Bioequivalence (bioavailability) of generic topical corticosteroids.

Abstract:

:A new, quantitative modification of the vasoconstrictor assay was used to measure bioavailability of generic topical corticosteroid products in two categories: betamethasone valerate 0.1% cream and triamcinolone 0.1% cream. Betamethasone valerate products could be separated into two distinct categories, and triamcinolone acetonide products could be grouped into three categories of activity. A survey of local pharmacies showed that generic substitution would be made for the prescribed brand of betamethasone valerate in 58% of cases and for the prescribed triamcinolone acetonide 75% of the time. Because of the prevalence of generic substitution of products that may not have equivalent bioavailability, some standardization of the bioavailability of topical products is needed.

journal_name

J Am Acad Dermatol

authors

Jackson DB,Thompson C,McCormack JR,Guin JD

doi

10.1016/s0190-9622(89)70091-8

subject

Has Abstract

pub_date

1989-05-01 00:00:00

pages

791-6

issue

5 Pt 1

eissn

0190-9622

issn

1097-6787

pii

S0190-9622(89)70091-8

journal_volume

20

pub_type

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