Abstract:
:While the cause of multiple sclerosis (MS) remains obscure, epidemiologic investigation suggests that environmental factors encountered years before onset could be responsible. Studies elucidating age-specific onset curves, worldwide distribution, epidemics, clustering, and risk of contraction after migration are consistent with the belief that MS may be caused by exposure to an infectious agent, possibly viral, at or shortly after puberty. Indirect evidence from serologic studies of serum and CSF shows elevated antibody titers to a number of viruses in MS patients. Although the absence of reproducible direct evidence of virus or viral remnants in brain tissue of patients with MS casts doubt on the viral hypothesis, it cannot be excluded. The theory that MS represents a complicated virus-host interaction with a secondary mechanism that initiates or prevents the process and its exacerbations implies that at least two components are present--one producing the disease and one immunizing against it. Results from studies of geographic distribution, migration, and age at onset make this model plausible. Further understanding of the molecular biology of viruses and results of epidemiologic studies of migration will help settle this argument and may lead to prevention of the disease.
journal_name
Postgrad Medjournal_title
Postgraduate medicineauthors
Gorelick PBdoi
10.1080/00325481.1989.11700620subject
Has Abstractpub_date
1989-03-01 00:00:00pages
125-8, 131-4issue
4eissn
0032-5481issn
1941-9260journal_volume
85pub_type
杂志文章,评审abstract::Atopic dermatitis is a chronic disease marked by exacerbations and remissions. It begins in early infancy and may persist into late adulthood. Flares of dermatitis may be precipitated by emotional stess, extremes or sudden changes in humidity or temperature, and other factors. Treatment consists primarily of the use o...
journal_title:Postgraduate medicine
pub_type: 杂志文章
doi:10.1080/00325481.1978.11714996
更新日期:1978-12-01 00:00:00
abstract::Acquired immunodeficiency syndrome (AIDS) is a new and frightening epidemic. Epidemiology has clearly delineated the mechanisms of spread as sexual intercourse, transfer of blood, and vertical transfer from infected mother to newborn child. Although much remains to be answered about infection with the AIDS virus, pres...
journal_title:Postgraduate medicine
pub_type: 杂志文章,评审
doi:10.1080/00325481.1989.11700636
更新日期:1989-03-01 00:00:00
abstract::Two cases of Listeria monocytogenes infection in patients receiving immunosuppressive treatment after kidney transplantation are described. In the first, the infection, which occurred soon after transplantation and was accompanied by signs of mild chronic rejection, was the immediate cause of death. The other case occ...
journal_title:Postgraduate medicine
pub_type: 杂志文章
doi:10.1080/00325481.1980.11715622
更新日期:1980-12-01 00:00:00
abstract::Triglyceride (TG) levels can increase for numerous reasons, including a sedentary lifestyle, an unhealthy diet, especially one rich in refined carbohydrates, and comorbidities. According to the National Cholesterol Education Program (NCEP), the normal TG level is < 150 mg/dL. Patients with very high TG (VHTG) levels (...
journal_title:Postgraduate medicine
pub_type: 杂志文章,评审
doi:10.3810/pgm.2009.07.2020
更新日期:2009-07-01 00:00:00
abstract::Several risks can be posed by travel, even when the stay is not protracted nor the destination exotic. Air travelers should consider the potential problems associated with decreased cabin pressure, hypoxia, and circadian dysrhythmia, problems that can contraindicate flying for some. Motion sickness can affect those tr...
journal_title:Postgraduate medicine
pub_type: 杂志文章
doi:10.1080/00325481.1983.11698368
更新日期:1983-04-01 00:00:00
abstract::Epidemiologic and clinical evidence clearly documents the relationship between elevated levels of low-density lipoprotein cholesterol (LDL-C) and risk of coronary heart disease (CHD). In order to reduce CHD risk, the National Cholesterol Education Program (NCEP) has identified LDL-C goals that can be achieved through ...
journal_title:Postgraduate medicine
pub_type: 杂志文章
doi:10.3810/pgm.04.2003.suppl26.137
更新日期:2003-04-01 00:00:00
abstract::Glaucoma is a group of diseases leading to characteristic cupping and damage of the optic nerve head associated with progressive visual loss. The exact mechanism of damage is unknown, but current research is pointing toward a multifactorial disease process, in which elevated intraocular pressure is just one of the fac...
journal_title:Postgraduate medicine
pub_type: 杂志文章,评审
doi:
更新日期:1996-05-01 00:00:00
abstract::This article on microcytic anemia is the first of several on laboratory investigation of anemia. Microcytic anemia, characterized by a mean corpuscular volume of less than 80 cu mu, is usually due to iron deficiency or chronic disease but may signify thalassemia minor. Exact identification of the cause is important, s...
journal_title:Postgraduate medicine
pub_type: 杂志文章
doi:10.1080/00325481.1979.11715037
更新日期:1979-01-01 00:00:00
abstract::In an era when air travel is commonplace, middle ear block is not unusual. Educating patients about the simple techniques they can perform at the first signs of a problem may save a business trip or vacation from becoming a trip to the emergency department and a train ride home. The most important preventive measure i...
journal_title:Postgraduate medicine
pub_type: 杂志文章,评审
doi:
更新日期:1994-08-01 00:00:00
abstract::Nearly every healthcare reform plan introduced in Congress this year addresses medical malpractice. Although the tort reform goals in the plans may be similar, the methods of achieving them differ substantially. To highlight the areas that need to be resolved, we set up a dialogue between a physician and a plaintiff's...
journal_title:Postgraduate medicine
pub_type: 杂志文章
doi:10.1080/00325481.1994.11945900
更新日期:1994-10-01 00:00:00
abstract::Throughout history, societies have circumscribed certain forms of intimacy in the family setting. Transgression has been punished by force of ecclesiastical rules and government statutes. However, no single definition of incest is widely accepted, as the degree of kinship in which marriage is allowed and the age of co...
journal_title:Postgraduate medicine
pub_type: 杂志文章
doi:10.1080/00325481.1989.11700738
更新日期:1989-06-01 00:00:00
abstract:OBJECTIVES:Our aim was to investigate the association of liver fibrosis and necroinflammation with HS in untreated young patients with chronic hepatitis B (CHB). MATERIALS AND METHODS:A retrospective study was conducted in a military hospital in Turkey. A total of 254 subjects with CHB were included in this study. The...
journal_title:Postgraduate medicine
pub_type: 杂志文章
doi:10.1080/00325481.2016.1221733
更新日期:2016-09-01 00:00:00
abstract::Systolic dysfunction of the heart represents a state of "prerenal" azotemia, in which the excess of total body salt and water is redistributed to venous and interstitial fluid compartments. This results in a diminished effective circulating blood volume and thereby decreases tissue perfusion. The kidneys perceive the ...
journal_title:Postgraduate medicine
pub_type: 杂志文章,评审
doi:
更新日期:1994-06-01 00:00:00
abstract::The cause, depth, and location of a laceration are major determining factors in its treatment. In all cases, the wound must be completely cleansed with irrigation under pressure and then examined radiographically if necessary and debrided. Successful repair depends on understanding and using the principles of wound he...
journal_title:Postgraduate medicine
pub_type: 杂志文章
doi:10.1080/00325481.1988.11700310
更新日期:1988-06-01 00:00:00
abstract::Acute cardiac events involving coronary symptoms, elevated enzyme levels, and electrocardiographic changes without the development of Q waves often result in higher rates of reinfarction and unstable angina than do more severe myocardial infarctions. The incidence of these non-Q wave events is on the rise, possibly be...
journal_title:Postgraduate medicine
pub_type: 杂志文章,评审
doi:10.3810/pgm.2000.02.890
更新日期:2000-02-01 00:00:00
abstract::The majority of patients can be easily weaned from mechanical ventilation, but a substantial minority pose considerable difficulty. In such cases, the cause of ventilator dependency should be identified and correctable factors should be rectified. An organized plan of management, a team approach, optimal pulmonary and...
journal_title:Postgraduate medicine
pub_type: 杂志文章,评审
doi:10.1080/00325481.1991.11700795
更新日期:1991-01-01 00:00:00
abstract::Penile lesions are a discomfiting affliction demanding skillful diagnosis and management by the primary care physician. This article discusses and illustrates 14 common types, delineating characteristics, course, and treatment. ...
journal_title:Postgraduate medicine
pub_type: 杂志文章
doi:10.1080/00325481.1981.11715853
更新日期:1981-09-01 00:00:00
abstract::Diabetic foot infections (DFIs) are a commonly encountered medical problem. They are associated with an increased frequency and length of hospitalization and risk for lower-extremity amputation. Furthermore, they have substantial economic consequences. Patients with diabetes mellitus are particularly susceptible to fo...
journal_title:Postgraduate medicine
pub_type: 杂志文章,评审
doi:10.3810/pgm.2012.03.2541
更新日期:2012-03-01 00:00:00
abstract::Asthma continues to cause unacceptably high rates of disability and death, largely because the severity of disease is underestimated and patients are inadequately educated about their disease. When patients understand what happens during an asthma attack and its aftermath, they are more likely to notice important symp...
journal_title:Postgraduate medicine
pub_type: 指南,杂志文章,评审
doi:10.1080/00325481.1991.11701034
更新日期:1991-09-01 00:00:00
abstract::Diarrhea is a common gastrointestinal problem in diabetes, and its prevalence has been underestimated. The cause of diabetic diarrhea is unknown, but it is probably related to gastrointestinal motility disturbances secondary to diabetic autonomic neuropathy. Other causes (especially primary malabsorption syndromes and...
journal_title:Postgraduate medicine
pub_type: 杂志文章
doi:10.1080/00325481.1992.11701372
更新日期:1992-06-01 00:00:00
abstract::Acute compartment syndrome is a surgical emergency. A high index of suspicion is needed in cases of severe contusion, especially if patient complaints seem to outweigh physical findings. Acute surgical fasciotomy is an effective treatment and should be carried out expeditiously if compartment pressures are elevated ov...
journal_title:Postgraduate medicine
pub_type: 杂志文章,评审
doi:10.3810/pgm.1999.03.599
更新日期:1999-03-01 00:00:00
abstract::Management of patients with diabetes mellitus and chronic kidney disease (CKD) is a challenging task because multiple factors in each condition may impact the other. Glycemic control offers significant benefits in the prevention of diabetic kidney disease (DKD), but other associated morbidities are also important to a...
journal_title:Postgraduate medicine
pub_type: 杂志文章,评审
doi:10.3810/pgm.2009.05.2002
更新日期:2009-05-01 00:00:00
abstract::Several pathologic processes can disturb the complex structures of the eyelids and orbital tissues and the muscles that enable their proper function. Some disorders, such as entropion and ectropion, are usually acquired in later years from laxity of supporting structures. Blepharoptosis has a range of causes, from agi...
journal_title:Postgraduate medicine
pub_type: 杂志文章
doi:10.1080/00325481.1985.11699225
更新日期:1985-12-01 00:00:00
abstract::Chronic pain is considered one of the most prevalent causes of costly and disabling medical conditions. This review will define chronic pain and its categories and then will summarize the effectiveness and side effects associated with the use of various antidepressants, including the tricyclics, the selective serotoni...
journal_title:Postgraduate medicine
pub_type: 杂志文章,评审
doi:10.1080/00325481.2016.1147925
更新日期:2016-01-01 00:00:00
abstract::Physicians must be alert to the possibility of abuse within the family and home. They should be well prepared to help victims begin the transition to a safer environment. An awareness of the prevalence of abuse and a high index of suspicion are the most effective clinical tools for assisting victims of domestic violen...
journal_title:Postgraduate medicine
pub_type: 杂志文章,评审
doi:10.3810/pgm.1996.07.11
更新日期:1996-07-01 00:00:00
abstract::Pseudomonas aeruginosa infections are a frequent cause of morbidity and mortality in hospitalized patients. Treatment of these infections is complicated by the intrinsic and acquired resistance of this bacterium to many commonly used antimicrobial agents. In this article, Drs Hauser and Sriram argue that careful consi...
journal_title:Postgraduate medicine
pub_type: 杂志文章,评审
doi:10.3810/pgm.2005.01.1571
更新日期:2005-01-01 00:00:00
abstract::Patient Notes are indexed alphabetically and by subject. The number immediately following the title is the number of the Patient Note, and the number in parentheses is the date of publication. This index includes all 82 Patient Notes published so far, from February 1, 1988, through this issue. ...
journal_title:Postgraduate medicine
pub_type: 杂志文章
doi:10.1080/00325481.1993.11701589
更新日期:1993-01-01 00:00:00
abstract::Auscultation is the core of pediatric cardiovascular evaluation and should be performed according to a routine. The four heart sounds should be sought in order at their usual locations, with particular attention to the second sound because of its important diagnostic role in congenital cyanotic heart disease. The next...
journal_title:Postgraduate medicine
pub_type: 杂志文章
doi:10.1080/00325481.1982.11716128
更新日期:1982-07-01 00:00:00
abstract::The present staging methods for non-small-cell lung cancer provide little more than epidemiologic assessment of prognosis for grossly defined groups of patients. Except in extreme instances, physicians can tell patients very little about their prognosis or the need for supplemental therapy. More effective and less tox...
journal_title:Postgraduate medicine
pub_type: 杂志文章,评审
doi:10.1080/00325481.1990.11704526
更新日期:1990-01-01 00:00:00
abstract::This article reviews the definition, mechanisms, epidemiology, and clinical sequelae of the metabolic syndrome and explores potential relationships between the metabolic syndrome, type 2 diabetes, and cardiovascular disease. Definitions for the metabolic syndrome proposed by the World Health Organization and the Natio...
journal_title:Postgraduate medicine
pub_type: 杂志文章,评审
doi:10.3810/pgm.12.2003.suppl31.175
更新日期:2003-12-01 00:00:00