Prevalence of psychosis in tuberculosis patients and their nontuberculosis family contacts in a multidrug treatment-resistant treatment center in Nigeria.

Abstract:

OBJECTIVE:This study aimed at determining the prevalence of psychosis in tuberculosis (TB) patients in comparison to nontuberculosis control and its correlation with disease pattern. METHOD:One hundred and fifteen patients with TB and 112 family members visiting the multidrug treatment-resistant treatment center at University College Hospital Ibadan Centre were screened for psychological distress with the General Health Questionnaire (GHQ-12). Presence of a psychotic condition was determined by the Psychosis Screening Questionnaire and the Structured Clinical Interview for DSM-IV Axis I Disorder and was compared with severity of pulmonary TB. RESULTS:After adjusting for age, predictors of high/positive GHQ include the following: duration of TB ≥4years [odds ratio (OR)=4.02, 95% confidence interval (CI)=1.29-11.13], extrapulmonary TB (OR=3.45, 95% CI=1.02-14.11), severe disease extent (OR=5.27, 95% CI=1.05-13.01) and disease category 2 (OR=2.38, 95% CI=1.01-7.99), and predictors of psychosis are as follows: duration of TB ≥4years (OR=3.99, 95% CI=1.51-9.88), extrapulmonary TB (OR=3.88, 95% CI=1.55-9.98), severe disease extent (OR=9.55, 95% CI=2.15-18.05) and disease category 2 (OR=2.86, 95% CI=1.14-7.55). CONCLUSION:In view of high prevalence of psychological distress and psychosis in TB, care of TB patients should include consultative-liaison psychiatric care.

journal_name

Gen Hosp Psychiatry

authors

Lasebikan VO,Ige OM

doi

10.1016/j.genhosppsych.2015.05.012

subject

Has Abstract

pub_date

2015-11-01 00:00:00

pages

542-7

issue

6

eissn

0163-8343

issn

1873-7714

pii

S0163-8343(15)00137-1

journal_volume

37

pub_type

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