Selective thromboxane inhibition after vascular protectant AGI-1067: results of assessment of lipoprotein profiles (ALPS) biomarkers in vitro and in vivo substudy.

abstract：:The relationship between vascular-specific epicardial adipose tissue (vEAT) volume and myocardial ischemia measured by fractional flow reserve (FFR) was not well investigated. Patients with typical and atypical chest pain undergoing coronary computed tomographic angiography scan followed by invasive coronary angiograp...

journal_title：Journal of thrombosis and thrombolysis

authors： Shan D,Wang X,Dou G,Zhang W,Jing J,He B,Li Y,Chen Y,Yang J

更新日期：2020-10-17 00:00:00

abstract：:Patients with heparin-induced thrombocytopenia (HIT) type II require anticoagulation with non-heparin immediate acting anticoagulants. Danaparoid may cross react with HIT-antibodies and lepirudin may generate anti-lepirudin antibodies influencing anticoagulation. We hypothesised, that the synthetic small molecular thr...

journal_title：Journal of thrombosis and thrombolysis

authors： Harenberg J,Jörg I,Fenyvesi T,Piazolo L

更新日期：2005-02-01 00:00:00

abstract：:Making a definitive diagnosis of heparin-induced thrombocytopenia (HIT) can be problematic. A prompt platelet rise following treatment has been proposed as a "post-test" criterion for diagnosis. However, the platelet response following discontinuation of heparin and initiation of a recommended alternative anticoagulan...

journal_title：Journal of thrombosis and thrombolysis

authors： Pon TK,Mahajan A,Rosenberg A,Amin A,Shah D,Jenkins I,Gupta V,Hofmann H,Bejjani A,White R

更新日期：2018-05-01 00:00:00

abstract：:Measurements of infarct size by use of tripenyltetrazoliumchloride (TTC) is a widely accepted method used to delineate the extent of myocardial necrosis following coronary occlusion and reperfusion in various animal experiments. There is controversy, however, regarding the optimal reperfusion time for estimating the m...

journal_title：Journal of thrombosis and thrombolysis

authors： Schwarz ER,Somoano Y,Hale SL,Kloner RA

更新日期：2000-10-01 00:00:00

abstract：:The dosage of warfarin is restricted due to its narrow therapeutic index, so, the required dose must be adapted individually to each patient. Variations in warfarin dosage are influenced by genetic factors, the changes in patient diet, anthropometric and clinical parameters. To determine whether VKORC1 G3730A and CYP4...

journal_title：Journal of thrombosis and thrombolysis

authors： Tatarunas V,Lesauskaite V,Veikutiene A,Grybauskas P,Jakuska P,Jankauskiene L,Bartuseviciute R,Benetis R

更新日期：2014-01-01 00:00:00

abstract：:Tranexamic acid (TXA) can reduce blood loss and transfusion rates in orthopaedic surgery. In this regard, a new viscoelastometric test (TPA-test, ClotPro), enables the monitoring of TXA effects. This prospective observational study evaluated and correlated TXA plasma concentrations (cTXA) following intravenous and ora...

journal_title：Journal of thrombosis and thrombolysis

authors： Groene P,Sappel SR,Saller T,Nitschke T,Sa PA,Paulus A,Chappell D,Schäfer ST

更新日期：2020-09-12 00:00:00

abstract：AIMS:Cancer patients have an increased risk for thromboembolism (TE). Factor V 1691 G-A(Leiden) (FVL) and prothrombin (PT) G20210A mutation are common inherited risk factor for TE. The aim of the study is to evaluate the prevalence of FVL and PT G20210A polymorphism in cancer patients with and without TE as compared to...

journal_title：Journal of thrombosis and thrombolysis

authors： Eroglu A,Ulu A,Cam R,Kurtman C,Akar N

更新日期：2007-02-01 00:00:00

abstract：:Pump thrombosis remains a serious complication of implantable ventricular assist device therapy and is associated with increased risk of morbidity and mortality. Optimal management strategies remain controversial and are guided largely by limited literature and expert opinion. Medical management of pump thrombosis, in...

journal_title：Journal of thrombosis and thrombolysis

authors： Weeks P,Sieg A,Rajapreyar I,Nathan S,Jumean M,Patel M,Radovancevic R,Kar B,Gregoric I

更新日期：2018-11-01 00:00:00

abstract：:We have applied the low molecular weight heparin dalteparin as once-daily subcutaneous injections to the treatment of deep vein thrombosis (DVT) on an outpatient basis since 1994. Until today, 377 consecutive patients with DVT below the inguinal ligament have been treated at home with dalteparin. The patients administ...

journal_title：Journal of thrombosis and thrombolysis

authors： Stockelberg D,Hansson E,Jonson T

更新日期：1998-09-01 00:00:00

abstract：:Dual antiplatelet therapy with aspirin and clopidogrel are recommended as adjuncts to fibrinolytic-treated patients with ST-elevation myocardial infarction (STEMI). However, the role of switching to ticagrelor within 24 h of fibrinolytics compared with clopidogrel continuation in this setting is uncertain. Hence, we c...

journal_title：Journal of thrombosis and thrombolysis

authors： Kheiri B,Osman M,Abdalla A,Haykal T,Barbarawi M,Zayed Y,Hicks M,Ahmed S,Bachuwa G,Hassan M,Bhatt DL

更新日期：2018-10-01 00:00:00

abstract：:Stroke and other thromboembolic events are mainly caused by emboli from heart, aorta and other arteries. In this paper we describe a group of 5 middle-aged patients suffering from emboli caused by large thrombi in the aorta. Since the development of giant thrombi under high flow conditions in the aorta is a pathophysi...

journal_title：Journal of thrombosis and thrombolysis

authors： Stoevesandt D,Klempt C,Scheubel R,Herr W,Hettwer S,Werdan K,Silber RE,Kraya T,Thews O,Schlitt A

更新日期：2013-02-01 00:00:00

abstract：:Plasminogen activator inhibitor (PAI-1), a member of the serine protein family, is the most active in vivo inhibitor of fibrinolysis induced by plasminogen, tissue plasminogen activator (tPA), and urokinase type plasminogen activator (uPA). While the association between elevated PAI-1 and thrombogenesis has been well ...

journal_title：Journal of thrombosis and thrombolysis

authors： Senno SL,Pechet L

更新日期：1999-08-01 00:00:00

abstract：:Patients with inflammatory bowel disease (IBD) have a 1.5-3.5-fold higher risk of thromboembolism when compared to the non-IBD population and the risk is much more prominent at the time of a flare. Arterial thromboembolism (ischemic stroke, focal white matter ischemia, cardiac ischemia, peripheral vascular disease and...

journal_title：Journal of thrombosis and thrombolysis

authors： Kohoutova D,Moravkova P,Kruzliak P,Bures J

更新日期：2015-05-01 00:00:00

abstract：:Fever is a presenting sign in some patients with acute deep venous thrombosis (DVT), but its influence on outcome has not been thoroughly investigated. RIETE is an ongoing, international, observational registry of consecutive patients with symptomatic, objectively confirmed, acute venous thromboembolism. The aim of th...

journal_title：Journal of thrombosis and thrombolysis

authors： Barba R,Di Micco P,Blanco-Molina A,Delgado C,Cisneros E,Villalta J,Morales MV,Bura-Riviere A,Debourdeau P,Monreal M

更新日期：2011-10-01 00:00:00

abstract：:Asymmetric dimethylarginine (ADMA) typically accumulates in the plasma of patients with chronic renal failure. Moreover, its plasma levels are raised in the presence of virtually all of the traditional cardiovascular risk factors. ADMA inhibits the three isoforms of nitric oxide (NO) synthase, thereby blunting the kno...

journal_title：Journal of thrombosis and thrombolysis

authors： Coluzzi G,Santucci E,Marzo F,Andreotti F

更新日期：2009-02-01 00:00:00

abstract：:Polycythemia vera (PV), essential thrombocythemia (ET) and idiopathic myelofibrosis (IMF), collectively known as Philadelphia-negative (Ph-negative) chronic myeloproliferative neoplasms (MPNs), MPNs represent the most common causes of splanchnic vein thrombosis (SVT), including Budd-Chiari syndrome (BCS) and portal ve...

journal_title：Journal of thrombosis and thrombolysis

authors： Yonal I,Pinarbası B,Hindilerden F,Hancer VS,Nalcaci M,Kaymakoglu S,Diz-Kucukkaya R

更新日期：2012-10-01 00:00:00

abstract：:Early rapid platelet inhibition with abciximab before primary percutaneous coronary intervention (PPCI) for ST-segment elevation myocardial infarction (STEMI) is suggested as beneficial. In previous studies on early abciximab administration clopidogrel was administered in cathlab in low loading dose. We investigated t...

journal_title：Journal of thrombosis and thrombolysis

authors： Dudek D,Rakowski T,Bartus S,Giszterowicz D,Dobrowolski W,Zmudka K,Zalewski J,Ochala A,Wieja P,Janus B,Dziewierz A,Legutko J,Bryniarski L,Dubiel JS

更新日期：2010-10-01 00:00:00

abstract：:Argatroban, a hepatically metabolized direct thrombin inhibitor, is approved for anticoagulation in patients with or at risk of heparin-induced thrombocytopenia (HIT) undergoing percutaneous coronary intervention (PCI). We investigated the effect of renal function on argatroban therapy during PCI. From previous argatr...

journal_title：Journal of thrombosis and thrombolysis

authors： Hursting MJ,Jang IK

更新日期：2010-01-01 00:00:00

abstract：:Thrombosis resolution is an important component of treatment for deep vein thrombosis (DVT) and multiple anticoagulants are now available. It is unknown whether rivaroxaban contributes to a higher degree of thrombus resolution compared to conventional anticoagulation with warfarin. Our objective was to compare thrombu...

journal_title：Journal of thrombosis and thrombolysis

authors： Houghton DE,Lekah A,Macedo TA,Hodge D,Saadiq RA,Little Y,Casanegra AI,McBane RD,Wysokinski WE

更新日期：2020-02-01 00:00:00

abstract：:It has been reported that platelet expression and plasma levels of soluble P-selectin are increased in patients with unstable coronary artery syndromes. However, the origin of soluble P-selectin remains unknown. We sought to determine whether platelet expression of P-selectin correlates with plasma levels in the popul...

journal_title：Journal of thrombosis and thrombolysis

authors： Gurbel PA,Kereiakes DJ,Serebruany VL

更新日期：2000-08-01 00:00:00

abstract：:A definitive diagnosis of heparin-induced thrombocytopenia (HIT) is difficult to make, especially in patients undergoing cardiac surgery. In this retrospective cohort study, we assessed the platelet count trends and the response to fondaparinux in a population of patients of suspected HIT after pulmonary endarterectom...

journal_title：Journal of thrombosis and thrombolysis

authors： Li JF,Wu LJ,Wen GY,Zhou RR,Liu F,Wang W,Yang SQ,Gong JN,Miao R,Gu S,Liu Y,Yang YH

更新日期：2020-09-07 00:00:00

abstract：:The effect of taurine on the plasma levels of L-arginine, asymmetrical dimethylarginine (ADMA) and L-arginine/ADMA ratio and nitric oxide was investigated in experimental endotoxemia. L-arginine and ADMA levels were quantified by high performance liquid chromatography with fluorescence detector. Nitric oxide level was...

journal_title：Journal of thrombosis and thrombolysis

authors： Balabanli B,Erdamar H,Türközkan N,Yaman H,Kurt Y

更新日期：2007-08-01 00:00:00

abstract：:Anticoagulation is often used in superior vena cava syndrome (SVCS) associated with cancer (i.e malignant SVCS), even without thrombosis, but its effect on outcomes has not been reported. We aimed to determine factors and outcomes associated with thrombosis and anticoagulation in malignant SVCS. Patients with malignan...

journal_title：Journal of thrombosis and thrombolysis

authors： Ratzon R,Tamir S,Friehmann T,Livneh N,Dudnik E,Rozental A,Hamburger-Avnery O,Pereg D,Derazne E,Brenner B,Raanani P,Ten Cate H,Spectre G,Leader A

更新日期：2019-01-01 00:00:00

abstract：:To assess the effect of cessation of dual antiplatelet therapy (DAPT) regimens containing 2nd generation P2Y12 inhibitors on platelet reactivity, in patients who completed 12 months of DAPT following an acute myocardial infarction. Clinical data has shown an increased cardiovascular risk in the 90 days following cessa...

journal_title：Journal of thrombosis and thrombolysis

authors： Witberg G,Bathish J,Bental T,Leshem-Lev D,Assali A,Kornowski R,Lev E

更新日期：2018-10-01 00:00:00

abstract：:Poloxamer 188 is a surfactant with hemorheological, antithrombotic, and neutrophil-inhibitory properties. This agent has been demonstrated to reduce infarct size and to improve left ventricular function in animal models of myocardial infarction and reperfusion, and recently in a randomized trial of patients receiving ...

journal_title：Journal of thrombosis and thrombolysis

authors： Kelly RF,Hursey TL,Patel RB,Parrillo JE,Schaer GL

更新日期：1998-07-01 00:00:00

abstract：:Hyperhomocysteinemia (HHcy) affects haemostasis and shifts its balance in favour of thrombosis. In vitro and in vivo studies suggested that HHcy may impair fibrinolysis either by influencing the plasma levels of fibrinolytic factors or by altering the fibrinogen structure. We investigated the influence of mild HHcy le...

journal_title：Journal of thrombosis and thrombolysis

authors： Cellai AP,Lami D,Antonucci E,Liotta AA,Rogolino A,Fedi S,Fiorillo C,Becatti M,Cenci C,Marcucci R,Abbate R,Prisco D

更新日期：2014-07-01 00:00:00

abstract：:The risk benefit decision in providing anticoagulation for patients with brain metastases is amongst the most difficult decisions faced by clinicians. The purpose of our study was to evaluate both the risk of intracerebral hemorrhage (ICH) associated with anticoagulation therapy and the effect of anticoagulation on su...

journal_title：Journal of thrombosis and thrombolysis

authors： Hunter BD,Minichiello T,Bent S

更新日期：2017-10-01 00:00:00

abstract：:Heparin-induced thrombocytopenia (HIT) is a prothrombotic condition and it is associated with increased in vivo thrombin generation that needs to be treated with non-heparin anticoagulants such as direct thrombin inhibitors (DTIs). DTIs require parenteral administration and are associated with a non negligible risk of...

journal_title：Journal of thrombosis and thrombolysis

authors： Sartori M,Favaretto E,Cini M,Legnani C,Cosmi B

更新日期：2015-10-01 00:00:00

abstract：:The American College of Chest Physicians (ACCP) has established guidelines for the treatment of VTE, but the generalizability to all populations is unclear. In this review we analyzed the rate of reporting and enrollment of blacks and women in clinical trials cited in the ACCP guidelines for treatment of unprovoked VT...

journal_title：Journal of thrombosis and thrombolysis

authors： Sullivan LT 2nd,Jackson LR 2nd,Thomas KL

更新日期：2016-08-01 00:00:00

abstract：:The duration of oral anticoagulant therapy for venous thromboembolism (VTE) depends on the risk of recurrence if treatment is stopped and the risk of bleeding if treatment is continued. If the risk of recurrence is low (e.g., thrombosis provoked by a major reversible risk factor such as surgery), 3 months of treatment...

journal_title：Journal of thrombosis and thrombolysis

authors： Kearon C

更新日期：2001-09-01 00:00:00