Non-insulin-dependent diabetes mellitus. Current status of oral hypoglycemic therapy.

Abstract:

:Proper treatment of non-insulin-dependent (type II) diabetes presents the physician with a number of choices. Diet and exercise should be tried first in many patients; if this regimen is unsuccessful, treatment with either insulin or a first- or second-generation sulfonylurea must be considered. Theoretically, second-generation agents are more advantageous than first-generation agents because they do not interact with other drugs. I do not believe that they are more efficacious, however, and they probably do not have fewer side effects if chlorpropamide (Diabinese) is eliminated from consideration. Future well-designed crossover studies may help to clarify this issue. Combined insulin and sulfonylurea therapy can be tried in obese patients resistant to large doses of insulin, although results are not dramatic. In all patients the goal is to reach acceptable fasting glucose levels and near-normal glycosylated hemoglobin values.

journal_name

Postgrad Med

journal_title

Postgraduate medicine

authors

Nelson RL

doi

10.1080/00325481.1987.11699825

subject

Has Abstract

pub_date

1987-05-01 00:00:00

pages

177-81, 184-6

issue

6

eissn

0032-5481

issn

1941-9260

journal_volume

81

pub_type

杂志文章
  • Is electroconvulsive therapy safe?

    abstract::Electroconvulsive therapy is controversial and readily arouses the passions of both its supporters and detractors. In this article, Dr Schoen, an internist, discusses various aspects of this 50-year-old technique, including risks, contraindications, and physiologic effects. ...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章,评审

    doi:10.1080/00325481.1990.11716347

    authors: Schoen RE

    更新日期:1990-05-01 00:00:00

  • Alpha 1-blocker combination therapy for hypertension.

    abstract::Combination therapy is a cost-effective and rational approach to treatment of severe hypertension and of mild to moderate hypertension that is refractory to monotherapy. The method has several advantages, most notably improved tolerability and enhanced antihypertensive efficacy. Long-term prospective studies are neede...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章,评审

    doi:10.3810/pgm.1998.09.581

    authors: Houston MC

    更新日期:1998-09-01 00:00:00

  • Contemporary therapy for acne. What, when, and how to prescribe.

    abstract::The use of topical tretinoin (Retin-A) for comedonal lesions, benzoyl peroxide for inflamed papules and pustules, and topical or oral antibiotics for more severe or widespread disease gives excellent results for the majority of patients with acne. At present, oral isotretinoin (13-cis-retinoic acid) (Accutane) should ...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章

    doi:10.1080/00325481.1985.11698996

    authors: Greer KE

    更新日期:1985-05-01 00:00:00

  • Outpatient management of inflammatory bowel disease. Let's keep it as simple as possible.

    abstract::Inflammatory bowel disease is a conglomeration of disorders of unclear etiology and pathogenesis. Confirming the diagnosis of active disease may be difficult but is critical to judicious therapy. Sulfasalazine (Azulfidine) and its newer derivatives mesalamine (Asacol, Rowasa) and olsalazine sodium (Dipentum) are used ...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章,评审

    doi:10.1080/00325481.1992.11701512

    authors: Butt JH

    更新日期:1992-11-01 00:00:00

  • Dissection of dizziness: with emphasis on labyrinthine vertigo.

    abstract::The three most common types of vertiginous episodes area benign positional vertigo, postural vertigo, and endolymphatic hydrops. One of these conditions will be found in more than 90% of patients who present with vertigo as their main complaint. A clear understanding of the differences among these three entities will ...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章

    doi:10.1080/00325481.1981.11715757

    authors: Maragos NE,Neel HB 3rd,McDonald TJ

    更新日期:1981-05-01 00:00:00

  • Advances in the diagnostic options for prostate cancer.

    abstract::Over the past decade, despite the controversies surrounding prostate cancer screening, significant refinements have improved its application. PSA screening, although it has been questioned, appears to confer a mortality benefit and remains the most effective way to identify the possible presence of prostate cancer. Me...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章

    doi:10.1080/00325481.2020.1822067

    authors: French WW,Wallen EM

    更新日期:2020-12-01 00:00:00

  • Pediatric aspects of nuclear medicine.

    abstract::During the last few years, the number, variety, and complexity of nuclear medical examinations that can be performed in children have increased impressively, due partly to recent accomplishments in radiopharmaceutical development and the availability of gamma scintillation cameras and computer systems for acquisition,...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章

    doi:10.1080/00325481.1975.11713991

    authors: Treves S

    更新日期:1975-03-01 00:00:00

  • When is pulmonary artery catheterization worth the risks?

    abstract::Bedside pulmonary artery catheterization has proven to be an important addition to the clinical assessment of critically ill patients. Properly used, the procedure may provide hemodynamic information that is not apparent from physical examination or radiography. It may be safely accomplished through various venous rou...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章,评审

    doi:10.1080/00325481.1991.11700825

    authors: Zimmerman FH

    更新日期:1991-02-01 00:00:00

  • Septic arthritis. Clinical approach to the 'hot joint'.

    abstract::Joint space infections continue to be among the most common forms of arthritis. Diagnosis can be difficult, particularly in the presence of underlying joint disease. Septic arthritis should be suspected in all patients who present with an acutely swollen joint. Immediate joint aspiration with Gram's stain and culture ...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章

    doi:10.1080/00325481.1986.11699270

    authors: Evanchick CE,Davis DE,Harrington TM

    更新日期:1986-02-01 00:00:00

  • Anemia of chronic disease.

    abstract::Anemia is one of the consistent findings with inflammation. Whether the anemia is helpful or harmful in the general context of the illness is unclear. It may be recognized by demonstration of iron-deficient erythropoiesis due to an internal block in iron supply. Only when its severity is disproportionate to the severi...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章

    doi:10.1080/00325481.1978.11714951

    authors: Finch CA

    更新日期:1978-10-01 00:00:00

  • Comparison of subjective effects of extended-release versus immediate-release oxycodone/acetaminophen tablets in healthy nondependent recreational users of prescription opioids: a randomized trial.

    abstract:BACKGROUND:Prescription opioids have substantial abuse potential. This study compared the positive subjective drug effects of a newly developed extended-release (ER) oxycodone (OC)/acetaminophen (acetyl-para-aminophenol [APAP]) formulation with those of immediate-release (IR) OC/APAP. METHODS:This randomized, double-b...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.3810/pgm.2014.07.2780

    authors: Morton T,Kostenbader K,Montgomery J,Devarakonda K,Barrett T,Webster L

    更新日期:2014-07-01 00:00:00

  • Effects of illness on thyroid function tests.

    abstract::Severe illness of any type predictably leads to abnormal results on thyroid function tests. The first apparent changes are a decrease in total triiodothyronine (T3) and an increase in reverse T3. As disease progresses, a marked decline in thyroxine and an increase in T3 resin uptake are observed. Thyrotropin levels re...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章

    doi:10.1080/00325481.1989.11700751

    authors: Felicetta JV

    更新日期:1989-06-01 00:00:00

  • Concomitant major vessel resection in pancreatic adenocarcinoma.

    abstract::Increasing evidence has contraindicated extended radical dissection of pancreatic adenocarcinoma (PC). With the recent improvement of perioperative management techniques and multimodal treatment strategy for PC, concomitant major vessel resection and reconstruction has thus been aggressively attempted in association w...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章,评审

    doi:10.1080/00325481.2015.1032180

    authors: Tsuchikawa T,Hirano S,Nakamura T,Okamura K,Tamoto E,Shichinohe T

    更新日期:2015-04-01 00:00:00

  • Primary localized breast cancer. Treatment options and informed choices.

    abstract::As understanding of the natural history of breast cancer has increased, radical mastectomy has given way to a preference for breast-sparing surgery and greater reliance on radiation therapy and chemotherapy. Probably the most important factor for selection of treatment is consultation with a multidisciplinary team ski...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章,评审

    doi:10.1080/00325481.1989.11704444

    authors: Schwade JG,Robinson DS,Love N

    更新日期:1989-10-01 00:00:00

  • Hirsutism and virilization. A systematic approach to benign and potentially serious causes.

    abstract::A woman with excessive body hair may visit a physician with concerns about fertility and general health as well as appearance. Fortunately, the cause is usually benign, most often polycystic ovarian syndrome. However, life-threatening causes must be quickly ruled out. Hirsutism secondary to endocrinopathies and tumors...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章,评审

    doi:

    authors: Marshburn PB,Carr BR

    更新日期:1995-01-01 00:00:00

  • Thromboembolism after hip surgery. Comparison of screening methods.

    abstract::Venous thromboembolism is a serious and, often, asymptomatic complication of hip surgery. A reliable screening test is needed to detect thrombi early to prevent death from pulmonary emboli. Noninvasive screening tests were ineffective in our study of 453 patients. We recommend early use of ventilation/perfusion lung s...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章

    doi:10.1080/00325481.1986.11699529

    authors: Mitsunaga MM,Ferris EB 3rd,Kong AY,Kistner RL,Mayfield GW,Lindberg RF,Jones DA

    更新日期:1986-09-15 00:00:00

  • Computer searching made easy. Program to find medical articles quickly.

    abstract::GRATEFUL MED is a computer program for searching the medical literature, designed with the novice in mind. It contains an extensive list of medical subject headings, so the user does not have to page through an index of key words before starting the search. Because of its efficiency and ease of operation, the program ...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章

    doi:10.1080/00325481.1988.11700124

    authors: Schell CL,Rathe RJ

    更新日期:1988-01-01 00:00:00

  • Liver transplantation. New hope for many patients.

    abstract::Because of the broad range of physiologic problems and the many potential sources of complications, liver transplantation patients require contributions from virtually the complete spectrum of medical science. The evolving specialty of liver transplantation has eagerly assimilated advances in surgical techniques, anes...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章,评审

    doi:10.1080/00325481.1990.11704566

    authors: Williams JW,Sabesin SM

    更新日期:1990-02-01 00:00:00

  • Normal growth and development: current concepts.

    abstract::Human growth and development are a continuum starting at conception. Prenatal growth can only be estimated at present but is an important consideration in an evaluation of a child's developmental status. Postnatal growth can be assessed for size attained (distance curve) or change over time (velocity curve). Velocity ...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章

    doi:10.1080/00325481.1977.11714699

    authors: Falkner F

    更新日期:1977-12-01 00:00:00

  • Diagnosis and management of nasal congestion: the role of intranasal corticosteroids.

    abstract::Nasal congestion is considered the most bothersome of allergic rhinitis (AR) symptoms and can significantly impair ability to function at work, home, and school. Effective management of AR-related nasal congestion depends on accurate diagnosis and appropriate treatment. Many individuals with AR and AR-related congesti...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章,评审

    doi:10.3810/pgm.2009.01.1961

    authors: Benninger M

    更新日期:2009-01-01 00:00:00

  • Beyond psychopharmacology. Psychosocial strategies for getting the best results when switching antipsychotic medications.

    abstract::Recent effectiveness studies have shown that over a year and a half, 3 of 4 study patients either stopped or changed their antipsychotic medication. This finding highlights the fact that psychopharmacologic treatments do not remain stable over the course of treatment. Our own interpretation is that these findings emph...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章,评审

    doi:

    authors: Scheifler PL,Weiden PJ

    更新日期:2006-09-01 00:00:00

  • Severe Pseudomonas aeruginosa infections. Tackling the conundrum of drug resistance.

    abstract::Pseudomonas aeruginosa infections are a frequent cause of morbidity and mortality in hospitalized patients. Treatment of these infections is complicated by the intrinsic and acquired resistance of this bacterium to many commonly used antimicrobial agents. In this article, Drs Hauser and Sriram argue that careful consi...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章,评审

    doi:10.3810/pgm.2005.01.1571

    authors: Hauser AR,Sriram P

    更新日期:2005-01-01 00:00:00

  • Hair loss. Common congenital and acquired causes.

    abstract::Hair loss is a common problem likely to be encountered by a clinical practitioner. The most frequent causes of hair loss in pediatric patients include tinea capitis, alopecia areata, traction alopecia, and trichotillomania. In the adult population, causes to be considered are alopecia areata and hair loss associated w...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章

    doi:10.1080/00325481.1986.11699358

    authors: Phillips JH 3rd,Smith SL,Storer JS

    更新日期:1986-04-01 00:00:00

  • Flexible sigmoidoscopy. Illuminating the pearls for passage.

    abstract::As efforts to improve screening for colon cancer have increased, so has the importance of routine flexible sigmoidoscopy. However, the procedure is still underused, and about half of primary care physicians who recommend it refer their patients to other physicians. Increased use of this valuable screening tool is an i...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章,评审

    doi:10.3810/pgm.1999.06.622

    authors: Davis PW,Stanfield CB

    更新日期:1999-06-01 00:00:00

  • Varicose veins. Their symptoms, complications, and management.

    abstract::Varicose veins are a common problem that still presents a major challenge to the physician and the patient. Complete surgical removal of the malfunctioning veins has proved to be the most effective management for significant varicosities, although several nonsurgical methods are available for mild cases or those not s...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章

    doi:10.1080/00325481.1979.11715178

    authors: Lofgren KA

    更新日期:1979-06-01 00:00:00

  • Occlusive peripheral arterial disease. Guidelines for office management.

    abstract::Occlusive peripheral arterial disease is rather easy to diagnose because of its characteristic symptoms and the ease with which the extremities and their circulation can be examined. Elevation and dependency tests give a rough but reliable estimate of the degree of ischemia, and if more objective data are desired, the...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章

    doi:10.1080/00325481.1982.11715993

    authors: Spittell JA Jr

    更新日期:1982-02-01 00:00:00

  • Dermatologic emergencies.

    abstract::Preview Several dermatoses are potentially fatal, and the mortality rate for some is quite high; prompt recognition and treatment are essential. Dr Gannon's succinct discussions of pemphigus vulgaris, necrotizing fasciitis, toxic epidermal necrolysis, Stevens-Johnson syndrome, toxic shock syndrome, and urticaria and a...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章

    doi:10.1080/00325481.1994.11945875

    authors: Gannon T

    更新日期:1994-07-01 00:00:00

  • When bleeding complicates oral anticoagulant therapy. How to anticipate, investigate, and treat.

    abstract::With use of the International Normalized Ratio (INR), physicians can accurately assess the intensity of anticoagulation in treatment programs and trials. Bleeding is the major complication of oral anticoagulant therapy, and its incidence can be lessened, with no loss of efficacy, by using less intense therapy (INR, 2 ...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章,评审

    doi:

    authors: Brigden ML

    更新日期:1995-09-01 00:00:00

  • The emerging new arthritis drugs. A clinician's opinion.

    abstract::In the face of deficiencies in our present system of introducing new drugs, clinicians must be committed to monitoring patients carefully. They must not be caught up in the hyperbole and excitement of the latest new drug, but instead should allow the crucible of time to teach them and the rest of the medical community...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章

    doi:10.1080/00325481.1983.11697799

    authors: Roth SH

    更新日期:1983-03-01 00:00:00

  • Sinusitis. Its association with asthma.

    abstract::Sinusitis may present as an indolent infection, without the classic symptoms and signs commonly expected, and will probably be missed in children who have only cough and persistent rhinorrhea unless this diagnosis is kept in mind. Plain radiography is the most commonly used diagnostic procedure for sinusitis, but comp...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章

    doi:10.1080/00325481.1990.11704634

    authors: Herrera AM,deShazo RD

    更新日期:1990-04-01 00:00:00