Abstract：
:In the ARTEMIS trial, 689 treatment-naïve, HIV-1-infected adults received darunavir/ritonavir (DRV/r) 800/100 mg every day or lopinavir/ritonavir (LPV/r) 800/200 mg total daily dose plus fixed-dose tenofovir/emtricitabine. Week 96 metabolic parameters are reported. Adverse events (AEs) classed as metabolism/nutrition disorders were observed in 14% of DRV/r and 22% of LPV/r patients. Lipid-related AEs were reported in fewer DRV/r (8%) than LPV/r (16%) patients. A small increase in glucose and insulin levels was observed at week 96 in both groups. Lipoma was the only lipodystrophy-related AE reported in >1% of patients (DRV/r, n = 1; LPV/r, n = 4) and no grade 3 or 4 lipodystrophy-related AEs were reported. No clinically relevant changes from baseline were seen in anthropometric measurements in either group. Median mid-waist/hip ratio at week 96 was comparable to baseline in both arms. Over 96 weeks, DRV/r had a similar effect on glucose and insulin levels but a more favourable lipid profile than LPV/r in treatment-naïve, HIV-infected patients.
journal_name
Int J STD AIDSjournal_title
International journal of STD & AIDSauthors
Arathoon E,Schneider S,Baraldi E,Lim PL,Opravil M,Van De Casteele T,Lavreys Ldoi
10.1258/ijsa.2012.012120subject
Has Abstractpub_date
2013-01-01 00:00:00pages
12-7issue
1eissn
0956-4624issn
1758-1052pii
ijsa.2012.012120journal_volume
24pub_type
杂志文章,随机对照试验abstract：:An HIV-positive African woman developed severe constitutional symptoms associated with rebound viraemia during a planned antiretroviral treatment interruption, requiring reinitiation of highly active antiretroviral therapy. ...
journal_title：International journal of STD & AIDS
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abstract：:Schistosomiasis is uncommon in the UK but is found in migrant populations and in those who travel to areas of endemic schistosomiasis. Apparent clinical symptoms may occur long after the patient has left an endemic area. Female urogenital schistosomiasis (arising from infection by Schistosoma haematobium, endemic in A...
journal_title：International journal of STD & AIDS
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journal_title：International journal of STD & AIDS
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abstract：:Gonorrhoea and chlamydia infections in women are often regarded as asymptomatic. Syndromic management of sexually transmitted disease (STDs), however, is partially based on vaginal symptoms. We sought to better identify STD-associated symptoms in women by development of composite genitourinary symptom constructs. Stan...
journal_title：International journal of STD & AIDS
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journal_title：International journal of STD & AIDS
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journal_title：International journal of STD & AIDS
pub_type： 临床试验,杂志文章,随机对照试验
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journal_title：International journal of STD & AIDS
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journal_title：International journal of STD & AIDS
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journal_title：International journal of STD & AIDS
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journal_title：International journal of STD & AIDS
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journal_title：International journal of STD & AIDS
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journal_title：International journal of STD & AIDS
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journal_title：International journal of STD & AIDS
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journal_title：International journal of STD & AIDS
pub_type： 临床试验,杂志文章
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