Abstract:
:The relationship between neuroleptic malignant syndrome (NMS) and malignant hyperthermia (MH) was investigated using the in vitro skeletal muscle contracture test to screen for MH-susceptibility in NMS patients. The maximum contracture tension which developed following exposure to halothane (1-3%), and incremental doses of fluphenazine (0.2-25.6 mM) was measured in muscle obtained from seven NMS, six MH, and six control patients. Comparison of the cumulative responses to fluphenazine revealed no significant differences among the groups. However, the response (mean +/- SEM) to halothane in the NMS group (1.7 +/- 0.7 g), which was similar to the response in the MH group (1.5 +/- 0.2 g), was significantly greater than the response found in controls (0.2 +/- 0.1 g). In addition, five of seven NMS patients could be diagnosed as MH-susceptible, based on the development of muscle contractures greater than 0.7 g in response to 1-3% halothane. In contrast, none of the controls were MH-susceptible. These findings appear to correlate with clinical evidence suggesting an association between NMS and MH.
journal_name
Anesthesiologyjournal_title
Anesthesiologyauthors
Caroff SN,Rosenberg H,Fletcher JE,Heiman-Patterson TD,Mann SCdoi
10.1097/00000542-198707000-00004subject
Has Abstractpub_date
1987-07-01 00:00:00pages
20-5issue
1eissn
0003-3022issn
1528-1175journal_volume
67pub_type
杂志文章相关文献
ANESTHESIOLOGY文献大全abstract:BACKGROUND:The discrepancy between predicted effect-site concentration and measured bispectral index is problematic during intravenous anesthesia with target-controlled infusion of propofol and remifentanil. We hypothesized that bispectral index during total intravenous anesthesia would be more accurately predicted by ...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0000000000001892
更新日期:2018-03-01 00:00:00
abstract:BACKGROUND:The observation that peripheral trauma causes enhanced spinal neuronal excitability has provided the scientific rationale for the concept of "pre-emptive analgesia." The premise has been that only noxious stimuli cause sensitization in sensory pathways, but this premise has not been tested in the conscious s...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199501000-00032
更新日期:1995-01-01 00:00:00
abstract::Recent reports have described resistance to pancuronium-induced neuromuscular blockade in patients chronically receiving anticonvulsants. This study examines the pharmacokinetics and pharmacodynamics of metocurine (MTC) in 12 patients undergoing craniotomy--six on chronic phenytoin therapy and six comparable controls....
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-198509000-00009
更新日期:1985-09-01 00:00:00
abstract::In view of evidence suggesting possible participation of cobalamin in cyanide metabolism, the effects of sodium nitroprusside (SNP) infusion on blood cyanide and plasma thiocyanate levels and serum vitamin B12 levels were examined in ten patients undergoing major orthopedic procedures. Whole blood cyanide concentratio...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-198104000-00009
更新日期:1981-04-01 00:00:00
abstract:BACKGROUND:Residual paralysis increases the risk of pulmonary complications but is difficult to detect. To test the hypothesis that accelerometry predicts effects of residual paralysis on pulmonary and upper airway function, the authors related tests of pulmonary and pharyngeal function to accelerometry of adductor pol...
journal_title:Anesthesiology
pub_type: 临床试验,杂志文章
doi:10.1097/00000542-200306000-00006
更新日期:2003-06-01 00:00:00
abstract:BACKGROUND:The dorsal horn of the spinal cord is a pivotal point for transmission of neuronal pain. During spinal and epidural anesthesia, the neurons of the dorsal horn are exposed to local anesthetics. Unfortunately, little is known about the action of local anesthetics on the major ionic conductances in dorsal horn ...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199801000-00025
更新日期:1998-01-01 00:00:00
abstract::Two groups of women, ASA physical status 1, undergoing surgery for primary breast cancer, were studied to assess the effect of alcohol intake on alfentanil pharmacodynamics. Patients in group 1 (n = 6) had an average daily consumption of 20-40 g alcohol. Patients in group 2 (n = 8) were life-long abstainers or drank o...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-198911000-00008
更新日期:1989-11-01 00:00:00
abstract:BACKGROUND:Vascular endothelium plays an important role in the regulation of vascular tone. Volatile anesthetics have been shown to attenuate endothelium-mediated relaxation in conductance arteries, such as aorta. However, significant differences in volatile anesthetic pharmacology between these large vessels and the s...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199501000-00024
更新日期:1995-01-01 00:00:00
abstract:BACKGROUND:Whether anesthetic agents administered during gamete intrafallopian transfer (GIFT) affect reproductive outcome is controversial. This multicenter pilot trial and survey had two purposes: to evaluate the effect of propofol, nitrous oxide, midazolam, and isoflurane on pregnancy outcome after GIFT, and to dete...
journal_title:Anesthesiology
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1097/00000542-199901000-00007
更新日期:1999-01-01 00:00:00
abstract::Whereas opiate receptor agonists have resulted in spinal cord damage; opiate receptor antagonists have demonstrated protection against spinal cord injury. Because opioids are used in clinical anesthesia, the effect of an opiate antagonist was evaluated on neurologic outcome in a rat model of spinal cord injury occurri...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-198909000-00019
更新日期:1989-09-01 00:00:00
abstract:BACKGROUND:Aqueous suspensions of the local anesthetic n-butyl-p-aminobenzoate (BAB), epidurally applied in terminal cancer patients, resulted in a sensory blockade, lasting up to several months. To investigate the mechanism of action on the cellular level, the effect of 100 microM BAB on Na+ action potentials and on N...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199506000-00018
更新日期:1995-06-01 00:00:00
abstract:BACKGROUND:The authors previously reported that the pulmonary vasodilator response to the sympathetic beta-adrenoreceptor agonist isoproterenol is potentiated during isoflurane anesthesia compared with the conscious state. In the present in vivo study, the authors tested the hypothesis that halothane and enflurane anes...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-200208000-00027
更新日期:2002-08-01 00:00:00
abstract::Complications after major surgery are a leading cause of morbidity and mortality. The etiology of postoperative complications is complex, but poor cardiorespiratory reserve appears to be a key factor. There is increasing interest in the use of central and mixed venous oxygen saturation to guide therapeutic interventio...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0b013e3181af59aa
更新日期:2009-09-01 00:00:00
abstract:BACKGROUND:The impact on the endothelial glycocalyx for the extravasation of colloidal infusion solutions has not been investigated sufficiently. METHODS:Isolated guinea pig hearts were perfused with Krebs-Henseleit buffer in a Langendorff mode. Solutions of 0.9% saline, 5% albumin (70 kd), or 6% hydroxyethyl starch (...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-200405000-00025
更新日期:2004-05-01 00:00:00
abstract::Measurement of serum fentanyl and alfentanil concentrations by radioimmunoassay (RIA) may result in significant errors and high variability when the technique described in the available fentanyl and alfentanil RIA kits is used. The authors found a 29-94% overestimation of measured fentanyl and alfentanil serum levels ...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-198409000-00010
更新日期:1984-09-01 00:00:00
abstract:BACKGROUND:Airway pressure-release ventilation provides ventilation comparable to controlled mechanical ventilation (CMV), but with lower peak airway pressures and less dead-space ventilation. To obtain these advantages for patients administered general anesthesia, the authors (1) designed a mode similar to airway pres...
journal_title:Anesthesiology
pub_type: 临床试验,杂志文章
doi:10.1097/00000542-199808000-00008
更新日期:1998-08-01 00:00:00
abstract:BACKGROUND:The minimum alveolar concentration (MAC) of volatile anesthetics is decreased during pregnancy, but MAC in the early postpartum period has not been reported. The aim of this study was to determine the MAC of isoflurane and to evaluate the relation between MAC and serum progesterone and beta-endorphin in pati...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199506000-00007
更新日期:1995-06-01 00:00:00
abstract:BACKGROUND:Nonimmobilizers are agents that lack anesthetic properties, although their chemical structure is very similar to known anesthetics. The primary action site of both agents, whether at the membrane or target protein level, is still a matter of debate. However, increasing evidence points to the distinct modific...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-200210000-00016
更新日期:2002-10-01 00:00:00
abstract:BACKGROUND:Ketamine is an anesthetic drug. Subanesthetic doses of ketamine have been shown to reduce interleukin-6 concentrations after surgery and to reduce mortality and the production of tumor necrosis factor alpha and interleukin 6 in septic animals. Similarly, adenosine was shown to reduce tumor necrosis factor al...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-200506000-00017
更新日期:2005-06-01 00:00:00
abstract::Exposure of resting rat diaphragm for one hour in vitro to halothane (1-1.5, 2-2.5 and 4-4.5 per cent in oxygen) produced significant alterations of intracellular glucose disposition. Glycolysis (as measured by lactate production) increased, while glycogen formation was inhibited in a dose-related fashion. Net glucose...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-197705000-00001
更新日期:1977-05-01 00:00:00
abstract::We sought to determine the percent delivery by metered-dose inhaler (MDI) of a preparation of salbutamol (albuterol) to the distal end of either pediatric-size tracheal tubes or a narrow-gauge catheter. A bench model consisting of a swivel actuator; 3.0-6.0-mm ID tracheal tubes all 16 cm in length or a 19-G (standard ...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199102000-00024
更新日期:1991-02-01 00:00:00
abstract::Neurophysiologic studies indicate that local anesthetic-induced seizures are generated in subcortical brain structures. The authors utilized a quantitative autoradiographic technique to measure cerebral metabolism during lidocaine-induced seizure activity in rats anesthetized with nitrous oxide. Local cerebral metabol...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-198101000-00007
更新日期:1981-01-01 00:00:00
abstract:BACKGROUND:Previous experimental and clinical studies have shown that anesthetic agents have varying effects on cancer prognosis; however, the results were inconsistent among these studies. The authors compared overall and recurrence-free survival in patients given volatile or intravenous anesthesia for digestive tract...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0000000000003440
更新日期:2020-10-01 00:00:00
abstract:BACKGROUND:The surface membrane Ca(2+)-adenosine triphosphatase and Na(+)-Ca(2+) exchanger transport Ca(2+) out of the ventricular myocyte, competing for cytosolic Ca(2+) with the Ca(2+)-adenosine triphosphatase located in the sarcoplasmic reticulum. In this study the authors examined the effects of halothane, isoflura...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-200206000-00027
更新日期:2002-06-01 00:00:00
abstract::The authors determined whether they could predict accurately the solubility of anesthetics in aqueous solutions at 37 degrees C, knowing the osmolarity and the pH of the solution and the solute composition. The partition coefficients of the four volatile anesthetics, isoflurane, enflurane, halothane, and methoxyfluran...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-198312000-00013
更新日期:1983-12-01 00:00:00
abstract:BACKGROUND:Sedative-hypnotic drugs not only increase sedation, but also impair memory as serum concentration increases. These drugs also produce profound changes in the auditory event-related potential (ERP). The ability of various ERP components to predict changes in sedation and memory produced by various drugs was t...
journal_title:Anesthesiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00000542-200110000-00018
更新日期:2001-10-01 00:00:00
abstract::The effect of physostigmine on the loss of consciousness and respiratory depression induced in rabbits by flunitrazepam, 1 mg/kg, was studied to demonstrate whether the restoration of consciousness and respiration rate results from an increase in central cholinergic activity or from an interference by physostigmine wi...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-198602000-00020
更新日期:1986-02-01 00:00:00
abstract:BACKGROUND:Diffusion of nitrous oxide into the cuff of the endotracheal tube results in an increase in cuff pressure. Excessive endotracheal tube cuff pressure may impair tracheal mucosal perfusion and cause tracheal damage and sore throat. Filling the cuff of the endotracheal tube with saline instead of air prevents t...
journal_title:Anesthesiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00000542-200111000-00015
更新日期:2001-11-01 00:00:00
abstract:BACKGROUND:Percutaneous cricothyroidotomy is a lifesaving procedure for airway obstruction in trauma victims who need airway establishment and cannot be intubated or in whom intubation has failed. METHODS:The purpose of this study was to examine whether there is a training effect using Seldinger technique emergency cr...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-200501000-00005
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND:Available treatments for neuropathic pain have modest efficacy and significant adverse effects, including abuse potential. Because oxidative stress is a key mechanistic node for neuropathic pain, the authors focused on the master regulator of the antioxidant response-nuclear factor erythroid 2-related factor...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0000000000003077
更新日期:2020-02-01 00:00:00