Comparison of the pharmacodynamic effects of ranolazine versus amlodipine on platelet reactivity in stable patients with coronary artery disease treated with dual antiplatelet therapy : The ROMAN (RanOlazine vs. aMlodipine on platelet reactivity in stable


:Amlodipine, commonly used for relief of ischemic symptoms in coronary artery disease (CAD), may affect clopidogrel-induced antiplatelet effects. It remains unknown if ranolazine, an antianginal drug that constitutes a pharmacologic alternative to calcium channel blockade, interferes with clopidogrel-induced antiplatelet effects. The aim of the ROMAN study was to compare the pharmacodynamic effects of ranolazine versus amlodipine on platelet reactivity in clopidogrel treated patients with CAD. A prospective, randomized, cross-over, open-label study conducted in a total of 210 CAD patients on aspirin (100 mg/q.d.) and clopidogrel (75 mg/q.d.) 1 month following percutaneous coronary intervention. Patients were randomly assigned to amlodipine (10 mg p.d., n = 105) or ranolazine (750 mg b.i.d., n = 105) for 15 days, and after a 1-week wash-out period, crossed-over treatment for 15 days. P2Y12 reaction units (PRU) were assessed at baseline and after each treatment sequence. High on-treatment platelet reactivity (HPR) was defined as a PRU > 208. Amlodipine was associated with higher PRU than ranolazine (182 ± 75 vs. 167 ± 64, p = 0.028). As compared with baseline, PRU increased significantly after treatment with amlodipine (p = 0.018), but was not different after ranolazine therapy (p = 0.871). Changes in platelet reactivity following amlodipine therapy appeared to depend on baseline HPR status, as PRU levels significantly increased only among HPR subjects. In stable CAD patients treated with dual antiplatelet therapy after PCI, concomitant treatment with amlodipine, but not ranolazine, interferes with clopidogrel-induced antiplatelet effects.


J Thromb Thrombolysis


Pelliccia F,Greco C,Gaudio C,Rosano G,Vitale C,Marazzi G,Rollini F,Angiolillo DJ




Has Abstract


2015-10-01 00:00:00












  • Magnesium Therapy for Acute Myocardial Infarction.

    abstract::The use of magnesium therapy for acute myocardial infarction remains controversial despite recent clinical trials such as ISIS-4. Magnesium has numerous beneficial effects in the setting of myocardial infarction, including inhibitory effects on platelet aggregation. Clinical trials of magnesium therapy for myocardial ...

    journal_title:Journal of thrombosis and thrombolysis

    pub_type: 杂志文章


    authors: Rabbani LE

    更新日期:1995-01-01 00:00:00

  • Incidence and outcomes of catheter related thrombosis (CRT) in patients with acute leukemia using a platelet-adjusted low molecular weight heparin regimen.

    abstract::Patients with acute leukemia frequently develop catheter-related thrombosis (CRT) despite concurrent thrombocytopenia. The incidence, treatment and outcomes of this complication are poorly documented. We undertook this study to determine the incidence of CRT in patients with acute leukemia and assess the safety and ef...

    journal_title:Journal of thrombosis and thrombolysis

    pub_type: 杂志文章


    authors: Htun KT,Ma MJY,Lee AYY

    更新日期:2018-10-01 00:00:00

  • Acute ischemic stroke patients with diabetes should not be excluded from intravenous thrombolysis.

    abstract::The benefit of intravenous thrombolysis (IVT) has been questioned for patients with diabetes mellitus (DM) in cases of acute ischemic stroke (IS). Our objective was to analyze the differences in outcome according to prior diagnosis of DM and the use or not of IVT. Observational study with inclusion of consecutive IS p...

    journal_title:Journal of thrombosis and thrombolysis

    pub_type: 杂志文章


    authors: Fuentes B,Cruz-Herranz A,Martínez-Sánchez P,Rodríguez-Sanz A,Ruiz Ares G,Prefasi D,Sanz-Cuesta BE,Lara-Lara M,Díez-Tejedor E

    更新日期:2014-11-01 00:00:00

  • Unfavourably altered plasma clot properties in patients with primary Raynaud's phenomenon: association with venous thromboembolism.

    abstract::Associations of Raynaud's phenomenon (RP) with venous thromboembolism (VTE) are unclear. We investigated the occurrence of RP together with prothrombotic state markers and fibrin clot properties in VTE patients. In this prospective cohort study we enrolled 360 patients free of known autoimmune disease. D-dimer, von Wi...

    journal_title:Journal of thrombosis and thrombolysis

    pub_type: 杂志文章


    authors: Żuk J,Snarska-Drygalska A,Malinowski KP,Papuga-Szela E,Natorska J,Undas A

    更新日期:2019-02-01 00:00:00

  • Performance of the right ventricular outflow tract/aortic diameter as a novel predictor of risk in patients with acute pulmonary embolism.

    abstract::Right ventricular (RV) enlargement, determined via the ratio of the right to left ventricular diameters (RV/LV) by CT imaging is used to classify the severity of acute pulmonary embolism (PE) and impacts treatment decisions. The RV/LV ratio may be an unreliable marker of RV dysfunction, due in part to the complex RV g...

    journal_title:Journal of thrombosis and thrombolysis

    pub_type: 杂志文章


    authors: Marginean A,Putnam A,Hirai T,Serritella A,Besser SA,Lee M,Friant J,Blair J,Shah A,Nathan S,Chung J,Paul J

    更新日期:2020-07-01 00:00:00

  • The occasional venous thromboses seen in patients with severe (homozygous) FXII deficiency are probably due to associated risk factors: a study of prevalence in 21 patients and review of the literature.

    abstract::According to our personal experience and to the study of the literature, 11 cases of venous thrombosis have been described as sporadic reports in patients with severe (homozygous) factor XII (FXII) deficiencies. In every cases but 4, associated risk factors were found to be present (pregnancy, post-partum period, surg...

    journal_title:Journal of thrombosis and thrombolysis

    pub_type: 杂志文章,评审


    authors: Girolami A,Randi ML,Gavasso S,Lombardi AM,Spiezia F

    更新日期:2004-04-01 00:00:00

  • Hyperhomocysteinemia in patients with pulmonary embolism is associated with impaired plasma fibrinolytic capacity.

    abstract::Hyperhomocysteinemia (HHcy) affects haemostasis and shifts its balance in favour of thrombosis. In vitro and in vivo studies suggested that HHcy may impair fibrinolysis either by influencing the plasma levels of fibrinolytic factors or by altering the fibrinogen structure. We investigated the influence of mild HHcy le...

    journal_title:Journal of thrombosis and thrombolysis

    pub_type: 临床试验,杂志文章


    authors: Cellai AP,Lami D,Antonucci E,Liotta AA,Rogolino A,Fedi S,Fiorillo C,Becatti M,Cenci C,Marcucci R,Abbate R,Prisco D

    更新日期:2014-07-01 00:00:00

  • Selective thromboxane inhibition after vascular protectant AGI-1067: results of assessment of lipoprotein profiles (ALPS) biomarkers in vitro and in vivo substudy.

    abstract:BACKGROUND:Oxidative stress play an important role triggering platelet/endothelial activation. AGI-1067 is a novel, phenolic antioxidant, and vascular protectant which dose-dependently inhibits PEA biomarkers in vitro. Whether treatment with AGI-1067 alters platelets in vivo is not known. We serially assessed release o...

    journal_title:Journal of thrombosis and thrombolysis

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Serebruany V,Malinin A,Qiu FH,Xu XC,Kunsch C,Scott R,ALPS Study Group.

    更新日期:2009-05-01 00:00:00

  • Regulatory, legislative, and policy updates with anticoagulant use.

    abstract::Thromboembolism afflicts millions of patients annually in the United States and is associated with a significant cost burden. Recent advances in oral anticoagulation have provided clinicians with more options for management of these diseases. Accordingly, regulatory, legislative, and policy-making organizations have i...

    journal_title:Journal of thrombosis and thrombolysis

    pub_type: 杂志文章,评审


    authors: Fanikos J,Buckley LF,Aldemerdash A,Terry KJ,Piazza G,Connors JM,Goldhaber SZ

    更新日期:2015-04-01 00:00:00

  • The effect of surface contact activation and temperature on plasma coagulation with an RNA aptamer directed against factor IXa.

    abstract::The anticoagulant properties of a novel RNA aptamer that binds FIXa depend collectively on the intensity of surface contact activation of human blood plasma, aptamer concentration, and its binding affinity for FIXa. Accordingly, anticoagulation efficiency of plasma containing any particular aptamer concentration is lo...

    journal_title:Journal of thrombosis and thrombolysis

    pub_type: 杂志文章


    authors: Krishnan A,Vogler EA,Sullenger BA,Becker RC

    更新日期:2013-01-01 00:00:00

  • EPC mobilization after erythropoietin treatment in acute ST-elevation myocardial infarction: the REVEAL EPC substudy.

    abstract::Erythropoietin (EPO) was hypothesized to mitigate reperfusion injury, in part via mobilization of endothelial progenitor cells (EPCs). The REVEAL trial found no reduction in infarct size with a single dose of EPO (60,000 U) in patients with ST-segment elevation myocardial infarction. In a substudy, we aimed to determi...

    journal_title:Journal of thrombosis and thrombolysis

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Povsic TJ,Najjar SS,Prather K,Zhou J,Adams SD,Zavodni KL,Kelly F,Melton LG,Hasselblad V,Heitner JF,Raman SV,Barsness GW,Patel MR,Kim RJ,Lakatta EG,Harrington RA,Rao SV

    更新日期:2013-11-01 00:00:00

  • Enoxaparin, a low molecular weight heparin, inhibits platelet-dependent prothrombinase assembly and activity by factor-Xa neutralization.

    abstract:BACKGROUND:The available evidence suggests strongly that intravascular thrombosis is mediated predominantly by tissue-factor and its activation of factor X, which in the presence of factor Va, calcium, and phospholipid (prothrombinase complex) effectively converts prothrombin to thrombin. In vitro experiments have show...

    journal_title:Journal of thrombosis and thrombolysis

    pub_type: 杂志文章,多中心研究


    authors: Spencer FA,Ball SP,Zhang Q,Liu L,Benoit S,Becker RC

    更新日期:2000-04-01 00:00:00

  • Attitudes to prescribing compression stockings for patients with acute DVT: the MASTER registry.

    abstract:UNLABELLED:Compression therapy is still not widely used for patients with deep vein thrombosis (DVT). This report provides information on Italian doctors' use of elastic stockings (ES) after acute DVT and identifies some predictors of prescription. MATERIAL AND METHODS:The MASTER multicenter registry collected informa...

    journal_title:Journal of thrombosis and thrombolysis

    pub_type: 杂志文章,多中心研究


    authors: Arpaia G,Carpenedo M,Pistelli R,Mastrogiacomo O,Cimminiello C,Agnelli G

    更新日期:2009-11-01 00:00:00

  • Monitoring the roles of prothrombin activation fragment 1 and 2 (F1 + 2) in patients with atrial fibrillation receiving rivaroxaban and apixaban.

    abstract::Factor Xa (FXa) inhibitors are recommended for use in fixed doses without laboratory monitoring. However, prior studies reported the importance of establishing biomarkers representing anticoagulation intensity related to bleeding or thrombotic events. To test the hypothesis that prothrombin activation fragment 1 and 2...

    journal_title:Journal of thrombosis and thrombolysis

    pub_type: 杂志文章


    authors: Ueno EI,Fujibayashi K,Sawaguchi J,Yasuda Y,Takano S,Fujioka N,Kawai Y,Fujita H,Tanaka Y,Kajinami K

    更新日期:2020-08-01 00:00:00

  • Is delayed facilitated percutaneous coronary intervention better than immediate in reperfused myocardial infarction? Six months follow up findings.

    abstract:BACKGROUND:There are several new strategies proposed to improve the outcome of patients with ST-elevation myocardial infarction (STEMI). One approach is the resurgent use of facilitated percutaneous coronary interventions (PCI). Until recently, deciding whether immediate PCI after combined treatment (facilitated PCI) i...

    journal_title:Journal of thrombosis and thrombolysis

    pub_type: 杂志文章,随机对照试验


    authors: Di Pasquale P,Cannizzaro S,Parrinello G,Giambanco F,Vitale G,Fasullo S,Scalzo S,Ganci F,La Manna N,Sarullo F,La Rocca G,Paterna S

    更新日期:2006-04-01 00:00:00

  • Circadian variations in pathogenesis of ST-segment elevation myocardial infarction: an optical coherence tomography study.

    abstract::Previous studies have reported a circadian variation in the onset of ST-segment elevation myocardial infarction (STEMI). However, underlying mechanisms for the circadian variation have not been fully elucidated. We investigated the relationship between onset of STEMI and the underlying pathology using optical coherenc...

    journal_title:Journal of thrombosis and thrombolysis

    pub_type: 杂志文章


    authors: Araki M,Yonetsu T,Kurihara O,Nakajima A,Lee H,Soeda T,Minami Y,Higuma T,Kimura S,Takano M,Yan BP,Adriaenssens T,Boeder NF,Nef HM,Kim CJ,Crea F,Kakuta T,Jang IK

    更新日期:2020-07-10 00:00:00

  • Patients treated for acute VTE during periods of treatment-related thrombocytopenia have high rates of recurrent thrombosis and transfusion-related adverse outcomes.

    abstract::Venous thromboembolism (VTE) is a common complication of hematologic malignancies. Prolonged periods of thrombocytopenia are experienced universally by patients undergoing treatment for these diseases, yet data to guide management of anticoagulation in this setting are lacking. To obtain data on the management and out...

    journal_title:Journal of thrombosis and thrombolysis

    pub_type: 杂志文章


    authors: Samuelson Bannow BT,Walter RB,Gernsheimer TB,Garcia DA

    更新日期:2017-11-01 00:00:00

  • Plasminogen deficiency.

    abstract::Plasminogen plays an important role in fibrinolysis as well as wound healing, cell migration, tissue modeling and angiogenesis. Congenital plasminogen deficiency is a rare autosomal recessive disorder that leads to the development of thick, wood-like pseudomembranes on mucosal surfaces, mostly seen in conjunctivas nam...

    journal_title:Journal of thrombosis and thrombolysis

    pub_type: 杂志文章,评审


    authors: Celkan T

    更新日期:2017-01-01 00:00:00

  • Comparison of clinical performance of four gastrointestinal bleeding risk scores in Chinese patients with atrial fibrillation receiving oral anticoagulants.

    abstract::Gastrointestinal bleeding is the most common bleeding complication during anticoagulant therapy. A reliable bleeding risk score can help the clinician assess risk of bleeding in individual patients and select the anticoagulant regimen. This study retrospectively analyzed the data of patients with atrial fibrillation w...

    journal_title:Journal of thrombosis and thrombolysis

    pub_type: 杂志文章


    authors: Lv MN,Zheng XC,Zhang HQ,Xu FD,Wu TT,Chen WJ,Xia XT,Fu JL,Jiang SJ,Zhang JH

    更新日期:2021-01-01 00:00:00

  • Thrombolysis with streptokinase during cardiopulmonary resuscitation: a single center experience and review of the literature.

    abstract:OBJECTIVE:To report our experience with use of thrombolysis with streptokinase during cardiopulmonary resuscitation of patients with cardiac arrest due to myocardial infarction. DESIGN:A case series. METHODS:Thrombolytic therapy (streptokinase) was administered during cardiopulmonary resuscitation of 4 patients with ...

    journal_title:Journal of thrombosis and thrombolysis

    pub_type: 杂志文章


    authors: Aliyev F,Habeb M,Babalik E,Karadag B

    更新日期:2005-12-01 00:00:00

  • Ticagrelor versus clopidogrel after fibrinolytic therapy in patients with ST-elevation myocardial infarction: a systematic review and meta-analysis of randomized clinical trials.

    abstract::Dual antiplatelet therapy with aspirin and clopidogrel are recommended as adjuncts to fibrinolytic-treated patients with ST-elevation myocardial infarction (STEMI). However, the role of switching to ticagrelor within 24 h of fibrinolytics compared with clopidogrel continuation in this setting is uncertain. Hence, we c...

    journal_title:Journal of thrombosis and thrombolysis

    pub_type: 杂志文章,meta分析


    authors: Kheiri B,Osman M,Abdalla A,Haykal T,Barbarawi M,Zayed Y,Hicks M,Ahmed S,Bachuwa G,Hassan M,Bhatt DL

    更新日期:2018-10-01 00:00:00

  • What is the required reperfusion period for assessment of myocardial infarct size using triphenyltetrazolium chloride staining in the rat?

    abstract::Measurements of infarct size by use of tripenyltetrazoliumchloride (TTC) is a widely accepted method used to delineate the extent of myocardial necrosis following coronary occlusion and reperfusion in various animal experiments. There is controversy, however, regarding the optimal reperfusion time for estimating the m...

    journal_title:Journal of thrombosis and thrombolysis

    pub_type: 杂志文章


    authors: Schwarz ER,Somoano Y,Hale SL,Kloner RA

    更新日期:2000-10-01 00:00:00

  • Eptifibatide-induced thrombocytopenia.

    abstract::Glycoprotein (GP) IIb/IIIa inhibitors reduce major adverse coronary events in patients with acute coronary syndromes undergoing percutaneous coronary interventions (PCI). Unlike the other GPIIb/IIIa inhibitors, eptifibatide is rarely associated with thrombocytopenia with only a few cases reported in the medical litera...

    journal_title:Journal of thrombosis and thrombolysis

    pub_type: 杂志文章


    authors: Refaat M,Smith AJ,Edmundowicz D

    更新日期:2008-04-01 00:00:00

  • Challenges and benefits of an inpatient anticoagulation service: one hospital's experience.

    abstract::While outpatient anticoagulation services (AMS) have existed extensively for a number of years, inpatient AMS have only recently begun to be implemented on a widespread basis. This is in direct response to anticoagulation regulations set forth by entities such as the Joint Commission (TJC) and the Centers for Medicare...

    journal_title:Journal of thrombosis and thrombolysis

    pub_type: 杂志文章


    authors: Burnett A,D'Angio R,Earl LE,Garcia D

    更新日期:2011-04-01 00:00:00

  • Coronary artery fistulae.

    abstract::Coronary artery fistulae (CAF) are rare congenital or acquired in which a connection forms between one of the coronary arteries and a heart chamber or with other vessels. This paper describes three cases of CAF along with their initial presentation, imaging findings and management. The first case is a rare form of CAF...

    journal_title:Journal of thrombosis and thrombolysis

    pub_type: 杂志文章,评审


    authors: Ali M,Kassem KM,Osei K,Effat M

    更新日期:2019-08-01 00:00:00

  • Fever and deep venous thrombosis. Findings from the RIETE registry.

    abstract::Fever is a presenting sign in some patients with acute deep venous thrombosis (DVT), but its influence on outcome has not been thoroughly investigated. RIETE is an ongoing, international, observational registry of consecutive patients with symptomatic, objectively confirmed, acute venous thromboembolism. The aim of th...

    journal_title:Journal of thrombosis and thrombolysis

    pub_type: 临床试验,杂志文章,多中心研究


    authors: Barba R,Di Micco P,Blanco-Molina A,Delgado C,Cisneros E,Villalta J,Morales MV,Bura-Riviere A,Debourdeau P,Monreal M

    更新日期:2011-10-01 00:00:00

  • D-Dimer elevation and adverse outcomes.

    abstract::D-Dimer is a biomarker of fibrin formation and degradation. While a D-dimer within normal limits is used to rule out the diagnosis of deep venous thrombosis and pulmonary embolism among patients with a low clinical probability of venous thromboembolism (VTE), the prognostic association of an elevated D-dimer with adve...

    journal_title:Journal of thrombosis and thrombolysis

    pub_type: 杂志文章,评审


    authors: Halaby R,Popma CJ,Cohen A,Chi G,Zacarkim MR,Romero G,Goldhaber SZ,Hull R,Hernandez A,Mentz R,Harrington R,Lip G,Peacock F,Welker J,Martin-Loeches I,Daaboul Y,Korjian S,Gibson CM

    更新日期:2015-01-01 00:00:00

  • Evaluation of a rapid turn-over, fully-automated ADAMTS13 activity assay: a method comparison study.

    abstract::Thrombotic thrombocytopenic purpura (TTP) is a life-threatening thrombotic microangiopathy caused by severely reduced activity of the von-Willebrand factor-cleaving protease ADAMTS13, mainly caused by anti-ADAMTS-13 antibodies. Although several test systems for ADAMTS13 measurement exist, long turn-around times hamper...

    journal_title:Journal of thrombosis and thrombolysis

    pub_type: 杂志文章


    authors: Stratmann J,Ward JN,Miesbach W

    更新日期:2020-10-01 00:00:00

  • The effect of the REG2 Anticoagulation System on thrombin generation kinetics: a pharmacodynamic and pharmacokinetic first-in-human study.

    abstract::The REG2 Anticoagulation System consists of pegnivacogin, a subcutaneously administered aptamer factor IXa inhibitor, and its intravenous active control agent, anivamersen. Its effect on thrombin generation is unknown. A prospectively designed thrombin generation study was conducted within the phase 1 ascending dose s...

    journal_title:Journal of thrombosis and thrombolysis

    pub_type: 杂志文章,随机对照试验


    authors: Vavalle JP,Rusconi CP,Zelenkofske S,Wargin WA,Ortel TL,Alexander JH,Povsic TJ,Becker RC

    更新日期:2014-10-01 00:00:00

  • Renal Vein Thrombosis and Selective Arterial or Venous Thrombolytic Therapy.

    abstract::Background: Renal vein thrombosis (RVT) complicating the nephrotic syndrome is associated with a poor prognosis. Methods/Results: RVT was diagnosed in 12 of 60 patients with a diagnosis of nephrotic syndrome suggested by computed tomography (CT) and subsequently confirmed by selective renal angiography. Fifty patients...

    journal_title:Journal of thrombosis and thrombolysis

    pub_type: 杂志文章


    authors: Wu ZL,Zhou KR,Liao Lt

    更新日期:1996-01-01 00:00:00