Abstract：
BACKGROUND:Confetti-like depigmentation was noted in patients reporting recent worsening of vitiligo. OBJECTIVE:We sought to determine if confetti-like depigmentation is a marker of rapidly progressing vitiligo. METHODS:Review of patient records and images of patients from a vitiligo registry resulted in 7 patients with 12 images that fit inclusion criteria and were evaluated for percent depigmentation by 3 independent reviewers. The Vitiligo Disease Activity Score and the Koebner Phenomenon in Vitiligo Score in an additional cohort of patients with confetti-like lesions were compared with patients who had vitiligo without confetti-like lesions. RESULTS:The mean percentage of depigmentation at baseline was 19.2%, which increased to 43.9% in images obtained at a mean of 16 weeks of follow-up. Vitiligo Disease Activity Score and Koebner Phenomenon in Vitiligo Score were significantly higher in the patients with confetti-like lesions compared with those without confetti-like lesions. A skin biopsy specimen of a confetti-like lesion in 1 patient revealed an inflammatory infiltrate in the papillary dermis with CD8(+) T cells localized to the dermoepidermal junction. LIMITATIONS:Small, single-center retrospective review and lack of full-body photographs are limitations. CONCLUSIONS:A confetti-like pattern of depigmentation may be a negative prognostic indicator for patients with rapidly progressing vitiligo. Further, prospective studies to evaluate this physical finding should be performed.
journal_name
J Am Acad Dermatoljournal_title
Journal of the American Academy of Dermatologyauthors
Sosa JJ,Currimbhoy SD,Ukoha U,Sirignano S,O'Leary R,Vandergriff T,Hynan LS,Pandya AGdoi
10.1016/j.jaad.2015.05.014subject
Has Abstractpub_date
2015-08-01 00:00:00pages
272-5issue
2eissn
0190-9622issn
1097-6787pii
S0190-9622(15)01684-9journal_volume
73pub_type
杂志文章abstract：:Langerhans cell histiocytosis (LCH) is regarded as a disorder of histiocytic cell proliferation of the Langerhans type, probably resulting from altered immunoregulation. Cutaneous involvement is frequent and often appears as a scaling papular eruption that resembles seborrheic dermatitis; when limited to the scalp, sc...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/0190-9622(93)70191-u
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abstract：:The term Richter syndrome (RS) describes the transformation of chronic lymphocytic leukemia into a high-grade lymphoma. RS occurs in 3% to 10% of chronic lymphocytic leukemia cases, and its onset is often characterized by the abrupt development of systemic symptoms (eg, fever in the absence of infection, night sweats,...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章,评审
doi：10.1016/j.jaad.2008.07.017
更新日期：2009-01-01 00:00:00
abstract：:The diagnostic value of parakeratosis is reviewed, with special emphasis on associated inflammatory tissue reaction patterns and the geometric pattern of the scale. Parakeratosis may also occur in disorders not primarily inflammatory in nature and those associations are addressed. Topics are divided into 6 categories:...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章,评审
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更新日期：2004-01-01 00:00:00
abstract：BACKGROUND:Keloid scars can itch and hurt, but little is known about the characteristics of these symptoms in keloids. Because itch and pain are carried by small nerve fibers, abnormal function of these fibers could be an explanation for such phenomena. OBJECTIVE:We sought to assess the characteristics of itch and pai...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/j.jaad.2004.07.054
更新日期：2004-12-01 00:00:00
abstract：BACKGROUND:The cause of lichen sclerosus et atrophicus (LSA) is unknown, but on the penis it is associated with chronic occlusion, that is, phimosis. Microscopic changes of LSA were seen unexpectedly in two acrochordons. OBJECTIVE:Our purpose was to further characterize this phenomenon. METHODS:A total of 449 acrocho...
journal_title：Journal of the American Academy of Dermatology
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更新日期：1993-05-01 00:00:00
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journal_title：Journal of the American Academy of Dermatology
pub_type： 临床试验,杂志文章
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journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1067/mjd.2001.117526
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journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/s0190-9622(79)70024-7
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journal_title：Journal of the American Academy of Dermatology
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doi：10.1016/0190-9622(90)70303-y
更新日期：1990-11-01 00:00:00
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journal_title：Journal of the American Academy of Dermatology
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doi：10.1016/s0190-9622(84)80042-0
更新日期：1984-01-01 00:00:00
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journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
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更新日期：1984-05-01 00:00:00
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journal_title：Journal of the American Academy of Dermatology
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更新日期：2020-08-01 00:00:00
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journal_title：Journal of the American Academy of Dermatology
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doi：10.1016/0190-9622(92)70057-m
更新日期：1992-02-01 00:00:00
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journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/s0190-9622(86)70110-2
更新日期：1986-05-01 00:00:00
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journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章,评审
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更新日期：1987-09-01 00:00:00
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journal_title：Journal of the American Academy of Dermatology
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journal_title：Journal of the American Academy of Dermatology
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journal_title：Journal of the American Academy of Dermatology
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journal_title：Journal of the American Academy of Dermatology
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journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
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journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
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更新日期：1984-05-01 00:00:00
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journal_title：Journal of the American Academy of Dermatology
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journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：
更新日期：1986-08-01 00:00:00
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journal_title：Journal of the American Academy of Dermatology
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更新日期：1996-10-01 00:00:00
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journal_title：Journal of the American Academy of Dermatology
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更新日期：1999-05-01 00:00:00
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journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/s0190-9622(86)70288-0
更新日期：1986-12-01 00:00:00
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journal_title：Journal of the American Academy of Dermatology
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更新日期：2011-03-01 00:00:00
