Abstract：
:The neurodevelopmental hypothesis of schizophrenia has gained increasing acceptance. This hypothesis assumes a disruption in the normal development of the brain, secondary to genetic factors, environmental factors, or, most likely, a combination of both. After a brief review of the various aetiologic models since the first description of the disease, we review relevant aspects of normal brain development and then focus on the pathologic findings supporting the neurodevelopmental hypothesis. Although this hypothesis of schizophrenia appears to be valid in some cases, it is important to keep in mind that there are many cases of schizophrenia in which one finds no documented brain abnormality. It therefore seems wrong to speak of schizophrenia in general as a neurodevelopmental disorder. It appears that there is a group of patients with schizophrenia who fit into a neurodevelopmental model. There is a need to further investigate whether these patients can be identified clinically and what this may imply with regard to treatment and prognosis.
journal_name
Nord J Psychiatryjournal_title
Nordic journal of psychiatryauthors
Mjellem N,Kringlen Edoi
10.1080/080394801317080792subject
Has Abstractpub_date
2001-01-01 00:00:00pages
301-9issue
5eissn
0803-9488issn
1502-4725journal_volume
55pub_type
杂志文章,评审abstract：:The purpose of this study was to assess the self-concept using the Offer Self-Image Questionnaire (OSIQ) in groups of Finnish adolescent girls with anorexia nervosa and bulimia nervosa, and a normal control group without an eating disorder. A total of 135 adolescent girls aged 16-21 (10 with anorexia nervosa, 10 with ...
journal_title：Nordic journal of psychiatry
pub_type： 杂志文章
doi：10.1080/08039480260389370
更新日期：2002-01-01 00:00:00
abstract：BACKGROUND:Recently, it was reported that antipsychotic treatment reverted Contactin Associated Protein-Like 3 (CASPR3, same as CNTNAP3) mRNA expressions in leukocytes of schizophrenia (SCZ) subjects to the same levels as healthy controls. CASPR3 was expressed in various regions of the mice brain (cortex, frontal lobes...
journal_title：Nordic journal of psychiatry
pub_type： 杂志文章
doi：10.1080/08039488.2017.1291720
更新日期：2017-05-01 00:00:00
abstract：BACKGROUND:Little is known of the use of mechanical restraint in adolescent psychiatry. AIMS:To investigate the frequency and features of mechanical restraint in the field of Finnish adolescent psychiatry. METHODS:The data were collected in the metropolitan area of Helsinki, Finland, with seven closed and eight open ...
journal_title：Nordic journal of psychiatry
pub_type： 杂志文章
doi：10.3109/08039488.2012.699552
更新日期：2013-04-01 00:00:00
abstract：AIM:Toxoplasma gondii may play a role in the development of psychiatric diseases by affecting the brain. The purpose of this study was to examine the relation between serum toxoplasma IgG positivity and obsessive-compulsive disorder (OCD) and generalized anxiety disorder (GAD) in children and adolescents. METHOD:Sixty...
journal_title：Nordic journal of psychiatry
pub_type： 杂志文章
doi：10.1080/08039488.2017.1385850
更新日期：2018-01-01 00:00:00
abstract：BACKGROUND:Domestic violence is a major problem in society. In spite of this, there are few studies on the treatment of men who voluntarily seek help to stop their violent behaviour towards intimate partners. Most studies are performed on court-ordered individuals. AIM:The objective of this study was to evaluate resul...
journal_title：Nordic journal of psychiatry
pub_type： 杂志文章,随机对照试验
doi：10.3109/08039488.2012.665080
更新日期：2012-10-01 00:00:00
abstract：:Background: As a result of deinstitutionalization of psychiatric treatment and care, many people with severe mental illness have been offered supported accommodation. However, research on this costly intervention in Norway has been scarce. Aims: The aim of this study was to prospectively investigate the clinical and d...
journal_title：Nordic journal of psychiatry
pub_type： 杂志文章
doi：10.1080/08039488.2019.1606938
更新日期：2019-01-01 00:00:00
abstract：:The aim of the present study was to investigate the applicability of a quality of life self-rating scale - the Lehman Quality of Life Questionnaire TL-30 - to evaluate the test-retest reliability of the TL-30 and finally to test the quality of life in schizophrenic patients compared with a general population. Patients...
journal_title：Nordic journal of psychiatry
pub_type： 杂志文章
doi：10.1080/08039480701773154
更新日期：2007-01-01 00:00:00
abstract：BACKGROUND:One of the goals in forensic psychiatric care is to reduce the risk of recidivism, but current knowledge about the general outcome of forensic psychiatric treatment is limited. AIMS:To analyse the rate of criminal recidivism and mortality after discharge in a sample of patients sentenced to forensic psychia...
journal_title：Nordic journal of psychiatry
pub_type： 杂志文章
doi：10.3109/08039488.2011.644578
更新日期：2012-09-01 00:00:00
abstract：BACKGROUND:Schizophrenia and related psychoses are associated with excess morbidity and mortality from cardiovascular disease (CVD). Single-site studies on CVD-related risk factors in representative samples of acutely admitted inpatients are scarce. AIMS:To assess the levels of risk factors related to CVD in patients ...
journal_title：Nordic journal of psychiatry
pub_type： 杂志文章
doi：10.3109/08039488.2010.522729
更新日期：2011-06-01 00:00:00
abstract：:Objective: To identify personality disorders comorbid with borderline personality disorder (BPD) that may confer greater risk for the presence of severe dissociative experiences. Method: Three hundred and one outpatients with a primary diagnosis of BPD were evaluated using the Structured Clinical Interview for DSM-IV ...
journal_title：Nordic journal of psychiatry
pub_type： 杂志文章
doi：10.1080/08039488.2019.1658127
更新日期：2019-11-01 00:00:00
abstract：:Research has been done into the ways in which mothers who have experienced a series of traumatic war-related experiences perceive and interpret emotions on their babies' faces. The IFEEL instrument was used, which proved to be an interesting instrument for achieving our research goal. The data were analysed using a re...
journal_title：Nordic journal of psychiatry
pub_type： 杂志文章
doi：10.1080/08039480410005521
更新日期：2004-01-01 00:00:00
abstract：BACKGROUND:There are differences across ethno-cultural groups in the degree of somatization among patients with major depressive disorder (MDD). Studies showed that the attribution style of somatic symptoms is an important predictor of health outcome in depressed patients. AIMS:The aims of this study were to investiga...
journal_title：Nordic journal of psychiatry
pub_type： 杂志文章
doi：10.3109/08039488.2014.950328
更新日期：2015-04-01 00:00:00
abstract：:Despite caregivers' impact on suicidal patients' compliance with treatment and suicide prevention, little is known about mental-health professionals' perceptions of work with suicidal patients. The roles of psychiatric staff's training and supervision in the care of suicidal patients were investigated by means of a po...
journal_title：Nordic journal of psychiatry
pub_type： 杂志文章
doi：10.1080/08039480310002705
更新日期：2003-01-01 00:00:00
abstract：BACKGROUND:Long acting injectable antipsychotics (LAI-APs) are considered a major advance in psychiatric treatment concerning treatment adherence and outcomes. Yet, both, doctors and patients remain sceptical. AIM:To explain the rationale for using LAI-APs, review their effectiveness and explore barriers to use. METH...
journal_title：Nordic journal of psychiatry
pub_type： 杂志文章,评审
doi：10.1080/08039488.2018.1525638
更新日期：2018-09-01 00:00:00
abstract：PURPOSE:Affective temperaments, hopelessness, alexithymia, and anxiety/agitation symptoms may play a significant role in the psychopathological characteristics of bipolar disorder (BD). Here, we aimed to investigate the eventual association between the mentioned explanatory variables and anxiety/agitation symptoms in B...
journal_title：Nordic journal of psychiatry
pub_type： 杂志文章
doi：10.1080/08039488.2017.1385851
更新日期：2018-01-01 00:00:00
abstract：:Obsessive-compulsive disorder (OCD) is a frequently encountered disorder in children and adolescents. Several characteristics make the disorder a challenge to diagnostic methods and treatment procedures including the diversity of symptoms, the delay of referral and the occurrence of comorbidity. The aim of the present...
journal_title：Nordic journal of psychiatry
pub_type： 杂志文章
doi：10.1080/08039480801984065
更新日期：2008-01-01 00:00:00
abstract：:The aim of this naturalistic and retrospective follow-up study was to identify putative predictors of suicide attempts among young adults at high risk with a particular view on adverse life events. One hundred young adults who had been given emergency treatment for mental health problems in child and adolescent outpat...
journal_title：Nordic journal of psychiatry
pub_type： 杂志文章
doi：10.1080/08039480500213626
更新日期：2005-01-01 00:00:00
abstract：:This study was carried out to examine associations between classroom climate and pupils' mental health in primary school, and whether pupils who had emotional and behavioural problems in the second grade are more vulnerable to the effects of a poor classroom climate 4 years later. The study was carried out by means of...
journal_title：Nordic journal of psychiatry
pub_type： 杂志文章
doi：10.1080/08039480260242787
更新日期：2002-01-01 00:00:00
abstract：:The aim of this study was to evaluate internal as well as external validity of the two most frequently used mania scales, the Young Mania Rating Scale (YMRS) and the Bech-Rafaelsen Mania Scale (MAS), in patients with DSM-IV mania. Mokken analysis was used to evaluate internal validity in which a coefficient of homogen...
journal_title：Nordic journal of psychiatry
pub_type： 杂志文章
doi：10.1080/08039480600601282
更新日期：2006-01-01 00:00:00
abstract：:The aim of the present study was to analyse outcome, time to remission, and predictors of time to remission in a cohort of Danish eating disorder patients. Seventy-eight patients (35 anorexic, 30 bulimic and 13 unspecified eating disorder patients) were interviewed 2(1/2) years after initial assessment. Method of asse...
journal_title：Nordic journal of psychiatry
pub_type： 杂志文章
doi：10.1080/08039480801984875
更新日期：2008-01-01 00:00:00
abstract：BACKGROUND:The information on whether long-term psychotherapy is superior in comparison with short-term therapies during a long time-perspective in the treatment of mood and anxiety disorder is incomplete. AIMS:The present study addresses this question in a clinical trial with an exceptionally long follow-up. METHODS...
journal_title：Nordic journal of psychiatry
pub_type： 杂志文章,随机对照试验
doi：10.3109/08039488.2012.680910
更新日期：2013-02-01 00:00:00
abstract：:Background: Body dysmorphic disorder (BDD) is preoccupation with perceived body defects leading to distress and impairment in social functioning. Most of adolescent BDD literature has been done on patients within the outpatient setting with prior versions of DSM with dearth of information about BDD and comorbid psychi...
journal_title：Nordic journal of psychiatry
pub_type： 杂志文章
doi：10.1080/08039488.2019.1612943
更新日期：2019-01-01 00:00:00
abstract：BACKGROUND:Many children are affected by parental substance use disorder. Beardslee's family intervention (BFI) is a family-based psycho-educative method for children of mentally ill parents, used in psychiatric practise in several Nordic countries. The method has also been used to some extent when a parent suffers fro...
journal_title：Nordic journal of psychiatry
pub_type： 杂志文章
doi：10.1080/08039488.2017.1308009
更新日期：2017-07-01 00:00:00
abstract：:The aim of the present study was to investigate the use and attitudes toward standardized assessment tools among clinicians in a public mental health service in Norway. A total of 606 clinicians provided feedback on their use and attitudes regarding psychometric qualities of such tools, their practicality, and their b...
journal_title：Nordic journal of psychiatry
pub_type： 杂志文章
doi：10.1080/08039488.2019.1642383
更新日期：2019-10-01 00:00:00
abstract：:The aim of the survey was to describe the proportion of smokers and alcohol users in a group of children and adolescents admitted to a German department of child and adolescent psychiatry and psychotherapy. In addition, the proportion of smokers in this group of patients was compared with the proportion in the general...
journal_title：Nordic journal of psychiatry
pub_type： 杂志文章
doi：10.1080/08039480801984073
更新日期：2008-01-01 00:00:00
abstract：BACKGROUND:The use of mechanical restraint (MR) is controversial, and large differences regarding the use of MR are often found among countries. In an earlier study, we observed that MR was used twice as frequently in Denmark than Norway. AIMS:To examine how presumed MR preventive factors of non-medical origin may exp...
journal_title：Nordic journal of psychiatry
pub_type： 杂志文章
doi：10.3109/08039488.2014.996600
更新日期：2015-08-01 00:00:00
abstract：BACKGROUND:Cultures play a significant role not only in the causation and management of emotional distress and psychiatric disorders but also in sexual variation and attitudes towards sexual minority groups. AIM:To discuss the potential impact of culture on sexual minorities. METHOD:This lecture reviews the relation ...
journal_title：Nordic journal of psychiatry
pub_type： 杂志文章,评审
doi：10.1080/08039488.2018.1525643
更新日期：2018-09-01 00:00:00
abstract：BACKGROUND:The Schedule for Affective Disorders and Schizophrenia-Present and Lifetime Version (K-SADS-PL) is a semi-structured interview based on the Diagnostic and Statistical Manual of Mental Disorders (DSM), and assesses past and present symptoms in children aged 6-18 years old. It has been translated into more tha...
journal_title：Nordic journal of psychiatry
pub_type： 杂志文章
doi：10.1080/08039488.2020.1733660
更新日期：2020-08-01 00:00:00
abstract：:Purpose: Identifying distinct dimensions of negative symptoms in First Episode Schizophrenia (FES) might result in a better understanding and treatment of this invalidating symptomatology. Aim of this study was to examine negative symptom structure in FES patients using the Positive and Negative Syndrome Scale (PANSS)...
journal_title：Nordic journal of psychiatry
pub_type： 杂志文章
doi：10.1080/08039488.2019.1695286
更新日期：2020-05-01 00:00:00
abstract：BACKGROUND:Previous meta-analyses of paediatric obsessive-compulsive disorder (OCD) have shown much higher effect size for standard individual cognitive behaviour therapy (SI-CBT) compared with control conditions than for serotonin reuptake inhibitors (SRIs) compared with placebo. Other factors, such as systematic diff...
journal_title：Nordic journal of psychiatry
pub_type： 杂志文章,meta分析,评审
doi：10.3109/08039488.2014.941395
更新日期：2015-02-01 00:00:00
