Abstract：
:Asymmetric dimethylarginine (ADMA) typically accumulates in the plasma of patients with chronic renal failure. Moreover, its plasma levels are raised in the presence of virtually all of the traditional cardiovascular risk factors. ADMA inhibits the three isoforms of nitric oxide (NO) synthase, thereby blunting the known cardioprotective effects of NO. Through its NO inhibitor actions, ADMA also exerts pro-apoptotic effects and suppresses progenitor cell mobilization, differentiation and function. Among patients with ischemic heart disease, low progenitor cell bioavailability and kidney dysfunction are emerging as strong predictors of death and recurrent cardiovascular events. We propose that patients with ischemic heart disease, kidney dysfunction, and high risk factor burden exhibit adverse cardiovascular outcomes, at least in part, through ADMA-mediated NO depression, enhanced apoptotic signalling, and reduced progenitor cell bioavailability, with consequent blunting of cardiovascular healing. Further research into the mechanisms that regulate the NO/ADMA balance may advance our understanding of cardiovascular diseases.
journal_name
J Thromb Thrombolysisjournal_title
Journal of thrombosis and thrombolysisauthors
Coluzzi G,Santucci E,Marzo F,Andreotti Fdoi
10.1007/s11239-007-0181-ysubject
Has Abstractpub_date
2009-02-01 00:00:00pages
168-71issue
2eissn
0929-5305issn
1573-742Xjournal_volume
27pub_type
杂志文章abstract：:It has been reported that platelet expression and plasma levels of soluble P-selectin are increased in patients with unstable coronary artery syndromes. However, the origin of soluble P-selectin remains unknown. We sought to determine whether platelet expression of P-selectin correlates with plasma levels in the popul...
journal_title：Journal of thrombosis and thrombolysis
pub_type： 临床试验,杂志文章,多中心研究
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journal_title：Journal of thrombosis and thrombolysis
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journal_title：Journal of thrombosis and thrombolysis
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doi：10.1007/s11239-019-01805-0
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journal_title：Journal of thrombosis and thrombolysis
pub_type： 临床试验,杂志文章,多中心研究
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pub_type： 杂志文章
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journal_title：Journal of thrombosis and thrombolysis
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doi：10.1007/s11239-014-1077-2
更新日期：2014-10-01 00:00:00
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journal_title：Journal of thrombosis and thrombolysis
pub_type： 杂志文章
doi：10.1007/s11239-007-0191-9
更新日期：2009-01-01 00:00:00
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journal_title：Journal of thrombosis and thrombolysis
pub_type： 杂志文章,多中心研究,随机对照试验
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更新日期：2009-05-01 00:00:00
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journal_title：Journal of thrombosis and thrombolysis
pub_type： 杂志文章,随机对照试验
doi：10.1007/s11239-014-1081-6
更新日期：2014-10-01 00:00:00
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journal_title：Journal of thrombosis and thrombolysis
pub_type： 杂志文章
doi：10.1007/s11239-015-1269-4
更新日期：2016-05-01 00:00:00
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journal_title：Journal of thrombosis and thrombolysis
pub_type： 杂志文章
doi：10.1007/s11239-019-01894-x
更新日期：2019-08-01 00:00:00
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journal_title：Journal of thrombosis and thrombolysis
pub_type： 临床试验,杂志文章
doi：10.1007/s11239-008-0262-6
更新日期：2009-07-01 00:00:00
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journal_title：Journal of thrombosis and thrombolysis
pub_type： 杂志文章
doi：10.1007/s11239-020-02254-w
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journal_title：Journal of thrombosis and thrombolysis
pub_type： 杂志文章
doi：10.1007/s11239-020-02316-z
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pub_type： 杂志文章
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journal_title：Journal of thrombosis and thrombolysis
pub_type： 杂志文章
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journal_title：Journal of thrombosis and thrombolysis
pub_type： 杂志文章,meta分析
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更新日期：2018-10-01 00:00:00
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journal_title：Journal of thrombosis and thrombolysis
pub_type： 杂志文章,多中心研究,随机对照试验
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journal_title：Journal of thrombosis and thrombolysis
pub_type： 杂志文章
doi：10.1007/s11239-018-1686-2
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pub_type： 杂志文章,随机对照试验
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更新日期：2019-04-01 00:00:00
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pub_type： 杂志文章
doi：10.1007/s11239-004-0170-3
更新日期：2004-08-01 00:00:00
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journal_title：Journal of thrombosis and thrombolysis
pub_type： 杂志文章,评审
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更新日期：2017-10-01 00:00:00
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journal_title：Journal of thrombosis and thrombolysis
pub_type： 杂志文章
doi：10.1007/s11239-019-01932-8
更新日期：2020-02-01 00:00:00
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journal_title：Journal of thrombosis and thrombolysis
pub_type： 杂志文章
doi：10.1007/s11239-016-1401-0
更新日期：2017-01-01 00:00:00
