Abstract:
:Glutathione (GSH) is an abundantly produced low-molecular-weight (LMW) thiol in many organisms. However, a number of Gram-positive bacteria do not produce GSH, but instead produce bacillithiol (BSH) as one of the major LMW thiols. Similar to GSH, studies have found that BSH has various roles in the cell, including protection against hydrogen peroxide, hypochlorite and disulfide stress. BSH also participates in the detoxification of thiol-reactive antibiotics and the electrophilic metabolite methylglyoxal. Recently, a number of studies have highlighted additional roles for BSH in the processing of intracellular metals. Herein, we examine the potential functions of BSH in the biogenesis of Fe-S clusters, cytosolic metal buffering and the prevention of metal intoxication.
journal_name
Curr Genetjournal_title
Current geneticsauthors
Rosario-Cruz Z,Boyd JMdoi
10.1007/s00294-015-0511-0subject
Has Abstractpub_date
2016-02-01 00:00:00pages
59-65issue
1eissn
0172-8083issn
1432-0983pii
10.1007/s00294-015-0511-0journal_volume
62pub_type
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