Abstract:
:Diabetic foot ulcers commonly precede diabetic foot osteomyelitis (DFO) and once the latter occurs, surgical management is often performed. The presence of osteomyelitis is an independent risk factor for the development of re-ulceration. We investigated the relationship between causative organisms in osteomyelitis and 1-year diabetic foot outcomes (re-ulceration, amputation, and death) following surgical management in an observational cohort of 223 patients. Univariate and multivariate analyses were performed for available demographic, clinical, and laboratory data. In addition, random forest plots were used to identify microbiologic predictors of 1-year outcomes. Patients with osteomyelitis managed surgically were younger and exhibited more painful peripheral neuropathy than outpatients with diabetes alone (both P < .0001). Osteomyelitis proximal margin cultures were diverse, at times polymicrobial, and included multidrug-resistant organisms in 13.9% of the cohort. In patients who underwent surgery, 44.5% experienced a re-ulceration on the same foot within 12 months of surgery. The presence of multidrug-resistant organisms on proximal bone culture was found to be a significant predictor of diabetic foot ulcer recurrence in univariate modelling (P < .001) and importance rankings. This is the first study to use prediction modelling to identify a relationship between multidrug-resistant organisms and diabetic foot ulcer recurrence following DFO.
journal_name
Int Wound Jjournal_title
International wound journalauthors
Schmidt BM,Ye W,Zhou Sdoi
10.1111/iwj.13439subject
Has Abstractpub_date
2020-12-01 00:00:00pages
1634-1641issue
6eissn
1742-4801issn
1742-481Xjournal_volume
17pub_type
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journal_title:International wound journal
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journal_title:International wound journal
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journal_title:International wound journal
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pub_type: 杂志文章,评审
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更新日期:2016-10-01 00:00:00
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pub_type: 杂志文章
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