Abstract:
:Continuous delivery of oxygen therapy has been observed to improve healing for individuals with an advanced diabetic foot ulcer (DFU). However, this intervention requires the purchasing of an oxygen delivery device and moist dressings. It is unknown whether this upfront financial investment represents good value for money. Thus the aim of this project is to evaluate the cost-effectiveness of treating advanced DFU using continuous delivery of oxygen compared with negative pressure wound therapy from the perspective of the public health care payer in Ontario, Canada. A microsimulation model was constructed with inputs from peer-reviewed journal publications and publicly available reports. The 5-year costs and quality-adjusted life-years were compared between treatment and comparator. Sensitivity analyses were conducted to evaluate the robustness of results. The model predicted that continuous delivery of oxygen would cost $4800 less compared with negative pressure wound therapy and increased quality-adjusted life years by 0.025. Lower cost and improved outcomes were observed in most scenario analyses. The results of this economic evaluation suggest that CDO therapy may reduce health care economic burden with a modest increase in quality of life outcomes. Health care decision-makers should consider the inclusion of CDO for the treatment of DFU.
journal_name
Int Wound Jjournal_title
International wound journalauthors
Chan BC,Campbell KEdoi
10.1111/iwj.13468subject
Has Abstractpub_date
2020-12-01 00:00:00pages
1791-1808issue
6eissn
1742-4801issn
1742-481Xjournal_volume
17pub_type
杂志文章abstract::Combinations of various treatment modalities were shown to be more effective than monotherapy when treating hypertrophic scars and keloids. This study was conducted to assess the effectiveness of combination therapy with non-ablative fractional laser and intralesional steroid injection. From May 2015 to June 2017, a t...
journal_title:International wound journal
pub_type: 杂志文章
doi:10.1111/iwj.13213
更新日期:2019-12-01 00:00:00
abstract::Pressure injuries are key clinical indicators of care standard. In Australia, pressure injuries increase length of hospital stay by 4.31 and cost $285 million annually. This pilot study examined the effectiveness of sacral dressing in reducing the prevalence of pressure injuries in older, high-risk patients. A non ran...
journal_title:International wound journal
pub_type: 临床试验,杂志文章
doi:10.1111/j.1742-481X.2012.01025.x
更新日期:2013-10-01 00:00:00
abstract::The aim of this study was to gain a better understanding of the venous leg ulcer (VLU) management in primary health care settings located in Melbourne metropolitan and rural Victoria, Australia. We explored health professionals' perspective on the use of the Australian and New Zealand Venous Leg Ulcer Clinical Practic...
journal_title:International wound journal
pub_type: 杂志文章
doi:10.1111/iwj.13334
更新日期:2020-06-01 00:00:00
abstract::The purpose of the study is to assess the effectiveness of low level laser therapy for wound healing when combined with the Extendicare Wound Prevention and Management Program. Sixteen residents at a Canadian Extendicare nursing home had a total of 27 sites treated consisting of 23 open wounds and 4 'at risk' areas. O...
journal_title:International wound journal
pub_type: 杂志文章
doi:10.1111/j.1742-481X.2008.00491.x
更新日期:2008-06-01 00:00:00
abstract::Pressure ulcers (PUs) are a common secondary complication experienced by community dwelling individuals with spinal cord injury (SCI). There is a paucity of literature on the health economic impact of PU in SCI population from a societal perspective. The objective of this study was to determine the resource use and co...
journal_title:International wound journal
pub_type: 杂志文章
doi:10.1111/j.1742-481X.2012.01002.x
更新日期:2013-08-01 00:00:00
abstract::Surgical patients are at risk of developing a perioperative pressure injury (ORPI) during surgery. Accurate assessment and prompt implementation of prevention strategies or treatment of ORPI are dependent on knowledge and skills of operating room (OR) nurses. The study examined the knowledge and attitude of OR nurses ...
journal_title:International wound journal
pub_type: 杂志文章
doi:10.1111/iwj.13295
更新日期:2020-04-01 00:00:00
abstract::Diabetic foot ulcers commonly precede diabetic foot osteomyelitis (DFO) and once the latter occurs, surgical management is often performed. The presence of osteomyelitis is an independent risk factor for the development of re-ulceration. We investigated the relationship between causative organisms in osteomyelitis and...
journal_title:International wound journal
pub_type: 杂志文章
doi:10.1111/iwj.13439
更新日期:2020-12-01 00:00:00
abstract::Pressure injuries are one of the most common and costly complications occurring in US hospitals. With up to 3 million patients affected each year, hospital-acquired pressure injuries (HAPIs) place a substantial burden on the US healthcare system. In the current study, US hospital discharge records from 9.6 million pat...
journal_title:International wound journal
pub_type: 杂志文章
doi:10.1111/iwj.13482
更新日期:2020-12-01 00:00:00
abstract::Randomised clinical trials (RCTs) to evaluate diabetic foot wound therapies have systematically eliminated large acute wounds from evaluation, focusing only on smaller chronic wounds. The purpose of this study was to evaluate the proportion and rate of wound healing in acute and chronic wounds after partial foot amput...
journal_title:International wound journal
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1111/j.1742-481X.2006.00270.x
更新日期:2007-03-01 00:00:00
abstract::Wound healing is a complex cellular and biochemical process and can be affected by several systemic and local factors. In this study, we aimed to discuss the aetiologic factors of non-healing wounds and the management of this complicated process with current information. The medical data of the patients who were admit...
journal_title:International wound journal
pub_type: 杂志文章
doi:10.1111/iwj.13292
更新日期:2020-04-01 00:00:00
abstract::This review and case study report considers the evidence to indicate that the progress of wound healing is negatively affected by the presence of stressors and in circumstances where patients are in pain. It considers the relationship between perceptions of pain, stress and delayed wound healing with a specific focus ...
journal_title:International wound journal
pub_type: 杂志文章,评审
doi:10.1111/j.1742-481X.2012.01038.x
更新日期:2013-12-01 00:00:00
abstract::Chronic wounds represent an aberrant biochemistry that creates a toxic proteolytic milieu which can be detrimental to the healing process. Rebalancing the wound microenvironment and addressing elevated protease activity (EPA) could therefore help facilitate healing. To understand how clinicians currently diagnose and ...
journal_title:International wound journal
pub_type: 杂志文章,评审
doi:10.1111/j.1742-481X.2012.01040.x
更新日期:2013-12-01 00:00:00
abstract::This data review reports the results of 15 patients who were treated with Vacuum-Assisted Closure (VAC) negative pressure therapy system in addition to the timed, intermittent delivery of an instilled topical solution for management of their complex, infected wounds. Prospective data for 15 patients treated with negat...
journal_title:International wound journal
pub_type: 杂志文章
doi:10.1111/j.1742-481X.2007.00423.x
更新日期:2008-06-01 00:00:00
abstract::For the past 20 years, super-oxidised solutions (SOSs) have been shown to be potent antimicrobials and disinfectants via oxidative damage. However, the potential toxicity of SOSs on eukaryotic cells has not been documented in vitro. This is relevant because oxygen and chlorine reactive species may possibly induce agei...
journal_title:International wound journal
pub_type: 杂志文章
doi:10.1111/j.1742-481X.2007.00331.x
更新日期:2007-09-01 00:00:00
abstract::Vacuum-assisted closure (VAC) therapy is a sophisticated system that maintains a closed, humid, sterile and isolated environment. Wound infection is considered a relative contraindication. The objective of this study is to extend the indications for VAC therapy to include infected wounds by demonstrating its ability t...
journal_title:International wound journal
pub_type: 杂志文章
doi:10.1111/iwj.12725
更新日期:2017-12-01 00:00:00
abstract::Use of silicone derivative and onion extract had been reported in the prevention of hypertrophic scarring. Our experience showed the preventive use of silicone derivative plus onion extract gel on hypertrophic scars after median sternotomy. In a randomized, double blinded, placebo-controlled study, 60 patients after m...
journal_title:International wound journal
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1742-481X.2011.00898.x
更新日期:2012-08-01 00:00:00
abstract::Keratin proteins have been shown to play a key role in wound healing. Controlled keratin gene (KRT) expression promotes cell growth, migration and differentiation, and as an example of the importance of keratin proteins, absence of KRT17 has been shown to delay wound closure. In addition, downregulation of KRT6 and KR...
journal_title:International wound journal
pub_type: 杂志文章
doi:10.1111/iwj.12245
更新日期:2016-02-01 00:00:00
abstract::The aim of the study was to evaluate the maintenance of the 30° side-lying lateral tilt position among aged care residents at the risk of developing pressure injuries when using the standard care pillow and a purpose-designed positioning device. An observational study was conducted. Participants were monitored during ...
journal_title:International wound journal
pub_type: 杂志文章
doi:10.1111/iwj.13142
更新日期:2019-10-01 00:00:00
abstract::This prospective, non comparative study evaluated the safety and effectiveness of an adhesive gelling foam dressing in pressure ulcer management. Twenty-three subjects with exuding pressure ulcers were recruited from seven centres in the USA and Canada. Study treatment included an adhesive gelling foam dressing, optio...
journal_title:International wound journal
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1111/j.1742-481X.2007.00428.x
更新日期:2008-03-01 00:00:00
abstract::A sandwich graft was applied to the debrided cortical bone layer of the tibia in the case of a 72-year-old male patient with full-thickness necrotic burn injury. The combined graft consisted of a dermal template material and autologous split thickness skin graft. After application, the graft was found totally accepted...
journal_title:International wound journal
pub_type: 杂志文章
doi:10.1111/j.1742-4801.2006.00175.x
更新日期:2006-03-01 00:00:00
abstract::Chemotaxis, mitogenesis, motogenesis and cytoprotection are common cellular events involved in both tumourigenesis and tissue repair, which appear amplified upon growth factors exposure. Epidermal growth factor (EGF) promotes these events in epithelial and mesenchymal cells through the binding to a specific tyrosine k...
journal_title:International wound journal
pub_type: 杂志文章,评审
doi:10.1111/j.1742-481X.2009.00622.x
更新日期:2009-10-01 00:00:00
abstract::To describe the steps needed for a successful implementation of an e-health programme (the Mobile Wound Care system) in rural Victoria, Australia and to provide recommendations for future e-health initiatives. Wound care is a major burden on the health care system. Optimal wound care was found to be impeded by issues ...
journal_title:International wound journal
pub_type: 杂志文章
doi:10.1111/iwj.12041
更新日期:2014-06-01 00:00:00
abstract::We evaluated the efficacy and safety of a povidone-iodine (PVP-I) foam dressing (Betafoam) for donor site dressing versus a hydrocellular foam dressing (Allevyn) and petrolatum gauze. This prospective Phase 4 study was conducted between March 2016 and April 2017 at eight sites in Korea. A total of 106 consenting patie...
journal_title:International wound journal
pub_type: 杂志文章
doi:10.1111/iwj.13043
更新日期:2019-04-01 00:00:00
abstract::Negative pressure wound therapy (NPWT) contracts the wound and alters the pressure in the tissue of the wound edge, which accelerates wound healing. The aim of this study was to examine the effect of the type (foam or gauze) and size (small or large) of wound filler for NPWT on wound contraction and tissue pressure. N...
journal_title:International wound journal
pub_type: 杂志文章
doi:10.1111/j.1742-481X.2011.00790.x
更新日期:2011-08-01 00:00:00
abstract::A 16-year-old girl with pyoderma gangrenosum (PG)-like skin lesions on the extremities, trunk and face developed Takayasu's arteritis (TA; pulseless disease). After 3 years under maintenance cyclosporin A therapy, the patient developed an ischaemic cerebral accident. Severe obstruction of both subclavian and left caro...
journal_title:International wound journal
pub_type: 杂志文章
doi:10.1111/j.1742-4801.2005.00103.x
更新日期:2005-12-01 00:00:00
abstract:BACKGROUND:This study was designed to elucidate the in vivo efficacy of epidermal growth factor (EGF) on wound healing in non diabetic and diabetic rats. METHODS:Ninety-six male Wistar-Albino rats were randomly divided into six groups. Saline-moistened gauze, pure gelatin or EGF in gelatin-microsphere dressings were u...
journal_title:International wound journal
pub_type: 杂志文章
doi:10.1111/j.1742-481X.2009.00584.x
更新日期:2009-04-01 00:00:00
abstract::Negative pressure therapy has been successfully applied to clean, closed incisions in patients at high-risk for wound complications. Using laser Doppler flowmetry, we evaluated peristernal perfusion after cardiac surgery via median sternotomy, assessing the influence of mammary artery harvesting and the impact of nega...
journal_title:International wound journal
pub_type: 杂志文章
doi:10.1111/j.1742-481X.2010.00743.x
更新日期:2011-02-01 00:00:00
abstract::Deep sternal wound infection (DSWI) is a fatal complication after median sternotomy. This study was to assess the effect of vacuum-assisted closure (VAC) combined with bi-pectoral muscle advancement flap therapy on rehabilitation for the treatment of DSWI. Fifty-two patients with DSWI underwent treatment of VAC and bi...
journal_title:International wound journal
pub_type: 杂志文章
doi:10.1111/iwj.13277
更新日期:2020-04-01 00:00:00
abstract::Chronic wounds are a growing challenge for physicians and health insurance agencies. The burden of affected patients is enormous, because of pain but also because of long-lasting therapies and dependence on nursing services. In other areas of medicine, computer-based diagnostics is established, yet, accurate wound doc...
journal_title:International wound journal
pub_type: 杂志文章
doi:10.1111/j.1742-481X.2007.00334.x
更新日期:2007-06-01 00:00:00
abstract::Facial traumatic events are commonly encountered in plastic and reconstructive surgery. Primary reconstruction is a reliable procedure with function and aesthetic considerations. We conduct a retrospective study of the experience of reconstructing facial traumatic defects in the first stage. One hundred and thirty-two...
journal_title:International wound journal
pub_type: 杂志文章
doi:10.1111/iwj.12598
更新日期:2017-02-01 00:00:00