Role of Computed Tomography Perfusion in Identification of Acute Lacunar Stroke Syndromes.


BACKGROUND AND PURPOSE:Lacunar syndromes correlate with a lacunar stroke on imaging in 50% to 60% of cases. Computed tomography perfusion (CTP) is becoming the preferred imaging modality for acute stroke triage. We aimed to estimate the sensitivity, specificity, and predictive values for noncontrast computed tomography and CTP in lacunar syndromes, and for cortical, subcortical, and posterior fossa regions. METHODS:A retrospective analysis of confirmed ischemic stroke patients who underwent acute CTP and follow-up magnetic resonance imaging between 2010 and 2018 was performed. Brain noncontrast computed tomography and CTP were assessed independently by 2 stroke neurologists. Receiver operating characteristic curve analysis was performed to estimate sensitivity, specificity, and area under the curve (AUC) for the detection of strokes in patients with lacunar syndromes using different CTP maps. RESULTS:We found 106 clinical lacunar syndromes, but on diffusion-weighted imaging, these consisted of 59 lacunar, 33 cortical, and 14 posterior fossa strokes. The discrimination of ischemia identification was very poor using noncontrast computed tomography in all 3 regions, but good for cortical (AUC, 0.82) and poor for subcortical and posterior regions (AUCs, 0.55 and 0.66) using automated core-penumbra maps. The addition of delay time and mean transient time maps substantially increased subcortical (AUC, 0.80) and slightly posterior stroke detection (AUC, 0.69). CONCLUSIONS:Analysis of mean transient time and delay time maps in combination with core-penumbra maps improves detection of subcortical and posterior strokes.






Garcia-Esperon C,Visser M,Churilov L,Miteff F,Bivard A,Lillicrap T,Levi CR,Spratt NJ,Parsons MW




Has Abstract


2021-01-01 00:00:00














  • Gender differences in treatment of severe carotid stenosis after transient ischemic attack.

    abstract:BACKGROUND AND PURPOSE:Gender differences in carotid endarterectomy (CEA) rates after transient ischemic attack are not well studied, although some reports suggest that eligible men are more likely to have CEA than women after stroke. METHODS:We retrospectively identified all patients diagnosed with transient ischemic...


    pub_type: 杂志文章


    authors: Poisson SN,Johnston SC,Sidney S,Klingman JG,Nguyen-Huynh MN

    更新日期:2010-09-01 00:00:00

  • Homocyst(e)ine and risk of cerebral infarction in a biracial population : the stroke prevention in young women study.

    abstract:BACKGROUND AND PURPOSE:Genetic enzyme variation and vitamin intake are important determinants of blood homocyst(e)ine levels. The prevalence of common genetic polymorphisms influencing homocyst(e)ine levels varies by race, and vitamin intake varies by socioeconomic status. Therefore, we examined the effect of vitamin i...


    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Kittner SJ,Giles WH,Macko RF,Hebel JR,Wozniak MA,Wityk RJ,Stolley PD,Stern BJ,Sloan MA,Sherwin R,Price TR,McCarter RJ,Johnson CJ,Earley CJ,Buchholz DW,Malinow MR

    更新日期:1999-08-01 00:00:00

  • Cigarette smoking and risk of stroke in the chinese adult population.

    abstract:BACKGROUND AND PURPOSE:We studied the relationship between cigarette smoking and stroke incidence and mortality in the Chinese adult population. METHODS:We conducted a prospective cohort study in a nationally representative sample of 169 871 Chinese men and women aged 40 years and older. Data on cigarette smoking and ...


    pub_type: 杂志文章


    authors: Kelly TN,Gu D,Chen J,Huang JF,Chen JC,Duan X,Wu X,Chen CS,He J

    更新日期:2008-06-01 00:00:00

  • Early Initiation of Direct Oral Anticoagulants After Onset of Stroke and Short- and Long-Term Outcomes of Patients With Nonvalvular Atrial Fibrillation.

    abstract::Background and Purpose- We aimed to compare outcomes of ischemic stroke patients with nonvalvular atrial fibrillation between earlier and later initiation of direct oral anticoagulants (DOACs) after stroke onset. Methods- From data for 1192 nonvalvular atrial fibrillation patients with acute ischemic stroke or transie...


    pub_type: 临床试验,杂志文章,多中心研究


    authors: Mizoguchi T,Tanaka K,Toyoda K,Yoshimura S,Itabashi R,Takagi M,Todo K,Shiozawa M,Yagita Y,Yoshimoto T,Terasaki T,Yamagami H,Takizawa S,Inoue M,Kamiyama K,Ihara M,Okada Y,Kitazono T,Koga M,SAMURAI Study Investigators.

    更新日期:2020-03-01 00:00:00

  • Cilostazol for Secondary Prevention of Stroke and Cognitive Decline: Systematic Review and Meta-Analysis.

    abstract:BACKGROUND AND PURPOSE:Cilostazol, a phosphodiesterase 3' inhibitor, is used in Asia-Pacific countries for stroke prevention, but rarely used elsewhere. In addition to weak antiplatelet effects, it stabilizes endothelium, aids myelin repair and astrocyte-neuron energy transfer in laboratory models, effects that may be ...


    pub_type: 杂志文章,meta分析


    authors: McHutchison C,Blair GW,Appleton JP,Chappell FM,Doubal F,Bath PM,Wardlaw JM

    更新日期:2020-08-01 00:00:00

  • Age-related changes in release of endothelium-derived relaxing factor from the carotid artery.

    abstract:BACKGROUND AND PURPOSE:The goal of this study was to determine whether release of endothelium-derived relaxing factor (EDRF) from carotid artery in response to acetylcholine is altered by aging. METHODS:Responses were examined in arteries from Wistar rats 6 to 8 months old (young rats), 24 to 26 months old (old rats),...


    pub_type: 杂志文章


    authors: Paternò R,Faraci FM,Heistad DD

    更新日期:1994-12-01 00:00:00

  • Elevated tissue plasminogen activator antigen and stroke risk: The Stroke Prevention In Young Women Study.

    abstract:BACKGROUND AND PURPOSE:Abnormalities in endogenous fibrinolysis are associated with an increased risk for stroke in men and older adults. We tested the hypothesis that elevated plasma tissue plasminogen activator (tPA) antigen, a marker for impaired endogenous fibrinolysis, is an independent risk factor for stroke in y...


    pub_type: 杂志文章


    authors: Macko RF,Kittner SJ,Epstein A,Cox DK,Wozniak MA,Wityk RJ,Stern BJ,Sloan MA,Sherwin R,Price TR,McCarter RJ,Johnson CJ,Earley CJ,Buchholz DW,Stolley PD

    更新日期:1999-01-01 00:00:00

  • Educational history is an independent predictor of cognitive deficits and long-term survival in postacute patients with mild to moderate ischemic stroke.

    abstract:BACKGROUND AND PURPOSE:Poststroke cognitive decline and white matter lesions (WML) are related to poor poststroke survival. Whether cognitive reserve as reflected by educational history associates with cognitive decline, recurrent strokes, and poststroke mortality independent of WML is not known. METHODS:A total of 48...


    pub_type: 杂志文章


    authors: Ojala-Oksala J,Jokinen H,Kopsi V,Lehtonen K,Luukkonen L,Paukkunen A,Seeck L,Melkas S,Pohjasvaara T,Karhunen P,Hietanen M,Erkinjuntti T,Oksala N

    更新日期:2012-11-01 00:00:00

  • Isolated and borderline isolated systolic hypertension relative to long-term risk and type of stroke: a 20-year follow-up of the national health and nutrition survey.

    abstract:BACKGROUND AND PURPOSE:Although the short-term risks of stroke and types of stroke associated with isolated systolic hypertension (ISH) and borderline isolated systolic hypertension (BISH) have been described, the long-term effects of these hypertensive conditions, particularly in younger individuals, are unclear. We p...


    pub_type: 杂志文章


    authors: Qureshi AI,Suri MF,Mohammad Y,Guterman LR,Hopkins LN

    更新日期:2002-12-01 00:00:00

  • Causal Effect of Lp(a) [Lipoprotein(a)] Level on Ischemic Stroke and Alzheimer Disease: A Mendelian Randomization Study.

    abstract::Background and Purpose- Stroke and Alzheimer disease are 2 major causes of neurological disability in aged people and shared overlapping predictors. In recent prospective studies, high Lp(a) [lipoprotein(a)] level is associated with high risk of stroke but low risk of Alzheimer disease. Whether this reflects a causal ...


    pub_type: 杂志文章


    authors: Pan Y,Li H,Wang Y,Meng X,Wang Y

    更新日期:2019-12-01 00:00:00

  • Measurement of vasomotor reserve in the transcranial Doppler-CO(2) test using an ultrasound contrast agent (Levovist).

    abstract:BACKGROUND AND PURPOSE:Determination of vasomotor reserve (VMR) with the transcranial Doppler-CO(2) (TCD-CO(2)) test is used to assess the risk of impending cerebral ischemia in patients with high-grade stenosis or occlusion of the internal carotid artery. In patients with a poor temporal window, however, this examinat...


    pub_type: 临床试验,杂志文章


    authors: Rohrberg M,Brodhun R

    更新日期:2001-06-01 00:00:00

  • Admission Brain Cortical Volume: An Independent Determinant of Poststroke Cognitive Vulnerability.

    abstract:BACKGROUND AND PURPOSE:Several markers of poststroke cognitive impairment have been reported. The role of brain cortical volume remains uncertain. The aim of this study was to evaluate the influence of brain cortical volume on cognitive outcomes using a voxel-based morphometry approach in subjects without prestroke dem...


    pub_type: 杂志文章


    authors: Sagnier S,Catheline G,Dilharreguy B,Munsch F,Bigourdan A,Poli M,Debruxelles S,Olindo S,Renou P,Rouanet F,Dousset V,Tourdias T,Sibon I

    更新日期:2017-08-01 00:00:00

  • Nonsteroidal lazaroid U78517F in models of focal and global ischemia.

    abstract::U78517F is a novel inhibitor of iron-catalyzed lipid peroxidation that combines the tetramethylchroman antioxidant ring portion of alpha-tocopherol with the amine of the previously described 21-aminosteroids (e.g., U74006F). U78517F inhibited 200 microM FeCl2-initiated lipid peroxidation in rat brain homogenates by 50...


    pub_type: 杂志文章


    authors: Hall ED,Pazara KE,Braughler JM,Linseman KL,Jacobsen EJ

    更新日期:1990-11-01 00:00:00

  • Decreased nighttime heart rate variability is associated with increased stroke risk.

    abstract:BACKGROUND AND PURPOSE:Prediction of stroke in healthy individuals is challenging and there is a diurnal variation of stroke onset. We hypothesized that heart rate variability with a focus on nighttime heart rate variability will predict the risk of stroke in apparently healthy middle-age and elderly subjects. METHODS...


    pub_type: 杂志文章


    authors: Binici Z,Mouridsen MR,Køber L,Sajadieh A

    更新日期:2011-11-01 00:00:00

  • Glial cells drive preconditioning-induced blood-brain barrier protection.

    abstract:BACKGROUND AND PURPOSE:The cerebrovascular contribution to ischemic preconditioning (IPC) has been scarcely explored. Using in vivo and in vitro approaches, we investigated the involvement of the blood-brain barrier and the role of its cellular components. METHODS:Seven-minute occlusion of the right middle cerebral ar...


    pub_type: 杂志文章


    authors: Gesuete R,Orsini F,Zanier ER,Albani D,Deli MA,Bazzoni G,De Simoni MG

    更新日期:2011-05-01 00:00:00

  • Rupture of the internal elastic lamina and vascular fragility in stroke-prone spontaneously hypertensive rats.

    abstract::We studied a possible relation between stroke and an enhanced susceptibility to rupture of the arterial internal elastic lamina by comparing stroke-prone spontaneously hypertensive rats with spontaneously hypertensive rats, which have a very low incidence of stroke. We quantified interruptions in the internal elastic ...


    pub_type: 杂志文章


    authors: Coutard M,Osborne-Pellegrin M

    更新日期:1991-04-01 00:00:00

  • Cellular actions of halothane on cat cerebral arterial muscle.

    abstract::The effects of halothane on intracellular membrane potential (Em) and force development in cat MCA were studied. Halothane (0.07-0.14 mM/1) relaxed isolated MCA which had developed myogenic tone. Measurement of Em showed that halothane depolarized this preparation in a dose-dependent fashion in the face of vessel rela...


    pub_type: 杂志文章


    authors: Harder DR,Gradall K,Madden JA,Kampine JP

    更新日期:1985-07-01 00:00:00

  • Venous sinus thrombosis associated with androgens in a healthy young man.

    abstract:BACKGROUND:Cerebral venous sinus thrombosis is rare and can be promoted by various conditions. We report the case of cerebral venous thrombosis in a patient using androgens. CASE DESCRIPTION:A 31-year-old man using androgens for bodybuilding was admitted for headache and vomiting. He had cerebral venous sinus thrombos...


    pub_type: 杂志文章


    authors: Jaillard AS,Hommel M,Mallaret M

    更新日期:1994-01-01 00:00:00

  • Ischemic Core and Hypoperfusion Volumes Correlate With Infarct Size 24 Hours After Randomization in DEFUSE 3.

    abstract::Background and Purpose- Accurate prediction of the subsequent infarct volume early after stroke onset helps determine appropriate interventions and prognosis. In the DEFUSE 3 trial (Endovascular Therapy Following Imaging Evaluation for Ischemic Stroke), we evaluated the accuracy of baseline ischemic core and hypoperfu...


    pub_type: 杂志文章,随机对照试验


    authors: Rao V,Christensen S,Yennu A,Mlynash M,Zaharchuk G,Heit J,Marks MP,Lansberg MG,Albers GW

    更新日期:2019-03-01 00:00:00

  • Lower central serotonergic responsivity is associated with preclinical carotid artery atherosclerosis.

    abstract:BACKGROUND AND PURPOSE:Central nervous system serotonergic neurotransmission appears to play a role in mood disorders, eating habits, and sleep, and also modulates blood pressure and metabolism. This investigation tested a hypothesized association between central serotonergic functioning and preclinical atherosclerosis...


    pub_type: 杂志文章


    authors: Muldoon MF,Mackey RH,Sutton-Tyrrell K,Flory JD,Pollock BG,Manuck SB

    更新日期:2007-08-01 00:00:00

  • Risk of recurrent subarachnoid hemorrhage after complete obliteration of cerebral aneurysms.

    abstract:BACKGROUND AND PURPOSE:The neck clipping of cerebral aneurysms is a well-established treatment for subarachnoid hemorrhage (SAH) caused by aneurysmal rupture. However, it is still unclear how great a risk of recurrence patients with a successfully treated aneurysm carry over a long-term period. METHODS:Of 425 patients...


    pub_type: 杂志文章


    authors: Tsutsumi K,Ueki K,Usui M,Kwak S,Kirino T

    更新日期:1998-12-01 00:00:00

  • Reduced risk of intracerebral hemorrhage with dynamic recreational exercise but not with heavy work activity.

    abstract:BACKGROUND AND PURPOSE:It is unclear whether intracerebral hemorrhage (ICH) is associated with dynamic or static exercise. Our aim was to assess whether such an association exists. METHODS:A case-control study was undertaken involving 331 consecutive cases of primary ICH and 331 age- and sex-matched community-based ne...


    pub_type: 杂志文章


    authors: Thrift AG,Donnan GA,McNeil JJ

    更新日期:2002-02-01 00:00:00

  • There's no place like home : an evaluation of early supported discharge for stroke.

    abstract:BACKGROUND AND PURPOSE:Because stroke management is aimed at facilitating community reintegration, it would be logical that the sooner the patient can be discharged home, the sooner reintegration can commence. The purpose of this study was to determine the effectiveness of prompt discharge combined with home rehabilita...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Mayo NE,Wood-Dauphinee S,Côté R,Gayton D,Carlton J,Buttery J,Tamblyn R

    更新日期:2000-05-01 00:00:00

  • South Asian patients with ischemic stroke: intracranial large arteries are the predominant site of disease.

    abstract:BACKGROUND AND PURPOSE:South Asians are the most prevalent ethnic group in the world. Intracranial disease is the most common vascular lesion worldwide. METHODS:We prospectively studied 200 consecutive ethnic South Asian patients with acute ischemic stroke in Singapore. RESULTS:Intracranial large-artery disease was p...


    pub_type: 信件


    authors: De Silva DA,Woon FP,Lee MP,Chen CP,Chang HM,Wong MC

    更新日期:2007-09-01 00:00:00

  • Dabigatran or Aspirin After Embolic Stroke of Undetermined Source in Patients With Patent Foramen Ovale: Results From RE-SPECT ESUS.

    abstract:BACKGROUND AND PURPOSE:Patent foramen ovale (PFO) may increase the risk of embolic stroke of undetermined source (ESUS). Guidelines suggest anticoagulation may be more effective than antiplatelets in preventing stroke in patients with ESUS and PFO when interventional closure is not performed. METHODS:Patients with ESU...


    pub_type: 杂志文章


    authors: Diener HC,Chutinet A,Easton JD,Granger CB,Kleine E,Marquardt L,Meyerhoff J,Zini A,Sacco RL

    更新日期:2021-01-28 00:00:00

  • Corpus callosum and experimental stroke: studies in callosotomized rats and acallosal mice.

    abstract:BACKGROUND AND PURPOSE:Interhemispheric inhibition via the corpus callosum has been proposed as an exacerbating factor in outcome from stroke. METHODS:We measured infarct volume and behavioral outcome after middle cerebral artery occlusion in callosotomized rats and acallosal mice. RESULTS:Neither callosotomy in rats...


    pub_type: 杂志文章


    authors: Jin K,Xie L,Sun F,Mao X,Greenberg DA

    更新日期:2011-09-01 00:00:00

  • Effect of collateral blood flow and cerebral vasomotor reactivity on the outcome of carotid artery occlusion.

    abstract:BACKGROUND AND PURPOSE:Evidence suggests that an alteration in cerebral hemodynamics plays a relevant role in the occurrence of stroke in patients with carotid occlusion. The purpose of the present study was to evaluate the relationships among baseline characteristics, type and number of collateral pathways, cerebral v...


    pub_type: 杂志文章


    authors: Vernieri F,Pasqualetti P,Matteis M,Passarelli F,Troisi E,Rossini PM,Caltagirone C,Silvestrini M

    更新日期:2001-07-01 00:00:00

  • Multilingual Validation of the Questionnaire for Verifying Stroke-Free Status in West Africa.

    abstract:BACKGROUND AND PURPOSE:The Questionnaire for Verifying Stroke-Free Status (QVSFS), a method for verifying stroke-free status in participants of clinical, epidemiological, and genetic studies, has not been validated in low-income settings where populations have limited knowledge of stroke symptoms. We aimed to validate ...


    pub_type: 杂志文章,多中心研究


    authors: Sarfo F,Gebregziabher M,Ovbiagele B,Akinyemi R,Owolabi L,Obiako R,Akpa O,Armstrong K,Akpalu A,Adamu S,Obese V,Boa-Antwi N,Appiah L,Arulogun O,Mensah Y,Adeoye A,Tosin A,Adeleye O,Tabi-Ajayi E,Phillip I,Sani A,Isa

    更新日期:2016-01-01 00:00:00

  • Is the acetazolamide test valid for quantitative assessment of maximal cerebral autoregulatory vasodilation? An experimental study.

    abstract:BACKGROUND AND PURPOSE:The cerebral vasodilating effect of acetazolamide (ACZ) injection has been used as an index of the autoregulatory vasodilation (or cerebral perfusion reserve). The question of whether the ACZ test assesses the maximal autoregulatory vasodilating capacity is not definitely resolved. The effects of...


    pub_type: 杂志文章


    authors: Démolis P,Florence G,Thomas L,Tran Dinh YR,Giudicelli JF,Seylaz J,Alkayed NJ

    更新日期:2000-02-01 00:00:00

  • Plaque ulceration and lumen thrombus are the main sources of cerebral microemboli in high-grade internal carotid artery stenosis.

    abstract:BACKGROUND AND PURPOSE:Previous work has shown that rates of cerebral microemboli downstream of high-grade internal carotid artery stenosis are higher in recently symptomatic compared with asymptomatic patients. In addition, microembolic rates decline after carotid endarterectomy. We conducted a prospective investigati...


    pub_type: 杂志文章


    authors: Sitzer M,Müller W,Siebler M,Hort W,Kniemeyer HW,Jäncke L,Steinmetz H

    更新日期:1995-07-01 00:00:00