Abstract:
:Cholesterolemia is associated with pro-oxidative and proinflammatory effects. Glucomannan- or glucomannan plus spirulina-enriched surimis were included in cholesterol-enriched high-saturated diets to test the effects on lipemia; antioxidant status (glutathione status, and antioxidant enzymatic levels, expressions and activities); and inflammation biomarkers (endothelial nitric oxide synthase (eNOS), inducible nitric oxide synthase (iNOS), tumor necrosis factor alpha (TNF-α)) in Zucker fa/fa rats. Groups of eight rats each received diet containing squid-surimi (C), squid-surimi cholesterol-enriched diet (HC), glucomannan-squid-surimi cholesterol-enriched diet (HG), or glucomannan-spirulina-squid-surimi cholesterol-enriched diet (HGS) over a period of 7 weeks. HC diet induced severe hyperlipemia, hepatomegalia, increased inflammation markers, and impaired antioxidant status significantly (at least p < 0.05) vs. C diet. HG diet decreased lipemia and liver size and normalized antioxidant status to C group levels, but increased TNF-α with respect to HC diet (p < 0.05). In general terms, 3 g/kg of spirulina in diet maintained the positive results observed in the HG diet but, in addition, increased inflammation index [eNOS/(eNOS + iNOS)] and decreased plasma TNF-α (both p < 0.05). In conclusion, glucomannan plus a small amount of spirulina blocks negative effects promoted by hypercholesterolemic diets. Although more studies are needed, present results suggest the utility of including glucomannan and/or spirulina as functional ingredients into fish derivates to be consumed by people on metabolic syndrome risk.
journal_name
J Physiol Biochemjournal_title
Journal of physiology and biochemistryauthors
Vázquez-Velasco M,González-Torres L,López-Gasco P,Bastida S,Benedí J,González-Muñoz MJ,Sánchez-Muniz FJdoi
10.1007/s13105-015-0425-9subject
Has Abstractpub_date
2015-12-01 00:00:00pages
611-22issue
4eissn
1138-7548issn
1877-8755pii
10.1007/s13105-015-0425-9journal_volume
71pub_type
杂志文章abstract::Epigenetics has an important role in the regulation of metabolic adaptation to environmental modifications. In this sense, the determination of epigenetic changes in non-invasive samples during the development of metabolic diseases could play an important role in the procedures in primary healthcare practice. To help ...
journal_title:Journal of physiology and biochemistry
pub_type: 杂志文章
doi:10.1007/s13105-017-0560-6
更新日期:2016-08-01 00:00:00
abstract::Several studies have suggested that oxidative stress might cause and aggravate the inflammatory state associated with obesity and could be the link between excessive weight gain and its related disorders such as insulin resistance and cardiovascular diseases. Thus, antioxidant treatment has been proposed as a therapy ...
journal_title:Journal of physiology and biochemistry
pub_type: 杂志文章
doi:10.1007/BF03165968
更新日期:2009-03-01 00:00:00
abstract::In the absence of progesterone (P), the anti-P at the receptor RU486 reduces basal and GnRH-stimulated LH secretion both in vivo and in vitro, demonstrating the existence of a ligand-independent activation of progesterone receptor (LIAPR). The aim of the present study was to determine which component of the intracellu...
journal_title:Journal of physiology and biochemistry
pub_type: 杂志文章
doi:10.1007/BF03165804
更新日期:2006-03-01 00:00:00
abstract::Lipoic acid (LA) is an antioxidant with therapeutic properties on several diseases like diabetes and obesity. Apelin is a novel adipokine with potential beneficial actions on glucose metabolism and insulin resistance. The aim of this study was to examine in 3T3-L1 adipocytes the effects of LA on apelin gene expression...
journal_title:Journal of physiology and biochemistry
pub_type: 杂志文章
doi:10.1007/s13105-011-0087-1
更新日期:2011-09-01 00:00:00
abstract::Conjugated linoleic acid (CLA) refers to a mixture of naturally occurring positional and geometric isomers of linoleic acid that exist in dairy products and meat. The aim of the present work was to study the effects of c-9,t-11 and t-10,c-12 CLA isomers on body fat accumulation and serum lipids in hamsters fed an athe...
journal_title:Journal of physiology and biochemistry
pub_type: 杂志文章
doi:10.1007/BF03179915
更新日期:2003-09-01 00:00:00
abstract::Total level of O-acetyl-L-serine(thiol)lyase (OASTL) activity observed in Monoraphidium braunii fed-repleted cells decreases up to 40% after 24 h the carbon source was removed from the culture; however, no significant change in the activity is observed in N-starved cells. On the other hand, sulfur starvation induces O...
journal_title:Journal of physiology and biochemistry
pub_type: 杂志文章
doi:
更新日期:1998-09-01 00:00:00
abstract::The weight loss observed in consumers of extracts of Citrus aurantium (bitter orange) has been tentatively attributed to the lipolytic and thermogenic effects of the alkaloids abundant in the unripe fruit. Synephrine, octopamine, tyramine, and other alkaloids have been repeatedly identified and quantified in Citrus me...
journal_title:Journal of physiology and biochemistry
pub_type: 杂志文章
doi:10.1007/s13105-011-0078-2
更新日期:2011-09-01 00:00:00
abstract::Regular physical exercise is recognized as a nonpharmacological therapeutic strategy in the treatment of metabolic syndrome, and has been proposed for improving obesity, diabetic status, insulin resistance, and immune response. The aim of the present study was to evaluate the effect of a regular exercise program (trea...
journal_title:Journal of physiology and biochemistry
pub_type: 杂志文章
doi:10.1007/s13105-012-0196-5
更新日期:2013-03-01 00:00:00
abstract::In the present study, we investigated the efficiency of rosmarinic acid (RA) in preventing the alteration of oxidative parameters in the liver and kidney of diabetic rats induced by streptozotocin (STZ). The animals were divided into six groups (n = 8): control, ethanol, RA 10 mg/kg, diabetic, diabetic/ethanol, and di...
journal_title:Journal of physiology and biochemistry
pub_type: 杂志文章
doi:10.1007/s13105-015-0438-4
更新日期:2015-12-01 00:00:00
abstract::Reduced nitric oxide availability and a heterogeneous pattern of nitric oxide synthase activity in some tissues have been reported in hypothyroidism. This study aimed at determining the effects of oral nitrate and L-arginine administration on serum, heart, and aorta nitric oxide metabolite concentrations in fetal hypo...
journal_title:Journal of physiology and biochemistry
pub_type: 杂志文章
doi:10.1007/s13105-013-0251-x
更新日期:2013-12-01 00:00:00
abstract::The purpose of this study was to apply the new approach for Metabolic Individual Risk-factor And Clustering Estimation (MIRACLE) score in a group of Spanish obese children and adolescents and to describe its relationship with other metabolic risk factors. 153 children with simple obesity were studied: 79 males and 74 ...
journal_title:Journal of physiology and biochemistry
pub_type: 杂志文章
doi:10.1007/BF03165766
更新日期:2007-12-01 00:00:00
abstract::Paeonol (Pae) is the main active ingredient from the root bark of Paeonia moutan and the grass of Radix Cynanchi Paniculati. Numerous reports indicate that Pae effectively inhibits several types of cancer lines. In this study, we report that Pae hinders prostate cancer growth both in vivo and in vitro. Human prostate ...
journal_title:Journal of physiology and biochemistry
pub_type: 杂志文章
doi:10.1007/s13105-016-0537-x
更新日期:2017-05-01 00:00:00
abstract::Pouteria campechiana (Kunth) Baehni. is used as a remedy for coronary trouble, liver disorders, epilepsy, skin disease, and ulcer. Therefore, the present study aims to investigate the antioxidant and hepatoprotective effect of polyphenolic-rich P. campechiana fruit extract against acetaminophen-intoxicated rats. Total...
journal_title:Journal of physiology and biochemistry
pub_type: 杂志文章
doi:10.1007/s13105-013-0274-3
更新日期:2014-03-01 00:00:00
abstract::The aim of this study was to determine the characteristic features which contribute to inappropriate eating attitudes in people suffering from anorexia nervosa, based on an analysis of recent data. Factors influencing these attitudes have a genetic, neurobiological, biochemical, affective-motivational, cognitive, and ...
journal_title:Journal of physiology and biochemistry
pub_type: 杂志文章,评审
doi:10.1007/s13105-016-0540-2
更新日期:2017-05-01 00:00:00
abstract::Low shear stress (LSS) occurs in areas where atherosclerosis is prevalent. Many studies have revealed that signal transducer and activator of transcription 1 (STAT1) plays a significant role in cardiovascular disease. Nonetheless, the mechanism underlying the connection between STAT1 and LSS is not fully understood. T...
journal_title:Journal of physiology and biochemistry
pub_type: 杂志文章
doi:10.1007/s13105-020-00729-1
更新日期:2020-02-01 00:00:00
abstract::The effect of long-lasting in vivo restriction of nitric oxide (NO) bioavailability on cardiac and renal P-type ATPases critical for intracellular ion homeostasis is controversial. Previous work has shown in eNOS knockout (eNOS(-/-)) mice hearts that Na(+)/K(+)- and Ca(2+)-ATPase activities were depressed but the unde...
journal_title:Journal of physiology and biochemistry
pub_type: 杂志文章
doi:10.1007/s13105-012-0203-x
更新日期:2013-06-01 00:00:00
abstract::Due to its noninvasive, convenient, and practical nature, salivary testosterone (sal-T) and cortisol (sal-C) are frequently used in a clinical and applied setting. However, few studies report biological and analytical error and even fewer report the 'critical difference' which is the change required before a true biol...
journal_title:Journal of physiology and biochemistry
pub_type: 杂志文章,随机对照试验
doi:10.1007/s13105-014-0368-6
更新日期:2014-12-01 00:00:00
abstract::The number of patients that suffer some type of spinal cord lesion in recent years are high and have increased because of factors such as traffic accidents. Although their life expectancy has increased, cardiovascular illnesses is one of the main causes of morbidity and mortality. Since the degree of physical fitness ...
journal_title:Journal of physiology and biochemistry
pub_type: 杂志文章
doi:10.1007/BF03179863
更新日期:2003-03-01 00:00:00
abstract::In order to obtain healthier goat milk as far as its fat composition is concerned, milk production and composition trials were carried out with Granadina goats kept in semi-extensive breeding conditions. The animals were feeding indoors with a concentrate supplemented or not with 7% of fat conveniently protected again...
journal_title:Journal of physiology and biochemistry
pub_type: 杂志文章
doi:10.1007/BF03179791
更新日期:2000-09-01 00:00:00
abstract::Since the discovery of leptin in 1994, the adipose tissue (AT) is not just considered a passive fat storage organ but also an extremely active secretory and endocrine organ that secretes a large variety of hormones, called adipokines, involved in energy metabolism. Adipokines may not only contribute to AT dysfunction ...
journal_title:Journal of physiology and biochemistry
pub_type: 杂志文章,评审
doi:10.1007/s13105-020-00736-2
更新日期:2020-05-01 00:00:00
abstract::Analysis of the posttranslational modification of proteins, such as phosphorylation, might yield misleading results due to the presence of other proteins with similar electrophoretic properties that coimmunoprecipitate with the target protein. The aim of the present work was to develop a reliable, easy and economical ...
journal_title:Journal of physiology and biochemistry
pub_type: 杂志文章
doi:10.1007/BF03178839
更新日期:2008-09-01 00:00:00
abstract::The influence of maternal fat mass and obesity (FTO) gene polymorphism on neonatal insulin sensitivity/resistance biomarkers and lipoprotein profile has not been tested. The study aimed to assess the association between the FTO rs9939609 polymorphism in mother-neonate couples and neonatal anthropometrical measurements...
journal_title:Journal of physiology and biochemistry
pub_type: 杂志文章
doi:10.1007/s13105-016-0467-7
更新日期:2016-06-01 00:00:00
abstract::Our previous findings demonstrated that hypothermia enhances the reduction potential in the liver and helps to maintain the plasmatic antioxidant pool. Here, we aimed to elucidate if hypothermia protects against hypoxia-induced oxidative stress damage in rat liver. Several hepatic markers of oxidative stress were comp...
journal_title:Journal of physiology and biochemistry
pub_type: 杂志文章
doi:10.1007/s13105-016-0500-x
更新日期:2016-12-01 00:00:00
abstract::In response to stress, the hypothalamus releases cortiticotropin releasing hormone (CRH) that travels to the anterior pituitary, where it stimulates the release of adrenocorticotropic hormone (ACTH). ACTH travels to the adrenal cortex, where it stimulates the release of cortisol and other steroids that liberate energy...
journal_title:Journal of physiology and biochemistry
pub_type: 杂志文章,评审
doi:10.1007/s13105-012-0227-2
更新日期:2013-09-01 00:00:00
abstract::Chronic renal disease is characterized by the accumulation of extracellular matrix proteins in the kidney and a loss of renal function. Tubulointerstitial fibrosis has been reported to play an important role in the progression of chronic renal diseases. Transforming growth factor-beta1 (TGF-beta1) is a profibrotic cyt...
journal_title:Journal of physiology and biochemistry
pub_type: 杂志文章
doi:10.1007/BF03168452
更新日期:2005-09-01 00:00:00
abstract::Adiponectin exerts vasodilatory effects. Irbesartan, an angiotensin receptor blocker, possesses partial peroxisome proliferator-activated receptor gamma (PPAR-γ) agonist activity and increases circulating adiponectin. This study explored the effect of irbesartan alone and in combination with adiponectin on blood press...
journal_title:Journal of physiology and biochemistry
pub_type: 杂志文章
doi:10.1007/s13105-016-0497-1
更新日期:2016-12-01 00:00:00
abstract::In pregnancy there occurs maternal tolerance to the foetus. Several mechanisms have been proposed to explain this phenomenon. The main immune population in the decidua are macrophages and natural killer cells, but with some "special" suppressor characteristics. There is also a predominant TH2 response. The non classic...
journal_title:Journal of physiology and biochemistry
pub_type: 杂志文章,评审
doi:10.1007/BF03167033
更新日期:2004-09-01 00:00:00
abstract::Connections between the midbrain dorsolateral periaqueductal grey (dlPAG) and the pontine A5 region have been shown. The stimulation of both regions evokes similar cardiovascular responses: tachycardia and hypertension. Accordingly, we have studied the interactions between dlPAG and A5 region in spontaneously breathin...
journal_title:Journal of physiology and biochemistry
pub_type: 杂志文章
doi:10.1007/s13105-020-00761-1
更新日期:2020-11-01 00:00:00
abstract::Adiponectin, a hormone produced by adipocytes, is involved in glucose metabolism and insulin sensitivity. The production of this adipokine is impaired in obesity and insulin resistance. Eicosapentaenoic acid (EPA) is a dietary n-3 polyunsaturated fatty acid that improves insulin sensitivity in several models of obesit...
journal_title:Journal of physiology and biochemistry
pub_type: 杂志文章
doi:10.1007/BF03174067
更新日期:2006-06-01 00:00:00
abstract::Oxidative stress has been shown to induce apoptosis in cancer cells. Therefore, one might suspect that antioxidants may inhibit reactive oxygen species (ROS) and prevent apoptosis of cancer cells. No study has been carried out so far to elucidate the effects of N-acetylcysteine (NAC) on bleomycin-induced apoptosis in ...
journal_title:Journal of physiology and biochemistry
pub_type: 杂志文章
doi:10.1007/s13105-012-0173-z
更新日期:2012-12-01 00:00:00