outcomes are as ...
journal_title:International journal of STD & AIDS
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