Abstract:
:A single-blind randomized follow-up study was conducted to evaluate the efficacy and tolerance of roxithromycin 300 mg once a day compared to doxycycline 200 mg day 1 and 100 mg day 2-10 in the treatment of genital chlamydial infection in men and women and non-specific urethritis (NSU) in men. A total of 211 patients (200 men and 11 women) between 18 and 46 years were enrolled. The women were excluded from the efficacy analysis because of the low number, but were included in the tolerance analysis. The clinical (clearance of polymorphonuclear leucocytes in urethral smears) and bacteriological response was evaluated one and 11 days after the treatment. Of 113 included men with chlamydial infection, 105 (93%) and 96 (85%) were evaluable on respective follow-up visits and of 87 included men with NSU, 74 (85%) and 64 (74%) were evaluable one and 11 days after treatment, respectively. The bacteriological eradication rate immediately after the treatment in chlamydia positive patients was 92.7% and 100% for roxithromycin and doxycycline, respectively, and 91.8% and 100% at follow-up. The clinical cure rate of all evaluable patients was 83.1% and 80.7% for roxithromycin and doxycycline, respectively, one day after the treatment and 80.5% and 85.3% for the two drugs, respectively, 11 days after treatment. None of these observed differences was statistically significant. The diagnosis did not influence the clinical response rate with either drug. Probable and possible drug-related side-effects were more common after doxycycline than after roxithromycin, 35% and 19% respectively (P = 0.0032).(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Int J STD AIDSjournal_title
International journal of STD & AIDSauthors
Lidbrink P,Bygdeman S,Emtestam L,Gajecki M,Lapins J,Weden Udoi
10.1177/095646249300400211subject
Has Abstractpub_date
1993-03-01 00:00:00pages
110-3issue
2eissn
0956-4624issn
1758-1052journal_volume
4pub_type
临床试验,杂志文章,随机对照试验abstract::This study looks at the sensitivity of microscopy in the diagnosis of Neisseria gonorrhoeae (NG), the effect of microscopy on time to treatment of NG and the added value of microscopy in the management of gonorrhoea. Women diagnosed with NG at an inner city genitourinary (GU) medicine clinic between August 2005 and Ju...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/095646207782193876
更新日期:2007-10-01 00:00:00
abstract::We report the case of a patient with a large Buschke-Lowenstein tumour which had previously recurred following local excision. A preferred treatment modality for this rare variant of human papillomavirus has not been clearly defined. Treatment with chemo-radiotherapy in this case resulted in complete resolution of the...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/ijsa.2009.009012
更新日期:2009-10-01 00:00:00
abstract::Due to demographic changes in people living with HIV (PLHIV), physicians are challenged with age-related comorbidities and their management. In the absence of comprehensive data collection, the burden of comorbidities and co-medication in addition to antiretroviral therapy (ART) remains unclear for the German real-wor...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1177/0956462420942020
更新日期:2020-12-15 00:00:00
abstract::The limited published data support the assumption that lesbians are a low risk group for sexually transmitted diseases (STDs). However, there are virtually no contemporary data and the older papers do not take into account genital wart virus infection, now the third most prevalent STD in Britain. One of the dangers in...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1177/095646249000100304
更新日期:1990-05-01 00:00:00
abstract::We report a case of secondary syphilis mimicking lupus vulgaris in an HIV-infected patient. A 21-year-old Brazilian man presented with a two-month history of asymptomatic cutaneous lesions accompanied by fever and fatigue. Dermatological evaluation revealed an erythematous, crusted, large plaque on the neck with the '...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1177/0956462418795590
更新日期:2018-12-01 00:00:00
abstract::Our objective was to determine the prevalence of HIV and the distribution of HIV-related diseases among adult, medical inpatients. Consecutive admissions were recruited and a single ELISA assay was used to determine HIV infection. Demographic and clinical details were extracted from clinical records. Of 507 patients, ...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/0956462011923336
更新日期:2001-06-01 00:00:00
abstract::This guideline is intended to serve as a framework for those working in any location where sexually transmitted infections (STIs) are managed. It offers recommendations which will need to be adapted depending on local facilities and policies, and is not intended to be all encompassing. This guideline should be read in...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章,实务指引
doi:10.1258/ijsa.2012.012115
更新日期:2012-09-01 00:00:00
abstract::Female entertainment and sex workers (FESW) have high rates of alcohol and amphetamine-type stimulant (ATS) use, increasing risk for HIV/sexually transmitted infections (STI), and other negative outcomes. A prospective cohort of 1,198 FESW in a HIV/ATS use prevention intervention in Cambodia was assessed for alcohol a...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1177/0956462420964647
更新日期:2020-12-13 00:00:00
abstract::Haematogenous dissemination of undiagnosed urinary tuberculosis after performing extracorporeal shock-wave lithotripsy (ESWL) is extremely rare. Herein, we report a 41-year-old male who presented with urosepsis to the emergency room; catheterization was performed and retention resolved. He had a tattoo on his left arm...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1177/0956462413498580
更新日期:2014-03-01 00:00:00
abstract::We evaluated Cobas Amplicor, a highly automated polymerase chain reaction (PCR) system, to test first-void urine (FVU) and urethral swab specimens for Chlamydia trachomatis and Neisseria gonorrhoeae in men attending a sexually transmitted infection (STI) clinic. Results were compared against an in-house radioimmune do...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/0956462981921594
更新日期:1998-01-01 00:00:00
abstract::The two major risk groups for acquisition of HIV in the UK are gay men and IDUs. Individuals from these risk groups vary in a number of respects in their life-style, which have the potential to affect the course of their HIV disease. This study compares gay men and IDUs from the Lothian Region of Scotland with respect...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1177/095646249400500608
更新日期:1994-11-01 00:00:00
abstract::Integrase strand transfer inhibitors (INSTIs) are a class of antiretroviral drugs with high virologic efficacy and excellent tolerability. Recent evidence showed a possible link of dolutegravir-based regimens with weight gain, and a relationship between raltegravir use and changes in adipose tissue density and metabol...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1177/0956462420955075
更新日期:2020-12-01 00:00:00
abstract::The acute-phase protein C-reactive protein (CRP) is a sensitive marker of inflammation and tissue damage. We measured CRP in 109 HIV-1 antibody-positive patients admitted to hospital for investigation. In 67 patients with intercurrent infection (of whom 27 were afebrile at presentation) CRP levels were 2.2-483.5 mg/dL...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/0956462054094006
更新日期:2005-06-01 00:00:00
abstract::Women who have a prevention mindset may opt for concurrent use of oral pre-exposure prophylaxis (PrEP) and all forms of contraception; we therefore assessed how contraception may influence PrEP use or vice versa. We analyzed data from Kenyan and Ugandan HIV-uninfected non-pregnant women in sero-discordant partnerships...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1177/0956462420951501
更新日期:2020-11-01 00:00:00
abstract::A 23-year-old man was admitted to our hospital with severe thrombocytopaenia. He had unprotected sexual contact 6 weeks earlier. He was diagnosed with acute HIV infection by means of HIV RNA viral load testing and HIV-associated thrombocytopaenia. Although his thrombocytopaenia improved immediately with short-term dex...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1177/0956462414531937
更新日期:2015-03-01 00:00:00
abstract::Risk factors for HIV infection in partners of HIV-seropositive index cases were investigated in a cross-sectional survey. Between September 1992 and April 1994 a total of 251 HIV-infected persons and 76 of their sexual partners were interviewed at the main sexually transmitted diseases (STDs) clinic in Trinidad. All p...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/0956462981921918
更新日期:1998-03-01 00:00:00
abstract::The objective of this paper was to identify and describe enhanced sexual health services (ESHSs) commissioned for testing, diagnosis and management of sexually transmitted infections (STIs) in primary and community care settings in England. ESHSs commissioned by Primary Care Trusts (PCTs) in England were determined by...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/ijsa.2010.010198
更新日期:2010-09-01 00:00:00
abstract::The effects of seminal high-risk human papillomavirus (HPV) DNA were assessed on the quality of semen. Semen samples of 65 men participating in the ongoing Finnish HPV Family Study were collected. Semen analyses were done by the guidelines of the Nordic Association for Andrology. HPV DNA was detected by nested polymer...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/0956462042395122
更新日期:2004-11-01 00:00:00
abstract::The aim of this study is to identify the demographic and diagnostic characteristics of patients attending a genitourinary medicine clinic with booked appointments and compare them with those of walk-in attendees. During a period of three months, 749 patients were seen with new episodes; 61% of them had booked appointm...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/ijsa.2008.008308
更新日期:2009-03-01 00:00:00
abstract::Sexually transmitted diseases (STDs) interact uniquely with HIV infection, regardless of the form of sexual transmission of HIV. Both STDs and HIV infection are behaviorally and biologically intertwined with one another. This concept is called epidemiologic synergy since they facilitate the sexual transmission of on...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章,评审
doi:10.1258/0956462961917735
更新日期:1996-01-01 00:00:00
abstract::This study of sexual behaviour in the city of Lisbon is based on data obtained from 2 random samples, one of individuals aged 16-20 (n = 400) and another of individuals over the age of 20 (n = 400). Samples have been stratified by district, gender and age. Data were obtained by personal interview and by questionnaires...
journal_title:International journal of STD & AIDS
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1177/095646249500600108
更新日期:1995-01-01 00:00:00
abstract::Tetracycline resistant Neisseria gonorrhoeae (TRNG) contain a 25.2 MDa TetM plasmid encoding a 68 KDa cytoplasmic protein which confers high-level tetracycline resistance. The aim of this study was to subtype all TRNG isolated in Scotland between 1992 and 1998. Subtyping was performed by a polymerase chain reaction (P...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/0956462991913204
更新日期:1999-10-01 00:00:00
abstract::This is a cross-sectional study based on an open web survey with the primary objective to assess associations between the use of apps for seeking sex partners and vulnerabilities related to human immunodeficiency virus (HIV) acquisition among men who have sex with men (MSM) in Brazil. Participants were recruited to th...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1177/0956462420945940
更新日期:2020-10-01 00:00:00
abstract::The Russian HIV epidemic is primarily fuelled by injection drug use, but heterosexual spread may be playing an increasing role in transmission. Government-funded AIDS clinics provide most HIV treatment in Russia, and represent an important contact point between the medical community and infected population. Little is ...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/ijsa.2012.011463
更新日期:2012-10-01 00:00:00
abstract::We report two cases who attended the genitourinary medicine clinic for the treatment of epididymo-orchitis. They did not respond to treatment and subsequent ultrasound sonography (USS) of testis confirmed microlithiasis and excluded any inflammatory process or carcinoma in situ. Because of its association with testicu...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/ijsa.2007.007184
更新日期:2008-04-01 00:00:00
abstract::Little is known about the prevalence of rectal chlamydial infection amongst men who have sex with men (MSM). Previous studies using culture methods reported this to be between 4-6%. The emergence of nucleic acid amplification tests has significantly increased the sensitivity and specificity for chlamydial detection, m...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/095646204322916588
更新日期:2004-03-01 00:00:00
abstract::The objective of this study was to audit the management of syphilis in our integrated sexual health clinic according to the British Association for Sexual Health and HIV (BASHH) guideline using the 'Treponemal Infection Care' (TIC) audit tool devised by our clinic. The case notes of patients diagnosed with all stages ...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/ijsa.2011.010392
更新日期:2011-05-01 00:00:00
abstract::The copper intrauterine contraceptive device (IUCD) is strongly associated with bacterial vaginosis (BV). Hormonal influences may play a role in the control of vaginal flora. It is unclear whether use of the progesterone-incorporated intrauterine system (IUS; Mirena) is associated with abnormal vaginal flora or genita...
journal_title:International journal of STD & AIDS
pub_type: 临床试验,杂志文章
doi:10.1258/ijsa.2008.008391
更新日期:2009-06-01 00:00:00
abstract::Chlamydia trachomatis and Neisseria gonorrhoeae testing guidance recommends extragenital screening with locally validated nucleic acid amplification tests, with anatomical sites tested separately. Evidence supports multi-patient combined aliquot pooled sampling (PS) for population screening; evidence for within-patien...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1177/0956462417742318
更新日期:2018-05-01 00:00:00
abstract::A 48-year-old woman with HIV infection developed Cushingoid features while she was taking ritonavir-boosted darunavir. Cushing's syndrome was confirmed due to the drug interaction between ritonavir and budesonide. Diagnosis of iatrogenic Cushing's syndrome in HIV-positive patients who are on ritonavir-boosted protease...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/ijsa.2011.011408
更新日期:2012-07-01 00:00:00