abstract：:Limited evidence exists regarding management of recurrent venous thromboembolism (VTE) that occurs during anticoagulant therapy. We aimed to describe patient characteristics, drug therapy management, and outcomes of patients with VTE recurrence during anticoagulant therapy. We identified 30 relevant episodes of VTE re...

journal_title：Journal of thrombosis and thrombolysis

authors： Lai N,Jones AE,Johnson SA,Witt DM

更新日期：2021-01-23 00:00:00

abstract：:The current, global situation regarding the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic and its potentially devastating clinical manifestations, i.e. coronavirus disease 2019 (COVID-19), took the world by storm, as millions of people have been infected worldwide and more than 1,600,000 patien...

journal_title：Journal of thrombosis and thrombolysis

authors： Moschonas IC,Tselepis AD

更新日期：2021-01-15 00:00:00

abstract：:Direct oral anticoagulant (DOAC) starter packs are designed for unique treatment dosing for acute venous thromboembolism (VTE). Inappropriate use of 30-day DOAC starter packs in patients with atrial fibrillation (AF) may increase the risk for bleeding events given higher dosing in the first 1-3 weeks of treatment. A r...

journal_title：Journal of thrombosis and thrombolysis

authors： Feng Y,Pai CW,Seiler K,Barnes GD

更新日期：2021-01-03 00:00:00

abstract：:Patients with Coronavirus-associated disease-2019 (COVID-19) display alterations of the hemostatic system and the presence of a prothrombotic status frequently leading to vascular complications. However, the impact of COVID-19 on platelet activity, aggregation and agglutination still needs to be clarified. We measured...

journal_title：Journal of thrombosis and thrombolysis

authors： Ruberto F,Chistolini A,Curreli M,Frati G,Marullo AGM,Biondi-Zoccai G,Mancone M,Sciarretta S,Miraldi F,Alessandri F,Ceccarelli G,Barone F,Santoro C,Alvaro D,Pugliese F,Pulcinelli FM,Policlinico Umberto I COVID-19 Group.

更新日期：2021-01-02 00:00:00

abstract：:Heparin induced thrombocytopenia (HIT) is a life and limb-threatening complication of heparin exposure. The misdiagnosis of this disease can have major consequences on the patients. The objective of this study was to evaluate a diagnostic strategy that combines the 4Ts score with the result of HemosIL® AcuStar HIT-IgG...

journal_title：Journal of thrombosis and thrombolysis

authors： Marashi-Sabouni Z,Vayne C,Ibrahim-Kosta M,Guidon C,Loundou A,Guery EA,Morange PE,Camoin-Jau L

更新日期：2021-01-01 00:00:00

abstract：:To analyze the efficacy and safety of activated prothrombin complex concentrates (aPCC) and four-factor prothrombin complex concentrates (4F-PCC) to prevent hematoma expansion in patients taking apixaban or rivaroxaban with intracranial hemorrhage (ICH). In this multicenter, retrospective study, sixty-seven ICH patien...

journal_title：Journal of thrombosis and thrombolysis

authors： Castillo R,Chan A,Atallah S,Derry K,Baje M,Zimmermann LL,Martin R,Groysman L,Stern-Nezer S,Minokadeh A,Nova A,Huang W,Cang W,Schomer K

更新日期：2021-01-01 00:00:00

abstract：:Gastrointestinal bleeding is the most common bleeding complication during anticoagulant therapy. A reliable bleeding risk score can help the clinician assess risk of bleeding in individual patients and select the anticoagulant regimen. This study retrospectively analyzed the data of patients with atrial fibrillation w...

journal_title：Journal of thrombosis and thrombolysis

authors： Lv MN,Zheng XC,Zhang HQ,Xu FD,Wu TT,Chen WJ,Xia XT,Fu JL,Jiang SJ,Zhang JH

更新日期：2021-01-01 00:00:00

abstract：:The predictive value of and the influencing factors associated with early neurological improvement (ENI) among patients with acute basilar artery occlusion (BAO) have not been well studied. The present study aimed to evaluate whether ENI predicted a better functional outcome and to identify the influencing factors of ...

journal_title：Journal of thrombosis and thrombolysis

authors： Sun X,Zhang H,Tong X,Gao F,Deng Y,Ma G,Ma N,Mo D,Song L,Liu L,Huo X,Miao Z

更新日期：2021-01-01 00:00:00

abstract：:External validation is a prerequisite in order for a prediction model to be introduced into clinical practice. Nonetheless, methodologically intact external validation studies are a scarce finding. Utilization of big datasets can help overcome several causes of methodological failure. However, transparent reporting is...

journal_title：Journal of thrombosis and thrombolysis

authors： Nikolakopoulos I,Nourabadi S,Eldredge JB,Anand L,Zhang M,Qiu M,Rosenberg D,Spyropoulos AC

更新日期：2021-01-01 00:00:00

abstract：:Whitmania pigra Whitman (W. pigra) has been widely employed in decoction for the treatment of blood stasis syndrome for many years in China. The aim of the present study was to explore the anti-venous thrombosis (VT) mechanism of the aqueous extract of W. pigra (AEW) in rats. Rats were orally administered with AEW. A ...

journal_title：Journal of thrombosis and thrombolysis

authors： Li P,Lin B,Tang P,Ye Y,Wu Z,Gui S,Zhan Y,Yang W,Lin B

更新日期：2020-11-17 00:00:00

abstract：:Multiple clinical risk prediction tools for hospital acquired venous thromboembolism (HA-VTE) have been developed. The objectives of this study were to develop and assess the feasibility of data extraction from Electronic Medical Records (EMR) from an enterprise database warehouse (EDW) and to test the validity of a p...

journal_title：Journal of thrombosis and thrombolysis

authors： Schultz RF,Sharathkumar A,Kwon S,Doerfer K,Lales G,Bhat R

更新日期：2020-11-01 00:00:00

abstract：:Several autopsy studies showed microthrombi in pulmonary circulation of severe COVID-19 patients. The major limitation of these investigations is that the autopsy provided static information. Some of these alterations could be secondary to the disseminated intravascular coagulation (DIC) observed as the final standard...

journal_title：Journal of thrombosis and thrombolysis

authors： do Espírito Santo DA,Lemos ACB,Miranda CH

更新日期：2020-11-01 00:00:00

abstract：:Patients with COVID-19 are known to be at risk of developing both venous, arterial and microvascular thrombosis, due to an excessive immuno-thrombogenic response to the SARS-CoV-2 infection. Overlapping syndromes of COVID-19 associated coagulopathy with consumptive coagulopathy and microangiopathy can be seen in criti...

journal_title：Journal of thrombosis and thrombolysis

authors： Fan BE,Ng J,Chan SSW,Christopher D,Tso ACY,Ling LM,Young BE,Wong LJL,Sum CLL,Tan HT,Ang MK,Lim GH,Ong KH,Kuperan P,Chia YW

更新日期：2020-10-24 00:00:00

abstract：:One of the major mechanisms of action of chemo-radiation is to induce cellular senescence, which exerts crucial roles in age-related pathology. The concept of senescence is evolved, and the novel understanding of senescence-associated reprogramming/stemness has emerged. This new concept emphasizes senescence as not on...

journal_title：Journal of thrombosis and thrombolysis

authors： Dominic A,Hamilton D,Abe JI

更新日期：2020-10-20 00:00:00

abstract：:The relationship between vascular-specific epicardial adipose tissue (vEAT) volume and myocardial ischemia measured by fractional flow reserve (FFR) was not well investigated. Patients with typical and atypical chest pain undergoing coronary computed tomographic angiography scan followed by invasive coronary angiograp...

journal_title：Journal of thrombosis and thrombolysis

authors： Shan D,Wang X,Dou G,Zhang W,Jing J,He B,Li Y,Chen Y,Yang J

更新日期：2020-10-17 00:00:00

abstract：:Cardiac disease following radiation therapy represents a major consideration in the treatment of a variety of malignancies. Damage to the heart can manifest in a variety of pathologies including ischemic cardiac disease, cardiomyopathy, valvular dysfunction, arrhythmias, and pericarditis. This damage has been shown to...

journal_title：Journal of thrombosis and thrombolysis

authors： Frankart AJ,Nagarajan R,Pater L

更新日期：2020-10-08 00:00:00

abstract：:Edoxaban, alongside other direct oral anticoagulants (DOAC), is increasingly used for prevention of thromboembolism, including stroke. Despite DOAC therapy, however, annual stroke rate in patients with atrial fibrillation remains 1-2%. Rapid exclusion of relevant anticoagulation is necessary to guide thrombolysis or r...

journal_title：Journal of thrombosis and thrombolysis

authors： Härtig F,Birschmann I,Peter A,Hörber S,Ebner M,Sonnleitner M,Spencer C,Bombach P,Stefanou MI,Kuhn J,Mengel A,Ziemann U,Poli S

更新日期：2020-10-01 00:00:00

abstract：:Thrombotic thrombocytopenic purpura (TTP) is a life-threatening thrombotic microangiopathy caused by severely reduced activity of the von-Willebrand factor-cleaving protease ADAMTS13, mainly caused by anti-ADAMTS-13 antibodies. Although several test systems for ADAMTS13 measurement exist, long turn-around times hamper...

journal_title：Journal of thrombosis and thrombolysis

authors： Stratmann J,Ward JN,Miesbach W

更新日期：2020-10-01 00:00:00

abstract：:The relation of device related thrombosis (DRT) and major bleeding after left atrial appendage closure (LAAC) to laboratory thrombosis and hemostasis markers has not been studied. We performed a prospective case control study to identify clinical characteristics and laboratory markers in patients who developed DRT and...

journal_title：Journal of thrombosis and thrombolysis

authors： Sherwood M,Bliden KP,Ilkhanoff L,Venkataraman G,Strickberger A,Yazdani S,McSwain R,Rashid H,Navarese EP,Plummer T,Batchelor W,Chaudhary R,Tantry US,Gurbel PA

更新日期：2020-10-01 00:00:00

abstract：:Persisting heparin-induced thrombocytopenia (HIT) is characterized by ongoing thrombocytopenia more than 7 days after stopping heparin. It is part of cases referred to as autoimmune HIT (aHIT). In contrast to typical HIT cases, aHIT involves heparin-independent platelet activation mechanism highlighted by a strongly p...

journal_title：Journal of thrombosis and thrombolysis

authors： Roberge G,Tritschler T,MacGillivray C,Dufresne L,Nagpal SK,Scarvelis D

更新日期：2020-10-01 00:00:00

abstract：:A perceived increased risk of bleeding is one of the most frequent reasons for withholding anticoagulation for stroke prevention in atrial fibrillation (AF). We previously conducted a randomized controlled trial of alert-based computerized decision support to increase prescription of anticoagulation in hospitalized pa...

journal_title：Journal of thrombosis and thrombolysis

authors： Piazza G,Hurwitz S,Carroll B,Goldhaber SZ

更新日期：2020-09-30 00:00:00

abstract：:Intracerebral hemorrhage (ICH) can be a devastating complication of coronavirus disease (COVID-19). We aimed to assess risk factors associated with ICH in this population. We performed a retrospective cohort study of adult patients admitted to NYU Langone Health system between March 1 and April 27 2020 with a positive...

journal_title：Journal of thrombosis and thrombolysis

authors： Melmed KR,Cao M,Dogra S,Zhang R,Yaghi S,Lewis A,Jain R,Bilaloglu S,Chen J,Czeisler BM,Raz E,Lord A,Berger JS,Frontera JA

更新日期：2020-09-24 00:00:00

abstract：:Tranexamic acid (TXA) can reduce blood loss and transfusion rates in orthopaedic surgery. In this regard, a new viscoelastometric test (TPA-test, ClotPro), enables the monitoring of TXA effects. This prospective observational study evaluated and correlated TXA plasma concentrations (cTXA) following intravenous and ora...

journal_title：Journal of thrombosis and thrombolysis

authors： Groene P,Sappel SR,Saller T,Nitschke T,Sa PA,Paulus A,Chappell D,Schäfer ST

更新日期：2020-09-12 00:00:00

abstract：:A definitive diagnosis of heparin-induced thrombocytopenia (HIT) is difficult to make, especially in patients undergoing cardiac surgery. In this retrospective cohort study, we assessed the platelet count trends and the response to fondaparinux in a population of patients of suspected HIT after pulmonary endarterectom...

journal_title：Journal of thrombosis and thrombolysis

authors： Li JF,Wu LJ,Wen GY,Zhou RR,Liu F,Wang W,Yang SQ,Gong JN,Miao R,Gu S,Liu Y,Yang YH

更新日期：2020-09-07 00:00:00

abstract：:Coagulation dysfunction and inflammatory status were compared between diabetic and non-diabetic COVID-19 patients. The standardized mean difference (SMD) and its 95% confidence interval (CI) was computed for the difference of inflammatory and hypercoagulability markers. The levels of serum ferritin (standardized mean ...

journal_title：Journal of thrombosis and thrombolysis

authors： Varikasuvu SR,Varshney S,Dutt N

更新日期：2020-09-05 00:00:00

abstract：:Deep vein thrombosis (DVT) in hemiplegic patients mainly affects hemiplegic limbs, DVT can also occur only in healthy limbs, and some hemiplegic patients have DVT in both limbs. Characteristics and risk factors of DVT in hemiplegic, healthy, and bilateral limbs are unknown. To describe the proportion, risk factors, ex...

journal_title：Journal of thrombosis and thrombolysis

authors： Liang F,Chao M,Li JB,Ye XM

更新日期：2020-08-27 00:00:00

abstract：:No study investigated the possible detrimental effect of stress hyperglycemia on patients affected acute ischemic stroke (AIS) undergoing intravenous thrombolysis (IVT). A new index, the glucose-to-glycated hemoglobin ratio (GAR), has been developed for assessing stress hyperglycemia. We retrospectively analyzed data ...

journal_title：Journal of thrombosis and thrombolysis

authors： Merlino G,Smeralda C,Gigli GL,Lorenzut S,Pez S,Surcinelli A,Marini A,Valente M

更新日期：2020-08-24 00:00:00

abstract：:Infective endocarditis (IE) remains a severe illness with high mortality rate, despite advances in antibiotic therapy and cardiac surgery. If infectious bacteria and platelets are two key players of human IE vegetation developmental process, their interactions and respective roles in fully developed late-stage IE vege...

journal_title：Journal of thrombosis and thrombolysis

authors： Baudoin JP,Camoin-Jau L,Prasanth A,Habib G,Lepidi H,Hannachi N

更新日期：2020-08-04 00:00:00

abstract：:This study investigates the association between the treatment with heparin and mortality in patients admitted with Covid-19. Routinely recorded, clinical data, up to the 24th of April 2020, from the 2075 patients with Covid-19, admitted in 17 hospitals in Spain between the 1st of March and the 20th of April 2020 were ...

journal_title：Journal of thrombosis and thrombolysis

authors： Ayerbe L,Risco C,Ayis S

更新日期：2020-08-01 00:00:00

abstract：:Factor Xa (FXa) inhibitors are recommended for use in fixed doses without laboratory monitoring. However, prior studies reported the importance of establishing biomarkers representing anticoagulation intensity related to bleeding or thrombotic events. To test the hypothesis that prothrombin activation fragment 1 and 2...

journal_title：Journal of thrombosis and thrombolysis

authors： Ueno EI,Fujibayashi K,Sawaguchi J,Yasuda Y,Takano S,Fujioka N,Kawai Y,Fujita H,Tanaka Y,Kajinami K

更新日期：2020-08-01 00:00:00

abstract：:Patients with non-valvular atrial fibrillation who are under chronic oral anticoagulant therapy (OAC) treatment frequently require interruption of OAC treatment. By examining the presence of left atrial/left atrial appendage (LA/LAA) thrombus or dense spontaneous echo contrast (SEC) with transesophageal echocardiograp...

journal_title：Journal of thrombosis and thrombolysis

authors： Durmaz E,Karadag B,İkitimur B,Ebren C,Tokdil H,Koca D,Ozmen E,Polat F,Ohtaroglu Tokdil K,Raimoglu U,Mutlu D,Atici A,Ongen Z

更新日期：2020-08-01 00:00:00

abstract：:Amniotic fluid embolism (AFE) is a catastrophic condition in the peripartum period and still remains as a leading cause of maternal death. Although over 80% of cases of AFE cases are accompanied by coagulopathy, the pathology of disseminated intravascular coagulation is not well understood not only because of its rari...

journal_title：Journal of thrombosis and thrombolysis

authors： Fudaba M,Tachibana D,Misugi T,Nakano A,Koyama M

更新日期：2020-07-29 00:00:00

abstract：:Previous studies have reported a circadian variation in the onset of ST-segment elevation myocardial infarction (STEMI). However, underlying mechanisms for the circadian variation have not been fully elucidated. We investigated the relationship between onset of STEMI and the underlying pathology using optical coherenc...

journal_title：Journal of thrombosis and thrombolysis

authors： Araki M,Yonetsu T,Kurihara O,Nakajima A,Lee H,Soeda T,Minami Y,Higuma T,Kimura S,Takano M,Yan BP,Adriaenssens T,Boeder NF,Nef HM,Kim CJ,Crea F,Kakuta T,Jang IK

更新日期：2020-07-10 00:00:00

abstract：:The outbreak of 2019 novel coronavirus disease (COVID-19) began since early December 2019, and has been declared as a public health emergency by the World Health Organization. Due to the hypercoagulable state, blood stasis and endothelial injury, severe patients with COVID-19 are at high risk for thrombosis. We report...

journal_title：Journal of thrombosis and thrombolysis

authors： Zhou B,She J,Wang Y,Ma X

更新日期：2020-07-01 00:00:00

abstract：:Anticoagulant plasma concentrations and patient characteristics might affect the benefit-risk balance of therapy. The study objective was to assess the impact of model-predicted rivaroxaban exposure and patient characteristics on outcomes in patients receiving rivaroxaban for venous thromboembolism (VTE) prophylaxis (...

journal_title：Journal of thrombosis and thrombolysis

authors： Reinecke I,Solms A,Willmann S,Spiro TE,Peters G,Weitz JI,Mueck W,Garmann D,Schmidt S,Zhang L,Fox KAA,Berkowitz SD

更新日期：2020-07-01 00:00:00

abstract：:Right ventricular (RV) enlargement, determined via the ratio of the right to left ventricular diameters (RV/LV) by CT imaging is used to classify the severity of acute pulmonary embolism (PE) and impacts treatment decisions. The RV/LV ratio may be an unreliable marker of RV dysfunction, due in part to the complex RV g...

journal_title：Journal of thrombosis and thrombolysis

authors： Marginean A,Putnam A,Hirai T,Serritella A,Besser SA,Lee M,Friant J,Blair J,Shah A,Nathan S,Chung J,Paul J

更新日期：2020-07-01 00:00:00

abstract：:The optimal antithrombotic therapy for patients undergoing TAVI with concomitant indication for oral anticoagulation remains unclear. In this high-risk population group, there is a paucity of data with regards to the use of DOACs. In the present study we compared long-term clinical outcomes of TAVI patients requiring ...

journal_title：Journal of thrombosis and thrombolysis

authors： Kalogeras K,Jabbour RJ,Ruparelia N,Watson S,Kabir T,Naganuma T,Vavuranakis M,Nakamura S,Malik IS,Mikhail G,Dalby M,Panoulas V

更新日期：2020-07-01 00:00:00

abstract：:The role of the A>G polymorphism at position 19911 in the prothrombin gene (factor [F] 2 at rs3136516) as a risk factor for venous thromboembolism [VTE] is still unclear. To evaluate the presence of the F2 polymorphism in VTE patients compared to healthy blood donors and to adjust the results for common inherited thro...

journal_title：Journal of thrombosis and thrombolysis

authors： Limperger V,Kenet G,Kiesau B,Köther M,Schmeiser M,Langer F,Juhl D,Shneyder M,Franke A,Klostermeier UK,Mesters R,Rühle F,Stoll M,Steppat D,Kowalski D,Rocke A,Kuta P,Bajorat T,Torge A,Neuner B,Junker R,Nowak-Göttl

更新日期：2020-06-27 00:00:00

abstract：:The impact of platelet parameters on the cardiovascular risk is still debated. Gender differences in platelet volume indexes and turnover have been previously reported, potentially conditioning their role in the development of coronary artery disease (CAD). However, few studies have addressed, so far, the impact of ge...

journal_title：Journal of thrombosis and thrombolysis

authors： Negro F,Verdoia M,Tonon F,Nardin M,Kedhi E,De Luca G,Novara Atherosclerosis Study Group (NAS).

更新日期：2020-05-01 00:00:00

abstract：:There were limited studies comparing the anterior (AC) and posterior (PC) circulation acute ischemic strokes (AIS). Our study aimed to evaluate distinct features of AC and PC strokes regarding clinical, vascular risk, pathogenesis and outcome factors after endovascular procedures. This multicenter prospective study re...

journal_title：Journal of thrombosis and thrombolysis

authors： Huo X,Raynald,Gao F,Ma N,Mo D,Sun X,Song L,Jia B,Pan Y,Wang Y,Liu L,Zhao X,Wang Y,Miao Z,ANGEL investigators.

更新日期：2020-05-01 00:00:00