Improvement of dumping syndrome and oversecretion of glucose-dependent insulinotropic polypeptide following a switch from olanzapine to quetiapine in a patient with schizophrenia.

Abstract:

:Among the most important adverse effects of antipsychotics is abnormal glucose metabolism, which includes not only hyperglycemia but hyperinsulinemia and hypoglycemia. We have previously described five patients who experienced hypoglycemia during treatment with antipsychotics. Thus, an anamnesis of gastric surgery, which often causes dumping syndrome, and treatment with antipsychotics may synergistically induce hypoglycemia. We describe here a patient with schizophrenia under treatment of olanzapine and an anamnesis of gastric surgery, who experienced late dumping syndrome, hyperinsulinemia and overactivation of glucose-dependent insulinotropic polypeptide. Dumping syndrome, however, was improved after the patient was switched from olanzapine to quetiapine.

journal_name

Gen Hosp Psychiatry

authors

Watanabe A,Fukui N,Suzuki Y,Motegi T,Igeta H,Tsuneyama N,Someya T

doi

10.1016/j.genhosppsych.2015.03.012

subject

Has Abstract

pub_date

2015-07-01 00:00:00

pages

372.e5-6

issue

4

eissn

0163-8343

issn

1873-7714

pii

S0163-8343(15)00056-0

journal_volume

37

pub_type

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