Early neuropsychiatric involvement in antiphospholipid syndrome.

Abstract:

OBJECTIVE:Neuropsychiatric symptoms may be the main manifestations and very early symptoms of developing autoimmune diseases. Early detection and treatment could reverse psychotic symptoms and restore cognitive function. CASE REPORT:A 24-year-old woman presented with acute psychotic symptoms. Routine physical examinations revealed only mild fever. Due to positive antiphospholipid antibodies, low protein S with elevated d-dimer and brain hypoperfusion, early-phase antiphospholipid syndrome (APS) was suspected. Early immunomodulation treatment led to complete remission of the psychotic symptoms, preservation of cognitive function and prevention of APS progression. CONCLUSION:Since early detection and treatment can reverse the progression of autoimmune diseases with central nervous system involvement, these should be highlighted when managing high-risk patients.

journal_name

Gen Hosp Psychiatry

authors

Lai JY,Wu PC,Chen HC,Lee MB

doi

10.1016/j.genhosppsych.2012.02.005

subject

Has Abstract

pub_date

2012-09-01 00:00:00

pages

579.e1-3

issue

5

eissn

0163-8343

issn

1873-7714

pii

S0163-8343(12)00065-5

journal_volume

34

pub_type

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