Abstract：
BACKGROUND:Clostridium difficile (CD) is the leading cause of health care-associated diarrhea and can result in asymptomatic carriage. Rates of asymptomatic CD colonization on hospital admission range from 1.4%-21%. The objective of this study was to evaluate host and bacterial factors associated with colonization on admission. METHODS:The Consortium de recherche québécois sur le Clostridium difficile study provided data for analysis, including demographic information, known risk factors, and potential confounding factors, prospectively collected for 5,232 patients from 6 hospitals in Quebec and Ontario over 15 months from 2006-2007. Stool or rectal swabs were obtained for culture on admission. Pulsed-field gel electrophoresis was performed on the isolates. The presence of antibody against CD toxins A and B was measured. RESULTS:There were 212 (4.05%) patients colonized with CD on admission, and 5,020 patients were not colonized with CD. Multivariate logistic regression analysis showed that hospitalization within the last 12 months, use of corticosteroids, prior CD infection, and presence of antibody against toxin B were associated with colonization on admission. Of patients colonized on admission, 79.4% had non-NAP1, non-NAP2 strains. CONCLUSION:There are identifiable risk factors among asymptomatic CD carriers that could serve in their detection and provide a basis for targeted screening.
journal_name
Am J Infect Controljournal_title
American journal of infection controlauthors
Kong LY,Dendukuri N,Schiller I,Bourgault AM,Brassard P,Poirier L,Lamothe F,Béliveau C,Michaud S,Turgeon N,Toye B,Frost EH,Gilca R,Dascal A,Loo VGdoi
10.1016/j.ajic.2014.11.024subject
Has Abstractpub_date
2015-03-01 00:00:00pages
248-53issue
3eissn
0196-6553issn
1527-3296pii
S0196-6553(14)01366-2journal_volume
43pub_type
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