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Irritable temperament and lifetime psychotic symptoms as predictors of anxiety symptoms in bipolar disorder.

Abstract：

PURPOSE:Affective temperaments, hopelessness, alexithymia, and anxiety/agitation symptoms may play a significant role in the psychopathological characteristics of bipolar disorder (BD). Here, we aimed to investigate the eventual association between the mentioned explanatory variables and anxiety/agitation symptoms in BD. MATERIALS AND METHODS:We recruited at the Section of Psychiatry, Department of Neuroscience, University of Genoa (Italy), 92 BD inpatients having a mean age of 52 (±13.8) years. Participants were assessed using specific psychometric instruments. Anxiety/agitation symptoms have been evaluated using the 11-item of the Beck Depression Inventory II (BDI-II). RESULTS:Overall, 53.8% of participants presented with anxiety/agitation symptoms and 46.2% without. The two groups significantly differed about socio-economic status, lifetime psychotic symptoms, and residual depressive symptoms between episodes. Anxiety/agitation symptoms significantly correlated with irritable affective temperament (r = 0.407; p = .01), hopelessness (r = 0.541; p ≤ .001), difficulty identifying feelings (r = 0.440; p ≤ .001), difficulty describing feelings (r = 0.437; p ≤ .001), and externally oriented-thinking (r = 0.393; p ≤ .001). After multivariate analyses, irritable affective temperament (OR = 2.457, p ≤ .01) and less lifetime psychotic symptoms (OR = 0.007, p ≤ .05) remained the only significant variables associated with anxiety/agitation symptoms. CONCLUSIONS:The generalization of the main findings is limited by the small sample size and cross-sectional study design. Nevertheless, our results suggest that the careful assessment of affective temperaments and psychotic symptoms may help to early identify BD patients suffering from anxiety/agitation symptoms and may allow to perform targeted interventions in the clinical practice.

journal_name

Nord J Psychiatry

journal_title

Nordic journal of psychiatry

authors

Serafini G,Geoffroy PA,Aguglia A,Adavastro G,Canepa G,Pompili M,Amore M

doi

10.1080/08039488.2017.1385851

subject

Has Abstract

pub_date

2018-01-01 00:00:00

pages

63-71

issue

eissn

0803-9488

issn

1502-4725

journal_volume

pub_type

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Irritable temperament and lifetime psychotic symptoms as predictors of anxiety symptoms in bipolar disorder.