Abstract:
BACKGROUND:The exact mechanisms for antipsychotic-induced extrapyramidal side-effects have remained obscure despite intensive research. Previous studies have highlighted a central role for nigral dopamine D(2) receptors in the control of motor functions. AIMS:The aim of the present study was to examine relationships between dopamine D(2) receptor binding in both substantia nigra and temporal cortex with extrapyramidal symptoms among antipsychotic-treated patients with schizophrenia. METHODS:Single-photon emission-computed tomography (SPECT) ligand [(123)I]epidepride was used to determine dopamine D(2/3) apparent binding potential in 13 antipsychotic-treated (seven with clozapine, four with olanzapine and two with haloperidol) patients with schizophrenia. Extrapyramidal symptoms were assessed with the Simpson and Angus Scale (SAS). RESULTS:A statistically significant correlation was observed between dopamine D(2/3) receptor apparent binding potential in the substantia nigra and extrapyramidal side-effects (r = -0.62, P = 0.024). No correlations were detected in the temporal cortex between dopamine D(2/3) receptor binding and extrapyramidal side-effects. CONCLUSIONS:These findings support the role of dopamine D(2) autoreceptors in substantia nigra regarding drug-induced movement disorders.
journal_name
Nord J Psychiatryjournal_title
Nordic journal of psychiatryauthors
Tuppurainen H,Kuikka JT,Viinamäki H,Husso M,Tiihonen Jdoi
10.3109/08039480903484076subject
Has Abstractpub_date
2010-08-01 00:00:00pages
233-8issue
4eissn
0803-9488issn
1502-4725journal_volume
64pub_type
杂志文章abstract:BACKGROUND:It is widely accepted that depression is associated with deficits in a range of cognitive domains. However, there is no consensus regarding the neuropsychological profile in depression. AIM:The aim of the present report is to test the cognitive effort hypothesis as a possible framework for understanding the...
journal_title:Nordic journal of psychiatry
pub_type: 杂志文章
doi:10.3109/08039488.2010.494311
更新日期:2011-02-01 00:00:00
abstract::Aims: This study describes changes in alcohol habits in age and gender strata among the Swedish general population during the 21-year period following the Swedish EU membership in 1995. Methods: The Alcohol Use Disorders Identification Test (AUDIT) was distributed as a postal questionnaire to randomly selected cross-s...
journal_title:Nordic journal of psychiatry
pub_type: 杂志文章
doi:10.1080/08039488.2019.1660912
更新日期:2019-11-01 00:00:00
abstract:BACKGROUND:Declared suicidal intent and physical danger are both considered important components in defining suicidal behaviors (SB). AIMS:1) To investigate characteristics of serious suicidal behaviors (SSB), defined by either suicidal intent or lethality; 2) To determine any difference in terms of socio-demographic,...
journal_title:Nordic journal of psychiatry
pub_type: 杂志文章,多中心研究
doi:10.3109/08039488.2013.767934
更新日期:2014-01-01 00:00:00
abstract::Objective: Misophonia is a neurophysiological disorder, phenotypically characterized by heightened autonomic nervous system arousal which is accompanied by a high magnitude of emotional reactivity to repetitive and pattern-based auditory stimuli. This study identifies the prevalence of psychiatric symptoms in misophon...
journal_title:Nordic journal of psychiatry
pub_type: 杂志文章
doi:10.1080/08039488.2019.1609086
更新日期:2019-01-01 00:00:00
abstract:PURPOSE:Neurocognitive outcomes are frequently used as indicators of real-world functioning in schizophrenia spectrum disorders (SSD). These test results may be influenced by individual differences, such as affective dispositions. Here we investigate the relationship between positive and negative affect and neuropsycho...
journal_title:Nordic journal of psychiatry
pub_type: 杂志文章
doi:10.1080/08039488.2020.1862294
更新日期:2021-01-06 00:00:00
abstract::Background: Obsessive-compulsive disorder (OCD) is a common psychiatric illness in children and adolescents. Previous evidence suggests that fluoxetine is effective in the treatment of OCD in children and adolescents. However, those studies had small sample sizes. As a result, a systematic review, which is a more powe...
journal_title:Nordic journal of psychiatry
pub_type: 杂志文章,meta分析
doi:10.1080/08039488.2020.1744037
更新日期:2020-10-01 00:00:00
abstract:BACKGROUND AND AIM:The Danish Health and Medicines Authority assembled a group of experts to develop a national clinical guideline for patients with schizophrenia and complex mental health needs. Within this context, ten explicit review questions were formulated, covering several identified key issues. METHODS:Systema...
journal_title:Nordic journal of psychiatry
pub_type: 杂志文章,实务指引
doi:10.3109/08039488.2015.1074285
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Few studies have focused on conduct problems and co-occurring problems among the youngest children in schools, such as social, internalizing and attention problems. In particular, there is a lack of studies that differentiate between boys and girls in terms of such problems. AIM:The aim of the current study...
journal_title:Nordic journal of psychiatry
pub_type: 杂志文章,评审
doi:10.3109/08039488.2012.731432
更新日期:2013-08-01 00:00:00
abstract::Conduct disorder (CD) is a condition that describes an aggressive, antisocial and criminal individual with social maladjustment. A diagnostician must consider symptoms, time and function when making a diagnosis. The aim of the article is to provide a general outline of the CD diagnosis described in DSM, using three da...
journal_title:Nordic journal of psychiatry
pub_type: 杂志文章,评审
doi:10.1080/08039480802626939
更新日期:2009-01-01 00:00:00
abstract::The aim of the present study was to investigate the applicability of a quality of life self-rating scale - the Lehman Quality of Life Questionnaire TL-30 - to evaluate the test-retest reliability of the TL-30 and finally to test the quality of life in schizophrenic patients compared with a general population. Patients...
journal_title:Nordic journal of psychiatry
pub_type: 杂志文章
doi:10.1080/08039480701773154
更新日期:2007-01-01 00:00:00
abstract:OBJECTIVE:To gain insight into the management of children and adolescents with mental health problems by their GPs as the GPs describe it. DESIGN:A qualitative analysis of data from focus group interviews with GPs. SETTING:Western Coast of Norway. SUBJECTS:A strategic sample of 19 GPs. RESULTS:According to the info...
journal_title:Nordic journal of psychiatry
pub_type: 杂志文章
doi:10.1080/08039480902907692
更新日期:2009-01-01 00:00:00
abstract::The objective of the study was to investigate how the ethnic variable has been used in mental health research, in theory, in measurement and classification criteria. Journal articles published 1990-2004 that address original research on psychopathology, treatment and mental health services and with "ethnic" or "ethnic...
journal_title:Nordic journal of psychiatry
pub_type: 杂志文章,评审
doi:10.1080/08039480802044414
更新日期:2008-01-01 00:00:00
abstract::Background: As a result of deinstitutionalization of psychiatric treatment and care, many people with severe mental illness have been offered supported accommodation. However, research on this costly intervention in Norway has been scarce. Aims: The aim of this study was to prospectively investigate the clinical and d...
journal_title:Nordic journal of psychiatry
pub_type: 杂志文章
doi:10.1080/08039488.2019.1606938
更新日期:2019-01-01 00:00:00
abstract::Purpose: The aim of this study is to compare differences in metacognitive beliefs between patients with bipolar disorder type I (BPDI) with previous suicide attempts (BPDI+), those without suicide attempts (BPDI-), and a control group. It also discusses the relationship between metacognitive beliefs and suicidal behav...
journal_title:Nordic journal of psychiatry
pub_type: 杂志文章
doi:10.1080/08039488.2019.1649722
更新日期:2019-10-01 00:00:00
abstract:BACKGROUND:In 2003, the German psychiatrist Michael Linden proposed the new mental disorder concept of "post-traumatic embitterment disorder (PTED)". PTED is defined as the mental reaction to a critical event that is normal, but not everyday, such as conflict at work. The patient sees this event as unjust and as a viol...
journal_title:Nordic journal of psychiatry
pub_type: 杂志文章
doi:10.3109/08039480903398185
更新日期:2010-05-04 00:00:00
abstract::Some of the most frequently reported mental health problems in traumatized refugees are depression, anxiety and post-traumatic stress disorder (PTSD). The aim of this paper is to describe a group of tortured refugees referred to the Rehabilitation and Research Centre for Torture Victims (RCT) and to study the importan...
journal_title:Nordic journal of psychiatry
pub_type: 杂志文章
doi:10.1080/08039480500504982
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:The ward atmosphere of psychiatric care units has a major impact on treatment and satisfaction for both patients and staff. The Ward Atmosphere Scale (WAS) was developed to capture the ward atmosphere in different psychiatric settings and is a well-established instrument for this purpose. However, there is n...
journal_title:Nordic journal of psychiatry
pub_type: 杂志文章
doi:10.3109/08039480903524913
更新日期:2010-10-01 00:00:00
abstract:BACKGROUND:The Rorschach Inkblot Method is regarded as an important clinical instrument for detailed diagnostic description of the integrative capacities of individuals in psychotic states and as an instrument for measuring progression in the course of treatment. AIMS:To describe relevant Rorschach variables at baseli...
journal_title:Nordic journal of psychiatry
pub_type: 杂志文章
doi:10.3109/08039488.2011.595500
更新日期:2012-04-01 00:00:00
abstract::The objective of this study was to account for acute stress disorder (ASD) and post-traumatic stress disorder (PTSD) morbidity in a self-report survey of traffic accident victims and to evaluate the relationship between ASD and PTSD in this sample, and furthermore, to find both a model of independent variables account...
journal_title:Nordic journal of psychiatry
pub_type: 杂志文章,多中心研究
doi:10.1080/08039480410006304
更新日期:2004-01-01 00:00:00
abstract::Family therapy has emerged as the treatment of choice for young patients with anorexia nervosa, yet there is insufficient knowledge about what actually happens within the family unit in these cases. The purpose of the present study was to investigate how a family undergoing treatment due to an anorectic child changes ...
journal_title:Nordic journal of psychiatry
pub_type: 杂志文章
doi:10.1080/080394802760322132
更新日期:2002-01-01 00:00:00
abstract:BACKGROUND:Depressive personality is commonly seen in clinical practice, and today only one exclusive self-report instrument-the Depressive Personality Disorder Inventory (DPDI)-is available for its assessment based on the DSM-IV description of the construct. AIMS:The purpose of this research was to evaluate a Swedish...
journal_title:Nordic journal of psychiatry
pub_type: 杂志文章
doi:10.3109/08039488.2011.611251
更新日期:2012-06-01 00:00:00
abstract:BACKGROUND:The Schedule for Affective Disorders and Schizophrenia-Present and Lifetime Version (K-SADS-PL) is a semi-structured interview based on the Diagnostic and Statistical Manual of Mental Disorders (DSM), and assesses past and present symptoms in children aged 6-18 years old. It has been translated into more tha...
journal_title:Nordic journal of psychiatry
pub_type: 杂志文章
doi:10.1080/08039488.2020.1733660
更新日期:2020-08-01 00:00:00
abstract:BACKGROUND:Epilepsy is accompanied by many psychiatric disorders and continues to be a disease that disturbs the functioning and quality of life (QOL) of patients. AIMS:To assess the frequency of psychiatric disorders occurring in epileptic patients, determine depression and anxiety levels, and compare the results wit...
journal_title:Nordic journal of psychiatry
pub_type: 杂志文章
doi:10.3109/08039488.2011.565798
更新日期:2011-12-01 00:00:00
abstract::Background: Body dysmorphic disorder (BDD) is preoccupation with perceived body defects leading to distress and impairment in social functioning. Most of adolescent BDD literature has been done on patients within the outpatient setting with prior versions of DSM with dearth of information about BDD and comorbid psychi...
journal_title:Nordic journal of psychiatry
pub_type: 杂志文章
doi:10.1080/08039488.2019.1612943
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:One of the goals in forensic psychiatric care is to reduce the risk of recidivism, but current knowledge about the general outcome of forensic psychiatric treatment is limited. AIMS:To analyse the rate of criminal recidivism and mortality after discharge in a sample of patients sentenced to forensic psychia...
journal_title:Nordic journal of psychiatry
pub_type: 杂志文章
doi:10.3109/08039488.2011.644578
更新日期:2012-09-01 00:00:00
abstract::The objective of this study was to examine whether social risk factors adjusted for gender and some well-known perinatal risk factors were related to parental descriptions of deviant behaviour in 3(1/2)-year-old children. The study was a prospective cohort study of 1345 mothers enrolled during early pregnancy. Parents...
journal_title:Nordic journal of psychiatry
pub_type: 杂志文章
doi:10.1080/08039480310000743
更新日期:2004-01-01 00:00:00
abstract:BACKGROUND:Patients with bipolar disorder have neurocognitive impairments, which are associated with poor functional outcomes. AIMS:This study evaluated the neurocognitive effects of aripiprazole in adolescents and young adults with bipolar disorder. METHODS:This was a 24-week, observational, prospective study perfor...
journal_title:Nordic journal of psychiatry
pub_type: 杂志文章
doi:10.3109/08039488.2011.643484
更新日期:2012-09-01 00:00:00
abstract:PURPOSE:Affective temperaments, hopelessness, alexithymia, and anxiety/agitation symptoms may play a significant role in the psychopathological characteristics of bipolar disorder (BD). Here, we aimed to investigate the eventual association between the mentioned explanatory variables and anxiety/agitation symptoms in B...
journal_title:Nordic journal of psychiatry
pub_type: 杂志文章
doi:10.1080/08039488.2017.1385851
更新日期:2018-01-01 00:00:00
abstract::Purpose: This study examined a developmental model that links affect-regulation difficulties in childhood with three dimensions of alexithymia in adolescence (difficulty identifying feelings, difficulty describing feelings, and externally oriented thinking) and substance use and depression in adulthood, while accounti...
journal_title:Nordic journal of psychiatry
pub_type: 杂志文章
doi:10.1080/08039488.2019.1634758
更新日期:2019-08-01 00:00:00
abstract:BACKGROUND:Little is known of the use of mechanical restraint in adolescent psychiatry. AIMS:To investigate the frequency and features of mechanical restraint in the field of Finnish adolescent psychiatry. METHODS:The data were collected in the metropolitan area of Helsinki, Finland, with seven closed and eight open ...
journal_title:Nordic journal of psychiatry
pub_type: 杂志文章
doi:10.3109/08039488.2012.699552
更新日期:2013-04-01 00:00:00