Comparison of the pharmacodynamic effects of ranolazine versus amlodipine on platelet reactivity in stable patients with coronary artery disease treated with dual antiplatelet therapy : The ROMAN (RanOlazine vs. aMlodipine on platelet reactivity in stable


:Amlodipine, commonly used for relief of ischemic symptoms in coronary artery disease (CAD), may affect clopidogrel-induced antiplatelet effects. It remains unknown if ranolazine, an antianginal drug that constitutes a pharmacologic alternative to calcium channel blockade, interferes with clopidogrel-induced antiplatelet effects. The aim of the ROMAN study was to compare the pharmacodynamic effects of ranolazine versus amlodipine on platelet reactivity in clopidogrel treated patients with CAD. A prospective, randomized, cross-over, open-label study conducted in a total of 210 CAD patients on aspirin (100 mg/q.d.) and clopidogrel (75 mg/q.d.) 1 month following percutaneous coronary intervention. Patients were randomly assigned to amlodipine (10 mg p.d., n = 105) or ranolazine (750 mg b.i.d., n = 105) for 15 days, and after a 1-week wash-out period, crossed-over treatment for 15 days. P2Y12 reaction units (PRU) were assessed at baseline and after each treatment sequence. High on-treatment platelet reactivity (HPR) was defined as a PRU > 208. Amlodipine was associated with higher PRU than ranolazine (182 ± 75 vs. 167 ± 64, p = 0.028). As compared with baseline, PRU increased significantly after treatment with amlodipine (p = 0.018), but was not different after ranolazine therapy (p = 0.871). Changes in platelet reactivity following amlodipine therapy appeared to depend on baseline HPR status, as PRU levels significantly increased only among HPR subjects. In stable CAD patients treated with dual antiplatelet therapy after PCI, concomitant treatment with amlodipine, but not ranolazine, interferes with clopidogrel-induced antiplatelet effects.


J Thromb Thrombolysis


Pelliccia F,Greco C,Gaudio C,Rosano G,Vitale C,Marazzi G,Rollini F,Angiolillo DJ




Has Abstract


2015-10-01 00:00:00












  • SARS-CoV-2 infection and thrombotic complications: a narrative review.

    abstract::The current, global situation regarding the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic and its potentially devastating clinical manifestations, i.e. coronavirus disease 2019 (COVID-19), took the world by storm, as millions of people have been infected worldwide and more than 1,600,000 patien...

    journal_title:Journal of thrombosis and thrombolysis

    pub_type: 杂志文章,评审


    authors: Moschonas IC,Tselepis AD

    更新日期:2021-01-15 00:00:00

  • The impact of a pulmonary embolism response team on the efficiency of patient care in the emergency department.

    abstract::The concept of a pulmonary embolism response team (PERT) is multidisciplinary, with the hope that it may positively impact patient care, hospital efficiency, and outcomes in the treatment of patients with intermediate and high risk pulmonary embolism (PE). Clinical characteristics of a baseline population of patients ...

    journal_title:Journal of thrombosis and thrombolysis

    pub_type: 杂志文章


    authors: Wright C,Elbadawi A,Chen YL,Patel D,Mazzillo J,Acquisto N,Groth C,Van Galen J,Delehanty J,Pietropaoli A,Trawick D,James White R,Cameron P,Gosev I,Barrus B,Kumar NG,Cameron SJ

    更新日期:2019-08-01 00:00:00

  • Bleeding risk factors associated with argatroban therapy in the critically ill.

    abstract::Argatroban is a parenteral direct thrombin inhibitor labeled for anticoagulation in patients with confirmed or suspected heparin-induced thrombocytopenia in the United States. Currently there are no studies evaluating bleeding risk factors in Intensive Care Unit patients.To determine bleeding risk factors associated w...

    journal_title:Journal of thrombosis and thrombolysis

    pub_type: 临床试验,杂志文章


    authors: Doepker B,Mount KL,Ryder LJ,Gerlach AT,Murphy CV,Philips GS

    更新日期:2012-11-01 00:00:00

  • Low levels of activated factor VII in systemic sclerosis.

    abstract:INTRODUCTION:Recent investigations show that activated factor VII, the primary enzyme in the extrinsic pathway of blood coagulation, exerts additional extra-coagulant functions, such as apoptosis and angiogenesis. On the basis of these recent acquisitions, the present study was aimed to evaluate activated factor VII in...

    journal_title:Journal of thrombosis and thrombolysis

    pub_type: 杂志文章


    authors: Volpe A,Salvagno GL,Lippi G,Caramaschi P,Montagnana M,Canestrini S,Carletto A,Bambara LM,Biasi D,Guidi GC

    更新日期:2006-10-01 00:00:00

  • Resolution of acute lower extremity deep vein thrombosis with rivaroxaban compared to warfarin.

    abstract::Thrombosis resolution is an important component of treatment for deep vein thrombosis (DVT) and multiple anticoagulants are now available. It is unknown whether rivaroxaban contributes to a higher degree of thrombus resolution compared to conventional anticoagulation with warfarin. Our objective was to compare thrombu...

    journal_title:Journal of thrombosis and thrombolysis

    pub_type: 杂志文章


    authors: Houghton DE,Lekah A,Macedo TA,Hodge D,Saadiq RA,Little Y,Casanegra AI,McBane RD,Wysokinski WE

    更新日期:2020-02-01 00:00:00

  • Evaluation of direct oral anticoagulants for the treatment of cancer-associated thrombosis: an update.

    abstract::Cancer is associated with an increased risk of venous thromboembolism of four to sixfold. Cancer-related interventions such as chemotherapy, hormonal therapy and indwelling central venous catheters also increase the risk of venous thromboembolism. Low molecular weight heparin for at least 3-6 months is the current sta...

    journal_title:Journal of thrombosis and thrombolysis

    pub_type: 杂志文章,评审


    authors: Franco-Moreno A,Cabezón-Gutiérrez L,Palka-Kotlowsa M,Villamayor-Delgado M,García-Navarro M

    更新日期:2019-04-01 00:00:00

  • Sodium-hydrogen exchange and platelet function.

    abstract::On stimulation of platelets with agonists, for example, thrombin, a rapid rise in intracellular pH is observed. This alkalinization is mediated by an increase in transport activity of the Na(+)/H(+) exchanger isoform NHE1. In addition to this Na(+)/H(+) exchange mechanism, platelets express bicarbonate/chloride exchan...

    journal_title:Journal of thrombosis and thrombolysis

    pub_type: 杂志文章,评审


    authors: Rosskopf D

    更新日期:1999-07-01 00:00:00

  • Response variability to aspirin and one-year prediction of vascular events in patients with stable coronary artery disease.

    abstract::The aim of this study was to assess the association between "aspirin non responsiveness" in patients with coronary artery diseases (CAD) and the risk of major adverse cardiovascular events (MACE). 204 patients with CAD receiving aspirin (250 mg/d) were included. Both Collagen/Epinephrine Closure Time (CEPI-CT) and uri...

    journal_title:Journal of thrombosis and thrombolysis

    pub_type: 杂志文章


    authors: Addad F,Chakroun T,Abderazek F,Ben-Farhat M,Hamdi S,Dridi Z,Gamra H,Hassine M,Samama MM,Elalamy I

    更新日期:2010-01-01 00:00:00

  • Home management of INR in the public health system: feasibility of self-management of oral anticoagulation and long-term performance of individual POC devices in determining INR.

    abstract::The home prothrombin time/international normalized ratio (PT/INR) self-management could be convenient for patients, enhancing treatment compliance and improving the quality of the oral anticoagulation. However, patient self-management (PSM) of oral anticoagulation may not be feasible for up to half of the patients due...

    journal_title:Journal of thrombosis and thrombolysis

    pub_type: 杂志文章


    authors: da Silva Saraiva S,Orsi FA,Santos MP,Machado T,Montalvão S,Costa-Lima C,de Paula EV,Colella MP,Annichino-Bizzacchi J

    更新日期:2016-07-01 00:00:00

  • Associations between model-predicted rivaroxaban exposure and patient characteristics and efficacy and safety outcomes in the prevention of venous thromboembolism.

    abstract::Anticoagulant plasma concentrations and patient characteristics might affect the benefit-risk balance of therapy. The study objective was to assess the impact of model-predicted rivaroxaban exposure and patient characteristics on outcomes in patients receiving rivaroxaban for venous thromboembolism (VTE) prophylaxis (...

    journal_title:Journal of thrombosis and thrombolysis

    pub_type: 杂志文章


    authors: Reinecke I,Solms A,Willmann S,Spiro TE,Peters G,Weitz JI,Mueck W,Garmann D,Schmidt S,Zhang L,Fox KAA,Berkowitz SD

    更新日期:2020-07-01 00:00:00

  • Clopidogrel and aspirin after ischemic stroke or transient ischemic attack: an updated systematic review and meta-analysis of randomized clinical trials.

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    journal_title:Journal of thrombosis and thrombolysis

    pub_type: 杂志文章,meta分析


    authors: Kheiri B,Osman M,Abdalla A,Haykal T,Swaid B,Ahmed S,Chahine A,Hassan M,Bachuwa G,Al Qasmi M,Bhatt DL

    更新日期:2019-02-01 00:00:00

  • Are surgical patients at risk of venous thromboembolism currently meeting the Surgical Care Improvement Project performance measure for appropriate and timely prophylaxis?

    abstract::The US Surgical Care Improvement Project (SCIP) has approved two performance measures to improve venous thromboembolism (VTE) prevention. SCIP-VTE-2 measures the proportion of surgery patients who received appropriate VTE prophylaxis within 24 h prior to surgery to 24 h after surgery. This study assesses the current r...

    journal_title:Journal of thrombosis and thrombolysis

    pub_type: 杂志文章


    authors: Deitelzweig SB,Lin J,Hussein M,Battleman D

    更新日期:2010-07-01 00:00:00

  • Differing coagulation profiles of patients with monoclonal gammopathy of undetermined significance and multiple myeloma.

    abstract::The link between myeloma and thrombosis is well established. Monoclonal gammopathy of undetermined significance (MGUS) has also been associated with an increased risk of thrombosis. It was recently demonstrated that patients with myeloma display changes in thromboelastometry that may indicate a prothrombotic state. Th...

    journal_title:Journal of thrombosis and thrombolysis

    pub_type: 杂志文章


    authors: Crowley MP,Quinn S,Coleman E,Eustace JA,Gilligan OM,O'Shea SI

    更新日期:2015-02-01 00:00:00

  • Intramyocardial injection of DNA encoding vascular endothelial growth factor in a myocardial infarction model.

    abstract::In a previous study, we observed that one injection of 500 microg of DNA for the plasmid encoding for vascular endothelial growth factor (ph VEGF(165)) into one site in a rat myocardial infarction model resulted in neovascularization confined to angiomatous structures that did not contribute to regional myocardial blo...

    journal_title:Journal of thrombosis and thrombolysis

    pub_type: 杂志文章


    authors: Kloner RA,Dow J,Chung G,Kedes LH

    更新日期:2000-12-01 00:00:00

  • Interaction of angiotensin-converting enzyme and apolipoprotein E gene polymorphisms in ischemic stroke involving large-vessel disease.

    abstract::A relationship between apolipoprotein E (Apo E) genotype and angiotensin-converting enzyme (ACE) insertion-deletion (Ins-Del) mutation and stroke was suggested. We investigated the association of Apo E4 and ACE Ins/Del genotypes with stroke risk and changes in serum lipids in 228 consecutive Tunisian stroke patients, ...

    journal_title:Journal of thrombosis and thrombolysis

    pub_type: 杂志文章


    authors: Saidi S,Zammiti W,Slamia LB,Ammou SB,Almawi WY,Mahjoub T

    更新日期:2009-01-01 00:00:00

  • Aspirin dosing in cardiovascular disease prevention and management: an update.

    abstract::Aspirin has been in use for prevention and management of cardiovascular diseases for several decades. Clinical and epidemiological literature suggests that while net benefits of aspirin in primary prevention of CVDs are less clear, the benefits of aspirin in acute scenarios and secondary prevention settings are well e...

    journal_title:Journal of thrombosis and thrombolysis

    pub_type: 杂志文章,评审


    authors: Ganjehei L,Becker RC

    更新日期:2015-11-01 00:00:00

  • The impact of schistosomes and schistosomiasis on murine blood coagulation and fibrinolysis as determined by thromboelastography (TEG).

    abstract::Schistosomes are parasitic platyhelminths that currently infect over 200 million people and cause the chronic debilitating disease schistosomiasis. While these large intravascular parasites can disturb blood flow, surprisingly they do not appear to provoke thrombus formation around them in vivo. In order to determine ...

    journal_title:Journal of thrombosis and thrombolysis

    pub_type: 杂志文章


    authors: Da'dara AA,de Laforcade AM,Skelly PJ

    更新日期:2016-05-01 00:00:00

  • Guidance for the prevention and treatment of cancer-associated venous thromboembolism.

    abstract::Venous thromboembolism (VTE) is a highly prevalent complication of malignancy with emerging changes in incidence, diagnosis and treatment paradigms. This manuscript, initiated by the Anticoagulation Forum, provides clinical guidance based on existing guidelines and consensus expert opinion where guidelines are lacking...

    journal_title:Journal of thrombosis and thrombolysis

    pub_type: 杂志文章,评审


    authors: Khorana AA,Carrier M,Garcia DA,Lee AY

    更新日期:2016-01-01 00:00:00

  • Benefits versus risks of pharmacological prophylaxis to prevent symptomatic venous thromboembolism in unselected medical patients revisited. Meta-analysis of the medical literature.

    abstract::A significant proportion of the outcomes reported in trials assessing venous thromboembolism (VTE) prophylaxis in medical patients are related to asymptomatic events found on routine imaging studies. The implications of these events are controversial. Moreover, such trials did not always reflect the patient mix in tod...

    journal_title:Journal of thrombosis and thrombolysis

    pub_type: 杂志文章,评审


    authors: Vardi M,Steinberg M,Haran M,Cohen S

    更新日期:2012-07-01 00:00:00

  • Pharmacological intervention at disparate sites in the coagulation cascade: comparison of anti-thrombotic efficacy vs bleeding propensity in a rat model of acute arterial thrombosis.

    abstract::The Tissue Factor/Factor VIIa (TF/FVIIa) complex is an attractive target for pharmacological interruption of thrombin generation and hence blood coagulation, as this complex is the initiation point of the extrinsic pathway of coagulation. TF is a cell membrane-associated protein that interacts with soluble FVIIa to ac...

    journal_title:Journal of thrombosis and thrombolysis

    pub_type: 杂志文章


    authors: Szalony JA,Taite BB,Girard TJ,Nicholson NS,LaChance RM

    更新日期:2002-10-01 00:00:00

  • Interhospital transfer on intravenous thrombolysis in patients with acute ischemic stroke in three chinese municipal stroke centers.

    abstract::We included acute ischemic stroke (AIS) patients who received recombinant tissue plasminogen activator (rt-PA) at three stroke centers via either interhospital transfer or direct presentation and compared the clinical outcomes and time metrics to analyze the impact of interhospital transfer on intravenous thrombolysis...

    journal_title:Journal of thrombosis and thrombolysis

    pub_type: 杂志文章,多中心研究


    authors: Ding Y,Ji Z,Ma L,Zhai T,Gu Z,Niu J,Liu Y

    更新日期:2019-11-01 00:00:00

  • Management of very high risk pregnancy with secondary anti-phospholipid syndrome and triple positivity to the anti-phospholipid antibodies.

    abstract::There is a significantly increased risk of pregnancy complications in women with anti-phospholipid syndrome (APS). The risk is further heightened in those with previous arterial or venous thromboembolism and so-called 'triple positivity' for anti-phospholipid antibodies (i.e., when lupus anticoagulant, and anti-cardio...

    journal_title:Journal of thrombosis and thrombolysis

    pub_type: 杂志文章


    authors: Rose HL,Ho WK

    更新日期:2014-11-01 00:00:00

  • Genetic determinants of platelet response to clopidogrel.

    abstract::Antiplatelet agents are the mainstay treatment in the prevention and management of atherothrombotic complications. However, a substantial interpatient variability in response to clopidogrel has been reported. Furthermore, patients with coronary artery disease and lesser platelet inhibition in response to clopidogrel a...

    journal_title:Journal of thrombosis and thrombolysis

    pub_type: 杂志文章,评审


    authors: Kubica A,Kozinski M,Grzesk G,Fabiszak T,Navarese EP,Goch A

    更新日期:2011-11-01 00:00:00

  • Factors influencing early neurological improvement after mechanical thrombectomy among patients with acute basilar artery occlusion: a single center prospective observational cohort study.

    abstract::The predictive value of and the influencing factors associated with early neurological improvement (ENI) among patients with acute basilar artery occlusion (BAO) have not been well studied. The present study aimed to evaluate whether ENI predicted a better functional outcome and to identify the influencing factors of ...

    journal_title:Journal of thrombosis and thrombolysis

    pub_type: 杂志文章


    authors: Sun X,Zhang H,Tong X,Gao F,Deng Y,Ma G,Ma N,Mo D,Song L,Liu L,Huo X,Miao Z

    更新日期:2021-01-01 00:00:00

  • Using big data to retrospectively validate the COMPASS-CAT risk assessment model: considerations on methodology.

    abstract::External validation is a prerequisite in order for a prediction model to be introduced into clinical practice. Nonetheless, methodologically intact external validation studies are a scarce finding. Utilization of big datasets can help overcome several causes of methodological failure. However, transparent reporting is...

    journal_title:Journal of thrombosis and thrombolysis

    pub_type: 杂志文章


    authors: Nikolakopoulos I,Nourabadi S,Eldredge JB,Anand L,Zhang M,Qiu M,Rosenberg D,Spyropoulos AC

    更新日期:2021-01-01 00:00:00

  • Oral anticoagulation control: the European perspective.

    abstract::We describe the results of a novel complete care package using point-of-care INR testing and computerized decision support for the management of oral anticoagulation by nurse-led primary care clinics in the United Kingdom. We found such therapy to be as safe and effective as traditional hospital-based care for oral an...

    journal_title:Journal of thrombosis and thrombolysis

    pub_type: 杂志文章,评审


    authors: Fitzmaurice DA

    更新日期:2006-02-01 00:00:00

  • Treatment of Deep Vein Thrombosis with Low Molecular Weight Heparin at Patient's Home.

    abstract::We have applied the low molecular weight heparin dalteparin as once-daily subcutaneous injections to the treatment of deep vein thrombosis (DVT) on an outpatient basis since 1994. Until today, 377 consecutive patients with DVT below the inguinal ligament have been treated at home with dalteparin. The patients administ...

    journal_title:Journal of thrombosis and thrombolysis

    pub_type: 杂志文章


    authors: Stockelberg D,Hansson E,Jonson T

    更新日期:1998-09-01 00:00:00

  • Association of TIMI myocardial perfusion grade and ST-segment resolution with cardiovascular magnetic resonance measures of microvascular obstruction and infarct size following ST-segment elevation myocardial infarction.

    abstract:BACKGROUND:Impairment of coronary microvascular perfusion is common among patients with ST-segment elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (PCI). Cardiovascular magnetic resonance imaging (CMR) can identify microvascular obstruction (MO) following reperfusion of S...

    journal_title:Journal of thrombosis and thrombolysis

    pub_type: 杂志文章


    authors: Appelbaum E,Kirtane AJ,Clark A,Pride YB,Gelfand EV,Harrigan CJ,Kissinger KV,Manning WJ,Gibson CM

    更新日期:2009-02-01 00:00:00

  • Abnormal asymmetric dimethylarginine/nitric oxide balance in patients with documented coronary artery disease: relation to renal function and homocysteine.

    abstract:BACKGROUND:As an endogenous inhibitor of nitric oxide production, asymmetric dimethylarginine (ADMA) is reported to be associated with coronary artery disease (CAD). METHODS:We measured plasma levels of ADMA, nitrate + nitrite (NOx), total homocysteine (tHCY), and renal function in 106 people with angiographic evidenc...

    journal_title:Journal of thrombosis and thrombolysis

    pub_type: 杂志文章


    authors: Ilhan N,Seckin D,Ilhan N,Ozbay Y

    更新日期:2007-06-01 00:00:00

  • Monitoring the roles of prothrombin activation fragment 1 and 2 (F1 + 2) in patients with atrial fibrillation receiving rivaroxaban and apixaban.

    abstract::Factor Xa (FXa) inhibitors are recommended for use in fixed doses without laboratory monitoring. However, prior studies reported the importance of establishing biomarkers representing anticoagulation intensity related to bleeding or thrombotic events. To test the hypothesis that prothrombin activation fragment 1 and 2...

    journal_title:Journal of thrombosis and thrombolysis

    pub_type: 杂志文章


    authors: Ueno EI,Fujibayashi K,Sawaguchi J,Yasuda Y,Takano S,Fujioka N,Kawai Y,Fujita H,Tanaka Y,Kajinami K

    更新日期:2020-08-01 00:00:00