Abstract:
:HIV-1 and HSV-2 are frequent genital co-infections in women. To determine how self-collected genital swabs compare to provider-collected cervicovaginal lavage, paired self-collected genital swabs and cervicovaginal lavage from women co-infected with HIV-1 and HSV-2 were evaluated. Women were in an acyclovir clinical trial and their samples were tested for HIV-1 RNA (361 samples) and HSV-2 DNA (378 samples). Virus shedding, quantity and acyclovir effect were compared. HIV-1 and HSV-2 were more frequently detected in self-collected genital swabs: 74.5% of self-collected genital swabs and 63.6% of cervicovaginal lavage had detectable HIV-1 (p ≤ 0.001, Fisher's exact test) and 29.7% of self-collected genital swabs and 19.3% of cervicovaginal lavage had detectable HSV-2 (p ≤ 0.001) in the placebo month. Cervicovaginal lavage and self-collected genital swabs virus levels were correlated (Spearman's rho, 0.68 for HIV; 0.61 for HSV-2) and self-collected genital swabs levels were generally higher. In multivariate modeling, self-collected genital swabs and cervicovaginal lavage could equally detect the virus-suppressive effect of acyclovir: for HIV-1, proportional odds ratios were 0.42 and 0.47 and for HSV-2, they were 0.10 and 0.03 for self-collected genital swabs and cervicovaginal lavage, respectively. Self-collected genital swabs should be considered for detection and measurement of HIV-1 and HSV-2 in clinical trials and other studies as they are a sensitive method to detect virus and can be collected in the home with frequent sampling.
journal_name
Int J STD AIDSjournal_title
International journal of STD & AIDSauthors
McNicholl JM,Leelawiwat W,Whitehead S,Hanson DL,Evans-Strickfaden T,Cheng CY,Chonwattana W,Mueanpai F,Kittinunvorakoon C,Markowitz L,Dunne EFdoi
10.1177/0956462416650123subject
Has Abstractpub_date
2017-03-01 00:00:00pages
372-379issue
4eissn
0956-4624issn
1758-1052pii
0956462416650123journal_volume
28pub_type
临床试验,杂志文章abstract::The objectives were, first, to determine the sensitivity and specificity of the Osmetech Microbial Analyser (OMA) for the diagnosis of bacterial vaginosis (BV) and, secondly, to determine the factors that interfere with the performance of the test. Women presenting to a genitourinary medicine clinic underwent routine ...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
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journal_title:International journal of STD & AIDS
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journal_title:International journal of STD & AIDS
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journal_title:International journal of STD & AIDS
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abstract::We sought to describe the prevalence, trends and factors associated with late diagnosis of HIV infection between 2001 and 2008 in Catalonia, Spain. Adults over 13 years of age with available CD4 cell counts, who were notified to the Catalonia Voluntary HIV Surveillance System between January 2001 and December 2008, we...
journal_title:International journal of STD & AIDS
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journal_title:International journal of STD & AIDS
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abstract::Sub-Saharan Africa disproportionately represents the largest incidence of both HIV/AIDS and internal conflicts. The impact of conflict on HIV incidence is largely unknown. Current epidemiological evidence paradoxically suggests that in most populations affected by conflict, HIV prevalence is lower than surrounding com...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章,评审
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abstract::We evaluated associations between history of syphilis infection and both cognitive function and depressive symptoms in people living with HIV (PLHIV) and comparable HIV-negative controls. Syphilis serological tests, cognitive function and depression were assessed in PLHIV and controls participating in the Pharmacokine...
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journal_title:International journal of STD & AIDS
pub_type: 临床试验,杂志文章,随机对照试验
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abstract::The effects of seminal high-risk human papillomavirus (HPV) DNA were assessed on the quality of semen. Semen samples of 65 men participating in the ongoing Finnish HPV Family Study were collected. Semen analyses were done by the guidelines of the Nordic Association for Andrology. HPV DNA was detected by nested polymer...
journal_title:International journal of STD & AIDS
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journal_title:International journal of STD & AIDS
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:International journal of STD & AIDS
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journal_title:International journal of STD & AIDS
pub_type: 临床试验,杂志文章,随机对照试验
doi:
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journal_title:International journal of STD & AIDS
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journal_title:International journal of STD & AIDS
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