Extrapyramidal side-effects and dopamine D(2/3) receptor binding in substantia nigra.

Abstract:

BACKGROUND:The exact mechanisms for antipsychotic-induced extrapyramidal side-effects have remained obscure despite intensive research. Previous studies have highlighted a central role for nigral dopamine D(2) receptors in the control of motor functions. AIMS:The aim of the present study was to examine relationships between dopamine D(2) receptor binding in both substantia nigra and temporal cortex with extrapyramidal symptoms among antipsychotic-treated patients with schizophrenia. METHODS:Single-photon emission-computed tomography (SPECT) ligand [(123)I]epidepride was used to determine dopamine D(2/3) apparent binding potential in 13 antipsychotic-treated (seven with clozapine, four with olanzapine and two with haloperidol) patients with schizophrenia. Extrapyramidal symptoms were assessed with the Simpson and Angus Scale (SAS). RESULTS:A statistically significant correlation was observed between dopamine D(2/3) receptor apparent binding potential in the substantia nigra and extrapyramidal side-effects (r = -0.62, P = 0.024). No correlations were detected in the temporal cortex between dopamine D(2/3) receptor binding and extrapyramidal side-effects. CONCLUSIONS:These findings support the role of dopamine D(2) autoreceptors in substantia nigra regarding drug-induced movement disorders.

journal_name

Nord J Psychiatry

authors

Tuppurainen H,Kuikka JT,Viinamäki H,Husso M,Tiihonen J

doi

10.3109/08039480903484076

subject

Has Abstract

pub_date

2010-08-01 00:00:00

pages

233-8

issue

4

eissn

0803-9488

issn

1502-4725

journal_volume

64

pub_type

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