Are small farms more performant than larger ones in developing countries?

abstract：:Traumatic brain injury (TBI) is a major cause of mortality and morbidity. Preventative measures reduce injury incidence and/or severity, yet one-third of hospitalized patients with TBI die from secondary pathological processes that develop during supervised care. Neutrophils, which orchestrate innate immune responses,...

journal_title：Science advances

authors： Vaibhav K,Braun M,Alverson K,Khodadadi H,Kutiyanawalla A,Ward A,Banerjee C,Sparks T,Malik A,Rashid MH,Khan MB,Waters MF,Hess DC,Arbab AS,Vender JR,Hoda N,Baban B,Dhandapani KM

更新日期：2020-05-29 00:00:00

abstract：:The ability of cytosolic lipopolysaccharide (LPS) to activate caspase-11-dependent nonclassical inflammasome is intricately controlled to avoid excessive inflammatory responses. However, very little is known about the regulatory role of various metabolic pathways in the control of caspase-11 activation. Here, we demon...

journal_title：Science advances

authors： Chen R,Zeng L,Zhu S,Liu J,Zeh HJ,Kroemer G,Wang H,Billiar TR,Jiang J,Tang D,Kang R

更新日期：2019-05-22 00:00:00

abstract：:Traumatic spinal cord injury (SCI) brings numerous inflammatory cells, including macrophages, from the circulating blood to lesions, but pathophysiological impact resulting from spatiotemporal dynamics of macrophages is unknown. Here, we show that macrophages centripetally migrate toward the lesion epicenter after inf...

journal_title：Science advances

authors： Kobayakawa K,Ohkawa Y,Yoshizaki S,Tamaru T,Saito T,Kijima K,Yokota K,Hara M,Kubota K,Matsumoto Y,Harimaya K,Ozato K,Masuda T,Tsuda M,Tamura T,Inoue K,Edgerton VR,Iwamoto Y,Nakashima Y,Okada S

更新日期：2019-05-15 00:00:00

abstract：:In addition to their conventional uses, metal-organic frameworks (MOFs) have recently emerged as an interesting class of functional materials and precursors of inorganic materials for electrochemical energy storage and conversion technologies. This class of MOF-related materials can be broadly categorized into two gro...

journal_title：Science advances

authors： Wu HB,Lou XWD

更新日期：2017-12-01 00:00:00

abstract：:Since its domestication in the Fertile Crescent ~8000 to 10,000 years ago, wheat has undergone a complex history of spread, adaptation, and selection. To get better insights into the wheat phylogeography and genetic diversity, we describe allele distribution through time using a set of 4506 landraces and cultivars ori...

journal_title：Science advances

authors： Balfourier F,Bouchet S,Robert S,De Oliveira R,Rimbert H,Kitt J,Choulet F,International Wheat Genome Sequencing Consortium.,BreedWheat Consortium.,Paux E

更新日期：2019-05-29 00:00:00

abstract：:Transcription factors control gene expression in all life. This raises the question of what is the smallest protein that can support such activity. In nature, Cro from bacteriophage λ is one of the smallest known repressors (66 amino acids), and activators are typically much larger (e.g., λ cI, 237 amino acids). Previ...

journal_title：Science advances

authors： Brödel AK,Rodrigues R,Jaramillo A,Isalan M

更新日期：2020-06-10 00:00:00

abstract：:Sleep serves disparate functions, most notably neural repair, metabolite clearance and circuit reorganization. Yet the relative importance remains hotly debated. Here, we create a novel mechanistic framework for understanding and predicting how sleep changes during ontogeny and across phylogeny. We use this theory to ...

journal_title：Science advances

authors： Cao J,Herman AB,West GB,Poe G,Savage VM

更新日期：2020-09-18 00:00:00

abstract：:A novel, thin-film platform that preserves live viruses, bacteria, antibodies, and enzymes without refrigeration for extended periods of time is described. Studies with recombinant adenovirus in an optimized formulation that supports recovery of live virus through 16 freeze-thaw cycles revealed that production of an a...

journal_title：Science advances

authors： Bajrovic I,Schafer SC,Romanovicz DK,Croyle MA

更新日期：2020-03-04 00:00:00

abstract：:Toxins efficiently deliver cargo to cells by binding to cell surface ligands, initiating endocytosis, and escaping the endolysosomal pathway into the cytoplasm. We took advantage of this delivery pathway by conjugating an attenuated diphtheria toxin to siRNA, thereby achieving gene downregulation in patient-derived gl...

journal_title：Science advances

authors： Arnold AE,Smith LJ,Beilhartz GL,Bahlmann LC,Jameson E,Melnyk RA,Shoichet MS

更新日期：2020-05-01 00:00:00

abstract：:Grippers are widely used for the gripping, manipulation, and assembly of objects with a wide range of scales, shapes, and quantities in research, industry, and our daily lives. A simple yet universal solution is very challenging. Here, we manage to address this challenge utilizing a simple shape memory polymer (SMP) b...

journal_title：Science advances

authors： Linghu C,Zhang S,Wang C,Yu K,Li C,Zeng Y,Zhu H,Jin X,You Z,Song J

更新日期：2020-02-14 00:00:00

abstract：:When a dynamic system undergoes a cyclic evolution, a geometric phase that depends only on the path traversed in parameter space can arise in addition to the normal dynamical phase. These geometric phases have profound impacts in both quantum and classical physics. In addition to the geometric phase associated with ba...

journal_title：Science advances

authors： Wang S,Ma G,Chan CT

更新日期：2018-02-16 00:00:00

abstract：:Calcium silicate hydrate (C-S-H) is the binder in concrete, the most used synthetic material in the world. The main weakness of concrete is the lack of elasticity and poor flexural strength considerably limiting its potential, making reinforcing steel constructions necessary. Although the properties of C-S-H could be ...

journal_title：Science advances

authors： Picker A,Nicoleau L,Burghard Z,Bill J,Zlotnikov I,Labbez C,Nonat A,Cölfen H

更新日期：2017-11-29 00:00:00

abstract：:Recent research on piezoelectric materials is predominantly devoted to enhancing the piezoelectric coefficient, but overlooks its sign, largely because almost all of them exhibit positive longitudinal piezoelectricity. The only experimentally known exception is ferroelectric polymer poly(vinylidene fluoride) and its c...

journal_title：Science advances

authors： You L,Zhang Y,Zhou S,Chaturvedi A,Morris SA,Liu F,Chang L,Ichinose D,Funakubo H,Hu W,Wu T,Liu Z,Dong S,Wang J

更新日期：2019-04-19 00:00:00

abstract：:Cytosolic RNA sensing is a prerequisite for initiation of innate immune response against RNA viral pathogens. Signaling through RIG-I (retinoic acid-inducible gene I)-like receptors (RLRs) to TBK1 (Tank-binding kinase 1)/IKKε (IκB kinase ε) kinases is transduced by mitochondria-associated MAVS (mitochondrial antiviral...

journal_title：Science advances

authors： Xiang W,Zhang Q,Lin X,Wu S,Zhou Y,Meng F,Fan Y,Shen T,Xiao M,Xia Z,Zou J,Feng XH,Xu P

更新日期：2016-07-01 00:00:00

abstract：:The rapid growth of deformable and stretchable electronics calls for a deformable and stretchable power source. We report a scalable approach for energy harvesters and self-powered sensors that can be highly deformable and stretchable. With conductive liquid contained in a polymer cover, a shape-adaptive triboelectric...

journal_title：Science advances

authors： Yi F,Wang X,Niu S,Li S,Yin Y,Dai K,Zhang G,Lin L,Wen Z,Guo H,Wang J,Yeh MH,Zi Y,Liao Q,You Z,Zhang Y,Wang ZL

更新日期：2016-06-17 00:00:00

abstract：:Humans and animals have a "number sense," an innate capability to intuitively assess the number of visual items in a set, its numerosity. This capability implies that mechanisms to extract numerosity indwell the brain's visual system, which is primarily concerned with visual object recognition. Here, we show that netw...

journal_title：Science advances

authors： Nasr K,Viswanathan P,Nieder A

更新日期：2019-05-08 00:00:00

abstract：:Ascomycota, the largest and most well-studied phylum of fungi, contains three subphyla: Saccharomycotina (budding yeasts), Pezizomycotina (filamentous fungi), and Taphrinomycotina (fission yeasts). Despite its importance, we lack a comprehensive genome-scale phylogeny or understanding of the similarities and differenc...

journal_title：Science advances

authors： Shen XX,Steenwyk JL,LaBella AL,Opulente DA,Zhou X,Kominek J,Li Y,Groenewald M,Hittinger CT,Rokas A

更新日期：2020-11-04 00:00:00

abstract：:Adenosine and its receptors play a key role in bone homeostasis and regeneration. Extracellular adenosine is generated from CD39 and CD73 activity in the cell membrane, through conversion of adenosine triphosphate to adenosine monophosphate (AMP) and AMP to adenosine, respectively. Despite the relevance of CD39/CD73 t...

journal_title：Science advances

authors： Shih YV,Liu M,Kwon SK,Iida M,Gong Y,Sangaj N,Varghese S

更新日期：2019-08-21 00:00:00

abstract：:When a medium is rapidly heated and cooled, heat transfers to its surroundings as sound. A controllable source of this sound is realized through joule heating of thin, conductive films by an alternating current. Here, we show that arrays of these sources generate sound unique to this mechanism. From the sound alone, w...

journal_title：Science advances

authors： Tatnell DM,Heath MS,Hepplestone SP,Hibbins AP,Hornett SM,Horsley SAR,Horsell DW

更新日期：2020-07-01 00:00:00

abstract：:In the post-Moore era, an electrically driven monolithic optoelectronic integrated circuit (OEIC) fabricated from a single material is pursued globally to enable the construction of wafer-scale compact computing systems with powerful processing capabilities and low-power consumption. We report a monolithic plasmonic i...

journal_title：Science advances

authors： Liu Y,Zhang J,Liu H,Wang S,Peng LM

更新日期：2017-10-20 00:00:00

abstract：:Since Darwin's conception of sexual selection theory, scientists have struggled to identify the evolutionary forces underlying the pervasive differences between male and female behavior, morphology, and physiology. The Darwin-Bateman paradigm predicts that anisogamy imposes stronger sexual selection on males, which, i...

journal_title：Science advances

authors： Janicke T,Häderer IK,Lajeunesse MJ,Anthes N

更新日期：2016-02-12 00:00:00

abstract：:Rising temperatures in the Arctic Ocean region are responsible for changes such as reduced ice cover, permafrost thawing, and increased river discharge, which, together, alter nutrient and carbon cycles over the vast Arctic continental shelf. We show that the concentration of radium-228, sourced to seawater through se...

journal_title：Science advances

authors： Kipp LE,Charette MA,Moore WS,Henderson PB,Rigor IG

更新日期：2018-01-03 00:00:00

abstract：:The discovery of high-temperature superconductivity in cuprates ranks among the major scientific milestones of the past half century, yet pivotal questions regarding the complex phase diagram of these materials remain unanswered. Generally thought of as doped charge-transfer insulators, these complex oxides exhibit ps...

journal_title：Science advances

authors： Pelc D,Popčević P,Požek M,Greven M,Barišić N

更新日期：2019-01-25 00:00:00

abstract：:We investigate the emergence of global alignment in colonies of dividing rod-shaped cells under confinement. Using molecular dynamics simulations and continuous modeling, we demonstrate that geometrical anisotropies in the confining environment give rise to an imbalance in the normal stresses, which, in turn, drives a...

journal_title：Science advances

authors： You Z,Pearce DJG,Giomi L

更新日期：2021-01-22 00:00:00

abstract：:Stroke is the most common cause of adult disability in developed countries, largely because spontaneous recovery is often incomplete, and no pharmacological means to hasten the recovery exist. It was recently shown that mesencephalic astrocyte-derived neurotrophic factor (MANF) induces alternative or M2 activation of ...

journal_title：Science advances

authors： Mätlik K,Anttila JE,Kuan-Yin T,Smolander OP,Pakarinen E,Lehtonen L,Abo-Ramadan U,Lindholm P,Zheng C,Harvey B,Arumäe U,Lindahl M,Airavaara M

更新日期：2018-05-23 00:00:00

abstract：:[This corrects the article DOI: 10.1126/sciadv.aar3761.]. ...

journal_title：Science advances

authors：

更新日期：2018-07-06 00:00:00

abstract：:The concept of repair is widely used by nature to heal molecules such as proteins, lipids, sugars, and DNA that are damaged by hydrogen atom abstraction resulting from oxidative stress. We show that this strategy, rather undocumented in the field of synthetic organic chemistry, can be used in a radical chain reaction ...

journal_title：Science advances

authors： Povie G,Suravarapu SR,Bircher MP,Mojzes MM,Rieder S,Renaud P

更新日期：2018-07-20 00:00:00

abstract：:Slow slip events have been suggested to trigger subduction earthquakes. However, examples to date have been poorly recorded, occurring offshore, where data are sparse. Better understanding of slow slip events and their influence on subsequent earthquakes is critical for hazard forecasts. We analyze a well-recorded eve...

journal_title：Science advances

authors： Voss N,Dixon TH,Liu Z,Malservisi R,Protti M,Schwartz S

更新日期：2018-10-31 00:00:00

abstract：:The development of advanced chemical-to-electrical energy conversions requires fast and efficient electrocatalysis of multielectron/multiproton reactions, such as the oxygen reduction reaction (ORR). Using molecular catalysts, correlations between the reaction rate and energy efficiency have recently been identified. ...

journal_title：Science advances

authors： Martin DJ,Mercado BQ,Mayer JM

更新日期：2020-03-13 00:00:00

abstract：:The Late Paleogene surface height and paleoenvironment for the core area of the Qinghai-Tibetan Plateau (QTP) remain critically unresolved. Here, we report the discovery of the youngest well-preserved fossil palm leaves from Tibet. They were recovered from the Late Paleogene (Chattian), ca. 25.5 ± 0.5 million years, p...

journal_title：Science advances

authors： Su T,Farnsworth A,Spicer RA,Huang J,Wu FX,Liu J,Li SF,Xing YW,Huang YJ,Deng WY,Tang H,Xu CL,Zhao F,Srivastava G,Valdes PJ,Deng T,Zhou ZK

更新日期：2019-03-06 00:00:00