Impact of early abciximab administration on myocardial reperfusion in patients with ST-segment elevation myocardial infarction pretreated with 600 mg of clopidogrel before percutaneous coronary intervention.

abstract：:Heparin-induced thrombocytopenia (HIT) is a prothrombotic condition and it is associated with increased in vivo thrombin generation that needs to be treated with non-heparin anticoagulants such as direct thrombin inhibitors (DTIs). DTIs require parenteral administration and are associated with a non negligible risk of...

journal_title：Journal of thrombosis and thrombolysis

authors： Sartori M,Favaretto E,Cini M,Legnani C,Cosmi B

更新日期：2015-10-01 00:00:00

abstract：:Intracerebral hemorrhage (ICH) can be a devastating complication of coronavirus disease (COVID-19). We aimed to assess risk factors associated with ICH in this population. We performed a retrospective cohort study of adult patients admitted to NYU Langone Health system between March 1 and April 27 2020 with a positive...

journal_title：Journal of thrombosis and thrombolysis

authors： Melmed KR,Cao M,Dogra S,Zhang R,Yaghi S,Lewis A,Jain R,Bilaloglu S,Chen J,Czeisler BM,Raz E,Lord A,Berger JS,Frontera JA

更新日期：2020-09-24 00:00:00

abstract：:Objective: To define the changing incidence, risk, and therapy of acute myocardial infarction (A311). Data sources: Review of contemporary AMI data from the University of Alberta Hospitals, six other sites of the Clinical Quality Improvement Network (CQIN), and other Canadian and international centers. Data synthesis:...

journal_title：Journal of thrombosis and thrombolysis

authors： Montague T,Montague P,Barnes M,Taylor L,Wowk L,Fassbender K,Ackman M,Martin S,Armstrong PW,Teo K

更新日期：1996-01-01 00:00:00

abstract：:In experimentally induced myocardial ischemia, mild hypothermia (33-35 degrees C) has a robust cardioprotective effect. Tissue plasminogen activator (t-PA) is a profibrinolytic enzyme that is released from the vascular endothelial cells in response to ischemia and other injurious stimuli. t-PA has also been found to h...

journal_title：Journal of thrombosis and thrombolysis

authors： van der Pals J,Götberg M,Olivecrona GK,Brogren H,Jern S,Erlinge D

更新日期：2010-04-01 00:00:00

abstract：:Direct oral anticoagulants are associated with rates of major bleeding which are not negligible, albeit lower than those associated with vitamin K antagonists. No specific reversal agent for factor Xa (FXa) direct inhibitors is currently available for clinical use. A modified activated human FXa decoy protein, andexan...

journal_title：Journal of thrombosis and thrombolysis

authors： Sartori M,Cosmi B

更新日期：2018-04-01 00:00:00

abstract：BACKGROUND:Apoptosis causes myocardiocyte loss during and after myocardial infarction. Therapeutic approaches designed to arrest apoptosis would be a significant new development in the recovery of acute myocardial infarction (AMI). In order to examine apoptotic markers in the circulation, serum levels of p53 and cytoch...

journal_title：Journal of thrombosis and thrombolysis

authors： Dincer Y,Himmetoglu S,Bozcali E,Vural VA,Akcay T

更新日期：2010-01-01 00:00:00

abstract：:Making a definitive diagnosis of heparin-induced thrombocytopenia (HIT) can be problematic. A prompt platelet rise following treatment has been proposed as a "post-test" criterion for diagnosis. However, the platelet response following discontinuation of heparin and initiation of a recommended alternative anticoagulan...

journal_title：Journal of thrombosis and thrombolysis

authors： Pon TK,Mahajan A,Rosenberg A,Amin A,Shah D,Jenkins I,Gupta V,Hofmann H,Bejjani A,White R

更新日期：2018-05-01 00:00:00

abstract：:Gastrointestinal bleeding is the most common bleeding complication during anticoagulant therapy. A reliable bleeding risk score can help the clinician assess risk of bleeding in individual patients and select the anticoagulant regimen. This study retrospectively analyzed the data of patients with atrial fibrillation w...

journal_title：Journal of thrombosis and thrombolysis

authors： Lv MN,Zheng XC,Zhang HQ,Xu FD,Wu TT,Chen WJ,Xia XT,Fu JL,Jiang SJ,Zhang JH

更新日期：2021-01-01 00:00:00

abstract：:We assessed the contribution of serum homocysteine levels, an independent risk factor for vascular disease, and of the methylenetetrahydrofolate reductase (MTHFR) C677T mutation to the variability of carotid intimal-medial thickness (IMT) in patients with non-insulin-dependent diabetes mellitus (NIDDM). Ninety-five pa...

journal_title：Journal of thrombosis and thrombolysis

authors： Mazza A,Motti C,Nulli A,Pastore A,Andreotti F,Ammaturo V,Bianco P,Santoro E,Federici G,Cortese C

更新日期：1999-10-01 00:00:00

abstract：:We report a case of infective endocarditis (IE) involving the posterior mitral leaflet (PML) with calcific embolization in a patient with hypertrophic obstructive cardiomyopathy (HOCM). Amongst HOCM patients with IE, the anterior mitral leaflet and basal septal myocardium are almost always involved due to the endocard...

journal_title：Journal of thrombosis and thrombolysis

authors： Lather N,Niziolek K,Toth P,Harris DM

更新日期：2015-02-01 00:00:00

abstract：:Non vitamin K oral anticoagulants (NOACs) do not require regular monitoring but information about their pharmacodynamic effect may be importantin situations like trauma, stroke oremergent surgery. Currently, no standardized point-of-care test is available to evaluate the anticoagulant effects of NOACs. We evaluated th...

journal_title：Journal of thrombosis and thrombolysis

authors： Bliden KP,Chaudhary R,Mohammed N,Muresan AA,Lopez-Espina CG,Cohen E,Raviv G,Doubleday M,Zaman F,Mathew B,Tantry US,Gurbel PA

更新日期：2017-05-01 00:00:00

abstract：:Thromboembolic events are frequent and serious complications of acute lymphoblastic leukaemia treatment. The importance of chemotherapy in the pathogenesis of this increased risk is enhanced by the fact that thrombosis rarely occurs at diagnosis. Our study aims at investigating the effect of chemotherapy on pro-coagul...

journal_title：Journal of thrombosis and thrombolysis

authors： Pluchart C,Poitevin G,Colinart-Thomas M,Guimard G,Audonnet S,Terryn C,Nguyen P

更新日期：2019-08-01 00:00:00

abstract：:The best strategy in atrial fibrillation (AF) after > 12 months after an acute coronary syndrome or in patients with chronic coronary syndrome without an indication for interventional revascularization remains unclear. European guidelines generally recommend therapy with oral anticoagulation (OAC) alone, whereas North...

journal_title：Journal of thrombosis and thrombolysis

authors： Wernly B,Bhatt DL,Polzin A,Jung C

更新日期：2020-02-01 00:00:00

abstract：:Rivaroxaban is a direct factor Xa inhibitor, which is rapidly absorbed in the upper gastrointestinal (GI) tract. In large trials, it has been shown to be effective and safe in VTE treatment. However, in these trials patients with morbid obesity were not reported and it is unknown if the standard dosage of 20 mg rivaro...

journal_title：Journal of thrombosis and thrombolysis

authors： Mahlmann A,Gehrisch S,Beyer-Westendorf J

更新日期：2013-11-01 00:00:00

abstract：:We hypothesized that women are more prone to develop coronary dissections during PCI due to potential balloon-oversizing or gender specific plaque and vascular characteristics. To date, a gender related difference in edge dissection has not been systematically studied. The Massachusetts General Hospital Optical Cohere...

journal_title：Journal of thrombosis and thrombolysis

authors： Zeglin-Sawczuk M,Jang IK,Kato K,Yonetsu T,Kim S,Choi SY,Kratlian C,Lee H,Dauerman HL

更新日期：2013-11-01 00:00:00

abstract：:The adverse impact of the development of cardiogenic shock in the setting of acute myocardial infarction was first described by Killip and Kimball in 1967. While the in-hospital mortality rate in patients with myocardial infarction and no evidence of heart failure was only 6%, the mortality rate in those patients who ...

journal_title：Journal of thrombosis and thrombolysis

authors： Levine GN,Hochman JS

更新日期：1995-01-01 00:00:00

abstract：:Erythropoietin (EPO) was hypothesized to mitigate reperfusion injury, in part via mobilization of endothelial progenitor cells (EPCs). The REVEAL trial found no reduction in infarct size with a single dose of EPO (60,000 U) in patients with ST-segment elevation myocardial infarction. In a substudy, we aimed to determi...

journal_title：Journal of thrombosis and thrombolysis

authors： Povsic TJ,Najjar SS,Prather K,Zhou J,Adams SD,Zavodni KL,Kelly F,Melton LG,Hasselblad V,Heitner JF,Raman SV,Barsness GW,Patel MR,Kim RJ,Lakatta EG,Harrington RA,Rao SV

更新日期：2013-11-01 00:00:00

abstract：:Limited evidence exists regarding management of recurrent venous thromboembolism (VTE) that occurs during anticoagulant therapy. We aimed to describe patient characteristics, drug therapy management, and outcomes of patients with VTE recurrence during anticoagulant therapy. We identified 30 relevant episodes of VTE re...

journal_title：Journal of thrombosis and thrombolysis

authors： Lai N,Jones AE,Johnson SA,Witt DM

更新日期：2021-01-23 00:00:00

abstract：:Unfractionated heparin (UFH) plasma protein binding and elimination might be impaired in patients with chronic kidney disease (CKD-defined as creatinine clearance <60 ml/min). It is currently unknown at which UFH bolus dose persistent prolongation of activated partial thromboplastin time (aPTT) occurs in ST-segment el...

journal_title：Journal of thrombosis and thrombolysis

authors： Kikkert WJ,van Brussel PM,Damman P,Claessen BE,van Straalen JP,Vis MM,Baan J Jr,Koch KT,Peters RJ,de Winter RJ,Piek JJ,Tijssen JG,Henriques JP

更新日期：2016-04-01 00:00:00

abstract：:Amniotic fluid embolism (AFE) is a catastrophic condition in the peripartum period and still remains as a leading cause of maternal death. Although over 80% of cases of AFE cases are accompanied by coagulopathy, the pathology of disseminated intravascular coagulation is not well understood not only because of its rari...

journal_title：Journal of thrombosis and thrombolysis

authors： Fudaba M,Tachibana D,Misugi T,Nakano A,Koyama M

更新日期：2020-07-29 00:00:00

abstract：:Acute myocardial infarction is initiated by plaque disruption of a fatty plaque with a thin fibrous cap which has been infiltrated by macrophages. The macrophages are attracted and stimulated by oxidized lipids to secrete metalloproteinases which dissolve collagen and arterial wall matrix and to synthesize tissue fact...

journal_title：Journal of thrombosis and thrombolysis

authors： Chesebro JH,Badimon JJ,Hassinger NL,McBane RD,Fuster V V

更新日期：1995-01-01 00:00:00

abstract：:Several autopsy studies showed microthrombi in pulmonary circulation of severe COVID-19 patients. The major limitation of these investigations is that the autopsy provided static information. Some of these alterations could be secondary to the disseminated intravascular coagulation (DIC) observed as the final standard...

journal_title：Journal of thrombosis and thrombolysis

authors： do Espírito Santo DA,Lemos ACB,Miranda CH

更新日期：2020-11-01 00:00:00

abstract：UNLABELLED:Platelet P-selectin and activated glycoprotein IIb-IIIa (GPIIb-IIIa) are markers of platelet activation and mediates platelet aggregation. Prasugrel (Pras) 5 mg may be used in very elderly (VE) acute coronary syndrome (ACS) patients undergoing PCI, but its effect on platelet P-selectin and activated GPIIb-II...

journal_title：Journal of thrombosis and thrombolysis

authors： Wagner H,Lood C,Borna C,Gidlöf O,Truedsson L,Brown P,Zhou C,Winters K,Jakubowski JA,Erlinge D

更新日期：2016-10-01 00:00:00

abstract：INTRODUCTION:While the CURE trial demonstrated the benefits of clopidogrel in acute coronary syndromes, patients receiving glycoprotein IIb/IIIa antagonists were excluded. Given the frequent coadministration of these two medications, we sought to examine their interaction and their combined effect on platelet inhibitio...

journal_title：Journal of thrombosis and thrombolysis

authors： Talreja D,Lubbe D,Orford JL,Lennon R,DiBattiste PM,Berger PB

更新日期：2004-08-01 00:00:00

abstract：:The Porthidium genus is represented by the P. lansbergii rozei and P. lansbergii hutmanni (Plh) subspecies in Venezuela. The venom components of these have been little studied, probably due to the low incidence of reported accidents, although acute and serious local effects such as invasive edema and disseminated ecch...

journal_title：Journal of thrombosis and thrombolysis

authors： López-Johnston JC,de Bosch N,Scannone H,Rodríguez-Acosta A

更新日期：2007-12-01 00:00:00

abstract：:Plasminogen activator inhibitor (PAI-1), a member of the serine protein family, is the most active in vivo inhibitor of fibrinolysis induced by plasminogen, tissue plasminogen activator (tPA), and urokinase type plasminogen activator (uPA). While the association between elevated PAI-1 and thrombogenesis has been well ...

journal_title：Journal of thrombosis and thrombolysis

authors： Senno SL,Pechet L

更新日期：1999-08-01 00:00:00

abstract：:Aortic stenosis (AS) accounts for the majority of valvular abnormalities requiring surgical intervention. Platelet dysfunction has been demonstrated among patients with severe aortic stenosis which may predispose patients to bleeding or ischemic events. Surgical aortic valve replacement (AVR) is the standard therapy f...

journal_title：Journal of thrombosis and thrombolysis

authors： Lynch DR Jr,Dantzler D,Robbins M,Zhao D

更新日期：2013-05-01 00:00:00

abstract：:There were limited studies comparing the anterior (AC) and posterior (PC) circulation acute ischemic strokes (AIS). Our study aimed to evaluate distinct features of AC and PC strokes regarding clinical, vascular risk, pathogenesis and outcome factors after endovascular procedures. This multicenter prospective study re...

journal_title：Journal of thrombosis and thrombolysis

authors： Huo X,Raynald,Gao F,Ma N,Mo D,Sun X,Song L,Jia B,Pan Y,Wang Y,Liu L,Zhao X,Wang Y,Miao Z,ANGEL investigators.

更新日期：2020-05-01 00:00:00

abstract：:We report a case of acquired thrombotic thrombocytopenic purpura (TTP) in a 34-year old patient with a prior diagnosis of systemic lupus erythematosis (SLE) who was recently started on hydroxychloroquine. Presenting symptoms included fevers, sore throat and productive cough with progressive weakness, dyspnea on exerti...

journal_title：Journal of thrombosis and thrombolysis

authors： Mar N,Mendoza Ladd A

更新日期：2011-01-01 00:00:00

abstract：:Schistosomes are parasitic platyhelminths that currently infect over 200 million people and cause the chronic debilitating disease schistosomiasis. While these large intravascular parasites can disturb blood flow, surprisingly they do not appear to provoke thrombus formation around them in vivo. In order to determine ...

journal_title：Journal of thrombosis and thrombolysis

authors： Da'dara AA,de Laforcade AM,Skelly PJ

更新日期：2016-05-01 00:00:00