当前位置： SCI文献检索 > JOURNAL OF THROMBOSIS AND THROMBOLYSIS期刊下所有文献 > Clinical implications of elevated PAI-1 revisited: multiple arterial thrombosis in a patient with essential thrombocythemia and elevated plasminogen activator inhibitor-1 (PAI-1) levels: a case report and review of the literature.

Clinical implications of elevated PAI-1 revisited: multiple arterial thrombosis in a patient with essential thrombocythemia and elevated plasminogen activator inhibitor-1 (PAI-1) levels: a case report and review of the literature.

Abstract：

:Plasminogen activator inhibitor (PAI-1), a member of the serine protein family, is the most active in vivo inhibitor of fibrinolysis induced by plasminogen, tissue plasminogen activator (tPA), and urokinase type plasminogen activator (uPA). While the association between elevated PAI-1 and thrombogenesis has been well studied for several disease processes, including coronary disease, postoperative deep vein thrombosis (DVT), myocardial infarction, malignancy, and diabetes, few studies have concentrated on the correlation between elevated PAI-1 levels and thrombogenesis in patients with myeloproliferative disorders. Essential thrombocythemia (ET), a chronic myeloproliferative disorder, characterized by the overproduction of poorly functioning platelets, is associated with both thrombotic and hemorrhagic life-threatening complications. Although the events resulting in thrombogenesis in such patients may be multifactorial in nature, an association between elevated PAI-1 levels and thrombus formation has been proposed. Herein we present a patient diagnosed with ET complicated by multiple episodes of arterial thrombosis. Elevations in PAI-1 levels were documented repeatedly. The role of elevated PAI-1 when associated with other disease processes is also discussed.

journal_name

J Thromb Thrombolysis

journal_title

Journal of thrombosis and thrombolysis

authors

Senno SL,Pechet L

doi

10.1023/a:1008907001042

subject

Has Abstract

pub_date

1999-08-01 00:00:00

pages

105-12

issue

2

eissn

0929-5305

issn

1573-742X

journal_volume

8

pub_type

杂志文章,评审

相关文献

JOURNAL OF THROMBOSIS AND THROMBOLYSIS文献大全
  • Circulating lipid levels and risk of coronary artery disease in a large group of patients undergoing coronary angiography.

    abstract：:A main underlying pathology of coronary artery disease is the deposition of cholesterol in the arteries supplying blood to the heart that leads to stenosis and myocardial infarction. We tested if dyslipidemia is a risk factor for coronary artery disease in the Lebanese population, and studied the role of the total cho...

    journal_title：Journal of thrombosis and thrombolysis

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1007/s11239-014-1069-2

    authors： Platt DE,Ghassibe-Sabbagh M,Youhanna S,Hager J,Cazier JB,Kamatani Y,Salloum AK,Haber M,Romanos J,Doueihy B,Mouzaya F,Kibbani S,Sbeite H,Deeb ME,Chammas E,El Bayeh H,Khazen G,Gauguier D,Zalloua PA,Abchee AB,FGENTCA

    更新日期：2015-01-01 00:00:00

  • Postoperative pulmonary embolism in a young female accompanying with Factor V Leiden mutation and hereditary sypherocytosis.

    abstract：:A 20 year-old female, heterozygous for Factor V Leiden mutation (FVLM) is presented. Her personal history was prominent for severe anaemia during her gestation. Aetiology of anaemia was found to be hereditary spherocytosis (HS). Intrauterine foetal death had occurred at 20 weeks of gestational age. Two days after cure...

    journal_title：Journal of thrombosis and thrombolysis

    pub_type： 杂志文章

    doi：10.1023/B:THRO.0000040491.79092.11

    authors： Karnak D,Beder S,Kayacan O,Berk O

    更新日期：2004-06-01 00:00:00

  • Thrombolytic effect of subtilisin QK on carrageenan induced thrombosis model in mice.

    abstract：:Subtilisin QK, a new fibrinolytic enzyme, could cleave directly cross-linked fibrin in vitro. To verify the thrombolytic function of Subtilisin QK in vivo, the thrombolytic effect of purified Subtilisin QK on tail-thrombus of mouse was investigated. After injected with carrageenan, the tail-thrombus of Subtilisin QK t...

    journal_title：Journal of thrombosis and thrombolysis

    pub_type： 杂志文章

    doi：10.1007/s11239-009-0333-3

    authors： Yan F,Yan J,Sun W,Yao L,Wang J,Qi Y,Xu H

    更新日期：2009-11-01 00:00:00

  • The association between treatment with heparin and survival in patients with Covid-19.

    abstract：:This study investigates the association between the treatment with heparin and mortality in patients admitted with Covid-19. Routinely recorded, clinical data, up to the 24th of April 2020, from the 2075 patients with Covid-19, admitted in 17 hospitals in Spain between the 1st of March and the 20th of April 2020 were ...

    journal_title：Journal of thrombosis and thrombolysis

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s11239-020-02162-z

    authors： Ayerbe L,Risco C,Ayis S

    更新日期：2020-08-01 00:00:00

  • Comparison of initial warfarin response in obese patients versus non-obese patients.

    abstract：:Achieving therapeutic anticoagulation with warfarin is complicated by substantial inter-patient and intra-patient variability with numerous factors known to influence dose requirements. Obesity is one factor for which there remains no study to date investigating its initial effect on warfarin response assessed by INR,...

    journal_title：Journal of thrombosis and thrombolysis

    pub_type： 临床试验,杂志文章

    doi：10.1007/s11239-012-0811-x

    authors： Wallace JL,Reaves AB,Tolley EA,Oliphant CS,Hutchison L,Alabdan NA,Sands CW,Self TH

    更新日期：2013-07-01 00:00:00

  • A dose-finding clinical trial of staphylokinase SY162 in patients with long-term venous access catheter thrombotic occlusion.

    abstract：BACKGROUND:We investigated the safety and efficacy of several dosing regimens of catheter-directed staphylokinase (SY162) bolus administration for the treatment of long-term venous access catheter occlusion. METHODS:This open-label, ascending dose study enrolled 24 subjects. Three doses of SY162 were evaluated in thre...

    journal_title：Journal of thrombosis and thrombolysis

    pub_type： 临床试验,杂志文章

    doi：10.1007/s11239-006-0006-4

    authors： Verhamme P,Goossens G,Maleux G,Collen D,Stas M

    更新日期：2007-08-01 00:00:00

  • Embolic events caused by aortic thrombi: an underestimated entity?

    abstract：:Stroke and other thromboembolic events are mainly caused by emboli from heart, aorta and other arteries. In this paper we describe a group of 5 middle-aged patients suffering from emboli caused by large thrombi in the aorta. Since the development of giant thrombi under high flow conditions in the aorta is a pathophysi...

    journal_title：Journal of thrombosis and thrombolysis

    pub_type： 杂志文章

    doi：10.1007/s11239-012-0775-x

    authors： Stoevesandt D,Klempt C,Scheubel R,Herr W,Hettwer S,Werdan K,Silber RE,Kraya T,Thews O,Schlitt A

    更新日期：2013-02-01 00:00:00

  • Clopidogrel and aspirin after ischemic stroke or transient ischemic attack: an updated systematic review and meta-analysis of randomized clinical trials.

    abstract：:Recurrent stroke is common immediately following a transient ischemic attack (TIA) or ischemic stroke. Dual antiplatelet therapy (DAPT) with clopidogrel and aspirin may provide greater protection against subsequent stroke than monotherapy. Electronic databases were searched for randomized clinical trials (RCTs) compar...

    journal_title：Journal of thrombosis and thrombolysis

    pub_type： 杂志文章,meta分析

    doi：10.1007/s11239-018-1786-z

    authors： Kheiri B,Osman M,Abdalla A,Haykal T,Swaid B,Ahmed S,Chahine A,Hassan M,Bachuwa G,Al Qasmi M,Bhatt DL

    更新日期：2019-02-01 00:00:00

  • Diabetes mellitus is associated with increased bleeding in pulmonary embolism receiving conventional anticoagulant therapy: findings from a "real-world" study.

    abstract：:Bleeding refers to the most important complication during anticoagulation therapy in patients with pulmonary embolism (PE). However, the incidence and risk factors of bleeding in Chinese population with anticoagulant therapy remains unknown. Although diabetes mellitus (DM) has been demonstrated to increase the risk of...

    journal_title：Journal of thrombosis and thrombolysis

    pub_type： 杂志文章

    doi：10.1007/s11239-017-1473-5

    authors： Zhang Z,Zhai Z,Yang Y,Wan J,Xie W,Zhu J,Shen YH,Wang C

    更新日期：2017-05-01 00:00:00

  • Comparison of clinical performance of four gastrointestinal bleeding risk scores in Chinese patients with atrial fibrillation receiving oral anticoagulants.

    abstract：:Gastrointestinal bleeding is the most common bleeding complication during anticoagulant therapy. A reliable bleeding risk score can help the clinician assess risk of bleeding in individual patients and select the anticoagulant regimen. This study retrospectively analyzed the data of patients with atrial fibrillation w...

    journal_title：Journal of thrombosis and thrombolysis

    pub_type： 杂志文章

    doi：10.1007/s11239-020-02152-1

    authors： Lv MN,Zheng XC,Zhang HQ,Xu FD,Wu TT,Chen WJ,Xia XT,Fu JL,Jiang SJ,Zhang JH

    更新日期：2021-01-01 00:00:00

  • Acute Myocardial Infarction and the Role of Aspirin, Heparin, and Warfarin.

    abstract：:Acute myocardial infarction is initiated by plaque disruption of a fatty plaque with a thin fibrous cap which has been infiltrated by macrophages. The macrophages are attracted and stimulated by oxidized lipids to secrete metalloproteinases which dissolve collagen and arterial wall matrix and to synthesize tissue fact...

    journal_title：Journal of thrombosis and thrombolysis

    pub_type： 杂志文章

    doi：10.1007/BF01060732

    authors： Chesebro JH,Badimon JJ,Hassinger NL,McBane RD,Fuster V V

    更新日期：1995-01-01 00:00:00

  • Aspirin resistance and genetic polymorphisms.

    abstract：:Differences in genetic makeup or polymorphisms can affect individual drug response. Detecting genetic variation may help predict how a patient will respond to a drug and could be used as a tool to select optimal therapy, tailor dosage regimens, and improve clinical outcomes. The data are replete relative to the therap...

    journal_title：Journal of thrombosis and thrombolysis

    pub_type： 杂志文章,评审

    doi：10.1023/a:1022066305399

    authors： Cambria-Kiely JA,Gandhi PJ

    更新日期：2002-08-01 00:00:00

  • Incidence and outcomes of catheter related thrombosis (CRT) in patients with acute leukemia using a platelet-adjusted low molecular weight heparin regimen.

    abstract：:Patients with acute leukemia frequently develop catheter-related thrombosis (CRT) despite concurrent thrombocytopenia. The incidence, treatment and outcomes of this complication are poorly documented. We undertook this study to determine the incidence of CRT in patients with acute leukemia and assess the safety and ef...

    journal_title：Journal of thrombosis and thrombolysis

    pub_type： 杂志文章

    doi：10.1007/s11239-018-1711-5

    authors： Htun KT,Ma MJY,Lee AYY

    更新日期：2018-10-01 00:00:00

  • COVID-19 associated coagulopathy in critically ill patients: A hypercoagulable state demonstrated by parameters of haemostasis and clot waveform analysis.

    abstract：:Patients with COVID-19 are known to be at risk of developing both venous, arterial and microvascular thrombosis, due to an excessive immuno-thrombogenic response to the SARS-CoV-2 infection. Overlapping syndromes of COVID-19 associated coagulopathy with consumptive coagulopathy and microangiopathy can be seen in criti...

    journal_title：Journal of thrombosis and thrombolysis

    pub_type： 杂志文章

    doi：10.1007/s11239-020-02318-x

    authors： Fan BE,Ng J,Chan SSW,Christopher D,Tso ACY,Ling LM,Young BE,Wong LJL,Sum CLL,Tan HT,Ang MK,Lim GH,Ong KH,Kuperan P,Chia YW

    更新日期：2020-10-24 00:00:00

  • Paradoxical thrombosis, part 2: anticoagulant and antiplatelet therapy.

    abstract：:Arterial thrombosis is the leading causes of morbidity and mortality worldwide, whereas venous thrombosis is the most common preventable cause of hospital death. In either case, venous and arterial thrombosis should be considered autonomous entities, with only minor overlaps in terms of risk factors, predisposing cond...

    journal_title：Journal of thrombosis and thrombolysis

    pub_type： 杂志文章,评审

    doi：10.1007/s11239-012-0748-0

    authors： Lippi G,Favaloro EJ,Franchini M

    更新日期：2012-10-01 00:00:00

  • Characteristic and prognosis of acute large vessel occlusion in anterior and posterior circulation after endovascular treatment: the ANGEL registry real world experience.

    abstract：:There were limited studies comparing the anterior (AC) and posterior (PC) circulation acute ischemic strokes (AIS). Our study aimed to evaluate distinct features of AC and PC strokes regarding clinical, vascular risk, pathogenesis and outcome factors after endovascular procedures. This multicenter prospective study re...

    journal_title：Journal of thrombosis and thrombolysis

    pub_type： 杂志文章

    doi：10.1007/s11239-020-02054-2

    authors： Huo X,Raynald,Gao F,Ma N,Mo D,Sun X,Song L,Jia B,Pan Y,Wang Y,Liu L,Zhao X,Wang Y,Miao Z,ANGEL investigators.

    更新日期：2020-05-01 00:00:00

  • Point-of-care testing of coagulation in patients treated with edoxaban.

    abstract：:Edoxaban, alongside other direct oral anticoagulants (DOAC), is increasingly used for prevention of thromboembolism, including stroke. Despite DOAC therapy, however, annual stroke rate in patients with atrial fibrillation remains 1-2%. Rapid exclusion of relevant anticoagulation is necessary to guide thrombolysis or r...

    journal_title：Journal of thrombosis and thrombolysis

    pub_type： 杂志文章

    doi：10.1007/s11239-020-02143-2

    authors： Härtig F,Birschmann I,Peter A,Hörber S,Ebner M,Sonnleitner M,Spencer C,Bombach P,Stefanou MI,Kuhn J,Mengel A,Ziemann U,Poli S

    更新日期：2020-10-01 00:00:00

  • Sulfonylureas are not associated with increased mortality in diabetics treated with thrombolysis for acute myocardial infarction.

    abstract：BACKGROUND:Sulfonylurea compounds may impair ischemic preconditioning and endogenous fibrinolysis. Increased mortality has been reported in diabetics receiving these drugs prior to admission for acute myocardial infarction when treated by direct angioplasty. Although thrombolytics are currently employed far more freque...

    journal_title：Journal of thrombosis and thrombolysis

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1023/a:1012979622945

    authors： Halkin A,Roth A,Jonas M,Behar S

    更新日期：2001-10-01 00:00:00

  • Acute Myocardial Infarction in Canada: New Epidemiologic Insights on Incidence, Therapy, and Risk.

    abstract：:Objective: To define the changing incidence, risk, and therapy of acute myocardial infarction (A311). Data sources: Review of contemporary AMI data from the University of Alberta Hospitals, six other sites of the Clinical Quality Improvement Network (CQIN), and other Canadian and international centers. Data synthesis:...

    journal_title：Journal of thrombosis and thrombolysis

    pub_type： 杂志文章

    doi：10.1007/BF00132402

    authors： Montague T,Montague P,Barnes M,Taylor L,Wowk L,Fassbender K,Ackman M,Martin S,Armstrong PW,Teo K

    更新日期：1996-01-01 00:00:00

  • Clinical application of procedural platelet monitoring during percutaneous coronary intervention among patients at increased bleeding risk.

    abstract：:The goal of platelet function testing in the catheterization laboratory is to provide information about the platelet contributions to the risk of thrombotic or hemorrhagic events and optimization of anti-platelet therapy for percutaneous interventions. We present several illustrative cases in which platelet monitoring...

    journal_title：Journal of thrombosis and thrombolysis

    pub_type： 杂志文章

    doi：10.1023/a:1011228817265

    authors： Mukherjee D,Chew DP,Robbins M,Yadav JS,Raymond RE,Moliterno DJ

    更新日期：2001-04-01 00:00:00

  • The post-thrombotic syndrome: the forgotten morbidity of deep venous thrombosis.

    abstract：:The postthrombotic syndrome (PTS) is the most common complication of deep venous thrombosis (DVT) yet has received little attention from clinicians and researchers. Clinically, PTS is characterized by chronic pain, swelling, heaviness and other signs in the affected limb. In severe cases, venous ulcers may develop. PT...

    journal_title：Journal of thrombosis and thrombolysis

    pub_type： 杂志文章,评审

    doi：10.1007/s11239-006-5574-9

    authors： Kahn SR

    更新日期：2006-02-01 00:00:00

  • Home management of INR in the public health system: feasibility of self-management of oral anticoagulation and long-term performance of individual POC devices in determining INR.

    abstract：:The home prothrombin time/international normalized ratio (PT/INR) self-management could be convenient for patients, enhancing treatment compliance and improving the quality of the oral anticoagulation. However, patient self-management (PSM) of oral anticoagulation may not be feasible for up to half of the patients due...

    journal_title：Journal of thrombosis and thrombolysis

    pub_type： 杂志文章

    doi：10.1007/s11239-016-1335-6

    authors： da Silva Saraiva S,Orsi FA,Santos MP,Machado T,Montalvão S,Costa-Lima C,de Paula EV,Colella MP,Annichino-Bizzacchi J

    更新日期：2016-07-01 00:00:00

  • Management of periprocedural anticoagulant therapy: a novel individualized approach-a transeusophageal echocardiographic study.

    abstract：:Patients with non-valvular atrial fibrillation who are under chronic oral anticoagulant therapy (OAC) treatment frequently require interruption of OAC treatment. By examining the presence of left atrial/left atrial appendage (LA/LAA) thrombus or dense spontaneous echo contrast (SEC) with transesophageal echocardiograp...

    journal_title：Journal of thrombosis and thrombolysis

    pub_type： 杂志文章

    doi：10.1007/s11239-020-02104-9

    authors： Durmaz E,Karadag B,İkitimur B,Ebren C,Tokdil H,Koca D,Ozmen E,Polat F,Ohtaroglu Tokdil K,Raimoglu U,Mutlu D,Atici A,Ongen Z

    更新日期：2020-08-01 00:00:00

  • Polymorphism induced sensitivity to warfarin: a review of the literature.

    abstract：:Warfarin is a widely prescribed anticoagulant used for prophylaxis and treatment of venous and arterial thrombosis. Although warfarin is considered very efficacious, it has substantial risks associated with its use, specifically the risk of hemorrhage. Genetic variants associated with the metabolism of (S)-warfarin by...

    journal_title：Journal of thrombosis and thrombolysis

    pub_type： 杂志文章,评审

    doi：10.1023/B:THRO.0000011376.12309.af

    authors： Palkimas MP Jr,Skinner HM,Gandhi PJ,Gardner AJ

    更新日期：2003-06-01 00:00:00

  • Associations between model-predicted rivaroxaban exposure and patient characteristics and efficacy and safety outcomes in the prevention of venous thromboembolism.

    abstract：:Anticoagulant plasma concentrations and patient characteristics might affect the benefit-risk balance of therapy. The study objective was to assess the impact of model-predicted rivaroxaban exposure and patient characteristics on outcomes in patients receiving rivaroxaban for venous thromboembolism (VTE) prophylaxis (...

    journal_title：Journal of thrombosis and thrombolysis

    pub_type： 杂志文章

    doi：10.1007/s11239-020-02078-8

    authors： Reinecke I,Solms A,Willmann S,Spiro TE,Peters G,Weitz JI,Mueck W,Garmann D,Schmidt S,Zhang L,Fox KAA,Berkowitz SD

    更新日期：2020-07-01 00:00:00

  • Platelet response to direct thrombin inhibitor or fondaparinux treatment in patients with suspected heparin-induced thrombocytopenia.

    abstract：:Making a definitive diagnosis of heparin-induced thrombocytopenia (HIT) can be problematic. A prompt platelet rise following treatment has been proposed as a "post-test" criterion for diagnosis. However, the platelet response following discontinuation of heparin and initiation of a recommended alternative anticoagulan...

    journal_title：Journal of thrombosis and thrombolysis

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s11239-018-1646-x

    authors： Pon TK,Mahajan A,Rosenberg A,Amin A,Shah D,Jenkins I,Gupta V,Hofmann H,Bejjani A,White R

    更新日期：2018-05-01 00:00:00

  • Reasons for exclusion from intravenous thrombolysis in stroke patients admitted to the Stroke Unit.

    abstract：:Intravenous (IV) thrombolysis is the treatment in ischemic stroke, but only the minority of patients receive this medication. The primary objective of this study was to explore the reasons associated with the decision not to offer IV thrombolysis to stroke patients admitted to the Stroke Unit (SU). We conducted a retr...

    journal_title：Journal of thrombosis and thrombolysis

    pub_type： 杂志文章

    doi：10.1007/s11239-016-1406-8

    authors： Cappellari M,Bosco M,Forlivesi S,Tomelleri G,Micheletti N,Carletti M,Bovi P

    更新日期：2016-11-01 00:00:00

  • Novel sila-amide derivatives of N-acetylcysteine protects platelets from oxidative stress-induced apoptosis.

    abstract：:Oxidative stress-induced platelet apoptosis is one among the many causes for the development and progression of many disorders like cardiovascular diseases, arthritis, Alzheimer's disease and many chronic inflammatory responses. Many studies have demonstrated the less optimal effect of N-acetyl cysteine (NAC) in oxida...

    journal_title：Journal of thrombosis and thrombolysis

    pub_type： 杂志文章

    doi：10.1007/s11239-016-1450-4

    authors： Paul M,Thushara RM,Jagadish S,Zakai UI,West R,Kemparaju K,Girish KS

    更新日期：2017-02-01 00:00:00

  • Review of venous thromboembolism and race: the generalizability of treatment guidelines for high-risk populations.

    abstract：:The American College of Chest Physicians (ACCP) has established guidelines for the treatment of VTE, but the generalizability to all populations is unclear. In this review we analyzed the rate of reporting and enrollment of blacks and women in clinical trials cited in the ACCP guidelines for treatment of unprovoked VT...

    journal_title：Journal of thrombosis and thrombolysis

    pub_type： 杂志文章,评审

    doi：10.1007/s11239-016-1352-5

    authors： Sullivan LT 2nd,Jackson LR 2nd,Thomas KL

    更新日期：2016-08-01 00:00:00

  • Screening for paroxysmal nocturnal hemoglobinuria (PNH) in patients presenting with cerebral sinovenous thrombosis (CSVT): Results of a FLAER based flowcytometry study in Indian patients.

    abstract：:Patients with paroxysmal nocturnal hemoglobinuria (PNH) may present with thrombosis at unusual sites, of which cerebral sinovenous thrombosis (CSVT) is one and screening for PNH is recommended in this condition. Though many patients diagnosed with PNH develop CSVT, it is unclear how many patients with PNH would presen...

    journal_title：Journal of thrombosis and thrombolysis

    pub_type： 杂志文章

    doi：10.1007/s11239-019-01982-y

    authors： Sharma S,Ahluwalia J,Atreja CB,Modi M,Sachdeva MS,Kumar N,Bose P,Bose SK,Uppal V,Lal V,Varma N

    更新日期：2020-05-01 00:00:00