Abstract:
:In 2010/2011, regional commissioners withdrew payment for the fixed-dose combination Combivir, forcing a switch to component drugs. This was deemed clinically acceptable and annual savings of £44 k expected. We estimated the true costs of switching and examined patient outcomes. Information for 46 patients using Combivir was extracted from case notes for each clinical contact in the 12 months pre- and post-switch (clinician seen, tests, antiretrovirals). Post-switch care costs £93/patient more annually versus pre-switch (95% CI £424 to £609), yielding £4278/year more post-switch for all patients. Drug and pathology costs were more expensive post-switch and extra clinical visits required. None of these results were statistically significant. Forty-two per cent of patients switched directly or in the subsequent year to an alternative fixed-dose combination rather than generics. Costs in this group were significantly higher post-switch driven by drug cost. Six patients (13%) reported problems with the switch including confusion around dosing and new side effects. As less-expensive generic antiretroviral drugs become available, it may appear cheaper to switch from fixed-dose combinations to component drugs. However, the additional clinical costs involved may outweigh the initial cost savings of the drugs and switching may cause confusion for some patients, risking loss of adherence.
journal_name
Int J STD AIDSjournal_title
International journal of STD & AIDSauthors
Taylor R,Carlin E,Sadique Z,Ahmed I,Adams EJdoi
10.1177/0956462414530588subject
Has Abstractpub_date
2015-02-01 00:00:00pages
75-80issue
2eissn
0956-4624issn
1758-1052pii
0956462414530588journal_volume
26pub_type
杂志文章abstract::SummarySexually transmitted diseases (STDs) are leading causes of substantial morbidity worldwide. Identification of risk factors for estimating STD risk provides opportunities for optimising service delivery in clinical settings, including improving case finding accuracy and increasing cost-efficiency by limiting the...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章,评审
doi:10.1177/0956462414555930
更新日期:2015-10-01 00:00:00
abstract::Syphilis rates have been increasing in men who have sex with men (MSM) in London. To describe risk behaviour and refine public health interventions, we conducted prospective enhanced surveillance of new syphilis cases in MSM attending selected London sexual health clinics (SHCs) between October 2016 and January 2017. ...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1177/0956462418814998
更新日期:2019-04-01 00:00:00
abstract::Highly active antiretroviral therapy (HAART) has transformed HIV-1 infection from an invariably fatal disease into a chronic infection requiring lifelong treatment. However, the challenges we still face are the urgent need to provide affordable sustainable therapy to the millions of infected individuals who live in re...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章,评审
doi:10.1258/095646206777689035
更新日期:2006-07-01 00:00:00
abstract::The sensitivity of the Captia Syphilis G anti-treponemal IgG enzyme immunoassay (EIA-IgG) was compared with the Treponema pallidum haemagglutination assay (TPHA) and the Fluorescent Treponemal Antibody Absorbed (FTA-Abs) test as a marker for past syphilis in 28 HIV-infected and 31 HIV-negative patients with a past his...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1177/095646249500600207
更新日期:1995-03-01 00:00:00
abstract::We describe a recent outbreak of syphilis in young heterosexuals in the north west of England. A cluster of 12 cases of syphilis (7 primary and 5 early latent) was identified in Rochdale in heterosexuals aged 20 or under. Nine were women. Five were asymptomatic at presentation. This outbreak occurred in a group not us...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/ijsa.2011.011031
更新日期:2011-09-01 00:00:00
abstract::For people immunosuppressed by human immunodeficiency virus (HIV), we expect an increase in cancer incidence similar to that documented in transplant patients. We examined the cancer spectrum in an HIV-infected cohort, specifically malignancies not currently associated with acquired immunodeficiency syndrome (AIDS), i...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/0956462991913574
更新日期:1999-12-01 00:00:00
abstract::We aim to clarify the prevalence of Mycoplasma genitalium in asymptomatic men in Japan. First-catch urine specimens were obtained from 187 asymptomatic Japanese men and examined for the presence of M. genitalium using a polymerase chain reaction (PCR)-based assay. Two (1.1%) of 187 first-catch urine specimens were pos...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/0956462971919877
更新日期:1997-04-01 00:00:00
abstract::Two hundred consecutive patients with herpes zoster attending the skin clinic at the Kilimanjaro Christian Medical Centre (KCMC) were examined and checked for HIV infection. They ranged in age from 10 months to 86 years with the majority in their 20s and 30s. The dermatomes involved were thoracic (97), trigeminal (50)...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/0956462001915804
更新日期:2000-04-01 00:00:00
abstract::The objectives of the study were, 1. To ascertain if sexual health physicians and practitioners believe a question concerning a past history of non-consensual sex should be asked routinely and are asking it. 2. To identify whether sexual health services have established protocols to integrate this question into practi...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/095646203321605530
更新日期:2003-05-01 00:00:00
abstract::For the purpose of surveillance of the acquired immunodeficiency syndrome (AIDS) in developing countries, the World Health Organization (WHO) has recommended criteria for the clinical case definition of AIDS in adults and children. In a preliminary examination of children in Zambia a number of patients with obvious AI...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1177/095646249300400204
更新日期:1993-03-01 00:00:00
abstract::A national Scottish audit of 282 patients with HIV infection attending 11 clinics showed the following levels of performance against quality improvement Scotland Sexual Health Services Standards: syphilis serology was offered in the previous six months to 55% of patients (range: 12-97% of patients in individual clinic...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/ijsa.2011.011379
更新日期:2012-06-01 00:00:00
abstract::The purpose of this study was to investigate internal medicine residents' HIV-related knowledge and their attitudes towards caring for HIV-infected patients, and determine the extent to which these variables influence their care-providing intention. A cross-sectional survey was conducted in 56 internal medicine reside...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/0956462011923787
更新日期:2001-09-01 00:00:00
abstract::Accelerating antiretroviral therapy (ART) administration, improving retention, and achieving viral suppression in low- and middle-income countries must be prioritized. We evaluated trends and disparities in these milestones in a large Latin American cohort. Adults starting ART (ARTstart) from 2003 to 2014 at Caribbean...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1177/0956462417714094
更新日期:2018-01-01 00:00:00
abstract::The Russian HIV epidemic is primarily fuelled by injection drug use, but heterosexual spread may be playing an increasing role in transmission. Government-funded AIDS clinics provide most HIV treatment in Russia, and represent an important contact point between the medical community and infected population. Little is ...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/ijsa.2012.011463
更新日期:2012-10-01 00:00:00
abstract::The purpose of this paper is to assess the internal consistency of self-reported condom use among sex workers in Puerto Plata and Santo Domingo, Dominican Republic. We examined the responses to questions about condom use among 4 cross-sectional samples of sex workers. We compared measures based on: (1) questions using...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/0956462981922089
更新日期:1998-04-01 00:00:00
abstract::We investigated the process and time required to collect 450 interviews in a project to determine the most efficacious behavioural surveillance approaches to detect changes in gonorrhoea prevalence. In total, 150 respondents were recruited in each method. For each of place surveys (bars), gonorrhoea case interviews, a...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/095646207782716947
更新日期:2007-12-01 00:00:00
abstract::Individuals infected with HIV who are out of care are at a higher risk of HIV-related morbidity and mortality. It has been difficult to recruit a representative sample of out-of-care patients for epidemiological studies. Using a novel weighting method, we constructed a representative sample of out-of-care HIV patients...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1177/0956462415608334
更新日期:2016-10-01 00:00:00
abstract::We retrospectively analysed routinely collected baseline data of 2252 patients with HIV infection registered in the National Free Antiretroviral Treatment Program in Xinjiang province, China, from 2006 to 2011 to estimate the prevalence and predictors of anaemia at the initiation of combined antiretroviral therapy. An...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1177/0956462414531935
更新日期:2015-03-01 00:00:00
abstract::To determine the frequency, imaging characteristics, neuroanatomical distribution and dynamics of magnetic resonance imaging findings in HIV-associated cryptococcal meningitis in immunocompromised patients we compared patients without antiretroviral therapy with patients undergoing immune reconstitution. Neuroimaging ...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1177/0956462415574633
更新日期:2016-02-01 00:00:00
abstract::Our objective was to investigate whether Postal Test Kits (PTKs) for Chlamydia trachomatis in Edinburgh offer an alternative to genitourinary (GU) medicine clinic attendance. All PTKs returned in the Edinburgh area over a six-month period from August 2005 were audited. Data on age and previous access to GU medicine se...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/095646207780749718
更新日期:2007-05-01 00:00:00
abstract::HIV status awareness is key to prevention, linkage-to-care and treatment. Our study evaluated the accessibility and potential willingness of HIV self-testing among men who have sex with men (MSM) and transgender women in Peru. We surveyed four pharmacy chains in Peru to ascertain the commercial availability of the ora...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1177/0956462416630674
更新日期:2017-02-01 00:00:00
abstract::Implementation of the National Chlamydia Screening Programme in Cornwall commenced in April 2003. Initially, women in community venues were screened using urine samples. However, many of these urine samples were inhibitory to polymerase chain reaction (PCR), resulting in a high recall rate for women in the programme. ...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/095646207779949619
更新日期:2007-02-01 00:00:00
abstract::We assessed the validity of self-reported sex and condom use by comparing self-reports with prostate-specific antigen (PSA) detection in a prospective study of 210 female sex workers in Mombasa, Kenya. Participants were interviewed on recent sexual behaviours at baseline and 12-month follow-up visits. At both visits, ...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/095646207779949899
更新日期:2007-01-01 00:00:00
abstract::The frequency of spontaneous genital arousal (GA) and persistent genital arousal disorder (PGAD) in women is unknown. The aim of this study was to conduct an anonymous survey to assess the frequency and nature of spontaneous GA and PGAD in women attending a walk-in sexual health clinic in London. Female patients compl...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/ijsa.2008.008492
更新日期:2009-08-01 00:00:00
abstract::With the increasing incidence of chronic kidney disease in patients with human immunodeficiency virus (HIV), the number of HIV-infected patients requiring hemodialysis has also increased. Dolutegravir is an integrase inhibitor that is a common component of HIV treatment regimens. Currently, there is no guidance regard...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1177/0956462418816785
更新日期:2019-05-01 00:00:00
abstract::A single-blind randomized follow-up study was conducted to evaluate the efficacy and tolerance of roxithromycin 300 mg once a day compared to doxycycline 200 mg day 1 and 100 mg day 2-10 in the treatment of genital chlamydial infection in men and women and non-specific urethritis (NSU) in men. A total of 211 patients ...
journal_title:International journal of STD & AIDS
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1177/095646249300400211
更新日期:1993-03-01 00:00:00
abstract::The prevalence of viral and bacterial sexually transmitted diseases were studied in 101 men attending a dermatovenereal outpatient clinic in Mogadishu. A control group of 103 healthy adult men were included for the serological part of the study. Serological markers of hepatitis B virus (HBV), human immunodeficiency vi...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1177/095646249000100206
更新日期:1990-03-01 00:00:00
abstract::Patients with HIV infection have a higher propensity for infectious, inflammatory, neoplastic and metabolic disorders. The link with psoriasis vulgaris is explained by well-known pathophysiological phenomena and can be observed at any stage of infection. The aim of our study was to characterize the clinical spectrum o...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/ijsa.2011.010525
更新日期:2011-11-01 00:00:00
abstract::The persistent sexual arousal syndrome (PSAS) is a newly described entity where the woman becomes involuntarily genitally aroused for extended periods of time in the absence of sexual desire and is distressed by this situation. The cause of this sexual problem is not well understood. We describe such a case where the ...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/095646207779949592
更新日期:2007-02-01 00:00:00
abstract::The need for salvage treatment is related to the imperfection of current antiretroviral therapy. Sequential therapy with suboptimally suppressive regimens results in a need for this intervention. The aim of salvage treatment is as yet uncertain; virological suppression; immunoenhancement or stability or avoidance of c...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章,评审
doi:10.1258/0956462011923093
更新日期:2001-05-01 00:00:00