Abstract：
UNLABELLED:Schizophrenia, with incidence of 1% worldwide, is a common mental disorder. Phosphoinositide-3-kinases (PI3Ks) are a family of enzymes involved in cellular functions such as cell growth, proliferation, differentiation, motility, intracellular trafficking, and survival. These enzymes play an important role in the PI3K/AKT signalling pathway. The PIK3CA gene encodes the alpha catalytic subunit of the PI3K enzyme. The present study analysed the role of three SNPs of the PIK3CA gene (rs6443624 (A/C), rs7640662(C/G) and rs7621329(C/T)) in the development of schizophrenia. METHODS:In this case-controlled study, DNA was extracted from blood samples from 108 patients with schizophrenia and 108 healthy patients as controls. Genotypic analyses of PIK3CA SNPs rs6443624 (A/C), rs7640662(C/G) and rs7621329(C/T) were made using the tetra primer ARMS-PCR technique. RESULTS:The outcome shows significant difference between CT and the combined genotype (CT + TT) of rs7621329 and the risk of schizophrenia (OR = 6.4, 95% CI = 3.023-14.23, p < 0.0001). Outcome showed no significant difference for were for analyses of the rs6443624 and rs7640662 genotypes. CONCLUSIONS:These results indicate an association between PIK3CA gene polymorphism on the rs7621329(C/T) site and the risk of schizophrenia. Further study of the genetic population using a larger sample size is necessary in order to validate these present findings.
journal_name
Nord J Psychiatryjournal_title
Nordic journal of psychiatryauthors
Kordi-Tamandani DM,Mir Adoi
10.3109/08039488.2015.1092171subject
Has Abstractpub_date
2016-01-01 00:00:00pages
272-5issue
4eissn
0803-9488issn
1502-4725journal_volume
70pub_type
杂志文章abstract：BACKGROUND:Adolescents with attention-deficit/hyperactive disorder (ADHD) or autism spectrum disorder (ASD) are at high risk of anxiety and depression. This is important to identify in the clinical assessment to understand its impact. AIMS:The aim of this study is to investigate the correlation between parent- and sel...
journal_title：Nordic journal of psychiatry
pub_type： 杂志文章
doi：10.1080/08039488.2017.1367840
更新日期：2017-11-01 00:00:00
abstract：AIMS:Our general objective was to assess the psychological symptoms and the types of causal attributions linked to the symptoms among women chronic pain. METHODS:70 fibromyalgia (FM) patients, 56 chronic low back pain (CLBP) patients and 72 healthy controls were assessed within a general hospital setting, using the To...
journal_title：Nordic journal of psychiatry
pub_type： 杂志文章
doi：10.3109/08039488.2010.522596
更新日期：2011-04-01 00:00:00
abstract：BACKGROUND:The psychopathic traits measured with the Hare Psychopathy Checklist-Revised (PCL-R) in a representative national prisoner sample have not been studied in Finland before. It has been unclear whether there could occur some national differences or whether the PCL-R can be used for assessing psychopathic traits...
journal_title：Nordic journal of psychiatry
pub_type： 杂志文章
doi：10.3109/08039488.2013.780259
更新日期：2014-02-01 00:00:00
abstract：:A previous paper, in a series of three, presented the National Library of Medicine, Medline, PubMed and the MeSH system. Connection to PubMed via the Internet opens the PubMed search window that is the tool for retrieving references to scientific medical literature. This paper is intended as a tutorial for an inexperi...
journal_title：Nordic journal of psychiatry
pub_type： 杂志文章
doi：10.1080/08039480600790432
更新日期：2006-01-01 00:00:00
abstract：BACKGROUND:Patients with remitted bipolar disorder have cognitive impairments, particularly in executive functions. However, the findings of studies that investigated cognitive functions in unaffected relatives of patients with bipolar disorder are conflicting. AIMS:The aim of this study is to investigate executive fu...
journal_title：Nordic journal of psychiatry
pub_type： 杂志文章
doi：10.3109/08039488.2012.756062
更新日期：2014-01-01 00:00:00
abstract：:Depressive disorders constitute a common clinical problem. However, research on psychosocial impairment and treatment-related factors among adolescent outpatients with different diagnoses of depression is scarce. This study aimed at investigating consecutively referred outpatient adolescents with depressive syndrome c...
journal_title：Nordic journal of psychiatry
pub_type： 杂志文章
doi：10.1080/08039480510022981
更新日期：2005-01-01 00:00:00
abstract：BACKGROUND:Most studies find that patients with obsessive-compulsive disorder (OCD) have impaired memory and executive functions. Cognitive behavioural therapy (CBT) is the recommended psychotherapeutic treatment of patients with OCD. We hypothesized that impairments in memory and executive functions would predict poor...
journal_title：Nordic journal of psychiatry
pub_type： 杂志文章
doi：10.3109/08039488.2015.1074282
更新日期：2016-01-01 00:00:00
abstract：:Background: Obsessive-compulsive disorder (OCD) is a common psychiatric illness in children and adolescents. Previous evidence suggests that fluoxetine is effective in the treatment of OCD in children and adolescents. However, those studies had small sample sizes. As a result, a systematic review, which is a more powe...
journal_title：Nordic journal of psychiatry
pub_type： 杂志文章,meta分析
doi：10.1080/08039488.2020.1744037
更新日期：2020-10-01 00:00:00
abstract：PURPOSE:Neurocognitive outcomes are frequently used as indicators of real-world functioning in schizophrenia spectrum disorders (SSD). These test results may be influenced by individual differences, such as affective dispositions. Here we investigate the relationship between positive and negative affect and neuropsycho...
journal_title：Nordic journal of psychiatry
pub_type： 杂志文章
doi：10.1080/08039488.2020.1862294
更新日期：2021-01-06 00:00:00
abstract：:The purpose of the article: Brain-derived neurotrophic factor (BDNF) and matrix metalloproteinase-9 (MMP-9) are involved in the processes of neurogenesis, synaptic plasticity, learning and memory. Growing number of studies shows a relationship between BDNF or MMP-9 and schizophrenia. Also, BDNF and MMP-9 levels may be...
journal_title：Nordic journal of psychiatry
pub_type： 杂志文章
doi：10.1080/08039488.2019.1658126
更新日期：2019-11-01 00:00:00
abstract：BACKGROUND AND AIM:The Danish Health and Medicines Authority assembled a group of experts to develop a national clinical guideline for patients with schizophrenia and complex mental health needs. Within this context, ten explicit review questions were formulated, covering several identified key issues. METHODS:Systema...
journal_title：Nordic journal of psychiatry
pub_type： 杂志文章,实务指引
doi：10.3109/08039488.2015.1074285
更新日期：2016-01-01 00:00:00
abstract：:First-episode psychosis (FEP) patients are often given diagnoses that later have to be changed. The aim of this study was to measure the diagnostic stability in a total group of FEP patients; 146 FEP patients were followed longitudinally and prospectively. Their revised baseline diagnoses were compared with their 3-ye...
journal_title：Nordic journal of psychiatry
pub_type： 杂志文章,多中心研究
doi：10.1080/08039480701352454
更新日期：2007-01-01 00:00:00
abstract：BACKGROUND:Patients with affective disorder have higher mortality not only because of their affective illness but also because of a higher risk of death from physical illness especially cardiovascular diseases. AIM:To investigate the prevalence in a naturalistic cohort of patient treated at a Mood Disorder Clinic. ME...
journal_title：Nordic journal of psychiatry
pub_type： 杂志文章
doi：10.3109/08039488.2011.595821
更新日期：2012-04-01 00:00:00
abstract：:The objective of this study was to explore how sexual child abusers who meet the DSM-IV criteria for paedophilia differ from those who do not. We studied DSM-IV disorders and paedophilic interests in all cases of sexual child abuse referred to forensic psychiatric investigation in Sweden between 1993 and 1997 (n=185)....
journal_title：Nordic journal of psychiatry
pub_type： 杂志文章
doi：10.1080/08039480500360724
更新日期：2005-01-01 00:00:00
abstract：BACKGROUND:Schizophrenia causes great suffering for patients and families. Today, patients are treated with medications, but unfortunately many still have persistent symptoms and an impaired quality of life. During the last 20 years of research in cognitive behavioral therapy (CBT) for schizophrenia, evidence has been ...
journal_title：Nordic journal of psychiatry
pub_type： 杂志文章,meta分析,评审
doi：10.3109/08039488.2013.789074
更新日期：2014-04-01 00:00:00
abstract：BACKGROUND:Patients with schizophrenia suffer from wide range of deficits in neurocognitive functions of the brain, including visuospatial working memory. AIMS:This study aims at evaluating the effect of short-term smoking abstinence on different components of visuospatial working memory in smoker patients with schizo...
journal_title：Nordic journal of psychiatry
pub_type： 杂志文章,随机对照试验
doi：10.3109/08039488.2012.687765
更新日期：2013-04-01 00:00:00
abstract：:Previous studies on post-traumatic stress disorder (PTSD) investigated a variety of treatments and included mostly patients victims of sexual and combat assault. This study aimed to determine the short-term efficacy of eye movement desensitization and reprocessing (EMDR) in occupation-based PTSD. Employees of the publ...
journal_title：Nordic journal of psychiatry
pub_type： 杂志文章,随机对照试验
doi：10.1080/08039480601129408
更新日期：2007-01-01 00:00:00
abstract：:Background: An abnormal interaction between cognition and emotion may contribute to the development of obsessive-compulsive disorder (OCD). Aims: In this study, we aimed to evaluate theory of mind and emotion regulation skills in adolescents diagnosed with OCD. In addition, the results were evaluated in accordance wit...
journal_title：Nordic journal of psychiatry
pub_type： 杂志文章
doi：10.1080/08039488.2019.1652341
更新日期：2019-10-01 00:00:00
abstract：BACKGROUND:Although cognitive behavioural therapy (CBT) has been shown to be an efficacious treatment for social phobia (SP), many patients drop out or achieve little or no benefit from treatment. This fact is generally considered an argument for the importance of studies of predictor variables. AIMS:This paper system...
journal_title：Nordic journal of psychiatry
pub_type： 杂志文章,评审
doi：10.3109/08039480903426929
更新日期：2010-04-01 00:00:00
abstract：:The aim of the present study was to investigate the applicability of a quality of life self-rating scale - the Lehman Quality of Life Questionnaire TL-30 - to evaluate the test-retest reliability of the TL-30 and finally to test the quality of life in schizophrenic patients compared with a general population. Patients...
journal_title：Nordic journal of psychiatry
pub_type： 杂志文章
doi：10.1080/08039480701773154
更新日期：2007-01-01 00:00:00
abstract：BACKGROUND:Schizophrenia is a highly heterogeneous disease. Event-related potentials have been regarded to establish intermediate phenotypes of schizophrenia. Our previous study found that patients with deficit schizophrenia (DS) are relatively homogeneous and show a significantly longer onset latency of contingent neg...
journal_title：Nordic journal of psychiatry
pub_type： 杂志文章
doi：10.3109/08039488.2014.959562
更新日期：2015-04-01 00:00:00
abstract：BACKGROUND:Negative and stigmatizing attitudes towards persons with mental illness must be dealt with to facilitate the sufferers' social acceptance. AIM:The present study aimed at survey Swedish attitudes towards persons with mental illness related to factors impacting these attitudes. MATERIAL AND METHODS:New CAMI-...
journal_title：Nordic journal of psychiatry
pub_type： 杂志文章
doi：10.3109/08039488.2011.596947
更新日期：2012-04-01 00:00:00
abstract：BACKGROUND:Few studies have focused on the recent trends in clinical features child and adolescent inpatient. AIMS:This study focuses on the change in the characteristics of child and adolescent psychiatric inpatients in Finland. METHODS:The data collection was carried out on selected study days in 2000 and 2011. Que...
journal_title：Nordic journal of psychiatry
pub_type： 杂志文章
doi：10.3109/08039488.2016.1149617
更新日期：2016-08-01 00:00:00
abstract：:It is highly relevant to estimate to what extent a person with schizophrenia engages in occupations and participates in different life situations in order to understand the determinants of well-being in this group of people. This study aimed at examining the construct validity of the instrument Profile of Occupational...
journal_title：Nordic journal of psychiatry
pub_type： 杂志文章
doi：10.1080/08039480600636239
更新日期：2006-01-01 00:00:00
abstract：BACKGROUND:Central serous chorioretinopathy (CSC) has been associated with several psychological factors. But previous psychological data are limited and mainly restricted to male patients and small sample size. In this study we investigated psychosomatic complaints, personality factors, life events, and stress coping ...
journal_title：Nordic journal of psychiatry
pub_type： 杂志文章
doi：10.3109/08039488.2015.1041156
更新日期：2016-01-01 00:00:00
abstract：:Purpose: While the pivotal role of pharmacotherapy in psychiatry is universal, significant regional differences exist in drug use patterns. Herewith we compare the use of ATC psychotropic drugs (N05, psycholeptics and N06A, antidepressants) in 2010-2015 in the three Baltic Countries with reference to the Nordic Countr...
journal_title：Nordic journal of psychiatry
pub_type： 杂志文章
doi：10.1080/08039488.2019.1707283
更新日期：2020-05-01 00:00:00
abstract：:Aim: The aim of the study was two-fold: first, to assess the efficacy of an electronic real-time feedback system; second, to examine patient satisfaction.Methods: This was a mixed-method study. Data were collected from two psychiatric outpatient clinics using electronic patient feedback devices. The efficacy of the re...
journal_title：Nordic journal of psychiatry
pub_type： 杂志文章
doi：10.1080/08039488.2019.1684989
更新日期：2020-02-01 00:00:00
abstract：:Background Chronotype and insomnia have been related to the development and to an unfavourable course of depression. However, the mutual relationship of both risk factors is as yet unclear, especially in acute, clinically manifest depressive disorders. Aims The present study was carried out to elucidate the separate d...
journal_title：Nordic journal of psychiatry
pub_type： 杂志文章
doi：10.3109/08039488.2015.1112832
更新日期：2016-07-01 00:00:00
abstract：BACKGROUND:Unusual reactions to sensory stimuli are experienced by 90-95% of people with an autism spectrum condition (ASC). Self-reported sensory reactivity in ASC has mainly been measured with generic questionnaires developed and validated on data from the general population. Interest in sensory reactivity in ASC inc...
journal_title：Nordic journal of psychiatry
pub_type： 杂志文章
doi：10.3109/08039488.2015.1053984
更新日期：2016-01-01 00:00:00
abstract：PURPOSE:In this study, it is aimed to determine the level of test anxiety and self-esteem in the high school students preparing for the university exam in Bitlis, Turkey, and to investigate the effect of test anxiety on self-esteem. MATERIAL AND METHODS:Seven-hundred and twenty-four high school students who were prepa...
journal_title：Nordic journal of psychiatry
pub_type： 杂志文章
doi：10.1080/08039488.2017.1389986
更新日期：2018-02-01 00:00:00
