当前位置： SCI文献检索 > JOURNAL OF THROMBOSIS AND THROMBOLYSIS期刊下所有文献 > Andexanet alfa to reverse the anticoagulant activity of factor Xa inhibitors: a review of design, development and potential place in therapy.

Andexanet alfa to reverse the anticoagulant activity of factor Xa inhibitors: a review of design, development and potential place in therapy.

Abstract：

:Direct oral anticoagulants are associated with rates of major bleeding which are not negligible, albeit lower than those associated with vitamin K antagonists. No specific reversal agent for factor Xa (FXa) direct inhibitors is currently available for clinical use. A modified activated human FXa decoy protein, andexanet alfa, is being developed that binds FXa direct inhibitors in their active site, thus reversing their anticoagulant effect. The purpose of this article is to review the design, development and clinical trials of andexanet alfa. Andexanet alfa was shown to reverse FXa inhibitors anticoagulant activity both in thrombosis animal models, healthy volunteers and patients with acute major bleeding. Andexanet alfa has been studied in double-blind, placebo-controlled phase II and III studies. A preliminary report of the phase III study showed that an effective hemostasis was obtained after andexanet alfa infusion in the majority of the patients with acute major bleeding associated with FXa inhibitors. Additional studies are ongoing and andexanet alfa is expected to be launched in the market in the near future.

journal_name

J Thromb Thrombolysis

journal_title

Journal of thrombosis and thrombolysis

authors

Sartori M,Cosmi B

doi

10.1007/s11239-018-1617-2

subject

Has Abstract

pub_date

2018-04-01 00:00:00

pages

345-352

issue

3

eissn

0929-5305

issn

1573-742X

pii

10.1007/s11239-018-1617-2

journal_volume

45

pub_type

杂志文章,评审

相关文献

JOURNAL OF THROMBOSIS AND THROMBOLYSIS文献大全
  • Development of a new catheter prototype for laser thrombolysis under guidance of optical coherence tomography (OCT): validation of feasibility and efficacy in a preclinical model.

    abstract：:In this feasibility study, a novel catheter prototype for laser thrombolysis under the guidance of optical coherence tomography (OCT) was designed and evaluated in a preclinical model. Human arteries and veins were integrated into a physiological flow model and occluded with thrombi made from the Chandler Loop. There ...

    journal_title：Journal of thrombosis and thrombolysis

    pub_type： 杂志文章

    doi：10.1007/s11239-016-1470-0

    authors： Berndt R,Rusch R,Hummitzsch L,Lutz M,Heß K,Huenges K,Panholzer B,Otte C,Haneya A,Lutter G,Schlaefer A,Cremer J,Groß J

    更新日期：2017-04-01 00:00:00

  • Bleeding complications after contemporary pharmacoinvasive therapy for ST elevation myocardial infarction.

    abstract：BACKGROUND:Pharmacoinvasive therapy for the treatment of ST elevation myocardial infarction (STEMI) is a strategy that combines early restoration of coronary flow via pharmacologically induced thrombolysis with subsequent, prompt percutaneous coronary intervention (PCI). Prior studies suggesting a heightened bleeding r...

    journal_title：Journal of thrombosis and thrombolysis

    pub_type： 杂志文章

    doi：10.1007/s11239-005-0344-7

    authors： Gutierrez MJ,Aggarwal A,Gilbert K,Sobel BE,Dauerman HL

    更新日期：2004-12-01 00:00:00

  • Low levels of activated factor VII in systemic sclerosis.

    abstract：INTRODUCTION:Recent investigations show that activated factor VII, the primary enzyme in the extrinsic pathway of blood coagulation, exerts additional extra-coagulant functions, such as apoptosis and angiogenesis. On the basis of these recent acquisitions, the present study was aimed to evaluate activated factor VII in...

    journal_title：Journal of thrombosis and thrombolysis

    pub_type： 杂志文章

    doi：10.1007/s11239-006-8969-8

    authors： Volpe A,Salvagno GL,Lippi G,Caramaschi P,Montagnana M,Canestrini S,Carletto A,Bambara LM,Biasi D,Guidi GC

    更新日期：2006-10-01 00:00:00

  • Early changes in local hemostasis activation following percutaneous coronary intervention in stable angina patients: a comparison between drug-eluting and bare metal stents.

    abstract：BACKGROUND:Early change in local intracoronary hemostasis following drug-eluting (DES) and bare metal stent (BMS) implantation has never been assessed in stable angina patients. METHODS:Markers of local platelet activation (soluble glycoprotein V [sGPV] and P-Selectin [CD62P]), coagulation activation (tissue factor [T...

    journal_title：Journal of thrombosis and thrombolysis

    pub_type： 临床试验,杂志文章

    doi：10.1007/s11239-008-0266-2

    authors： Mahemuti A,Meneveau N,Seronde MF,Schiele F,Descotes-Genon V,Ecarnot F,Blonde MC,Mercier M,Racadot E,Bassand JP

    更新日期：2009-10-01 00:00:00

  • Functional testing of tranexamic acid effects in patients undergoing elective orthopaedic surgery.

    abstract：:Tranexamic acid (TXA) can reduce blood loss and transfusion rates in orthopaedic surgery. In this regard, a new viscoelastometric test (TPA-test, ClotPro), enables the monitoring of TXA effects. This prospective observational study evaluated and correlated TXA plasma concentrations (cTXA) following intravenous and ora...

    journal_title：Journal of thrombosis and thrombolysis

    pub_type： 杂志文章

    doi：10.1007/s11239-020-02272-8

    authors： Groene P,Sappel SR,Saller T,Nitschke T,Sa PA,Paulus A,Chappell D,Schäfer ST

    更新日期：2020-09-12 00:00:00

  • Thrombosis, anticoagulation and outcomes in malignant superior vena cava syndrome.

    abstract：:Anticoagulation is often used in superior vena cava syndrome (SVCS) associated with cancer (i.e malignant SVCS), even without thrombosis, but its effect on outcomes has not been reported. We aimed to determine factors and outcomes associated with thrombosis and anticoagulation in malignant SVCS. Patients with malignan...

    journal_title：Journal of thrombosis and thrombolysis

    pub_type： 杂志文章

    doi：10.1007/s11239-018-1747-6

    authors： Ratzon R,Tamir S,Friehmann T,Livneh N,Dudnik E,Rozental A,Hamburger-Avnery O,Pereg D,Derazne E,Brenner B,Raanani P,Ten Cate H,Spectre G,Leader A

    更新日期：2019-01-01 00:00:00

  • Association between percutaneous coronary intervention and long-term C-reactive protein levels in patients with acute coronary syndromes.

    abstract：:C-reactive protein (CRP) is an independent predictor of risk in ACS patients, and it has been previously shown that percutaneous coronary intervention (PCI) is associated with an early rise in CRP. To assess the long-term relationship between PCI and CRP, we compared CRP levels at baseline, 30 days, 4 months and 24 mo...

    journal_title：Journal of thrombosis and thrombolysis

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s11239-010-0463-7

    authors： Ray KK,Nazer B,Cairns R,Michael Gibson C,Cannon CP

    更新日期：2010-07-01 00:00:00

  • The impact of a pulmonary embolism response team on the efficiency of patient care in the emergency department.

    abstract：:The concept of a pulmonary embolism response team (PERT) is multidisciplinary, with the hope that it may positively impact patient care, hospital efficiency, and outcomes in the treatment of patients with intermediate and high risk pulmonary embolism (PE). Clinical characteristics of a baseline population of patients ...

    journal_title：Journal of thrombosis and thrombolysis

    pub_type： 杂志文章

    doi：10.1007/s11239-019-01875-0

    authors： Wright C,Elbadawi A,Chen YL,Patel D,Mazzillo J,Acquisto N,Groth C,Van Galen J,Delehanty J,Pietropaoli A,Trawick D,James White R,Cameron P,Gosev I,Barrus B,Kumar NG,Cameron SJ

    更新日期：2019-08-01 00:00:00

  • Von Willebrand factor with increased binding capacity is associated with reduced platelet aggregation but enhanced agglutination in COVID-19 patients: another COVID-19 paradox?

    abstract：:Patients with Coronavirus-associated disease-2019 (COVID-19) display alterations of the hemostatic system and the presence of a prothrombotic status frequently leading to vascular complications. However, the impact of COVID-19 on platelet activity, aggregation and agglutination still needs to be clarified. We measured...

    journal_title：Journal of thrombosis and thrombolysis

    pub_type： 杂志文章

    doi：10.1007/s11239-020-02339-6

    authors： Ruberto F,Chistolini A,Curreli M,Frati G,Marullo AGM,Biondi-Zoccai G,Mancone M,Sciarretta S,Miraldi F,Alessandri F,Ceccarelli G,Barone F,Santoro C,Alvaro D,Pugliese F,Pulcinelli FM,Policlinico Umberto I COVID-19 Group.

    更新日期：2021-01-02 00:00:00

  • Mechanisms of venous and arterial thrombosis in heparin-induced thrombocytopenia.

    abstract：:Since the reports by Weismann and Tobin in 1958 and Roberts et al. in 1964 called attention to paradoxical thrombosis in patients treated with heparin, the thrombotic aspect of the heparin-induced thrombocytopenia syndrome (HIT) has been emphasized. Yet to this day, the mechanism of thrombosis associated with HIT (HIT...

    journal_title：Journal of thrombosis and thrombolysis

    pub_type： 杂志文章,评审

    doi：10.1023/a:1027372901367

    authors： Walenga JM,Jeske WP,Messmore HL

    更新日期：2000-11-01 00:00:00

  • Relationship between the heparin management test and the HemoTec activated clotting time in patients undergoing percutaneous coronary intervention.

    abstract：:Point-of-care whole blood coagulation tests are critical in the management of patients who undergo percutaneous coronary intervention. The Hemochron and HemoTec devices have been traditionally used to measure the activated clotting time (ACT) in the cardiac catheterization laboratory. The heparin management test (HMT)...

    journal_title：Journal of thrombosis and thrombolysis

    pub_type： 杂志文章

    doi：10.1023/a:1011908803939

    authors： Tsimikas S,Beyer R,Hassankhani A

    更新日期：2001-05-01 00:00:00

  • Prothrombotic genetic risk factors in patients with very early ST-segment elevation myocardial infarction.

    abstract：:The contribution of prothrombotic genetic risk factors in the pathogenesis of premature acute myocardial infarction (MI) is controversial. We examined the prevalence of prothrombotic polymorphisms (G1691A of factor V gene [FV Leiden] and G20210A of prothrombin [FII] gene), deficiencies of natural anticoagulants (prote...

    journal_title：Journal of thrombosis and thrombolysis

    pub_type： 杂志文章

    doi：10.1007/s11239-017-1520-2

    authors： Rallidis LS,Gialeraki A,Tsirebolos G,Tsalavoutas S,Rallidi M,Iliodromitis E

    更新日期：2017-08-01 00:00:00

  • Enoxaparin, a low molecular weight heparin, inhibits platelet-dependent prothrombinase assembly and activity by factor-Xa neutralization.

    abstract：BACKGROUND:The available evidence suggests strongly that intravascular thrombosis is mediated predominantly by tissue-factor and its activation of factor X, which in the presence of factor Va, calcium, and phospholipid (prothrombinase complex) effectively converts prothrombin to thrombin. In vitro experiments have show...

    journal_title：Journal of thrombosis and thrombolysis

    pub_type： 杂志文章,多中心研究

    doi：10.1023/a:1018710526772

    authors： Spencer FA,Ball SP,Zhang Q,Liu L,Benoit S,Becker RC

    更新日期：2000-04-01 00:00:00

  • Oral anticoagulants in older adults with atrial fibrillation.

    abstract：:Atrial fibrillation (AF) is the most common arrhythmia in adults and contributes directly to adverse clinical events, ranging from ischemic stroke to heart failure and cardiovascular death. Because the incidence of AF and its attendant complications increase with age, there is a strong and growing need to develop safe...

    journal_title：Journal of thrombosis and thrombolysis

    pub_type： 杂志文章,评审

    doi：10.1007/s11239-013-0869-0

    authors： Bernacki GM,Becker RC

    更新日期：2013-11-01 00:00:00

  • Interhospital transfer on intravenous thrombolysis in patients with acute ischemic stroke in three chinese municipal stroke centers.

    abstract：:We included acute ischemic stroke (AIS) patients who received recombinant tissue plasminogen activator (rt-PA) at three stroke centers via either interhospital transfer or direct presentation and compared the clinical outcomes and time metrics to analyze the impact of interhospital transfer on intravenous thrombolysis...

    journal_title：Journal of thrombosis and thrombolysis

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s11239-019-01912-y

    authors： Ding Y,Ji Z,Ma L,Zhai T,Gu Z,Niu J,Liu Y

    更新日期：2019-11-01 00:00:00

  • Review of venous thromboembolism and race: the generalizability of treatment guidelines for high-risk populations.

    abstract：:The American College of Chest Physicians (ACCP) has established guidelines for the treatment of VTE, but the generalizability to all populations is unclear. In this review we analyzed the rate of reporting and enrollment of blacks and women in clinical trials cited in the ACCP guidelines for treatment of unprovoked VT...

    journal_title：Journal of thrombosis and thrombolysis

    pub_type： 杂志文章,评审

    doi：10.1007/s11239-016-1352-5

    authors： Sullivan LT 2nd,Jackson LR 2nd,Thomas KL

    更新日期：2016-08-01 00:00:00

  • Venous thromboembolism 2011-2018 in Stockholm: a demographic study.

    abstract：:Venous thromboembolism (VTE) is an important cause of morbidity and mortality in Western countries. The incidence rate of VTE is estimated at 1-2 cases per 1000 annually. This study was a population-based cohort study of previously treatment naïve patients with a first occurrence of venous thromboembolism (VTE), using...

    journal_title：Journal of thrombosis and thrombolysis

    pub_type： 杂志文章

    doi：10.1007/s11239-019-01966-y

    authors： Wändell P,Forslund T,Danin Mankowitz H,Ugarph-Morawski A,Eliasson S,Braunschwieg F,Holmström M

    更新日期：2019-11-01 00:00:00

  • Ultrastructure of a late-stage bacterial endocarditis valve vegetation.

    abstract：:Infective endocarditis (IE) remains a severe illness with high mortality rate, despite advances in antibiotic therapy and cardiac surgery. If infectious bacteria and platelets are two key players of human IE vegetation developmental process, their interactions and respective roles in fully developed late-stage IE vege...

    journal_title：Journal of thrombosis and thrombolysis

    pub_type： 杂志文章

    doi：10.1007/s11239-020-02232-2

    authors： Baudoin JP,Camoin-Jau L,Prasanth A,Habib G,Lepidi H,Hannachi N

    更新日期：2020-08-04 00:00:00

  • Are surgical patients at risk of venous thromboembolism currently meeting the Surgical Care Improvement Project performance measure for appropriate and timely prophylaxis?

    abstract：:The US Surgical Care Improvement Project (SCIP) has approved two performance measures to improve venous thromboembolism (VTE) prevention. SCIP-VTE-2 measures the proportion of surgery patients who received appropriate VTE prophylaxis within 24 h prior to surgery to 24 h after surgery. This study assesses the current r...

    journal_title：Journal of thrombosis and thrombolysis

    pub_type： 杂志文章

    doi：10.1007/s11239-009-0393-4

    authors： Deitelzweig SB,Lin J,Hussein M,Battleman D

    更新日期：2010-07-01 00:00:00

  • Secondary prevention strategies for coronary heart disease.

    abstract：:Patients with established coronary heart disease (CHD) have a high risk of subsequent cardiovascular events, including myocardial infarction (MI), stroke, and death from cardiovascular disease. Adherence to evidence-based secondary prevention therapies for CHD has improved in recent years but still remains suboptimal....

    journal_title：Journal of thrombosis and thrombolysis

    pub_type： 杂志文章,评审

    doi：10.1007/s11239-009-0381-8

    authors： Weiner SD,Rabbani LE

    更新日期：2010-01-01 00:00:00

  • Description of anti-Xa monitoring practices during low molecular weight heparin use.

    abstract：:Certain patient populations (pregnancy, cancer, renal impairment, and obesity) may be at higher risk of adverse events during low molecular weight heparin (LMWH) therapy and may benefit from anti-Xa monitoring. Yet, evidence supporting a standardized approach to anti-Xa monitoring correlated to clinical outcomes is la...

    journal_title：Journal of thrombosis and thrombolysis

    pub_type： 杂志文章

    doi：10.1007/s11239-019-01920-y

    authors： Lin A,Vazquez SR,Jones AE,Witt DM

    更新日期：2019-11-01 00:00:00

  • ABO blood group influences transfusion and survival after cardiac surgery.

    abstract：:ABO dependent variation in von Willebrand factor (vWf) and procoagulant factor VIII (FVIII) is a plausible mechanism for modulating perioperative hemostasis and bleeding. Group AB has the highest and group O the lowest vWf and FVIII levels. Therefore, we tested the hypothesis that ABO blood group is associated with pe...

    journal_title：Journal of thrombosis and thrombolysis

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s11239-013-1045-2

    authors： Welsby IJ,Phillips-Bute B,Mathew JP,Newman MF,Becker R,Rao S,Milano CA,Stafford-Smith M

    更新日期：2014-10-01 00:00:00

  • Characteristics and risk factors of deep vein thrombosis in hemiplegic, healthy and bilateral limbs of hemiplegic patients: a 10-year retrospective study.

    abstract：:Deep vein thrombosis (DVT) in hemiplegic patients mainly affects hemiplegic limbs, DVT can also occur only in healthy limbs, and some hemiplegic patients have DVT in both limbs. Characteristics and risk factors of DVT in hemiplegic, healthy, and bilateral limbs are unknown. To describe the proportion, risk factors, ex...

    journal_title：Journal of thrombosis and thrombolysis

    pub_type： 杂志文章

    doi：10.1007/s11239-020-02254-w

    authors： Liang F,Chao M,Li JB,Ye XM

    更新日期：2020-08-27 00:00:00

  • Comparison of warfarin versus DOACs in patients with concomitant indication for oral anticoagulation undergoing TAVI; results from the ATLAS registry.

    abstract：:The optimal antithrombotic therapy for patients undergoing TAVI with concomitant indication for oral anticoagulation remains unclear. In this high-risk population group, there is a paucity of data with regards to the use of DOACs. In the present study we compared long-term clinical outcomes of TAVI patients requiring ...

    journal_title：Journal of thrombosis and thrombolysis

    pub_type： 杂志文章

    doi：10.1007/s11239-019-01968-w

    authors： Kalogeras K,Jabbour RJ,Ruparelia N,Watson S,Kabir T,Naganuma T,Vavuranakis M,Nakamura S,Malik IS,Mikhail G,Dalby M,Panoulas V

    更新日期：2020-07-01 00:00:00

  • The influence of platelet activating factor on the effects of platelet agonists and antiplatelet agents in vitro.

    abstract：:We assessed the effect of the intercellular mediator of inflammation, platelet activating factor (PAF), on platelet function. The interaction between PAF and the platelet agonists ADP, thrombin and convulxin was analyzed in vitro in whole blood with the use of flow cytometry and was further characterized with the use ...

    journal_title：Journal of thrombosis and thrombolysis

    pub_type： 杂志文章

    doi：10.1007/s11239-008-0239-5

    authors： Keating FK,Schneider DJ

    更新日期：2009-07-01 00:00:00

  • Management of periprocedural anticoagulant therapy: a novel individualized approach-a transeusophageal echocardiographic study.

    abstract：:Patients with non-valvular atrial fibrillation who are under chronic oral anticoagulant therapy (OAC) treatment frequently require interruption of OAC treatment. By examining the presence of left atrial/left atrial appendage (LA/LAA) thrombus or dense spontaneous echo contrast (SEC) with transesophageal echocardiograp...

    journal_title：Journal of thrombosis and thrombolysis

    pub_type： 杂志文章

    doi：10.1007/s11239-020-02104-9

    authors： Durmaz E,Karadag B,İkitimur B,Ebren C,Tokdil H,Koca D,Ozmen E,Polat F,Ohtaroglu Tokdil K,Raimoglu U,Mutlu D,Atici A,Ongen Z

    更新日期：2020-08-01 00:00:00

  • Plasma accumulation of fondaparinux 2.5 mg in patients after total hip arthroplasty.

    abstract：:Fondaparinux (FPX), a selective inhibitor of factor Xa, is widely used for the prophylaxis of venous thromboembolism (VTE) after total joint arthroplasty. However, the association between plasma FPX concentration and adverse events and the occurrence of VTE has not been clarified thus far. We aimed to prospectively ev...

    journal_title：Journal of thrombosis and thrombolysis

    pub_type： 临床试验,杂志文章

    doi：10.1007/s11239-012-0773-z

    authors： Yukizawa Y,Inaba Y,Watanabe S,Yajima S,Kobayashi N,Ishida T,Iwamoto N,Hyonmin C,Nakamura M,Saito T

    更新日期：2012-11-01 00:00:00

  • Markers of coagulation dysfunction and inflammation in diabetic and non-diabetic COVID-19.

    abstract：:Coagulation dysfunction and inflammatory status were compared between diabetic and non-diabetic COVID-19 patients. The standardized mean difference (SMD) and its 95% confidence interval (CI) was computed for the difference of inflammatory and hypercoagulability markers. The levels of serum ferritin (standardized mean ...

    journal_title：Journal of thrombosis and thrombolysis

    pub_type： 信件

    doi：10.1007/s11239-020-02270-w

    authors： Varikasuvu SR,Varshney S,Dutt N

    更新日期：2020-09-05 00:00:00

  • Thrombolysis in Acute Myocardial Infarction Complicated by Cardiogenic Shock.

    abstract：:The adverse impact of the development of cardiogenic shock in the setting of acute myocardial infarction was first described by Killip and Kimball in 1967. While the in-hospital mortality rate in patients with myocardial infarction and no evidence of heart failure was only 6%, the mortality rate in those patients who ...

    journal_title：Journal of thrombosis and thrombolysis

    pub_type： 杂志文章

    doi：10.1007/BF01063156

    authors： Levine GN,Hochman JS

    更新日期：1995-01-01 00:00:00

  • Inflammatory cytokines, endothelial markers and adhesion molecules in rheumatoid arthritis: effect of intensive anti-inflammatory treatment.

    abstract：:Tumour necrosis factor alpha (TNF-alpha) and interlekin-6 (IL-6) are key inflammatory cytokines in the pathogenesis of rheumatoid arthritis (RA), a disease also associated with endothelial perturbation and increased serum levels of adhesion molecules. As relationships between these processes and molecules are unclear,...

    journal_title：Journal of thrombosis and thrombolysis

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1007/s11239-009-0370-y

    authors： Foster W,Carruthers D,Lip GY,Blann AD

    更新日期：2010-05-01 00:00:00