Effect of clozapine on psychological outcomes of caregivers of patients with treatment resistant schizophrenia.

Abstract:

BACKGROUND:There is limited information on caregiver outcomes of patients with treatment-resistant schizophrenia (TRS). AIM:This study aimed to evaluate the impact of short-term treatment with clozapine (i.e. 3 months) on caregiver burden, expressed emotions, caregiver abuse, and psychological morbidity among the caregivers in patients with TRS. 52 caregivers of patients with TRS were evaluated on the Family Burden Interview Schedule, Perceived Criticism Measure, Caregiver Abuse Screening Questionnaire, and General Health Questionnaire-12. RESULTS:Maximum caregiver burden was seen in the domain of disruption of routine family activities, and this was followed by the domains of disruption of family leisure, disruption of family interaction, and the effect on mental health on others. At the baseline assessment, three-fourth of the caregivers scored ≥12 on the objective burden. With 3 months of clozapine therapy, there was a significant reduction in the caregiver burden in all the domains of objective burden, subjective burden, and the global objective burden as per the clinician rating, in the expressed emotions as per both patients and the caregivers, caregiver abuse, and psychological morbidity among the caregivers. CONCLUSION:To conclude, this study suggests that caregivers of patients with TRS, experience significantly higher caregiver burden, and a large proportion of them suffer from psychological morbidity and indulge in expressed emotions and abuse of the patient. Treatment with clozapine for 3 months leads to a reduction in the caregiver burden, expressed emotions, caregiver abuse, and psychological morbidity among the caregivers.

journal_name

Nord J Psychiatry

authors

Verma M,Grover S,Chakrabarti S

doi

10.1080/08039488.2020.1804617

subject

Has Abstract

pub_date

2021-02-01 00:00:00

pages

118-123

issue

2

eissn

0803-9488

issn

1502-4725

journal_volume

75

pub_type

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