Abstract：
BACKGROUND:Epidermal spongiosis with exocytosis of eosinophils (ES) has been reported in biopsy specimens from patients with various dermatoses. Its diagnostic value and the patient's outcome remain poorly understood in those cases in which ES is not associated directly with diagnostic features of a bullous dermatosis. OBJECTIVE:We evaluated the clinical, histopathologic, and immunopathologic findings and their clinical correlation in patients who had ES in a biopsy specimen but who had no evidence of a bullous dermatosis. METHODS:A retrospective study of 150 cases with ES was performed. Clinical, histopathologic, direct immunofluorescence, and subsequent follow-up data were collected to assess final diagnosis and outcome. RESULTS:A total of 144 patients had generalized eruptions; of these, 34 (24%) had autoimmune bullous disease. Fourteen (41%) of those patients had neither a bullous nor a vesicular eruption. Other diagnoses included eczematous dermatitis, arthropod bites, scabies, and drug eruption. CONCLUSION:The majority of patients whose biopsy specimen revealed only ES had either dermatitis or autoimmune bullous disease, often in the prodromal phase. Direct immunofluorescence is often necessary to distinguish these diseases, and repeated testing may be needed for final diagnosis.
journal_name
J Am Acad Dermatoljournal_title
Journal of the American Academy of Dermatologyauthors
Ruiz E,Deng JS,Abell EAdoi
10.1016/s0190-9622(94)70120-2subject
Has Abstractpub_date
1994-06-01 00:00:00pages
973-6issue
6eissn
0190-9622issn
1097-6787pii
S0190-9622(94)70120-2journal_volume
30pub_type
杂志文章abstract：BACKGROUND:Vascular cell adhesion molecule-1 (VCAM-1) is an endothelial protein with adhesive properties for inflammatory cells including lymphocytes. Its role in skin disease and regulation in vivo are uncertain. OBJECTIVE:Our purpose was to determine expression of VCAM-1 in normal and inflamed skin and the effect on...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
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更新日期：1993-07-01 00:00:00
abstract：BACKGROUND:There is a lack of data on outcomes of management of pemphigus in children. OBJECTIVE:We sought to evaluate rituximab treatment in childhood and juvenile pemphigus. METHOD:All cases of pemphigus treated with rituximab in patients younger than 18 years were included. Clinical and epidemiologic data and deta...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
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更新日期：2014-10-01 00:00:00
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journal_title：Journal of the American Academy of Dermatology
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doi：10.1016/s0190-9622(99)70487-1
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journal_title：Journal of the American Academy of Dermatology
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abstract：:This report describes a 25-year-old white woman with lentigines, cutaneous myxomas, bilateral atrial myxomas, and cerebral artery aneurysms. We believe this case to be the fifth reported case of this unusual association in the medical literature, with the additional finding of a central nervous system aneurysm. In the...
journal_title：Journal of the American Academy of Dermatology
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journal_title：Journal of the American Academy of Dermatology
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doi：10.1016/j.jaad.2019.05.021
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journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章,评审
doi：10.1016/s0190-9622(89)70036-0
更新日期：1989-02-01 00:00:00
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journal_title：Journal of the American Academy of Dermatology
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journal_title：Journal of the American Academy of Dermatology
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journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
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更新日期：1983-11-01 00:00:00
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journal_title：Journal of the American Academy of Dermatology
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journal_title：Journal of the American Academy of Dermatology
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更新日期：2019-03-01 00:00:00
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journal_title：Journal of the American Academy of Dermatology
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doi：10.1016/j.jaad.2010.12.034
更新日期：2012-02-01 00:00:00
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journal_title：Journal of the American Academy of Dermatology
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doi：10.1016/j.jaad.2018.10.060
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journal_title：Journal of the American Academy of Dermatology
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journal_title：Journal of the American Academy of Dermatology
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更新日期：1993-05-01 00:00:00
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journal_title：Journal of the American Academy of Dermatology
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journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
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更新日期：1987-09-01 00:00:00
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journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
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更新日期：2020-09-14 00:00:00
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journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/0190-9622(90)70299-w
更新日期：1990-11-01 00:00:00
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journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章,评审
doi：10.1016/j.jaad.2005.08.062
更新日期：2006-06-01 00:00:00
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journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/j.jaad.2011.11.923
更新日期：2012-08-01 00:00:00
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journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/0190-9622(90)70262-g
更新日期：1990-09-01 00:00:00
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journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/s0190-9622(99)70443-3
更新日期：1999-04-01 00:00:00
abstract：:A recent familial case of hereditary epidermolytic palmoplantar keratoderma (Vörner type) that was treated with orally administered etretinate is reported herein. A review of the literature with regard to the clinical, genetic, and laboratory features of this rare genodermatosis is also presented. ...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章,评审
doi：10.1016/s0190-9622(87)70222-9
更新日期：1987-09-01 00:00:00
abstract：BACKGROUND:UVA induces tissue damage via the production of radical oxygen species. Adding antioxidants to UV filters in sunscreens is a novel photoprotective strategy. The topical application of antioxidants in sunscreen can potentially neutralize the UVA-induced free radicals. OBJECTIVES:We sought to assess the degre...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/j.jaad.2010.07.009
更新日期：2011-09-01 00:00:00
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journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章,评审
doi：10.1016/j.jaad.2019.08.089
更新日期：2020-05-01 00:00:00
