Abstract:
OBJECTIVE:To analyse the dosage pattern of antipsychotic drugs for schizophrenia in ambulatory care in Sweden. METHOD:The study was based on a nationwide consecutive weekly random sample of physicians during the period 1991-98 comprising 265,331 visits. RESULTS:In 515 visits (0.19%), antipsychotics were prescribed for schizophrenia. More than one antipsychotic (50 different combinations) was prescribed in 20% of the visits. Patients received higher total daily doses when prescribed more than one antipsychotic drug; mean dose in monotherapy was 210.7 chlorpromazine equivalents (CPZeq) and in polytherapy 406.8 CPZeq. CONCLUSION:Antipsychotics, in contrast to current recommendations, were prescribed as highly individualized therapies in a wide variety of doses and with a high frequency of polypharmacy. The combinations used are often unsuitable and may lead to unnecessary adverse effects.
journal_name
Nord J Psychiatryjournal_title
Nordic journal of psychiatryauthors
Bingefors K,Isacson D,Lindström Edoi
10.1080/08039480307280subject
Has Abstractpub_date
2003-01-01 00:00:00pages
263-9issue
4eissn
0803-9488issn
1502-4725pii
JXX387PNVHX8P2TXjournal_volume
57pub_type
杂志文章abstract:AIMS:Knowledge of sleep problems and their relationships among adolescent psychiatric patients is limited. This study investigated whether adolescents in specialty mental health care differ in rate and correlates of sleep problems from adolescents in a community sample; 2465 adolescents from a community sample were com...
journal_title:Nordic journal of psychiatry
pub_type: 杂志文章
doi:10.3109/08039480903282392
更新日期:2010-05-04 00:00:00
abstract::The purpose of the article: Brain-derived neurotrophic factor (BDNF) and matrix metalloproteinase-9 (MMP-9) are involved in the processes of neurogenesis, synaptic plasticity, learning and memory. Growing number of studies shows a relationship between BDNF or MMP-9 and schizophrenia. Also, BDNF and MMP-9 levels may be...
journal_title:Nordic journal of psychiatry
pub_type: 杂志文章
doi:10.1080/08039488.2019.1658126
更新日期:2019-11-01 00:00:00
abstract::Finland was the first European country to give a high priority to the development of specialized psychiatric services for adolescents. The aim of this paper is to 1) describe the development of these services, 2) study the status and the functioning of psychiatric services for adolescents in 2000 and 3) present some f...
journal_title:Nordic journal of psychiatry
pub_type: 杂志文章
doi:10.1080/08039480310000248
更新日期:2003-01-01 00:00:00
abstract::Aims: The current study explore the relationship between the trajectories of primary panic disorder symptoms and secondary depressive symptoms during guided internet-delivered cognitive behaviour therapy for panic disorder. Materials and methods: The patients (N=143) were recruited from an ongoing effectiveness study ...
journal_title:Nordic journal of psychiatry
pub_type: 杂志文章
doi:10.1080/08039488.2019.1646803
更新日期:2019-10-01 00:00:00
abstract::The aim of this study was to evaluate internal as well as external validity of the two most frequently used mania scales, the Young Mania Rating Scale (YMRS) and the Bech-Rafaelsen Mania Scale (MAS), in patients with DSM-IV mania. Mokken analysis was used to evaluate internal validity in which a coefficient of homogen...
journal_title:Nordic journal of psychiatry
pub_type: 杂志文章
doi:10.1080/08039480600601282
更新日期:2006-01-01 00:00:00
abstract::The association between alcohol dependence and suicidal behaviour is well established and patients with suicidal behaviour in treatment for alcohol dependence present a considerable challenge for clinical services. The aim of this study is to identify risk factors for suicide attempts and to evaluate the outcome of tr...
journal_title:Nordic journal of psychiatry
pub_type: 杂志文章
doi:10.1080/08039480802559965
更新日期:2009-01-01 00:00:00
abstract::Establishing post-traumatic stress disorder as a psychiatric diagnosis has only marginally increased awareness of traumatic experiences. Traumas are inconsistently recorded in initial psychiatric histories and, when observed, rarely reflected in the primary diagnosis and treatment. The present study aimed to investiga...
journal_title:Nordic journal of psychiatry
pub_type: 杂志文章
doi:10.1080/08039480410005828
更新日期:2004-01-01 00:00:00
abstract:OBJECTIVES:A body of research has demonstrated high rates of comorbidity among individuals with obsessive-compulsive disorder (OCD). Further, recent empirical evidence has demonstrated the relevance of death anxiety in OCD. Given that the trajectory towards OCD remains unclear, the current study aimed to examine which ...
journal_title:Nordic journal of psychiatry
pub_type: 杂志文章
doi:10.1080/08039488.2020.1817554
更新日期:2020-09-12 00:00:00
abstract:PURPOSE:Affective temperaments, hopelessness, alexithymia, and anxiety/agitation symptoms may play a significant role in the psychopathological characteristics of bipolar disorder (BD). Here, we aimed to investigate the eventual association between the mentioned explanatory variables and anxiety/agitation symptoms in B...
journal_title:Nordic journal of psychiatry
pub_type: 杂志文章
doi:10.1080/08039488.2017.1385851
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Little is known about expert psychiatric and psychological evidence in appeal cases. AIMS:To review the frequency, nature and impact of expert psychiatric and psychological evidence in the Supreme Court in Iceland over a 7-year period where all appeals in Iceland are heard. METHOD:All cases listed on the S...
journal_title:Nordic journal of psychiatry
pub_type: 杂志文章
doi:10.3109/08039481003624181
更新日期:2010-08-01 00:00:00
abstract:BACKGROUND:Many children are affected by parental substance use disorder. Beardslee's family intervention (BFI) is a family-based psycho-educative method for children of mentally ill parents, used in psychiatric practise in several Nordic countries. The method has also been used to some extent when a parent suffers fro...
journal_title:Nordic journal of psychiatry
pub_type: 杂志文章
doi:10.1080/08039488.2017.1308009
更新日期:2017-07-01 00:00:00
abstract::The purpose of the present study was to investigate the effectiveness of cognitive-behavioural group treatment of panic disorder and agoraphobia in a clinical setting. Fifty-three patients were offered treatment and assessed before, after and at follow-up 1 1/2-2 years after treatment. The study included an informal w...
journal_title:Nordic journal of psychiatry
pub_type: 杂志文章
doi:10.1080/08039480510027670
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND:The psychopathic traits measured with the Hare Psychopathy Checklist-Revised (PCL-R) in a representative national prisoner sample have not been studied in Finland before. It has been unclear whether there could occur some national differences or whether the PCL-R can be used for assessing psychopathic traits...
journal_title:Nordic journal of psychiatry
pub_type: 杂志文章
doi:10.3109/08039488.2013.780259
更新日期:2014-02-01 00:00:00
abstract::Previous research using Rorschach is sparse in rapists. The aim of this study of 10 violent male forensic psychiatric rapists was to describe them on a set of Rorschach variables, which are assumed to reflect psychopathic character, in order to increase our understanding of rapists. The participants were involved in a...
journal_title:Nordic journal of psychiatry
pub_type: 杂志文章
doi:10.1080/08039480801957327
更新日期:2008-01-01 00:00:00
abstract::The neurodevelopmental hypothesis of schizophrenia has gained increasing acceptance. This hypothesis assumes a disruption in the normal development of the brain, secondary to genetic factors, environmental factors, or, most likely, a combination of both. After a brief review of the various aetiologic models since the ...
journal_title:Nordic journal of psychiatry
pub_type: 杂志文章,评审
doi:10.1080/080394801317080792
更新日期:2001-01-01 00:00:00
abstract:PURPOSE:The reports regarding the status of the immune system in patients with chronic fatigue syndrome/myalgic encephalopathy (CFS/ME) have been inconclusive. We approached this question by comparing a strictly defined group of CFS/ME outpatients to healthy control individuals, and thereafter studied cytokines in subg...
journal_title:Nordic journal of psychiatry
pub_type: 杂志文章
doi:10.1080/08039488.2018.1493747
更新日期:2018-11-01 00:00:00
abstract::Studies conducted outside of Scandinavia indicate that most adolescents with substance misuse problems suffer from co-morbid mental disorders. The present study assessed the mental health of adolescents seeking help for substance misuse problems in a large Swedish city. Parents' mental health was also examined. The sa...
journal_title:Nordic journal of psychiatry
pub_type: 杂志文章
doi:10.1080/08039480701643423
更新日期:2007-01-01 00:00:00
abstract::Objective: To identify personality disorders comorbid with borderline personality disorder (BPD) that may confer greater risk for the presence of severe dissociative experiences. Method: Three hundred and one outpatients with a primary diagnosis of BPD were evaluated using the Structured Clinical Interview for DSM-IV ...
journal_title:Nordic journal of psychiatry
pub_type: 杂志文章
doi:10.1080/08039488.2019.1658127
更新日期:2019-11-01 00:00:00
abstract:BACKGROUND:Patients with affective disorder have higher mortality not only because of their affective illness but also because of a higher risk of death from physical illness especially cardiovascular diseases. AIM:To investigate the prevalence in a naturalistic cohort of patient treated at a Mood Disorder Clinic. ME...
journal_title:Nordic journal of psychiatry
pub_type: 杂志文章
doi:10.3109/08039488.2011.595821
更新日期:2012-04-01 00:00:00
abstract::Purpose: Target-shooting sport requires mental effort and concentration. Training may reduce inattentiveness and distractibility. There is little knowledge if children with symptoms of attention-deficit/hyperactivity disorder (ADHD) benefit from practicing target-shooting sport. Materials and methods: Our study aims t...
journal_title:Nordic journal of psychiatry
pub_type: 杂志文章
doi:10.1080/08039488.2019.1612467
更新日期:2019-01-01 00:00:00
abstract:PURPOSE:Neurocognitive outcomes are frequently used as indicators of real-world functioning in schizophrenia spectrum disorders (SSD). These test results may be influenced by individual differences, such as affective dispositions. Here we investigate the relationship between positive and negative affect and neuropsycho...
journal_title:Nordic journal of psychiatry
pub_type: 杂志文章
doi:10.1080/08039488.2020.1862294
更新日期:2021-01-06 00:00:00
abstract::Background Immunological mechanisms may be responsible for the development and maintenance of schizophrenia symptoms. Aim The aim of this study is to measure tumour necrosis factor-alpha (TNF-α), soluble tumour necrosis factor-alpha receptor I (sTNF-αRI), and soluble tumour necrosis factor-alpha receptor II (sTNF-αRII...
journal_title:Nordic journal of psychiatry
pub_type: 杂志文章
doi:10.3109/08039488.2015.1122079
更新日期:2016-07-01 00:00:00
abstract:BACKGROUND:Shame is an acknowledged part of several psychopathological conditions, but is underrepresented in clinical research. Cook's Internalized Shame Scale (ISS) is the most promising measure, but has mostly been used for testing small clinical samples biased toward depressive pathology and female participants. A...
journal_title:Nordic journal of psychiatry
pub_type: 杂志文章
doi:10.3109/08039480903398177
更新日期:2010-05-04 00:00:00
abstract:BACKGROUND:Unusual reactions to sensory stimuli are experienced by 90-95% of people with an autism spectrum condition (ASC). Self-reported sensory reactivity in ASC has mainly been measured with generic questionnaires developed and validated on data from the general population. Interest in sensory reactivity in ASC inc...
journal_title:Nordic journal of psychiatry
pub_type: 杂志文章
doi:10.3109/08039488.2015.1053984
更新日期:2016-01-01 00:00:00
abstract::The aim of the survey was to describe the proportion of smokers and alcohol users in a group of children and adolescents admitted to a German department of child and adolescent psychiatry and psychotherapy. In addition, the proportion of smokers in this group of patients was compared with the proportion in the general...
journal_title:Nordic journal of psychiatry
pub_type: 杂志文章
doi:10.1080/08039480801984073
更新日期:2008-01-01 00:00:00
abstract::Some of the most frequently reported mental health problems in traumatized refugees are depression, anxiety and post-traumatic stress disorder (PTSD). The aim of this paper is to describe a group of tortured refugees referred to the Rehabilitation and Research Centre for Torture Victims (RCT) and to study the importan...
journal_title:Nordic journal of psychiatry
pub_type: 杂志文章
doi:10.1080/08039480500504982
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:Patients with schizophrenia suffer from wide range of deficits in neurocognitive functions of the brain, including visuospatial working memory. AIMS:This study aims at evaluating the effect of short-term smoking abstinence on different components of visuospatial working memory in smoker patients with schizo...
journal_title:Nordic journal of psychiatry
pub_type: 杂志文章,随机对照试验
doi:10.3109/08039488.2012.687765
更新日期:2013-04-01 00:00:00
abstract:AIM:Toxoplasma gondii may play a role in the development of psychiatric diseases by affecting the brain. The purpose of this study was to examine the relation between serum toxoplasma IgG positivity and obsessive-compulsive disorder (OCD) and generalized anxiety disorder (GAD) in children and adolescents. METHOD:Sixty...
journal_title:Nordic journal of psychiatry
pub_type: 杂志文章
doi:10.1080/08039488.2017.1385850
更新日期:2018-01-01 00:00:00
abstract::Previous studies on post-traumatic stress disorder (PTSD) investigated a variety of treatments and included mostly patients victims of sexual and combat assault. This study aimed to determine the short-term efficacy of eye movement desensitization and reprocessing (EMDR) in occupation-based PTSD. Employees of the publ...
journal_title:Nordic journal of psychiatry
pub_type: 杂志文章,随机对照试验
doi:10.1080/08039480601129408
更新日期:2007-01-01 00:00:00
abstract::Purpose: While the pivotal role of pharmacotherapy in psychiatry is universal, significant regional differences exist in drug use patterns. Herewith we compare the use of ATC psychotropic drugs (N05, psycholeptics and N06A, antidepressants) in 2010-2015 in the three Baltic Countries with reference to the Nordic Countr...
journal_title:Nordic journal of psychiatry
pub_type: 杂志文章
doi:10.1080/08039488.2019.1707283
更新日期:2020-05-01 00:00:00