When bleeding complicates oral anticoagulant therapy. How to anticipate, investigate, and treat.

Abstract:

:With use of the International Normalized Ratio (INR), physicians can accurately assess the intensity of anticoagulation in treatment programs and trials. Bleeding is the major complication of oral anticoagulant therapy, and its incidence can be lessened, with no loss of efficacy, by using less intense therapy (INR, 2 to 3). INRs above the target range, marked variability in INRs, newly initiated therapy, previous bleeding, and a serious comorbid condition all constitute significant risk factors. While age over 65 is not a proven risk factor, the elderly are more sensitive to the effects of warfarin and require smaller doses. Meticulous attention should be paid to the concomitant use of any medications that may affect metabolism of warfarin or induce a concomitant qualitative platelet effect (specifically, aspirin and nonsteroidal antiinflammatory drugs) and to dietary modifications that significantly change vitamin K intake. Hematuria or gastrointestinal bleeding should always be assessed, since the chance of finding a clinically significant lesion is good, especially when the INR has been in the therapeutic range. While a minor prolongation of the INR without bleeding may be treated by watchful waiting, vitamin K administration and other therapeutic measures may be necessary in patients who are actively bleeding.

journal_name

Postgrad Med

journal_title

Postgraduate medicine

authors

Brigden ML

subject

Has Abstract

pub_date

1995-09-01 00:00:00

pages

153-4, 159-62, 164-5, passim

issue

3

eissn

0032-5481

issn

1941-9260

journal_volume

98

pub_type

杂志文章,评审
  • Viral infections in the elderly. The challenges of managing herpes zoster, influenza, and RSV.

    abstract::Viral diseases are an important cause of morbidity and mortality in elderly patients, whether they live in the community or in long-term care facilities. Management of viral infections in older adults is complicated by factors that include the infrequency or absence of common signs and symptoms of infection and advers...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章,评审

    doi:10.3810/pgm.2005.11.1687

    authors: Bader MS,McKinsey DS

    更新日期:2005-11-01 00:00:00

  • Pharmacologic therapy for bronchial asthma.

    abstract::Many drugs with which to treat reversible obstructive airway disease are available. Beta-adrenergic aerosols are the first line of defense; these are followed, when necessary, by either timed-release theophylline or oral beta-adrenergics. Often, a combination of these drugs must be used to achieve effective relief of ...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章

    doi:10.1080/00325481.1987.11699911

    authors: O'Loughlin JM

    更新日期:1987-07-01 00:00:00

  • Anorectal disorders. Five common causes of pain, itching, and bleeding.

    abstract::Hemorrhoids are a common source of anorectal symptoms, which are determined by their size. A helpful measure in small hemorrhoids is a high-fiber diet; in moderate lesions, ligature therapy is effective. Surgery should be reserved for large hemorrhoids. Anal fissures, probably caused by trauma to the anal canal during...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章,评审

    doi:

    authors: Metcalf A

    更新日期:1995-11-01 00:00:00

  • Bacillus coagulans significantly improved abdominal pain and bloating in patients with IBS.

    abstract:BACKGROUND:Symptoms of irritable bowel syndrome (IBS) can have a profound impact on emotional health and quality of life, and current treatments are sometimes unsatisfactory for patients facing this lifelong disease. Probiotics, which can normalize gastrointestinal microflora, may alleviate symptoms of IBS. OBJECTIVE:...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.3810/pgm.2009.03.1984

    authors: Hun L

    更新日期:2009-03-01 00:00:00

  • Telephone 'emergencies'. How to respond appropriately and effectively.

    abstract::While the appropriateness of giving medical advice on the telephone could be debated, this discussion is based on the assumption that few physicians can avoid providing this service to their patients. In fact, most physicians must respond often to telephone requests for advice. A large portion of these "emergency" cal...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章

    doi:10.1080/00325481.1987.11699699

    authors: Davidhizar RE,Wehlage DF

    更新日期:1987-02-01 00:00:00

  • Is electroconvulsive therapy safe?

    abstract::Electroconvulsive therapy is controversial and readily arouses the passions of both its supporters and detractors. In this article, Dr Schoen, an internist, discusses various aspects of this 50-year-old technique, including risks, contraindications, and physiologic effects. ...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章,评审

    doi:10.1080/00325481.1990.11716347

    authors: Schoen RE

    更新日期:1990-05-01 00:00:00

  • Bleeding esophagogastric varices. Ways to treat active episodes and prevent recurrence.

    abstract::Bleeding from esophagogastric varices carries a high mortality rate. Active variceal bleeding can usually be temporarily controlled medically with a combination of intravenous vasopressin and nitroglycerin, with balloon tamponade, or with endoscopic sclerotherapy. Because of the high likelihood of recurrence, long-ter...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章,评审

    doi:10.1080/00325481.1991.11700924

    authors: Marshall JB

    更新日期:1991-05-01 00:00:00

  • Deficiency of vitamins A, B, and C.

    abstract::Preview Although specific vitamin deficiency syndromes are relatively rare in the United States, primary care physicians may encounter them in elderly patients and persons who consume minimal diets. Knowledge of such deficiencies is crucial in the evaluation of these patients. The authors discuss manifestations of def...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章

    doi:10.1080/00325481.1990.11704615

    authors: Skelton WP,Skelton NK

    更新日期:1990-03-01 00:00:00

  • Pharmacologic therapy of asthma.

    abstract::Asthma is treated by avoiding the precipitants of symptoms, by a trial of hyposensitization (immunotherapy) if the precipitant cannot be avoided, and principally by pharmacologic therapy. Acute attacks have been most widely treated with epinephrine, but adrenergic aerosol bronchodilators and aminophylline are being us...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章

    doi:10.1080/00325481.1976.11714330

    authors: Ellis EF

    更新日期:1976-04-01 00:00:00

  • Life-threatening neck infections. Early diagnosis to forestall crisis.

    abstract::Infections of the neck become life-threatening with airway or systemic involvement. The first step in successful management is early recognition by the initial examiner. Patient evaluation includes a thorough history and physical examination, laboratory studies, and if the patient's condition is stable, roentgenograph...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章

    doi:10.1080/00325481.1984.11698815

    authors: Beck HJ,McCaffrey TV

    更新日期:1984-12-01 00:00:00

  • Pain severity and healthcare resource utilization in patients with osteoarthritis in the United States.

    abstract:OBJECTIVE:To evaluate healthcare resource utilization (HCRU) by osteoarthritis (OA) pain severity. METHODS:Cross-sectional surveys of US physicians and their patients were conducted between February and May 2017. Using the Numeric Rating Scale, patients were classified by self-reported pain intensity in the last week ...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章

    doi:10.1080/00325481.2020.1841988

    authors: Nalamachu S,Robinson RL,Viktrup L,Cappelleri JC,Bushmakin AG,Tive L,Mellor J,Hatchell N,Jackson J

    更新日期:2021-01-01 00:00:00

  • Diagnosing ascites: the value of abdominal paracentesis.

    abstract::Abdominal paracentesis is a useful and safe technique in the evaluation of ascites. The withdrawn ascitic fluid should be routinely analyzed for appearance, blood cell count, and amylase and total protein concentrations; examined cytologically; and cultured. Results should either substantiate the clinical diagnosis or...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章

    doi:10.1080/00325481.1978.11714844

    authors: Babb RR

    更新日期:1978-05-01 00:00:00

  • Drug-induced aseptic meningitis. Diagnosis leads to quick resolution.

    abstract::Drug-induced aseptic meningitis is a syndrome that should be considered in the differential diagnosis of acute and recurrent aseptic meningitis. It has been observed in all age-groups and can occur following the use of a wide spectrum of pharmaceutical agents. Presumptive diagnosis is made by demonstrating the resolut...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章,评审

    doi:10.1080/00325481.1991.11701123

    authors: Chaudhry HJ,Cunha BA

    更新日期:1991-11-15 00:00:00

  • The suicidal patient. The primary care physician's role in evaluation and treatment.

    abstract::Evaluation of the suicidal patient involves careful consideration of risk factors, including attention to subtle clues from the history, and mental status examination. The most urgent decision for the physician to make is whether or not to insist on hospitalization. If the need for inpatient care is uncertain, a "no s...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章

    doi:10.1080/00325481.1986.11699432

    authors: Smith CW Jr,Bope ET

    更新日期:1986-06-01 00:00:00

  • Low agreement between the modified diet and renal disease formula and the Cockcroft-Gault formula for assessing chronic kidney disease in cognitively impaired elderly outpatients.

    abstract:OBJECTIVE:Chronic kidney disease is a global public health concern. Glomerular filtration rate (GFR) prediction based on serum creatinine is used to assess renal function in the elderly. The Cockcroft-Gault (CG) formula, based on body surface area (CG/BSA formula), and the Modified Diet and Renal Disease formula (MDRD ...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章

    doi:10.3810/pgm.2010.11.2221

    authors: Alagiakrishnan K,Senthilselvan A

    更新日期:2010-11-01 00:00:00

  • Immunologically mediated lung diseases. Extrinsic allergic alveolitis and allergic bronchopulmonary aspergillosis.

    abstract::Early recognition and treatment of immunologically mediated diseases of the lung are vital to prevent irreparable damage. Extrinsic allergic alveolitis and allergic bronchopulmonary aspergillosis are often confused but should not be difficult to distinguish. The former is nonatopic and is marked by chills, fever, ches...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章

    doi:10.1080/00325481.1976.11714331

    authors: Slavin RG

    更新日期:1976-04-01 00:00:00

  • Adjunctive aripiprazole, olanzapine, or quetiapine for major depressive disorder: an analysis of number needed to treat, number needed to harm, and likelihood to be helped or harmed.

    abstract:OBJECTIVE:To describe the efficacy and safety of adjunctive aripiprazole, olanzapine, and quetiapine for major depressive disorder. DATA SOURCES:Published registration study reports, supplemented by clinical trial synopses as disclosed by manufacturers and product labeling. STUDY SELECTION:All available reports of st...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章,评审

    doi:10.3810/pgm.2010.07.2174

    authors: Citrome L

    更新日期:2010-07-01 00:00:00

  • Diabetes in pregnancy. No longer a barrier to successful outcome.

    abstract::There are three key goals in current management of the diabetic pregnancy. Normal diabetes control before conception and during the first trimester in an attempt to reduce the incidence of congenital abnormalities. This implies that all diabetic women of childbearing age should have counseling before pregnancy. Routin...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章

    doi:10.1080/00325481.1985.11698879

    authors: Hollander P,Maeder EC Jr

    更新日期:1985-02-01 00:00:00

  • Gastric emptying disorders. Tests and treatments.

    abstract::Tests to measure the volume of gastric contents are necessary to determine the nature of a gastric emptying disorder. The conditions that can affect gastric emptying are as varied as peptic ulcer disease, achlorhydria, viral and bacterial infections of the stomach, diabetes, scleroderma, anorexia nervosa, and CNS lesi...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章

    doi:10.1080/00325481.1987.11699726

    authors: McCallum RW

    更新日期:1987-02-15 00:00:00

  • Practical tips on prescribing home oxygen therapy.

    abstract::Oxygen therapy is tremendously valuable for patients with chronic respiratory insufficiency. A physician's prescription is needed to obtain Medicare, Medicaid, or insurance-company reimbursement, and certain guidelines must be followed: Patients are selected if significant hypoxemia is present, appropriate pharmacolog...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章

    doi:10.1080/00325481.1988.11700464

    authors: Petty TL

    更新日期:1988-11-01 00:00:00

  • Clinical effects of colesevelam in Hispanic subjects with primary hyperlipidemia and prediabetes.

    abstract:OBJECTIVE:To evaluate the efficacy and safety of colesevelam in Hispanic subjects with primary hyperlipidemia and prediabetes. MATERIALS AND METHODS:A 16-week, randomized, double-blind, placebo-controlled, multinational study evaluating colesevelam in participants with primary hyperlipidemia (low-density lipoprotein c...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.3810/pgm.2012.07.2564

    authors: Rosenstock J,Hernandez-Triana E,Handelsman Y,Misir S,Jones MR

    更新日期:2012-07-01 00:00:00

  • Prevalence of Iron Deficiency (ID) without anemia in the general population presenting to primary care clinics: a cross-sectional study.

    abstract:OBJECTIVES:There are no evidence-based recommendations to screen for iron deficiency in non-anemic patients, even though symptoms may be present. The aim of this study is to measure the prevalence of iron deficiency (ID) without anemia in the general population aged 18-50 presenting to primary care along with the incid...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章

    doi:10.1080/00325481.2020.1715701

    authors: Abuaisha M,Itani H,El Masri R,Antoun J

    更新日期:2020-04-01 00:00:00

  • Clues to the mystery of multiple sclerosis.

    abstract::While the cause of multiple sclerosis (MS) remains obscure, epidemiologic investigation suggests that environmental factors encountered years before onset could be responsible. Studies elucidating age-specific onset curves, worldwide distribution, epidemics, clustering, and risk of contraction after migration are cons...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章,评审

    doi:10.1080/00325481.1989.11700620

    authors: Gorelick PB

    更新日期:1989-03-01 00:00:00

  • Mycobacterium chimaera chorioretinitis as a biomarker of systemic disease activity following nosocomial acquisition during cardiopulmonary bypass.

    abstract::Objectives: To understand the role of ophthalmoscopic examination (dilated retina examination and widefield fundus photography) in the diagnosis and management of nosocomial acquisition of Mycobacterium chimaera following open heart surgery with cardiopulmonary bypass utilizing a heater-cooler unit, an entity that is ...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章

    doi:10.1080/00325481.2019.1697545

    authors: Colucciello M

    更新日期:2020-03-01 00:00:00

  • Brain failure in older patients. Uncovering treatable causes of a diminished ability to think.

    abstract::The term "brain failure" implies only dysfunction of a major organ system, not that an exact diagnosis has been made. Assessment and treatment of older patients with diminished cognitive ability can be challenging; however, the experience can also be extremely rewarding when a reversible condition is alleviated and th...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章,评审

    doi:

    authors: Paist SS 3rd,Martin JR

    更新日期:1996-05-01 00:00:00

  • Efficacy and renal outcomes of SGLT2 inhibitors in patients with type 2 diabetes and chronic kidney disease.

    abstract:OBJECTIVE:To review glucose-lowering efficacy and changes in renal function associated with sodium-glucose co-transporter 2 (SGLT2) inhibitors among patients with chronic kidney disease (CKD) and type 2 diabetes mellitus (T2DM). DATA SOURCES:A literature search of MEDLINE and Cochrane databases was performed from 2000...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章,评审

    doi:10.1080/00325481.2019.1549459

    authors: Kelly MS,Lewis J,Huntsberry AM,Dea L,Portillo I

    更新日期:2019-01-01 00:00:00

  • Bronchiectasis: the 'other' obstructive lung disease.

    abstract::Bronchiectasis belongs to the family of chronic obstructive lung diseases, even though it is much less common than asthma, chronic bronchitis, or emphysema. Clinical features of these entities overlap significantly. The triad of chronic cough, sputum production, and hemoptysis always should bring bronchiectasis to min...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章,评审

    doi:10.3810/pgm.1999.07.607

    authors: Mysliwiec V,Pina JS

    更新日期:1999-07-01 00:00:00

  • Key issues in nutrition. Supplementation through adulthood and old age.

    abstract::A varied and balanced diet is usually adequate to meet the energy, protein, vitamin, and mineral requirements of adults and the elderly. However, some high-risk groups may require supplementation or special dietary recommendations. Some examples are persons on a weight-loss diet, alcoholics, premenopausal women, women...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章

    doi:10.1080/00325481.1987.11699819

    authors: Fahey PJ,Boltri JM,Monk JS

    更新日期:1987-05-01 00:00:00

  • The parotid lump--don't biopsy it! An approach to avoiding misadventure.

    abstract::All lumps in the parotid region must be assumed to originate in the parotid gland. A mobile, superficial-appearing lesion cannot be assumed to be located just beneath the skin. Open incisional biopsy should never be used in approaching lumps in this region because of the danger of tumor seeding or damage to the facial...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章

    doi:10.1080/00325481.1987.11699754

    authors: Olsen KD

    更新日期:1987-03-01 00:00:00

  • Cecal volvulus: A diagnostic and therapeutic challenge.

    abstract::Cecal volvulus is a malrotational abnormality of the intestine that causes obstruction. Diagnosis is difficult and, if delayed, the results may be intestinal ischemia, perforation, sepsis, and even death. Cecal ischemia or gangrene cannot always be determined from physical and laboratory findings. Although not always ...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章

    doi:10.1080/00325481.1982.11716164

    authors: Weiss BD

    更新日期:1982-08-01 00:00:00