Astrocytes Protect against Isoflurane Neurotoxicity by Buffering pro-brain-derived Neurotrophic Factor.

abstract：BACKGROUND:Patient blood management combines the use of several transfusion alternatives. Integrated use of erythropoietin, cell saver, and/or postoperative drain reinfusion devices on allogeneic erythrocyte use was evaluated using a restrictive transfusion threshold. METHODS:In a factorial design, adult elective hip-...

journal_title：Anesthesiology

authors： So-Osman C,Nelissen RG,Koopman-van Gemert AW,Kluyver E,Pöll RG,Onstenk R,Van Hilten JA,Jansen-Werkhoven TM,van den Hout WB,Brand R,Brand A

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND:The authors determined the segmental effects of intracarotid verapamil in human subjects by using a novel method of measuring proximal and distal cerebrovascular resistance. Their hypothesis was that intracarotid verapamil, a calcium channel-blocking drug that augments cerebral blood flow and reverses arteri...

journal_title：Anesthesiology

authors： Joshi S,Meyers PM,Pile-Spellman J,Wang M,Sahlein DH

更新日期：2004-04-01 00:00:00

abstract：BACKGROUND:Human newborns, particularly those born before full term, are more susceptible to bacterial infections as a result of impaired host defense mechanisms. Compared with adults, circulating leukocytes from human newborns (preterm and full-term gestations) and newborn rabbits (full-term gestation) have low restin...

journal_title：Anesthesiology

authors： Ramamoorthy C,Kovarik WD,Winn RK,Harlan JM,Sharar SR

更新日期：1997-02-01 00:00:00

abstract：BACKGROUND:The authors developed a measure to determine whether maternal motivation to be present during induction (Motivation for Parental Presence during Induction of Anesthesia [MPPIA]) is related to children's anxiety during the induction process. METHODS:Mothers and children (aged 2-12 yr) undergoing outpatient, ...

journal_title：Anesthesiology

authors： Caldwell-Andrews AA,Kain ZN,Mayes LC,Kerns RD,Ng D

更新日期：2005-09-01 00:00:00

abstract：BACKGROUND:Our objective was to elucidate the direct effects of fentanyl and morphine on cardiac excitation-contraction coupling using individual, field-stimulated rat ventricular myocytes. METHODS:Freshly isolated myocytes were loaded with fura-2 and field stimulated (0.3 Hz) at 28 degrees C. Amplitude and timing of ...

journal_title：Anesthesiology

authors： Kanaya N,Zakhary DR,Murray PA,Damron DS

更新日期：1998-12-01 00:00:00

abstract：:Opioid receptors have been targeted for the treatment of pain and related disorders for thousands of years and remain the most widely used analgesics in the clinic. Mu (μ), kappa (κ), and delta (δ) opioid receptors represent the originally classified receptor subtypes, with opioid receptor like-1 (ORL1) being the leas...

journal_title：Anesthesiology

authors： Al-Hasani R,Bruchas MR

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND:Perfluorocarbon (PFC) liquids are known to improve gas exchange and pulmonary function in various models of acute respiratory failure. Vaporization has been recently reported as a new method of delivering PFC to the lung. Our aim was to study the effect of PFC vapor on the ventilation/perfusion (VA/Q) matchi...

journal_title：Anesthesiology

authors： Hübler M,Souders JE,Shade ED,Polissar NL,Schimmel C,Hlastala MP

更新日期：2001-12-01 00:00:00

abstract：:The relationship between neuroleptic malignant syndrome (NMS) and malignant hyperthermia (MH) was investigated using the in vitro skeletal muscle contracture test to screen for MH-susceptibility in NMS patients. The maximum contracture tension which developed following exposure to halothane (1-3%), and incremental dos...

journal_title：Anesthesiology

authors： Caroff SN,Rosenberg H,Fletcher JE,Heiman-Patterson TD,Mann SC

更新日期：1987-07-01 00:00:00

abstract：BACKGROUND:Oral gabapentin is approved as an anticonvulsant medication and to treat postherpetic neuralgia. Its nonopioid properties and presumed spinal site of analgesic action made the study on intrathecal gabapentin attractive to establish the minimum effective dose for a later, pivotal trial. METHODS:The authors e...

journal_title：Anesthesiology

authors： Rauck R,Coffey RJ,Schultz DM,Wallace MS,Webster LR,McCarville SE,Grigsby EJ,Page LM

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND:The Neurologic and Adaptive Capacity Score (NACS) is a multi-item scale that was published in 1982 to measure the effects of intrapartum drugs on the neonate. Although this scoring system has been widely used in obstetric anesthesia research, studies confirming its reliability have not been published. The pu...

journal_title：Anesthesiology

authors： Halpern SH,Littleford JA,Brockhurst NJ,Youngs PJ,Malik N,Owen HC

更新日期：2001-06-01 00:00:00

abstract：BACKGROUND:Resiniferatoxin is a potent capsaicin analog. Intrathecal administration leads to selective, prolonged opening of the transient receptor potential V1 ion channel, which is localized mainly to C-fiber primary afferent nociceptive sensory neurons. Following work in laboratory animals, the authors explored the ...

journal_title：Anesthesiology

authors： Brown DC,Iadarola MJ,Perkowski SZ,Erin H,Shofer F,Laszlo KJ,Olah Z,Mannes AJ

更新日期：2005-11-01 00:00:00

abstract：:To determine whether anesthesiologists, because of prolonged exposure to halothane or other inhalational anesthetics, might have higher death rates from all causes, from cancer, and from hepatic or renal disease than other physicians, the mortality rates of male and female members of the American Society of Anesthesio...

journal_title：Anesthesiology

authors： Lew EA

更新日期：1979-09-01 00:00:00

abstract：:Central and peripheral pulmonary mucociliary clearance was assessed by tantalum bronchography and serial chest roentgenograms in dogs. Thiopental, 25 mg/kg, did not change clearance from awake values. Halothane 1.2 MAC, for six hours, delayed both central and peripheral clearance by at least three hours. After halotha...

journal_title：Anesthesiology

authors： Forbes AR,Gamsu G

更新日期：1979-01-01 00:00:00

abstract：BACKGROUND:The aim of this study was to investigate the effects of two imidazoline-derived intravenous anesthetics, etomidate and midazolam, on vascular adenosine triphosphate-sensitive potassium (KATP) channel activity. METHODS:In isolated rat aorta, isometric tension was recorded to examine the anesthetic effects on...

journal_title：Anesthesiology

authors： Nakamura A,Kawahito S,Kawano T,Nazari H,Takahashi A,Kitahata H,Nakaya Y,Oshita S

更新日期：2007-03-01 00:00:00

abstract：BACKGROUND:Remifentanil anesthesia enhances postoperative pain in animals and humans. The authors evaluated the impact of the dose (microg x kg(-1) x min(-1)) and duration of remifentanil infusion, and the effects of a second surgery on postoperative pain sensitization. METHODS:Mice received different doses of remifen...

journal_title：Anesthesiology

authors： Cabañero D,Campillo A,Célérier E,Romero A,Puig MM

更新日期：2009-12-01 00:00:00

abstract：:The effects of subparalytic doses of succinylcholine and d-tubocurarine on epinephrine-induced cardiac arrhythmias during halothane anesthesia were evaluated in dogs. Succinylcholine markedly increased (P is less than .05) the arrhythmogenicity of epinephrine and d-tubocurarine slightly decreased (P is less than .05) ...

journal_title：Anesthesiology

authors： Tucker WK,Munson ES

更新日期：1975-01-01 00:00:00

abstract：BACKGROUND:Whether coronary steal is induced by inhaled anesthetic agents remains controversial in part because multiple factors determine collateral blood flow. METHODS:We used an established model to determine how halothane, isoflurane, and desflurane affect the hemodynamic determinants of coronary collateral blood ...

journal_title：Anesthesiology

authors： Mignella R,Buffington CW

更新日期：1995-10-01 00:00:00

abstract：:This study examined whether pain or stress can enhance the analgesic effects of spinally administered opiates. The experiments determined the effects of mechanically produced pain and of the stress of being restrained on the analgesic effects of 0.63 microgram of epidural sufentanil in rats using a tail-withdrawal pro...

journal_title：Anesthesiology

authors： Van den Hoogen RH,Bervoets K,Colpaert FC

更新日期：1988-07-01 00:00:00

abstract：BACKGROUND:Recent studies suggest that volatile anesthetics cause not only vasodilation but also vasoconstriction, depending on the experimental conditions. However, the mechanism of the constrictive effect of volatile anesthetics has not been clarified. The aim of this study was to evaluate the vasoconstrictor effects...

journal_title：Anesthesiology

authors： Kakuyama M,Hatano Y,Nakamura K,Toda H,Terasako K,Nishiwada M,Mori K

更新日期：1994-05-01 00:00:00

abstract：BACKGROUND:General anesthetics are thought to produce their hypnotic effects mainly by acting at ligand-gated ionic channels in the central nervous system (CNS). Although it is well established that volatile anesthetics significantly modify the activity of the acetylcholine nicotinic receptors of the neuromuscular junc...

journal_title：Anesthesiology

authors： Salord F,Keita H,Lecharny JB,Henzel D,Desmonts JM,Mantz J

更新日期：1997-03-01 00:00:00

abstract：BACKGROUND:Identifying functionally relevant anesthetic-binding sites in pentameric ligand-gated ion channels (pLGICs) is an important step toward understanding the molecular mechanisms underlying anesthetic action. The anesthetic propofol is known to inhibit cation-conducting pLGICs, including a prokaryotic pLGIC from...

journal_title：Anesthesiology

authors： Kinde MN,Bu W,Chen Q,Xu Y,Eckenhoff RG,Tang P

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND:Breast surgery is associated with a high incidence of postoperative nausea and vomiting. Propofol and prophylactic administration of ondansetron are associated with a lower incidence of postoperative nausea and vomiting. To date no comparison of these two drugs has been reported. A randomized study was done ...

journal_title：Anesthesiology

authors： Gan TJ,Ginsberg B,Grant AP,Glass PS

更新日期：1996-11-01 00:00:00

abstract：BACKGROUND:Factors determining renal function at organ recovery in deceased kidney donors are not well established. METHODS:The authors studied the prevalence and risk factors associated with elevated prerecovery creatinine and calculated glomerular filtration rate in 458 deceased organ donors identified through the C...

journal_title：Anesthesiology

authors： Blasi-Ibanez A,Hirose R,Feiner J,Freise C,Stock PG,Roberts JP,Niemann CU

更新日期：2009-02-01 00:00:00

abstract：:In late 1846, following his successful public demonstrations of surgical anesthesia, Boston dentist William T. G. Morton selected Letheon as the commercial name for the ether-based "preparation" he had used to produce insensibility to pain. We have not identified a first-hand account of the coinage of Letheon. Althoug...

journal_title：Anesthesiology

authors： Haridas RP,Gionfriddo M,Bause GS

更新日期：2019-12-01 00:00:00

abstract：BACKGROUND:Pain following thoracotomy can persist for years with an undetermined impact on quality of life. Factors hypothesized to modulate this painful experience include analgesic regimen, gender, and type of incision. METHODS:A total of 157 generally healthy patients of both genders scheduled for segmentectomy, lo...

journal_title：Anesthesiology

authors： Ochroch EA,Gottschalk A,Augostides J,Carson KA,Kent L,Malayaman N,Kaiser LR,Aukburg SJ

更新日期：2002-11-01 00:00:00

abstract：:Chronic muscle disuse decreases the sensitivity of skeletal muscle to nondepolarizing relaxants, such as metocurine (MTC). In this study, the authors determined whether chronic conditioning would produce the opposite effect and increase the sensitivity of skeletal muscle to MTC. Five dogs were exercised by daily runni...

journal_title：Anesthesiology

authors： Gronert GA,White DA,Shafer SL,Matteo RS

更新日期：1989-06-01 00:00:00

abstract：BACKGROUND:The minimum alveolar concentration (MAC) of volatile anesthetics is decreased during pregnancy, but MAC in the early postpartum period has not been reported. The aim of this study was to determine the MAC of isoflurane and to evaluate the relation between MAC and serum progesterone and beta-endorphin in pati...

journal_title：Anesthesiology

authors： Zhou HH,Norman P,DeLima LG,Mehta M,Bass D

更新日期：1995-06-01 00:00:00

abstract：BACKGROUND:Adding sodium bicarbonate to lidocaine to enhance its efficacy during peripheral nerve block is controversial. The authors studied the effect of adding sodium bicarbonate to lidocaine with and without epinephrine versus equivalent alkalinization by sodium hydroxide (NaOH) on onset, degree, and duration of pe...

journal_title：Anesthesiology

authors： Sinnott CJ,Garfield JM,Thalhammer JG,Strichartz GR

更新日期：2000-10-01 00:00:00

abstract：BACKGROUND:The purpose of this study was to evaluate a new, physiologically inspired method for the analysis of the electroencephalogram during propofol-remifentanil anesthesia. Based on fixed-order autoregressive moving-average modeling, this method was hypothesized to be capable of dissociating the effects that hypno...

journal_title：Anesthesiology

authors： Liley DT,Sinclair NC,Lipping T,Heyse B,Vereecke HE,Struys MM

更新日期：2010-08-01 00:00:00

abstract：BACKGROUND:Cardiac preconditioning, including that induced by halogenated anesthetics, is an innate protective mechanism against ischemia-reperfusion injury. The adenosine triphosphate-sensitive potassium (K(ATP)) channels are considered essential in preconditioning mechanism. However, it is unclear whether K(ATP) chan...

journal_title：Anesthesiology

authors： Marinovic J,Bosnjak ZJ,Stadnicka A

更新日期：2006-07-01 00:00:00